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See detailNF-kappaB: an important transcription factor in photobiology
Legrand-Poels, Sylvie ULg; Schoonbroodt, Sonia; Matroule, Jean-Yves et al

in Journal of Photochemistry and Photobiology B : Biology (1998)

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See detailNF-kB activity, and IL-8 and GM-CSF expression, in the milk of chorionic mastitis-affected cows
Boulanger, Delphine; Bureau, Fabrice ULg; Lekeux, Pierre ULg

in Pflügers Archiv : European Journal of Physiology (2002), 443

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See detailNF-kB activity, and IL-8 and GM-CSF expression, in the milk of chorionic mastitis-affected cows
Boulanger, Delphine; Bureau, Fabrice ULg; Lekeux, Pierre ULg

in National Mastitis Council Proceedings (2002)

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See detailNF-kB activity, and IL-8 and GM-CSF expression, in the milk of chronic mastitis-affected cows
Boulanger, D.; Bureau, Fabrice ULg; Lekeux, Pierre ULg

in Proceedings : National Mastitis Council, 41st Annual Meeting (2002)

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See detailNF-kB, stem cells and breast cancer: the links get stronger
Shostak, Kateryna ULg; Chariot, Alain ULg

in Breast Cancer Research [=BCR] (2011), 13(4), 214

Self-renewing breast cancer stem cells are key actors in perpetuating tumour existence and in treatment resistance and relapse. The molecular pathways required for their maintenance are starting to be ... [more ▼]

Self-renewing breast cancer stem cells are key actors in perpetuating tumour existence and in treatment resistance and relapse. The molecular pathways required for their maintenance are starting to be elucidated. Among them is the transcription factor NF-κB, which is known to play critical roles in cell survival, inflammation and immunity. Recent studies indicate that mammary epithelial NF-κB regulates the self-renewal of breast cancer stem cells in a model of Her2-dependent tumourigenesis. We will describe here the NF-κB-activating pathways that are involved in this process and in which progenitor cells this transcription factor is actually activated. [less ▲]

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See detailNF-kB-dependent cytokine production is abolished by cyclopentenone prostaglandins in lung epithelial cells
Bureau, Fabrice ULg

in Proceedings: Annual Congress of the European Respiratory Society (2001)

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See detailThe NF-κ B-independent functions of IKK subunits in immunity and cancer
Chariot, Alain ULg

in Trends in Cell Biology (2009), 19

The IKK complex is involved in transcriptional activation by phosphorylating the inhibitory molecule IkBa, a modification that triggers its subsequent degradation, allowing activation of NF-kB ... [more ▼]

The IKK complex is involved in transcriptional activation by phosphorylating the inhibitory molecule IkBa, a modification that triggers its subsequent degradation, allowing activation of NF-kB. Importantly, recent reports indicate that multiple cytoplasmic and nuclear proteins distinct from the NF-kB/IkB proteins are phosphorylated by the catalytic subunits of the IKK complex, IKKa or IKKb. Here we describe how the IKK subunits can play crucial roles in allergy, inflammation, immunity by targeting proteins such as SNAP23 and IRF7 but also in cancer by phosphorylating key molecules such as p53, TSC1 and FOXO3a through NF-kB-independent pathways. Thus, these recent findings considerably widen the biological roles played by these kinases and suggest that a full understanding of the biological roles played by IKKa and IKKb requires an exhaustive characterization of their substrates. [less ▲]

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See detailNF-κB transcription factor induces drug resistance through MDR1 expression in cancer cells
Bentires-Alj, Mohamed; Barbu, Véronique; Fillet, Marianne ULg et al

in Oncogene (2003), 22

The ubiquitous NF-kappaB transcription factor has been reported to inhibit apoptosis and to induce drug resistance in cancer cells. Drug resistance is the major reason for cancer therapy failure and ... [more ▼]

The ubiquitous NF-kappaB transcription factor has been reported to inhibit apoptosis and to induce drug resistance in cancer cells. Drug resistance is the major reason for cancer therapy failure and neoplastic cells often develop multiple mechanisms of drug resistance during tumor progression. We observed that NF-kappaB or P-glycoprotein inhibition in the HCT15 colon cancer cells led to increased apoptotic cell death in response to daunomycin treatment. Interestingly, NF-kappaB inhibition through transfection of a plasmid coding for a mutated IkappaB-alpha inhibitor increased daunomycin cell uptake. Indeed, the inhibition of NF-kappaB reduced mdr1 mRNA and P-glycoprotein expression in HCT15 cells. We identified a consensus NF-kappaB binding site in the first intron of the human mdr1 gene and demonstrated that NF-kappaB complexes could bind with this intronic site. Moreover, NF-kappaB transactivates an mdr1 promoter luciferase construct. Our data thus demonstrate a role for NF-kappaB in the regulation of the mdr1 gene expression in cancer cells and in drug resistance. [less ▲]

