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See detailIntrapericardial Bronchogenic Cyst Adherent to the Ascending Aorta.
DURIEUX, Rodolphe ULg; LAVIGNE, Jean-Paul ULg; SCAGNOL, Irène ULg et al

in Thoracic & Cardiovascular Surgeon (2012)

Bronchogenic cysts arise from an abnormal budding of the ventral diverticulum of the foregut or the tracheobronchial tree during embryogenesis. Pericardial location of these cysts is very rare. We ... [more ▼]

Bronchogenic cysts arise from an abnormal budding of the ventral diverticulum of the foregut or the tracheobronchial tree during embryogenesis. Pericardial location of these cysts is very rare. We describe a case of a young asymptomatic woman with an intrapericardial cystic mass compressing the right heart. Because of severe adhesions of the mass to the ascending aorta and to the right coronary artery, these structures were injured during surgical resection requiring the replacement of the ascending aorta and a coronary artery by-pass graft. Only the histopathologic findings provided the final diagnosis. [less ▲]

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See detailINTRAPERITONEAL ADHESIONS AFTER OPEN OR LAPAROSCOPIC ABDOMINAL PROCEDURE: AN EXPERIMENTAL STUDY IN THE RAT
Arung, Willy; Drion, Pierre ULg; CHERAMY-BIEN, Jean-Paul ULg et al

in Acta Chirurgica Belgica (2012, May), 112(3), 8546

Objectives: Adhesion formation is common after abdominal surgery. The incidence and severity of adhesion formation following open or laparoscopic surgery remain controversial. The role of CO2 ... [more ▼]

Objectives: Adhesion formation is common after abdominal surgery. The incidence and severity of adhesion formation following open or laparoscopic surgery remain controversial. The role of CO2 pneumoperitoneum is also largely discussed. This study aimed to compare adhesion formation following peritoneal injury by electrocoagulation performed through open or laparoscopic procedures in a rat model. Methods: Sixty male rats were randomized to undergo a 1.5cm peritoneal injury with unipolar cautery under general anesthesia: open surgery (group A, n=20), laparoscopic surgery with CO2 pneumoperitoneum (group B, n=20) and laparoscopic surgery with air pneumoperitoneum (group C, n=20). Duration of the procedures was fixed at 90 minutes in all groups, and pneumoperitoneum pressure at 10mmHg. Ten days later, the animals underwent a secondary laparotomy to score peritoneal adhesions using qualitative and quantitative parameters. Results: Forty-five rats developed at least one adhesion, respectively 95% in group A, 83% in group B and 55% in group C (P<0.01; Group C vs Group A, P<0.01). According to number, thickness, tenacity, vascularization, extent, type, and grading according to Zühkle classification, no significant difference was observed between groups A and B. The distribution of adhesions after open surgery was significantly different than after laparoscopic surgery (P<0.001). Interestingly, group C rats developed significantly less adhesions at the traumatized site, and their adhesions had less severe qualitative scores compared to open surgery (P<0.01). Conclusions: In this animal model, CO2 laparoscopic surgery did not decrease the formation of postoperative adhesion, compared to open surgery. The difference with the animals operated with air pneumoperitoneum emphasizes the role of CO2 in peritoneal injury leading to adhesion formation. [less ▲]

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See detailIntraperitoneal Adhesions After Open or Laparoscopic Abdominal Procedure: An Experimental Study in the Rat.
Arung, Willy; Drion, Pierre ULg; Honoré, Pierre ULg et al

in Surgical Endoscopy (2013), 27

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See detailIntraperitoneal Adhesions After Open or Laparoscopic Abdominal Procedure: An Experimental Study in the Rat.
Arung, Willy; Drion, Pierre ULg; CHERAMY-BIEN, Jean-Paul ULg et al

in Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A. (2012), 22(7), 651-657

Abstract Background: Adhesion formation is common after abdominal surgery. The incidence and severity of adhesion formation following open or laparoscopic surgery remain controversial. The role of CO(2 ... [more ▼]

