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See detailNonlinear vibration absorber coupled to a nonlinear primary system: A tuning methodology
Viguié, Régis ULg; Kerschen, Gaëtan ULg

in Journal of Sound & Vibration (2009), 326(3-5), 780-793

This paper addresses the problem of mitigating the vibration of nonlinear mechanical systems using nonlinear dynamical absorbers. One particular feature of the proposed absorber is that it is effective in ... [more ▼]

This paper addresses the problem of mitigating the vibration of nonlinear mechanical systems using nonlinear dynamical absorbers. One particular feature of the proposed absorber is that it is effective in a wide range of forcing amplitudes. A qualitative tuning methodology is developed and validated using numerical simulations. (C) 2009 Elsevier Ltd. All rights reserved. [less ▲]

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See detailNonlinearity Characterization for Nonlinear Dynamic System Identification Using an Expert Approach
Dimitriadis, Grigorios ULg; Vio, Gareth Arthur

in Proceedings of the 2006 International Conference on Noise and Vibration Engineering (2006, September)

The identification of nonlinear dynamic systems can be rendered significantly more parsimonious if the nonlinearity present in the system is known. While there are many successful non-parametric nonlinear ... [more ▼]

The identification of nonlinear dynamic systems can be rendered significantly more parsimonious if the nonlinearity present in the system is known. While there are many successful non-parametric nonlinear system identification methods, the resulting models do not describe the nonlinearity in physical terms and are difficult to obtain due to the large number of candidate terms that must be examined. In this paper an expert approach towards the characterization of nonlinearities in a dynamic system is presented. The methodology is based on simulations of dynamic systems with a variety of commonly occurring nonlinear functions. The responses of such systems to various types of excitation are analysed and rules are developed as to what nonlinearity is likely to be present in a system given the dynamic characteristics of measured responses. [less ▲]

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See detailNonlocal magnetic field-tuned quantum criticality in cubic CeIn3-xSnx (x=0.25)
Silhanek, Alejandro ULg; Ebihara, Takao; Harrison, N. et al

in Physical Review Letters (2006), 96(20),

We show that antiferromagnetism in lightly (approximate to 8%) Sn-doped CeIn3 terminates at a critical field mu H-0(c)=42 +/- 2 T. Electrical transport and thermodynamic measurements reveal the effective ... [more ▼]

We show that antiferromagnetism in lightly (approximate to 8%) Sn-doped CeIn3 terminates at a critical field mu H-0(c)=42 +/- 2 T. Electrical transport and thermodynamic measurements reveal the effective mass m(*) not to diverge, suggesting that cubic CeIn3 is representative of a critical spin-density wave (SDW) scenario, unlike the local quantum critical points reported in anisotropic systems such as CeCu6-xAux and YbRh2Si2-xGex. The existence of a maximum in m(*) at a lower field mu H-0(x)=30 +/- 1 T may be interpreted as a field-induced crossover from local moment to SDW behavior as the Neel temperature falls below the Fermi temperature. [less ▲]

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See detailNonmyeloablative allogeneic hematopoietic stem cell transplantation.
Baron, Frédéric ULg; Beguin, Yves ULg

in Journal of Hematotherapy & Stem Cell Research (2002), 11(2), 243-63

Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger and fitter patients. These observations led several groups to set up new (less toxic) transplant protocols (nonmyeloablative stem cell transplantation or NMSCT) based on a two-step approach: first, the use of immunosuppressive (but nonmyeloablative) preparative regimens providing sufficient immunosuppression to achieve engraftment of allogeneic hematopoietic stem cells and, in a second step, destruction of malignant cells by the GVL effect. Preliminary results showed that NMSCT were feasible with a relatively low transplant-related mortality (TRM), even in patients older than 65 years. In addition, strong antitumor responses were observed in several hematological malignancies as well as in some patients with renal cell carcinoma. After discussing the mechanisms and efficacy of the GVL effect as well as the rationale for NMSCT strategies, this article reviews the first results of ongoing clinical trials. Innovative modalities that may permit amplification of the GVL effect while minimizing the risk of GVHD are discussed. Because the benefits of NMSCT over alternative forms of treatment remain to be demonstrated, this strategy should be restricted to patients included in clinical trials. [less ▲]

