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See detailMRI of a presumptive trigeminal nerve tumor in a seven years old husky dog : a case report and review of the litterature
Saunders, J.; Clercx, Cécile ULg; Poncelet, Luc et al

in Veterinary Radiology & Ultrasound (1998), 39

Detailed reference viewed: 32 (0 ULg)
See detailMRI of intranasal tumors in dogs
Snaps, Frédéric ULg; Clercx, Cécile ULg; D'Harcour et al

Conference (1997)

Detailed reference viewed: 10 (5 ULg)
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See detailMRI of the normal tarsal joint in dogs
Lacroix; Trenteseaux; Francois et al

Poster (2001)

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See detailMRI preclinical detection and asymptomatic course of a progressive multifocal leucoencephalopathy (PML) under natalizumab therapy.
Phan-Ba, Rémy ULg; LOMMERS, Emilie ULg; TSHIBANDA, Luaba ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (2012), 83

Early detection of progressive multifocal leucoencephalopathy (PML) in the setting of natalizumab therapy currently is performed by rapid evaluation of new symptoms occurring in treated patients. The role ... [more ▼]

Early detection of progressive multifocal leucoencephalopathy (PML) in the setting of natalizumab therapy currently is performed by rapid evaluation of new symptoms occurring in treated patients. The role of MR scanning has not been investigated but holds promise since MR detection is highly sensitive for PML lesions. The authors report a case of presymptomatic PML of the posterior fossa detected by MR scans. Immediate suspension of natalizumab and plasma exchanges resulted in a rapid decline of natalizumab serum concentration. Intravenous steroids started together with plasma exchanges followed by an oral tapering course were used to minimise the immune reconstitution inflammatory syndrome. No symptoms (beyond mild headache) developed, and the repeat PCR for JC Virus (JCV) DNA detection performed 10 weeks later was negative. This case suggests that: (1) periodic brain MR scans may detect signs of presymptomatic PML in MS patients treated with natalizumab, (2) corticosteroid management of inflammatory reaction may contribute to optimal control of the immune reconstitution inflammatory syndrome routinely seen with natalizumab-associated PML and (3) early radiological detection of PML can have an excellent outcome even in a clinically critical region and despite prior immunosuppressant exposure. The potential benefit of regular MR scanning just using the T2/FLAIR modalities could be further investigated in order to detect early natalizumab-associated PML, leading to benign outcomes. [less ▲]

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See detailAn MRI study of the effect of treadmill training on bone morphology of the central and third tarsal bones of young Thoroughbred horses
Whitton, R. C.; Murray, R. C.; Buckley, C. et al

in Equine Veterinary Journal. Supplement (1999), 30

Training results in marked modelling of the subchondral bone of the carpus, but the effect of training on the subchondral bone of the distal tarsal joints is unknown. The aim of this study was to ... [more ▼]

Training results in marked modelling of the subchondral bone of the carpus, but the effect of training on the subchondral bone of the distal tarsal joints is unknown. The aim of this study was to determine whether training influenced modelling of the third and central tarsal bones in Thoroughbred horses. Twelve untrained Thoroughbred horses were divided into 2 groups. Group 1 underwent a 19 week progressive training regimen on a high speed treadmill. Group 2 were walked for 40 min daily. Images of left tarsi were obtained by magnetic resonance imaging (MRI) with a 0.5 Tesla superconducting magnet using a spin echo sequence. Sagittal and oblique sagittal slices were made perpendicular to the articular surfaces of the intertarsal joints and were analysed using image analysis software to measure the proportion of dense subchondral bone in the dorsal facet of each bone. Mean +/- s.d. percentage area of dense subchondral bone in the dorsal facet of the central tarsal bone in Group 1 was 47 +/- 8 medially, 46 +/- 4 sagitally and 50 +/- 11 dorsolaterally, whereas in Group 2 it was 39 +/- 16 medially, 43 +/- 8 sagitally and 53 +/- 7 dorsolaterally. For the third tarsal bone mean +/- s.d. percentage area of dense subchondral bone in Group 1 was 32 +/- 10 medially, 39 +/- 11 sagitally and 44 +/- 8 dorsolaterally, whereas in Group 2 it was 28 +/- 8 medially, 37 +/- 6 sagitally and 41 +/- 9 dorsolaterally. There was no significant difference in percentage area of dense subchondral bone between the trained and untrained horses. An effect of treadmill training of Thoroughbred horses on modelling of the central and third tarsal bones could not be demonstrated. [less ▲]