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See detailnFactors : un logiciel pour déterminer le nombre de facteurs à retenir dans une analyse factorielle exploratoire
Raîche, Gilles; Magis, David ULg

Scientific conference (2009, October)

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See detailNFKBIA Deletion in Glioblastomas.
Bredel, M.; Scholtens, D. M.; Yadav, A. K. et al

in New England Journal of Medicine [=NEJM] (2011)

Background Amplification and activating mutations of the epidermal growth factor receptor (EGFR) oncogene are molecular hallmarks of glioblastomas. We hypothesized that deletion of NFKBIA (encoding ... [more ▼]

Background Amplification and activating mutations of the epidermal growth factor receptor (EGFR) oncogene are molecular hallmarks of glioblastomas. We hypothesized that deletion of NFKBIA (encoding nuclear factor of kappa-light polypeptide gene enhancer in B-cells inhibitor-alpha), an inhibitor of the EGFR-signaling pathway, promotes tumorigenesis in glioblastomas that do not have alterations of EGFR. Methods We analyzed 790 human glioblastomas for deletions, mutations, or expression of NFKBIA and EGFR. We studied the tumor-suppressor activity of NFKBIA in tumor-cell culture. We compared the molecular results with the outcome of glioblastoma in 570 affected persons. Results NFKBIA is often deleted but not mutated in glioblastomas; most deletions occur in nonclassical subtypes of the disease. Deletion of NFKBIA and amplification of EGFR show a pattern of mutual exclusivity. Restoration of the expression of NFKBIA attenuated the malignant phenotype and increased the vulnerability to chemotherapy of cells cultured from tumors with NFKBIA deletion; it also reduced the viability of cells with EGFR amplification but not of cells with normal gene dosages of both NFKBIA and EGFR. Deletion and low expression of NFKBIA were associated with unfavorable outcomes. Patients who had tumors with NFKBIA deletion had outcomes that were similar to those in patients with tumors harboring EGFR amplification. These outcomes were poor as compared with the outcomes in patients with tumors that had normal gene dosages of NFKBIA and EGFR. A two-gene model that was based on expression of NFKBIA and O(6)-methylguanine DNA methyltransferase was strongly associated with the clinical course of the disease. Conclusions Deletion of NFKBIA has an effect that is similar to the effect of EGFR amplification in the pathogenesis of glioblastoma and is associated with comparatively short survival. [less ▲]

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See detailNG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injury.
Buss, Armin; Pech, Katrin; Kakulas, Byron A et al

in BMC Neurology (2009), 9

BACKGROUND: A major class of axon growth-repulsive molecules associated with CNS scar tissue is the family of chondroitin sulphate proteoglycans (CSPGs). Experimental spinal cord injury (SCI) has ... [more ▼]

BACKGROUND: A major class of axon growth-repulsive molecules associated with CNS scar tissue is the family of chondroitin sulphate proteoglycans (CSPGs). Experimental spinal cord injury (SCI) has demonstrated rapid re-expression of CSPGs at and around the lesion site. The pharmacological digestion of CSPGs in such lesion models results in substantially enhanced axonal regeneration and a significant functional recovery. The potential therapeutic relevance of interfering with CSPG expression or function following experimental injuries seems clear, however, the spatio-temporal pattern of expression of individual members of the CSPG family following human spinal cord injury is only poorly defined. In the present correlative investigation, the expression pattern of CSPG family members NG2, neurocan, versican and phosphacan was studied in the human spinal cord. METHODS: An immunohistochemical investigation in post mortem samples of control and lesioned human spinal cords was performed. All patients with traumatic SCI had been clinically diagnosed as having "complete" injuries and presented lesions of the maceration type. RESULTS: In sections from control spinal cord, NG2 immunoreactivity was restricted to stellate-shaped cells corresponding to oligodendrocyte precursor cells. The distribution patterns of phosphacan, neurocan and versican in control human spinal cord parenchyma were similar, with a fine reticular pattern being observed in white matter (but also located in gray matter for phosphacan). Neurocan staining was also associated with blood vessel walls. Furthermore, phosphacan, neurocan and versican were present in the myelin sheaths of ventral and dorsal nerve roots axons. After human SCI, NG2 and phosphacan were both detected in the evolving astroglial scar. Neurocan and versican were detected exclusively in the lesion epicentre, being associated with infiltrating Schwann cells in the myelin sheaths of invading peripheral nerve fibres from lesioned dorsal roots. CONCLUSION: NG2 and phosphacan were both present in the evolving astroglial scar and, therefore, might play an important role in the blockade of successful CNS regeneration. Neurocan and versican, however, were located at the lesion epicentre, associated with Schwann cell myelin on regenerating peripheral nerve fibres, a distribution that was unlikely to contribute to failed CNS axon regeneration. The present data points to the importance of such correlative investigations for demonstrating the clinical relevance of experimental data. [less ▲]