Abstract Background: Adhesion formation is common after abdominal surgery. The incidence and severity of adhesion formation following open or laparoscopic surgery remain controversial. The role of CO(2) pneumoperitoneum is also widely discussed. This study aimed to compare adhesion formation following peritoneal injury by electrocoagulation performed through open or laparoscopic procedures in a rat model. Materials and Methods: Sixty male rats were randomized to undergo a 1.5-cm peritoneal injury with unipolar cautery under general anesthesia: open surgery (Group A, n=20), laparoscopic surgery with CO(2) pneumoperitoneum (Group B, n=20), and laparoscopic surgery with air pneumoperitoneum (Group C, n=20). Duration of the procedures was fixed at 90 minutes in all groups, and pneumoperitoneum pressure was kept at 10 mm Hg. Ten days later, the animals underwent a secondary laparotomy to score peritoneal adhesions using qualitative and quantitative parameters. Results: Forty-five rats developed at least one adhesion: 95% in Group A, 83% in Group B, and 55% in Group C (P<.01; Group C versus Group A, P<.01). According to number, thickness, tenacity, vascularization, extent, type, and grading according to the Zuhkle classification, no significant difference was observed between Groups A and B. The distribution of adhesions after open surgery was significantly different than after laparoscopic surgery (P<.001). It is interesting that Group C rats developed significantly fewer adhesions at the traumatized site, and their adhesions had less severe qualitative scores compared with those after open surgery (P<.01). Conclusions: In this animal model, CO(2) laparoscopic surgery did not decrease the formation of postoperative adhesion, compared with open surgery. The difference with the animals operated on with air pneumoperitoneum emphasizes the role of CO(2) in peritoneal injury leading to adhesion formation. [less ▲]

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See detailIntraperitoneal antineoplastic drug delivery: experience with a cyclophosphamide, vincristine and prednisolone protocol in cats with malignant lymphoma.
Teske, Erik ULg; van Lankveld, A. J.; Rutteman, G. R.

in Veterinary and comparative oncology (2014), 12(1), 37-46

In this retrospective study, the efficacy and safety were examined for an intraperitoneal chemotherapy protocol-cyclophosphamide, vincristine and prednisolone (IP-COP) in 26 cats with malignant lymphoma ... [more ▼]

In this retrospective study, the efficacy and safety were examined for an intraperitoneal chemotherapy protocol-cyclophosphamide, vincristine and prednisolone (IP-COP) in 26 cats with malignant lymphoma. Certainly in cats fiercely resisting IV administration the IP route is a more practical method, safer for the administrator and less stressful for the cat. Complete remission (CR) rate was 76.9% (n = 20). Median duration of first remission was 421 days. Estimated 1- and 2-year disease free period were 67.1 and 48.0%, respectively. Median duration of survival was 388 days and estimated overall 1- and 2-year survival periods were 54.7 and 46.9% respectively. Young cats had a more favourable prognosis. Reaching CR was essential for long-term survival. No specific IP-related adverse events (AE) were seen. AE were generally scored as mild and were not excessively abundant. These results indicate that the IP route is a safe and effective alternative for the administration of COP protocol chemotherapeutics. [less ▲]

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See detailIntraperitoneal hyperthermic chemotherapy (IPHC) for treatment of peritoneal carcinomatosis
Detroz, Bernard ULg; Marchettini, P.; Joris, Jean ULg et al

in Acta Gastro-Enterologica Belgica (2001, January), 64(1), 80

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See detailIntraplate deformations measured using an absolute gravimeter across the Ardenne and the Roer Graben (North-Western Europe)
Van Camp, Michel; Camelbeek, Thierry; Warnant, René ULg

in Meurers, B.; Pail, R. (Eds.) Proceedings of the 1st Workshop on International Gravity Field Research (2004)

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See detailIntrasaccular injection of aminoglycosides: a novel method for temporary damaging fish inner ear hair cells
Faucher, Karine ULg; Aas-Hansen, Øyvind; Damsgard, Borge et al

Poster (2008, October)

