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See detailNicolas DOR, interview pt 6 : D'un Stardust de trop à N.Dor chanteur de jazz
Sacré, Robert ULg

Article for general public (1993)

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See detailNicolas Martella/ stratège des ressources humaines:note pédagogique
Robert, Jocelyne ULg

Learning material (2010)

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See detailNicolas Martella:stratège des ressources humaines-cas pédagogique
Robert, Jocelyne ULg

in Revue internationale de cas en gestion (2010), 8

Detailed reference viewed: 147 (14 ULg)
See detailNicolas Pietkin et Joseph Bastin
Droixhe, Daniel ULg

in Lejeune, R.; Stiennon, J. (Eds.) La Wallonie, le pays et les hommes : Lettres, arts-culture. Tome III (1979)

Detailed reference viewed: 38 (2 ULg)
See detailNicolas Sarkozy sur le yacht de Vincent Bolloré : étonnant, arrogant, indécent ?
Geuens, Geoffrey ULg

Article for general public (2007)

Detailed reference viewed: 49 (14 ULg)
See detailNicolas, à micros fermés pt 2
Sacré, Robert ULg

Article for general public (1992)

Interview de Nicoalas DOR, pt 2 : Jazz blanc...jazz noir

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See detailNicoletta CHERUBINI, Pierre nue, poème-légende des photographies de Nguyen Van Thong
Tilkin, Françoise ULg

in Catalogue de l'exposition Pierres nues (Liège, du 26 mai au 30 juin 1984) (1984)

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See detailNicotinamide enhances apoptosis of G(M)-CSF-treated neutrophils and attenuates endotoxin-induced airway inflammation in mice.
Fernandes, Claudia A.; Fievez, Laurence ULg; Ucakar, Bernard et al

in American journal of physiology. Lung cellular and molecular physiology (2011), 300(3), 354-61

Neutrophils constitute the first line of host defense against invading microorganisms. Yet their removal from the inflammatory environment is fundamental for injury restraint and resolution of ... [more ▼]

Neutrophils constitute the first line of host defense against invading microorganisms. Yet their removal from the inflammatory environment is fundamental for injury restraint and resolution of inflammation. Nicotinamide, a component of vitamin B(3), is known to modulate cell survival. In this study, we assessed the influence of nicotinamide on neutrophil apoptosis, both in vitro and in vivo in a mouse model of endotoxin-induced lung inflammation. In vitro, nicotinamide promoted apoptosis of human blood neutrophils in a dose-dependent manner in the presence of the apoptosis inhibitors granulocyte colony-stimulating factor and granulocyte/macrophage colony-stimulating factor. The highest concentration of nicotinamide completely neutralized the pro-survival effect of granulocyte (macrophage) colony-stimulating factor. Nicotinamide proapoptotic effect was associated with enhanced caspase-3 activity. In addition, nicotinamide slightly reduced neutrophil chemotaxis in vitro. In vivo, pulmonary nicotinamide delivery decreased the levels of cellular and biochemical inflammation markers and increased the percentage of apoptotic neutrophils in bronchoalveolar lavages. Our findings suggest that nicotinamide is an apoptotic stimulus for neutrophils, thereby contributing to the resolution of neutrophilic inflammation in the lungs. [less ▲]

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See detailNicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress.
Rongvaux, Anthony; Galli, Mara; Denanglaire, Sebastien et al

in Journal of Immunology (2008), 181(7), 4685-4695

Nicotinamide phosphoribosyl transferase (Nampt)/pre-B cell colony-enhancing factor (PBEF)/visfatin is a protein displaying multiple functional properties. Originally described as a cytokine-like protein ... [more ▼]

Nicotinamide phosphoribosyl transferase (Nampt)/pre-B cell colony-enhancing factor (PBEF)/visfatin is a protein displaying multiple functional properties. Originally described as a cytokine-like protein able to regulate B cell development, apoptosis, and glucose metabolism, this protein also plays an important role in NAD biosynthesis. To gain insight into its physiological role, we have generated a mouse strain expressing a conditional Nampt allele. Lack of Nampt expression strongly affects development of both T and B lymphocytes. Analysis of hemizygous cells and in vitro cell lines expressing distinct levels of Nampt illustrates the critical role of this protein in regulating intracellular NAD levels. Consequently, a clear relationship was found between intracellular Nampt levels and cell death in response to the genotoxic agent MNNG (N-methyl-N'-nitro-N-nitrosoguanidine), confirming that this enzyme represents a key regulator of cell sensitivity to NAD-consuming stress secondary to poly(ADP-ribose) polymerases overactivation. By using mutant forms of this protein and a well-characterized pharmacological inhibitor (FK866), we unequivocally demonstrate that the ability of the Nampt to regulate cell viability during genotoxic stress requires its enzymatic activity. Collectively, these data demonstrate that Nampt participates in cellular resistance to genotoxic/oxidative stress, and it may confer to cells of the immune system the ability to survive during stressful situations such as inflammation. [less ▲]