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See detailNG2-expressing cells in the subventricular zone are type C-like cells and contribute to interneuron generation in the postnatal hippocampus
Aguirre, Adan A.; Chittajallu, Ramesh; Belachew, Shibeshih ULg et al

in Journal of Cell Biology (2004), 165(4), 575-589

The subventricular zone (SVZ) is a source of neural progenitors throughout brain development. The identification and purification of these progenitors and the analysis of their lineage potential are ... [more ▼]

The subventricular zone (SVZ) is a source of neural progenitors throughout brain development. The identification and purification of these progenitors and the analysis of their lineage potential are fundamental issues for future brain repair therapies. We demonstrate that early postnatal NG2-expressing (NG2(+)) progenitor cells located in the SVZ self-renew in vitro and display phenotypic features of transit-amplifier type C-like multipotent cells. NG2(+) cells in the SVZ are highly proliferative and express the epidermal growth factor receptor, the transcription factors Dlx, Mash1, and Olig2, and the Lewis X (LeX) antigen. We show that grafted early postnatal NG2(+) cells generate hippocampal GABAergic interneurons that propagate action potentials and receive functional glutamatergic synaptic inputs. Our work identifies Dlx(+)/Mash1(+)/LeX(+)/NG2(+)/GFAP-negative cells of the SVZ as a new class of postnatal multipotent progenitor cells that may represent a specific cellular reservoir for renewal of postnatal and adult inhibitory interneurons in the hippocampus. [less ▲]

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See detailNGAL biomarqueur de lésion rénale
Gagneux-Brunon, Amandine; DELANAYE, Pierre ULg; LEGRAND, Delphine ULg et al

in Néphrologie & Thérapeutique (2012), 8(7), 508-515

Le diagnostic precoce de l’insufissance renale aigue (IRA) est necessaire et devrait se faire au stade de lesion renale avant meme la degradation du debit de filtration glomerulaire. Plusieurs ... [more ▼]

Le diagnostic precoce de l’insufissance renale aigue (IRA) est necessaire et devrait se faire au stade de lesion renale avant meme la degradation du debit de filtration glomerulaire. Plusieurs biomarqueurs d’atteinte renale aigue sont actuellement a l’etude. Parmi ceux-ci, le Neutrophil Gelatinase Associated Lipocalin (NGAL) semble l’un des plus prometteurs et fait l’objet de nombreuses publications. La performance diagnostique de NGAL, dose dans le plasma ou les urines, pour le depistage de l’IRA depend de nombreux facteurs. Bien que les donnees experimentales recentes soient en faveur de l’utilisation preferentielle du dosage urinaire de NGAL, les donnees cliniques issues de nombreuses etudes ne permettent pas de trancher formellement sur la superiorite du dosage urinaire par rapport au dosage plasmatique pour le depistage des atteintes renales aigues. Il n’en reste pas moins que sur le plan analytique, les techniques de dosage du NGAL urinaire sont actuellement plus fiables que celles du dosage plasmatique. La performance diagnostique de NGAL dans un contexte d’IRA est maximale en chirurgie cardiaque pediatrique. Les resultats, chez l’adulte en postoperatoire de chirurgie cardiaque et dans d’autres situations (reanimation, urgences, transplantation), sont moins convaincants. Par ailleurs, il n’est actuellement pas possible d’extrapoler des etudes cliniques une valeur seuil discriminante unique de NGAL, aussi bien dans les urines que dans le plasma. D’autres etudes sont necessaires pour valider definitivement NGAL comme biomarqueur de l’atteinte renale aigue et en preciser les conditions d’utilisation en pratique clinique. [less ▲]