Fish models are increasingly being used for hearing research investigations. Aminoglycoside antibiotics that are used for damaging the inner ear hair cells can have systemic side effects leading to death ... [more ▼]

Fish models are increasingly being used for hearing research investigations. Aminoglycoside antibiotics that are used for damaging the inner ear hair cells can have systemic side effects leading to death of study animals. This study aimed to compare two methods: i) systemic (intravenous) and ii) local (intrasaccular) gentamicin administration for induction of inner ear hair cell damage in the Atlantic cod, Gadus morhua (L.). Hair cell damage was assessed using scanning electron microscopy; hair cell density, prevalence of immature hair cells and kinocilia length were measured. Gentamicin-treated fish were compared with control and sham fish. Intravenous gentamicin led to dose-dependent mortality caused by nephrotoxicity. The only visible effect after treatment was more immature hair cells and shorter kinocilia, the effect on hair cell density was equivocal. Following intrasaccular gentamicin treatment, fish mortality was negligible, and hair cells were damaged regardless of dose. Here, we observed decreased hair cell density, high prevalence of immature hair cells, and significantly shortened kinocilia. Conclusion: intrasaccular injection is preferable to intravenous injection of gentamicin for the study of ototoxicity in the Atlantic cod. [less ▲]

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See detailIntrasellar arachnoid cysts.
Dubuisson, Annie ULg; Stevenaert, Achille ULg; Martin, Didier ULg et al

in Neurosurgery (2007), 61(3), 505-13513

OBJECTIVE: To evaluate the clinical, endocrinological, and radiological presentation of nine cases of surgically verified intrasellar arachnoid cysts and to discuss the physiopathological mechanisms of ... [more ▼]

OBJECTIVE: To evaluate the clinical, endocrinological, and radiological presentation of nine cases of surgically verified intrasellar arachnoid cysts and to discuss the physiopathological mechanisms of formation of these cysts. METHODS: Among 1540 patients presenting with pituitary lesions, nine presented with an intrasellar arachnoid cyst. Their charts were retrospectively reviewed. RESULTS: Presenting symptoms included headache (n = 2), visual symptoms (n = 3), menstrual irregularities (n = 2), rapid weight gain (n = 1), vertigo (n = 1), and/or confusion (n = 1). Two cysts were discovered incidentally. T1-weighted magnetic resonance imaging scans showed an intrasellar cystic lesion in all cases, with a huge suprasellar extension in six cases. The cyst was of the same intensity as the cerebrospinal fluid (CSF) in only two patients. A transsphenoidal approach allowed the transdural aspiration of fluid and injection of a water-soluble contrast agent under mild pressure. In three patients, the contrast infiltrated along the pituitary stalk toward the subarachnoid spaces; in the other patients, it remained in the intrasellar compartment. Cyst membranes were removed as completely as possible with fenestration toward the subarachnoid spaces in communicating cysts. In spite of tight packing of the sella and sphenoid sinus, CSF fistulae requiring reoperation developed in two patients. CONCLUSION: The clinical picture of an intrasellar arachnoid cyst resembles that of a nonfunctional pituitary adenoma. Magnetic resonance imaging scans typically show a cystic intrasellar lesion with suprasellar extension, containing isointense or, more often, hyperintense fluid on T1-weighted sequences. In spite of the risk of CSF fistulae, the preferred surgical approach is transsphenoidal. A physiopathological mechanism is proposed according to anatomic variations of the sellar diaphragma allowing penetration of subarachnoid spaces into the sellar compartment and their enlargement by a ball-valve mechanism. [less ▲]

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See detailIntrasellar Arachnoïd Cysts: Diagnosis, Management, and Pathophysiology.
Dubuisson, Annie ULg; Martin, Didier ULg; Bruggeman, L. et al

Conference (1995, April 22)

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See detailIntraspecific biodiversity in South East asian rodents: new insights for their conservation
Latinne, Alice ULg; Rivière, Taiana; Pagès, Marie ULg et al

Poster (2009, August)