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See detailMri-Pathological Correlations in Acute Traumatic Central Cord Syndrome: Case Report
Martin, Didier ULg; Schoenen, Jean ULg; Lenelle, Jacques ULg et al

in Neuroradiology (1992), 34(4), 262-6

Ante- and post-mortem MRI and detailed pathological examination were performed in a patient with a typical acute traumatic central cord syndrome (ATCCS) after a minor hyperextension injury to the neck who ... [more ▼]

Ante- and post-mortem MRI and detailed pathological examination were performed in a patient with a typical acute traumatic central cord syndrome (ATCCS) after a minor hyperextension injury to the neck who died 60 h later from heart failure. T2-weighted MRI showed a central hyperintense area at C3-4. There were disc protrusions, but no vertebral fracture or displacement. Histopathology disclosed severe axonal swelling and oedema in the dorsolateral fasciculi and, to a lesser degree, in the dorsal columns. In addition, an area of recent necrosis was found in the right anterior horn at C4-5. These findings suggest that the pathological hallmark of typical ATCCS is mechanical axonal disruption at a segmental level, but that more severe trauma may be accompanied by tissue destruction. [less ▲]

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See detailMrozenie nasienia u koni - stan obecny i perspektywy
Ponthier, Jérôme ULg

in Gajewski, Zdsislaw; Malinowski, Edward; Wehrend, Axel (Eds.) Rozrod Koni: aktualne poglady (2011, November 19)

Aim of this paper is to review equine semen freezing procedures. Spermatozoa formation inside the testis, spermatozoa anatomy and physiology will be summarized, highlighting structures and/or functions ... [more ▼]

Aim of this paper is to review equine semen freezing procedures. Spermatozoa formation inside the testis, spermatozoa anatomy and physiology will be summarized, highlighting structures and/or functions injured during freezing/thawing process. Current quality standards will be defined for fresh and thawed semen with a special attention on total and progressive motilities and different definitions of these parameters in literature. New ways of semen analysis (as flow cytometry) will be discussed for their scientific and clinical implications. Freezing procedures will and new freezing procedures will be discussed. Future developments and progress in freezing methods will be exposed, as prediction of post-thaw semen quality on fresh semen basis, improvement of freezing extenders and prevention of reactive oxygen species effects. [less ▲]

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See detailMrs Gandhi's Final Term and the Remaking of the Congress (I)'s Social Base
Maiorano, Diego ULg

in India Review (2012), 11(1),

This article examines the impact that national economic policies adopted during Indira Gandhi's final term in office (1980–84) had on four “national” social groups, namely the big industrialists, the ... [more ▼]

This article examines the impact that national economic policies adopted during Indira Gandhi's final term in office (1980–84) had on four “national” social groups, namely the big industrialists, the middle class, the rich peasantry, and the poor. The study argues that the Congress (I) chose the former two as its major allies, while the rich peasantry and the poor were relegated to a secondary position. In the process, the focus of India's strategy of development shifted from the agrarian to the industrial sector, and from the rural to the urban world. [less ▲]

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See detailLes MRSA et la peau. Nouveaux visages des HAMRSA, des CAMRSA et des PAMRSA.
Devillers, Céline; Pierard-Franchimont, Claudine ULg; Henry, Frédérique ULg et al

in Skin (2008), 11

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See detailMRSA, une menace réelle, un défit persistant !
MELIN, Pierrette ULg

Scientific conference (1994, April)

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See detailMRSA: le point de vue du bactériologiste
Bardiau, Marjorie ULg

Conference (2013, January)

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See detailMSC in clinics: Liver Transplantation
DETRY, Olivier ULg

Conference (2014, March 21)

For several years, mesenchymal stem cells (MSC) have been evaluated in vivo and in vitro for their immunomodulatory, anti-inflammatory, anti- ischemia-reperfusion injury and “tissue repair” properties ... [more ▼]