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See detailNGC 1624-2: a slowly rotating, X-ray luminous Of?cp star with an extraordinarily strong magnetic field
Wade, G. A.; Maíz Apellániz, J.; Martins, F. et al

in Monthly Notices of the Royal Astronomical Society (2012), 425

This paper presents a first observational investigation of the faint Of?p star NGC 1624-2, yielding important new constraints on its spectral and physical characteristics, rotation, magnetic field ... [more ▼]

This paper presents a first observational investigation of the faint Of?p star NGC 1624-2, yielding important new constraints on its spectral and physical characteristics, rotation, magnetic field strength, X-ray emission and magnetospheric properties. Modelling the spectrum and spectral energy distribution, we conclude that NGC 1624-2 is a main-sequence star of mass M ≃ 30 M[SUB]&sun;[/SUB], and infer an effective temperature of 35 ± 2 kK and log g = 4.0 ± 0.2. Based on an extensive time series of optical spectral observations we report significant variability of a large number of spectral lines, and infer a unique period of 157.99 ± 0.94 d which we interpret as the rotational period of the star. We report the detection of a very strong (5.35 ± 0.5 kG) longitudinal magnetic field <B[SUB]z[/SUB]>, coupled with probable Zeeman splitting of the Stokes I profiles of metal lines confirming a surface field modulus of 14 ± 1 kG, consistent with a surface dipole of polar strength ≳20 kG. This is the largest magnetic field ever detected in an O-type star, and the first report of Zeeman splitting of Stokes I profiles in such an object. We also report the detection of reversed Stokes V profiles associated with weak, high-excitation emission lines of O III, which we propose may form in the close magnetosphere of the star. We analyse archival Chandra ACIS-I X-ray data, inferring a very hard spectrum with an X-ray efficiency of log L[SUB]x[/SUB]/L[SUB]bol[/SUB] = -6.4, a factor of 4 larger than the canonical value for O-type stars and comparable to that of the young magnetic O-type star θ[SUP]1[/SUP] Ori C and other Of?p stars. Finally, we examine the probable magnetospheric properties of the star, reporting in particular very strong magnetic confinement of the stellar wind, with η[SUB]*[/SUB] ≃ 1.5 × 10[SUP]4[/SUP], and a very large Alfvén radius, R[SUB]Alf[/SUB] = 11.4 R[SUB]*[/SUB]. Based on spectropolarimetric observations obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers (INSU) of the Centre National de la Recherche Scientifique of France, and the University of Hawaii, as well as on observations obtained using the Narval spectropolarimeter at the Observatoire du Pic du Midi (France), which is operated by the INSU. The spectroscopic data were gathered with five facilities: the 9.2-m Hobby-Eberly Telescope at McDonald Observatory (MDO), the 3.5-m Telescope at Calar Alto Observatory (CAHA), the 1.5-m Telescope at the Observatorio de Sierra Nevada (OSN), the 4.2-m William Herschel Telescope at the Observatorio del Roque de los Muchachos (ORM) and the 2-m Himalayan Chandra Telescope at Indian Astronomical Observatory (IAO). [less ▲]

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See detailNGC 2000.0 The Complete New General Catalogue and Index of Nebulae and Star Clusters -- J. L. E. Dreyer
Manfroid, Jean ULg

in Ciel et Terre (1990), 106

Not Available

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See detailNGC6231: X-ray Properties of the Early-Type Star Population
Sana, H.; Nazé, Yaël ULg; Gosset, Eric ULg et al

in Massive Stars in Interactive Binaries (2007)

Based on a deep XMM-Newton observation of the young open cluster NGC6231, we derive the main X-ray properties of its early-type star population. Among the 610 X-ray sources detected in the field, 42 are ... [more ▼]