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See detailNonmyeloablative stem cell transplantation with CD8-depleted or CD34-selected peripheral blood stem cells.
Baron, Frédéric ULg; Baudoux, Etienne ULg; Frere, Pascale ULg et al

in Journal of Hematotherapy & Stem Cell Research (2002), 11(2), 301-14

To decrease the incidence of graft-versus-host disease (GVHD) observed after nonmyeloablative stem cell transplantation (NMSCT), we studied the feasibility of CD8-depleted or CD34-selected NMSCT followed ... [more ▼]

To decrease the incidence of graft-versus-host disease (GVHD) observed after nonmyeloablative stem cell transplantation (NMSCT), we studied the feasibility of CD8-depleted or CD34-selected NMSCT followed by CD8-depleted preemptive donor lymphocyte infusion (DLI) given in incremental doses on days 40 and 80. Fourteen patients with high-risk malignancies and an HLA-identical sibling (n = 8) or alternative donor (n = 6) but ineligible for a conventional transplant were included. Nonmyeloablative conditioning regimen consisted in 2 Gy total body irradiation (TBI) alone, 2 Gy TBI and fludarabine (previously untreated patients) or cyclophosphamide and fludarabine (patients who had previously received > or =12 Gy TBI). Patients 1-4 (controls) received unmanipulated peripheral blood stem cells (PBSC) and DLI and patients 5-14 CD8-depleted or CD34-selected PBSC followed by CD8-depleted DLI. Post-transplant immunosuppression was carried out with cyclosporine A (CsA) and mycophenolate mofetil (MMF). Initial engraftment was seen in all patients, but 1 patient (7%) later rejected her graft. The actuarial 180-day incidence of grades II-IV acute GVHD was 75% for patients 1-4 versus 0% for patients 5-14 (p = 0.0019). Five of 14 patients were in complete remission (CR) 180 days after the transplant and 6/14 had partial responses. The 1-year survival rate was 69%, and nonrelapse and relapse mortality rates were 16 and 18%, respectively. We conclude that CD8-depleted or CD34-selected NMSCT followed by CD8-depleted DLI is feasible and considerably decreases the incidence of acute GVHD while preserving engraftment and apparently also the graft-versus-leukemia (GVL) effect. Further studies are needed to confirm this encouraging preliminary report. [less ▲]

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See detailNonmyeloablative Transplantation
Baron, Frédéric ULg; Sandmaier, Brenda

in Hematopoietic Stem Cell Transplantation (2008)

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See detailNonnius et la cure de Spa
Marganne, Marie-Hélène ULg; Mélard, Marc; Lecomte, Jean et al

in Nonnius en de 'Diëtetiek'. Derde Symposium Geschiedenis der Geneeskundige Wetenschappen, 2 december 1995, Koninklijke Academie voor Genneeskunde van België (1996)

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See detailNonparametric additive location-scale models for interval censored data
Lambert, Philippe ULg

in Statistics and computing (2013), 23

An nonparametric additive model for the location and dispersion of a continuous response with an arbitrary smooth conditional distribution is proposed. B-splines are used to specify the three components ... [more ▼]

An nonparametric additive model for the location and dispersion of a continuous response with an arbitrary smooth conditional distribution is proposed. B-splines are used to specify the three components of the model. It can deal with interval censored data and multiple covariates. After a simulation study, the relation between age, the number of years of full-time education and the net income (provided as intervals) available per person in Belgian households is studied from survey data. [less ▲]

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See detailNonparametric censored regression using preliminary kernel smoothing
Heuchenne, Cédric ULg; Van Keilegom, Ingrid

in Proceedings of the 6th World Congress of the Bernoulli Society for Mathematical Statistics and Probability and the 67th Annual Meeting of the IMS (2004)

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See detailNonparametric Mean Preservation in Censored Regression
Heuchenne, Cédric ULg

Book published by VDM Verlag (2009)