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See detailNicotine restores endothelial dysfunction caused by excess sFlt1 and sEng in an in vitro model of preeclamptic vascular endothelium: a possible therapeutic role of nicotinic acetylcholine receptor (nAChR) agonists for preeclampsia.
Mimura, Kazuya; Tomimatsu, Takuji; Sharentuya, Namuxila et al

in American Journal of Obstetrics and Gynecology (2010), 202(5), 4641-6

OBJECTIVE: In this study we tested the hypothesis that nicotine restores proangiogenic functions to endothelial cells pretreated with soluble fms-like tyrosine kinase 1 and/or soluble endoglin. STUDY ... [more ▼]

OBJECTIVE: In this study we tested the hypothesis that nicotine restores proangiogenic functions to endothelial cells pretreated with soluble fms-like tyrosine kinase 1 and/or soluble endoglin. STUDY DESIGN: Wound healing assay and tube formation assay were performed using human umbilical vein endothelial cells treated with nicotine (10(-9) to 10(-6) M), and with various combinations of soluble fms-like tyrosine kinase 1 (100 ng/mL), soluble endoglin (100 ng/mL), and nicotine (10(-7) M). Enzyme-linked immunosorbent assay was performed to measure vascular endothelial growth factor, placental growth factor, and transforming growth factor-beta1 concentrations in the conditioned media treated with nicotine (10(-9) to 10(-6) M). RESULTS: Nicotine significantly facilitated endothelial migration and tube formation. By contrast, soluble fms-like tyrosine kinase 1 and/or soluble endoglin suppressed these endothelial functions. Nicotine restored these soluble fms-like tyrosine kinase 1 and/or soluble endoglin-reduced endothelial functions. Placental growth factor, but not transforming growth factor-beta1, production was significantly stimulated by the presence of nicotine. Vascular endothelial growth factor was undetectable. CONCLUSION: Our results suggest a possible mechanism for the protective effects of cigarette smoking against preeclampsia, thus proposing a therapeutic potential of nicotine or other nicotinic acetylcholine receptor agonists for preeclampsia. [less ▲]

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See detailNicotine restores endothelial dysfunction caused by excess sFLT1 and sEng in in vitro model pf preeclamptic vascular endothelium
Mimura, Kazuya; Tomimatsu, Takuji; Sharentuya, Namuxila et al

Poster (2009)

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See detailNicotine suppresses interleukin-6 production from vascular endothelial cells
Tomimatsu, Takuji; Sharentuya, Namuxila; Mimura, Kazuya et al

Poster (2009)

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See detailNicotine suppresses interleukin-6 production from vascular endothelial cells: a possible therapeutic role of nicotine for preeclampsia.
Sharentuya, Namuxila; Tomimatsu, Takuji; Mimura, Kazuya et al

in Reproductive Sciences (2010), 17(6), 556-63

Normal pregnancy is the controlled state of inflammation and this systemic inflammatory response is reported to be more intense in preeclampsia. The current study tested the hypothesis that maternal serum ... [more ▼]

Normal pregnancy is the controlled state of inflammation and this systemic inflammatory response is reported to be more intense in preeclampsia. The current study tested the hypothesis that maternal serum stimulates interleukin 6 (IL-6) production from endothelial cells and that nicotine inhibits these effects. Human umbilical vein endothelial cells (HUVECs) were incubated with or without 0.5% serum from healthy pregnant women at term (n = 5) and treated with or without nicotine (10(-9) to 10(-6) mol/L) in the presence of 0.5% serum. Cell survival was determined by colorimetric assay. Interleukin 6 concentration and nuclear transcription factor kappa B (NF-kB) activities were determined by enzyme-linked immunosorbent assay (ELISA)-based method. Interleukin 6 production by endothelial cells was significantly stimulated in the presence of maternal serum. Nicotine significantly preserved cell survival and suppressed IL-6 production from endothelial cells. Nicotine also significantly inhibited NF-kB activation in endothelial cells. Nicotine inhibited inflammatory reaction through NF-kB suppression in vitro model of maternal vascular endothelium, and this effect may be one of the explanations for the reduced risk of preeclampsia in smokers. [less ▲]