Based on a deep XMM-Newton observation of the young open cluster NGC6231, we derive the main X-ray properties of its early-type star population. Among the 610 X-ray sources detected in the field, 42 are associated with early-type stars. We investigate their L[SUB]X[/SUB]/L[SUB]bol[/SUB] relationship and confirm the clear dichotomy between O- and B-type stars. The cut-off line between the two behaviours occurs at L[SUB]bol[/SUB] ~ 10[SUP]38[/SUP] erg s[SUP]-1[/SUP] as previously proposed by Berghöfer et al. (1997). The distinction between single and binary stars is not clear cut, except for the colliding wind system HD152248. The X-ray detected B-stars in NGC6231 appear to be more luminous than predicted from the Berghöfer et al. relation. Though this suggests a bimodal distribution of the B-star X-ray emission, we caution however that these results might be biased by detection limits. Finally we investigate the X-ray variability of the detected sources and we find that about 40% of the X-ray emitters in the field of view present consistent signs of variability in the EPIC instruments. This fraction is much larger than previously thought. About one third of the early-type star population, either singles or binaries, further show variability. These variations do not seem to be exclusively related to binarity and could thus not be systematically interpreted in the framework of a wind-wind collision phenomenon. [less ▲]

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See detailNghiên cứu một số chỉ tiêu chất lượng thịt của bò Lai Sind, Brahman x Lai Sind và Charolais x Lai Sind tại Đăk Lăk
Hue, Pham The; Binh, Dang Vu; Chinh, Dinh Van et al

in Journal of Science and Development (2008), 4(4), 331-337

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See detailNghiên cứu và thiết kế hai kiểu chuồng nuôi nhông cát Leiolepis guttata (Cuvier, 1829) phù hợp với điều kiện nuôi và vốn đầu tư tại huyện Bắc Bình, tỉnh Bình Thuận
Tran, Tinh ULg; Tran, Ngoc Nguyen Kim Dieu; Vo, Kim Thong et al

in Journal of Agriculture Sciences and Technology (2014), 1/2014

Building of an enclosure for rearing of the spotted butterfly lizard, Leiolepis guttata (Cuvier, 1829), by the first farmer in 2004 (in Hong Chinh commune, Hoa Thang ward, Bac Binh district, Binh Thuan ... [more ▼]

Building of an enclosure for rearing of the spotted butterfly lizard, Leiolepis guttata (Cuvier, 1829), by the first farmer in 2004 (in Hong Chinh commune, Hoa Thang ward, Bac Binh district, Binh Thuan province) is considered as a fortuitous discovery which was the initiator of the current expanding trend of its rearing. Because L. guttata is a wild animal, with strong disease resistance and adaptation capacity, livestock farmers are presently not very interested in important aspects: rearing techniques, enclosure’s types, sex ratio, diseases’ prevention, etc. Notably the building of enclosures not perfectly suitable breeds a noticeable loss of the number of lizards and a reduction in the profits for the farmers. To this end, the building of two types of enclosures adapted to local rearing conditions and the investing capital available in Bac Binh district, Binh Thuan province is presently essential. We descrite two types of enclosure: the first one surrounded by a bricks (or breeze blocks) wall, the second one fended by a fiber cement corrugated sheets wall. Moreover, we suggest to introduce plants in order to build a vegetal cover nearer to the natural environment of L. guttata: shrubs and a plant carpet becoming the preferential refuge area of the spotted butterfly lizard. [less ▲]

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See detailNGOs and female circumcision in Egypt. An anthropological enquiry.
Mescoli, Elsa ULg

in Journal of the Anthropology of the Contemporary Middle East and Central Eurasia (in press)

In 1994, during the International Conference on Population and Development convened by the United Nations in Cairo, a shocking video was shown, realized by an operator of CNN and depicting the ... [more ▼]

In 1994, during the International Conference on Population and Development convened by the United Nations in Cairo, a shocking video was shown, realized by an operator of CNN and depicting the circumcision of a ten-year-old child living in this very same city. Discourses around female circumcision were not new in Egypt and in the international community, but what was considered as a new episode of a recurrent scandal (not the last one indeed) led to enhance the "war against bad government"[1]. A war fought by means of ideological weapons produced by expert knowledges among which the medical and the feminist ones. The assignment of a value to the state of integrity of the female body and to the women freedom of choice, both designed according to Western canons, led to different actions to “save” Egyptian women. In this context, development agencies fosters a widespread representation of the victim, constituted by the woman mutilated body. Such representation is functional to put in place programs which do not guarantee a freedom of choice, but rather require adherence to another female model, one that defines the "modern" woman. My article, based on ethnographic experience, aims at highlighting the complexity of such dynamics and the role played by humanitarianism within them. Female body becomes the arena where local and international economic powers operate, disregarding a real understanding of the practice, its meanings and its eventual change. ________________________________________ [1] Foucault, Michel. La nascita della clinica. Il ruolo della medicina nella costituzione delle scienze umane, Einaudi, Torino 1969: 48. [less ▲]

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