The aim of this book is to estimate the conditional mean of some functions depending on the response variable Y (moments, distributions...) in regression models where this response is possibly censored ... [more ▼]

The aim of this book is to estimate the conditional mean of some functions depending on the response variable Y (moments, distributions...) in regression models where this response is possibly censored. In parametric regression, polynomial and nonlinear conditional means are estimated in a new way while, in nonparametric regression, some new estimators are provided to approximate general L-functionals (conditional mean, trimmed mean, quantiles...). The ideas developed in those methods lead to establish more general results in nonparametric estimation of the conditional mean of functions depending on Y and other variables and where the response can follow other schemes of incomplete data (not only censored but also missing or length-biased data). For each procedure, asymptotic properties are established while finite sample behavior is studied via simulations. Examples from a variety of areas highlight the interest of using the proposed methodologies in practice. [less ▲]

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See detailNonparametric regression with cross-sectional data: an alternative to conditional product-limit estimators
Heuchenne, Cédric ULg; Laurent, Géraldine ULg

E-print/Working paper (2014)

Suppose the random vector (X,Y) satisfies the nonparametric regression model Y=m(X)+varepsilon, where m(x)=E[Y|X=x] and sigma²(x)=Var[varepsilon|X=x] are unknown smooth functions and the error varepsilon ... [more ▼]

Suppose the random vector (X,Y) satisfies the nonparametric regression model Y=m(X)+varepsilon, where m(x)=E[Y|X=x] and sigma²(x)=Var[varepsilon|X=x] are unknown smooth functions and the error varepsilon has zero mean and finite variance conditionally on X=x. The pair (X,Y) is obtained by cross-sectional sampling involving left-truncated and right-censored responses. The considered model is completely nonparametric but the conditional truncation distribution is assumed to be known. The novelty of this work is twofold: first, it extends the results on cross-sectional data to the conditional case and second, it generalizes the length bias results in the conditional case to right censoring and to any truncation distribution. New estimators for m(.) and sigma²(.) are constructed and relevant tools are used to quickly provide the main asymptotic properties for this kind of estimators. Extensive simulations are carried out and show that the new estimators outperform classical nonparametric estimators for left-truncated and right-censored data (when the truncation model is known). Finally, a data set on the mortality of diabetics is analyzed. [less ▲]

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See detailNonparametric regression with parametric selection bias
Heuchenne, Cédric ULg; Laurent, Géraldine ULg

in Proceedings of the 14th Conference of the ASMDA International Society (ASMDA2011) (2011, June)

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See detailNonparametric subspace identification of nonlinear structures - Application to a spacecraft
Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Proceedings of the 54th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference (2013, April)

The objective of the present paper is to address the identification of a strongly nonlinear satellite structure by exploiting a new nonlinear subspace identification method formulated in the frequency ... [more ▼]

The objective of the present paper is to address the identification of a strongly nonlinear satellite structure by exploiting a new nonlinear subspace identification method formulated in the frequency domain, referred to as the FNSI method. The modal parameters of the underlying linear structure and the coefficients of the nonlinear internal forces will be estimated by this approach. Moreover, because a priori knowledge about nonlinear behaviour may be limited, the paper also proposes a nonparametric spline-based modelling strategy, encapsulated in the FNSI method. The application of interest is the SmallSat spacecraft developed by EADS-Astrium, which possesses an impact-type nonlinear device consisting of eight mechanical stops limiting the motion of an inertia wheel mounted on an elastomeric interface. [less ▲]

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See detailNonpharmacological management
Bruyère, Olivier ULg

in Osteoporosis International (2013, April), 24(Suppl.1), 76

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See detailNonPharmacological modalities, nutraceuticals and dietary supplements as therapies
Henrotin, Yves ULg; Marty, Marc; Mobasheri, Ali

in Future medicine (2012)

This chapter discusses and critically appraises the nonpharmacological approaches that are currently available

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See detailNonpharmacological Therapies in the Management of Osteoarthritis
Henrotin, Yves ULg

Book published by Bentham Science Publishers Ltd. (2012)

Detailed reference viewed: 23 (3 ULg)