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See detailNicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials
lukasova, Martina; Hanson, Julien ULg; Tunaru, Sorin et al

in Trends in Pharmacological Sciences (2011)

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See detailNicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.
Hanson, Julien ULg; Gille, Andreas; Zwykiel, Sabrina et al

in Journal of Clinical Investigation (2010), 120(8), 2910-9

The antidyslipidemic drug nicotinic acid and the antipsoriatic drug monomethyl fumarate induce cutaneous flushing through activation of G protein-coupled receptor 109A (GPR109A). Flushing is a troublesome ... [more ▼]

The antidyslipidemic drug nicotinic acid and the antipsoriatic drug monomethyl fumarate induce cutaneous flushing through activation of G protein-coupled receptor 109A (GPR109A). Flushing is a troublesome side effect of nicotinic acid, but may be a direct reflection of the wanted effects of monomethyl fumarate. Here we analyzed the mechanisms underlying GPR109A-mediated flushing and show that both Langerhans cells and keratinocytes express GPR109A in mice. Using cell ablation approaches and transgenic cell type-specific GPR109A expression in Gpr109a-/- mice, we have provided evidence that the early phase of flushing depends on GPR109A expressed on Langerhans cells, whereas the late phase is mediated by GPR109A expressed on keratinocytes. Interestingly, the first phase of flushing was blocked by a selective cyclooxygenase-1 (COX-1) inhibitor, and the late phase was sensitive to a selective COX-2 inhibitor. Both monomethyl fumarate and nicotinic acid induced PGE2 formation in isolated keratinocytes through activation of GPR109A and COX-2. Thus, the early and late phases of the GPR109A-mediated cutaneous flushing reaction involve different epidermal cell types and prostanoid-forming enzymes. These data will help to guide new efficient approaches to mitigate nicotinic acid-induced flushing and may help to exploit the potential antipsoriatic effects of GPR109A agonists in the skin. [less ▲]

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See detailNiederländisch : Ein Sprachkurs für Schule, Beruf und Weiterbildung
Hennen, K.-H.; Neukirch, R.; Vromans, Joseph ULg et al

Book published by Max Hueber Verlag (1988)

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See detailNiederländisch : Ein Sprachkurs für Schule, Beruf und Weiterbildung. Arbeitsbuch
Hennen, K.-H.; Neukirch, R.; Vromans, Joseph ULg et al

Book published by Max Hueber Verlag (1989)

Detailed reference viewed: 15 (2 ULg)
See detailNiederländisch : Ein Sprachkurs für Schule, Beruf und Weiterbildung. Lehrerhandbuch
Hennen, K.-H.; Neukirch, R.; Vromans, Joseph ULg et al

Book published by Max Hueber Verlag (1989)

Detailed reference viewed: 9 (0 ULg)
See detailNiedrigviskose allophanate mit aktinisch härtbaren gruppen
Detrembleur, Christophe ULg; Weikard, Jan; Greszta-Franz, Dorota et al

Patent (2010)

Die vorliegende Erfindung betrifft niedrigviskose Umsetzungsprodukte von Polyisocyanaten, die aktivierte unter Einwirkung aktinischer Strahlung mit ethylenisch ungesättigten Verbindungen unter ... [more ▼]

Die vorliegende Erfindung betrifft niedrigviskose Umsetzungsprodukte von Polyisocyanaten, die aktivierte unter Einwirkung aktinischer Strahlung mit ethylenisch ungesättigten Verbindungen unter Polymerisation reagierende Gruppen enthalten, ein Verfahren zu ihrer Herstellung sowie deren Verwendung in Beschichtungsmitteln. [less ▲]

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See detailNiedrigviskose allophanate mit aktinisch härtbaren gruppen
Greszta-Frank, Dorota; Detrembleur, Christophe ULg; Weikard, Jan et al

Patent (2011)

Die vorliegende Erfindung betrifft niedrigviskose Umsetzungsprodukte von Polyisocyanaten, die aktivierte unter Einwirkung aktinischer Strahlung mit ethylenisch ungesättigten Verbindungen unter ... [more ▼]

Die vorliegende Erfindung betrifft niedrigviskose Umsetzungsprodukte von Polyisocyanaten, die aktivierte unter Einwirkung aktinischer Strahlung mit ethylenisch ungesättigten Verbindungen unter Polymerisation reagierende Gruppen enthalten, ein Verfahren zu ihrer Herstellung sowie deren Verwendung in Beschichtungsmitteln. [less ▲]

Detailed reference viewed: 28 (4 ULg)