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See detailIntraspecific bovine herpesvirus 1 recombinants carrying glycoprotein E deletion as a vaccine marker are virulent in cattle
Muylkens, Benoît ULg; Meurens, F.; Schynts, F. et al

in Journal of General Virology (2006), 87(Pt 8), 2149-2154

Vaccines used in control programmes of Bovine herpesvirus 1 (BoHV-1) utilize highly attenuated BoHV-1 strains marked by a deletion of the glycoprotein E (gE) gene. Since BoHV-1 recombinants are obtained ... [more ▼]

Vaccines used in control programmes of Bovine herpesvirus 1 (BoHV-1) utilize highly attenuated BoHV-1 strains marked by a deletion of the glycoprotein E (gE) gene. Since BoHV-1 recombinants are obtained at high frequency in experimentally coinfected cattle, the consequences of recombination on the virulence of gE-negative BoHV-1 were investigated. Thus, gE-negative BoHV-1 recombinants were generated in vitro from several virulent BoHV-1 and one mutant BoHV-1 deleted in the gC and gE genes. Four gE-negative recombinants were tested in the natural host. All the recombinants were more virulent than the gE-negative BoHV-1 vaccine and the gC- and gE-negative parental BoHV-1. The gE-negative recombinant isolated from a BoHV-1 field strain induced the highest severe clinical score. Latency and reactivation studies showed that three of the recombinants were reexcreted. Recombination can therefore restore virulence of gE-negative BoHV-1 by introducing the gE deletion into a different virulence background. [less ▲]

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See detailIntraspecific variation of copper tolerance of four endemic plant species from the katangan Copperbelt (D. R. Congo)
Boisson, Sylvain ULg; garin, olivier; Seleck, Maxime ULg et al

Conference (2014, August 04)

Harsh ecosystems are at the origin of speciation processes in plant communities. In metalliferous areas, plants develop physiological adaptations to tolerate metal excesses which lead to high species and ... [more ▼]

Harsh ecosystems are at the origin of speciation processes in plant communities. In metalliferous areas, plants develop physiological adaptations to tolerate metal excesses which lead to high species and population diversity. South of the Katanga province (D.R. Congo), plant communities occur on soils with one of the world’s largest concentrations of copper and cobalt. More than 600 species including 54 endemics are distributed along a copper gradient (up to 10 000 mg kg-1 available Cu) and the populations are isolated on more than 100 copper hills scattered in miombo forest. In order to improve restoration strategies of threatened species, we aimed to identify intraspecific copper tolerance of 4 endemic plant species from katangan copper outcrops: Crotalaria cobalticola, Diplolophium marthozianum, Gladiolus ledoctei and Triumfetta welwitschii. Seeds were collected in 3 different populations in the katangan Copperbelt and sown according three soil contamination modalities: control (no addition of Cu), 100 mg kg-1 and 1000 mg kg-1 of Cu concentration using hydrated copper (II) sulfate. For each combination (species x populations x soils), we had 10 repetitions. For each population, sample of 5 seeds was weighed before seedling in pot in November 2013. One individual by pot was kept for measures. Height (cm), number of leaves, number of flowers and number of fruits were measured once a week during one rainy season. For all species, no significant difference of copper tolerance appeared between populations. In contrast, populations had distinct germination rate and growth rate, especially for T. welwitshii and D. marthozianum. C. cobalticola grew significantly better in highly contaminated soil than other soils. G. ledoctei did not show any significant difference between populations and soil treatments. [less ▲]

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See detailIntrathecal clonidine and fentanyl with hyperbaric bupivacaine improves analgesia during cesarean section
Benhamou, Dan; Schneider, Markus; Brichant, Jean-François ULg et al

in Anesthesia and Analgesia (1998), 87

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See detailIntrathoracic pressure measurement in cattle : standardized procedure
Lekeux, Pierre ULg; Hajer, R.; Breukink, H. J.

in Canadian Journal of Comparative Medicine (Gardenvale, Quebec) (1984), 48

A procedure to standardize the position of an esophageal catheter (eso-cat) tip, used to measure intrathoracic pressure, was tested in ten healthy Dutch Friesians. The cattle were in normal condition with ... [more ▼]