For several years, mesenchymal stem cells (MSC) have been evaluated in vivo and in vitro for their immunomodulatory, anti-inflammatory, anti- ischemia-reperfusion injury and “tissue repair” properties. These characteristics could make them interesting in various clinical applications, and particularly in organ transplantation. Taking advantage of our centre expertise and experience concerning MSC use in graft-versus-host disease after bone marrow transplantation and using already functioning GMP-compliant laboratory able to produce clinical-grade MSC, we initiated in 2011 a first trial exploring safety and tolerability of third party MSC infusions after kidney or liver transplantation in a prospective phase I-II study. In this study, after successful transplantation, 10 liver and 10 kidney transplant recipients under standard immunosuppressive treatment (tacrolimus, mycophenolate, steroids) receive an intravenous infusion of 1.5 - 3x106/kg of third-party MSC, on post-operative day 3+/-2. These patients are prospectively compared to the same number of liver and kidney transplant recipients who meet inclusion criteria but do not receive MSC infusion. Safety is assessed by recording side effects, including opportunistic infections and cancers. Immunosuppressive potential is evaluated by rejection episode rates, graft/patient survivals, immunohistology of 3-month (kidney) and 6-month (liver) graft biopsies, and in vitro evaluation of recipient immunity profile. In a second step, reduction (kidney) and progressive weaning (liver) of immunosuppression is attempted in recipients who received MSC. Inclusion of liver patients is now complete, and to date 3 kidney patients received MSC. Primary results will be presented, and complete 6-month liver results are expected for the end of 2014. The next step will be to assert the immunosuppressive potential of MSC after organ transplantation, and the opportunity to develop larger randomised, controlled, phase III trials. [less ▲]

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See detailMSH2 gene dosage mediates azathioprine-induced carcinogenesis in mice
Chalastanis, A.; Penard-Lacronique, V.; Svrcek, M. et al

in Journal of the National Cancer Institute (2010)

Detailed reference viewed: 61 (34 ULg)
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See detailMT-ClustalW: Multithreading multiple sequence alignment
Chaichoompu, Kridsadakorn ULg; Kittitornkun, S.; Tongsima, S.

in the 20th International Parallel and Distributed Processing Symposium, 2006 (IPDPS 2006) (2006, April)

ClustalW is the most widely used tool for aligning multiple protein or nucleotide sequences. The alignment is achieved via three stages: pairwise alignment, guide tree generation and progressive alignment ... [more ▼]

ClustalW is the most widely used tool for aligning multiple protein or nucleotide sequences. The alignment is achieved via three stages: pairwise alignment, guide tree generation and progressive alignment. This paper analyzes and enhances a multithreaded implementation of ClustalW called ClustalW-SMP for higher throughput. Our goal is to maximize the degree of parallelism on multithreading ClustalW called MultiThreading-ClustalW (MT-ClustalW). As a result, bioinformatics laboratories are able to use this MT-ClustalW with much less energy consumption on multicore and SMP (Symmetric Multiprocessor) machines than that of PC clusters. The experiment results show that the MT-ClustalW framework can achieve a considerable speedup over the sequential ClustalW and original multithreaded ClustalW-SMP implementations. © 2006 IEEE. [less ▲]

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See detailMT-MMP Expression and localisation in human lung and breast cancers
Polette, M.; Nawrocki-Raby, B.; Gilles, Christine ULg et al

in Virchows Archiv : An International Journal of Pathology (1996), 428(1), 29-35

Thirteen primary pulmonary squamous cell carcinomas, 4 specimens of normal lung from around tumours, 4 benign proliferations of the mammary gland and 16 breast carcinomas were analysed by in situ ... [more ▼]