A procedure to standardize the position of an esophageal catheter (eso-cat) tip, used to measure intrathoracic pressure, was tested in ten healthy Dutch Friesians. The cattle were in normal condition with body weights (BW) between 52 and 670 kg and thoracic perimeters (TP) between 80 and 210 cm. The position of the neck and head was standardized. The eso-cat was introduced via the nose into the thoracic portion of the esophagus. The distance between the nares and the eso-cat tip (Lcat), which was positioned between the crossing point with the aorta and the caudal mediastinal lymph nodes, was measured for each animal. The regression equation, calculated between the Lcat and the BW and TP was, respectively: Lcat (cm) = 65 + 0.115 x BW (kg) (r2 = 0.99) and Lcat (cm) = 22 + 0.535 x TP (cm) (r2 = 0.97). The corresponding residual standard deviations were respectively 2.52 and 4.37 cm. The multiple and curvi-linear regression equation did not give a significantly better fit of the data [less ▲]

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See detailThe Intrathymic Expression of Insulin-Related Genes: Implications for Pathophysiology and Prevention of Type 1 Diabetes
Geenen, Vincent ULg; Lefebvre, P. J.

in Diabetes/Metabolism Reviews (1998), 14(1), 95-103

Recent experimental work has challenged and shattered the old concept of a sequestration of pancreatic islet antigens from developing T-cells within the thymic environment. There is now compelling ... [more ▼]

Recent experimental work has challenged and shattered the old concept of a sequestration of pancreatic islet antigens from developing T-cells within the thymic environment. There is now compelling evidence that the central immunological tolerance of the whole insulin family may be induced during the process of T-cell ontogeny in the thymus. Transcripts of insulin-like growth factor II (IGF-II), IGF-I and insulin genes have been characterized in human, rat and mouse thymuses. At the peptide level, IGF-II was shown to be the dominant polypeptide of the insulin family in the thymus from different species. Data are presented which support a dual role of thymic IGF-II both in T-cell development as well as in T-cell negative selection. Using animal models of autoimmune diabetes, current research is investigating the hypothesis that a defect of thymic T-cell education to the insulin family is implicated in the pathophysiology of human Type 1 diabetes. An efficient and secure prevention of Type 1 diabetes could be designed on the basis of the strong natural tolerogenic properties of the thymus. [less ▲]

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See detailIntratissular Lymphaticovenous Anastomoses Demonstrated by Perioperative Intramuscular Injection of 99mtc-Colloids
Heymans, Olivier; Fallais, Charles ULg; Hustinx, Roland ULg

in Lymphatic Research and Biology (2006), 4(1, Spring), 29-33

BACKGROUND: The existence of intratissular lymphaticovenous anastomoses has often been suggested, but it has never been demonstrated. This study aims at demonstrating the presence of such anastomoses ... [more ▼]

BACKGROUND: The existence of intratissular lymphaticovenous anastomoses has often been suggested, but it has never been demonstrated. This study aims at demonstrating the presence of such anastomoses. METHODS AND RESULTS: The free flap model was used to investigate the drainage of radiolabeled colloid particles whose size prevents direct passage to the blood vessels. The tracer was injected into the muscle or the skin during the surgical procedure. Blood samples were sequentially drawn from the venous pedicle over the 30 minutes that followed the tracer injection. The blood samples were counted using a gamma well-counter. In all 14 patients, the venous blood radioactivity steadily increased over time. Radiochemical analyses performed on the blood samples demonstrated that the radioactivity is related to the labeled colloids and not to free pertechnetate. Planar imaging performed 24 hours after the surgical procedure showed a significant liver uptake, and no accumulation in the area of normal lymphatic relays. CONCLUSIONS: As, in the free flap model, there is no lymphatic drainage through the classical pathways whatsoever, and since the size of the radiolabeled particles prevents them from directly entering the blood stream, the results strongly suggest the presence of functional intratissular lymphovenous anastomoses. [less ▲]

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