Thirteen primary pulmonary squamous cell carcinomas, 4 specimens of normal lung from around tumours, 4 benign proliferations of the mammary gland and 16 breast carcinomas were analysed by in situ hybridisation. Northern blot and immunohistochemistry for the expression of a recently described metalloproteinase (MMP), the MT-MMP (membrane-type matrix metalloproteinase). This MT-MMP can activate gelatinase A, involved in the degradation of basement membranes. In situ hybridisation revealed MT-MMP transcripts distributed in both tumour and stromal cells in squamous cell lung cancers, whereas these mRNAs were principally detected in stromal cells in close contact to tumour clusters in breast carcinomas and in lung adenocarcinomas. Northern blot analysis showed a parallel expression of MT-MMP and gelatinase A transcripts in both lung and breast cancers. Immunohistochemistry displayed a more extensive distribution of MT-MMP in pulmonary and mammary carcinomas with numerous labelled preinvasive and infiltrating cancer cells and stromal cells near the tumour cells. The large degree of expression of MT-MMP in these cancers indicates a potential role of this enzyme in tumour progression. The finding of MT-MMP transcripts in stromal cells in the vicinity of lung and breast tumour cells emphasises the cooperation between these cells and cancer cells for the expression of MT-MMP and in tumour invasion in vivo. [less ▲]

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See detailMT-MMPs as regulators of vessel stability associated with angiogenesis
Sounni, Nor Eddine ULg; Paye, Alexandra ULg; Host, Lorin et al

in Frontiers in Pharmacology of Anti-Cancer Drugs (2011), 2:111

The development of vascular system depends on the coordinated activity of a number of distinct families of molecules including growth factors and their receptors, cell adhesion molecules, extracellular ... [more ▼]

The development of vascular system depends on the coordinated activity of a number of distinct families of molecules including growth factors and their receptors, cell adhesion molecules, extracellular matrix (ECM) molecules, and proteolytic enzymes. Matrix metalloproteases (MMPs) are a family of ECM degrading enzymes required for both physiological and pathological angiogenesis. Increasing evidence, point to a direct role of membrane type-MMPs (MT-MMPs) in vascular system stabilization, maturation, and leakage. Our understanding of the nature of MT-MMP interaction with extracellular and cell surface molecules and their multiple roles in vessel walls and perivascular stroma may provide new insights into mechanisms underlying vascular cell-ECM interactions and cell fate decisions in pathological conditions. Regulation of vascular leakage by MT-MMP interactions with the ECM could also lead to novel targeting opportunities for drug delivery in tumor. This review will shed lights on the emerging roles of MT1-MMP and MT4-MMP in vascular system alterations associated with cancer progression. [less ▲]

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See detailMT1-MMP expression promotes tumor growth and angiogenesis
Sounni, Nor Eddine ULg

Conference (2001, April 19)

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See detailMT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression
Sounni, Nor Eddine ULg; Devy, L.; Hajitou, A. et al

in FASEB Journal (2002), 16(6), 555-564

Membrane type 1 metalloprotease (MT1-MMP) is a transmembrane metalloprotease that plays a major role in the extracellular matrix remodeling, directly by degrading several of its components and indirectly ... [more ▼]

Membrane type 1 metalloprotease (MT1-MMP) is a transmembrane metalloprotease that plays a major role in the extracellular matrix remodeling, directly by degrading several of its components and indirectly by activating pro-MMP2. We investigated the effects of MT1-MMP overexpression on in vitro and in vivo properties of human breast adenocarcinoma MCF7 cells, which do not express MT1-MMP or MMP-2. MT1-MMP and MMP-2 cDNAs were either transfected alone or cotransfected. All clones overexpressing MT1-MMP 1) were able to activate endogenous or exogenous pro-MMP-2, 2) displayed an enhanced in vitro invasiveness through matrigel-coated filters independent of MMP-2 transfection, 3) induced the rapid development of highly vascularized tumors when injected subcutaneously in nude mice, and 4) promoted blood vessels sprouting in the rat aortic ring assay. These effects were observed in all clones overexpressing MT1-MMP regardless of MMP-2 expression levels, suggesting that the production of MMP-2 by tumor cells themselves does not play a critical role in these events. The angiogenic phenotype of MT1-MMP-producing cells was associated with an up-regulation of VEGF expression. These results emphasize the importance of MT1-MMP during tumor angiogenesis and open new opportunities for the development of anti-angiogenic strategies combining inhibitors of MT1-MMP and VEGF antagonists. [less ▲]

Detailed reference viewed: 70 (10 ULg)