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See detailNon-LTE effects on H-3(+) emission in the jovian upper atmosphere
Melin, Henrik; Miller, Steve; Stallard, Tom et al

in Icarus: International Journal of Solar System Studies (2005), 178(1), 97-103

Calculations of column intensities are performed for a number of infrared transitions of the H-3(+) molecular ion, using a model atmosphere recently produced by Grodent et al. [2001. A self-consistent ... [more ▼]

Calculations of column intensities are performed for a number of infrared transitions of the H-3(+) molecular ion, using a model atmosphere recently produced by Grodent et al. [2001. A self-consistent model of the jovian auroral thermal structure. J. Geophys. Res. 106, 12933-12952]. The line intensities integrated along the line of sight through the model atmosphere are first computed assuming that all of the emitting energy levels are in local thermodynamic equilibrium (LTE). These results are compared with those derived from a detailed balance calculation using a method recently proposed by Oka and Epp [2004. Non-thermal rotational distribution of H-3(+). Astrophys. J. In press]. It is shown that the population of excited vibrational levels starts to depart from that derived from LTE at attitudes higher than 500 km (above the jovian cloud tops). This effect has been noted previously by Kim et it. [1992. Densities and vibrational distribution of H-3(+) in the jovian auroral atmosphere. J. Geophys. Res. 97, 6093-6101]. By 2000 km, all of the excited vibrational levels are Populated at less than 10% of the expected LTE value. This has important implications for the jovian upper atmosphere. In particular, the H-3(+) cooling effect will be greatly reduced high in the atmosphere. Modelled LTE line emission is greater than that derived from non-LTE modelling. Comparison of the non-LTE modelling with recent spectral measurements of the jovian auroral/polar regions in the L- and K-infrared windows shows that the Grodent et al. [2001. A self-consistent model of the jovian auroral thermal structure. J. Geophys. Res. 106, 12933-12952] profile overestimates the measured line intensity by similar to 3. Allowing for this, the non-LTE modelling shows that the column densities derived from (quasi-)LTE treatment of the measured line intensities may underestimate the real H-3(+) abundance by a factor of between 6 and 200. This means that attempts to derive important ionospheric properties, such as conductivity and related energy inputs due to magnetosphere-ionosphere coupling, front observed spectra will need to take this into account, if they are not to be seriously in error. (c) 2005 Elsevier Inc. All rights reserved. [less ▲]

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See detailLe non-marchand, frein ou moteur pour la croissance ?
Defourny, Jacques ULg; Mertens de Wilmars, Sybille ULg; Salamé, Marc

in Defourny, Jacques; Jacquemin, J.-Ch. (Eds.) Avec quelle croissance devons-nous apprendre à vivre ? (1996)

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See detailNon-myeloablative transplantation with CD8-depleted or unmanipulated peripheral blood stem cells: a phase II randomized trial.
Willems, Evelyne ULg; Baron, Frédéric ULg; Baudoux, Etienne ULg et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2009), 23(3), 608-10

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See detailNon-native prosody: production and perception of accent
Rasier, Laurent ULg; Caspers, Johanneke; Van Heuven, Vincent

Conference (2008)

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See detailNon-native variëteiten van het Nederlands: verwerving en didactiek
Rasier, Laurent ULg

Conference (2009)

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See detailA non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis.
Hagan, Christine L; Johnson, Russell J K; Dhulesia, Anne et al

in Protein Engineering, Design & Selection (2010), 23(7), 499-506

We report here the detailed characterisation of a non-naturally occurring variant of human lysozyme, I59T, which possesses a destabilising point mutation at the interface of the alpha- and beta-domains ... [more ▼]

We report here the detailed characterisation of a non-naturally occurring variant of human lysozyme, I59T, which possesses a destabilising point mutation at the interface of the alpha- and beta-domains. Although more stable in its native structure than the naturally occurring variants that give rise to a familial form of systemic amyloidosis, I59T possesses many attributes that are similar to these disease-associated species. In particular, under physiologically relevant conditions, I59T populates transiently an intermediate in which a region of the structure unfolds cooperatively; this loss of global cooperativity has been suggested to be a critical feature underlying the amyloidogenic nature of the disease-associated lysozyme variants. In the present study, we have utilised this variant to provide direct evidence for the generic nature of the conformational transition that precedes the ready formation of the fibrils responsible for lysozyme-associated amyloid disease. This non-natural variant can be expressed at higher levels than the natural amyloidogenic variants, enabling, for example, singly isotopically labelled protein to be generated much more easily for detailed structural studies by multidimensional NMR spectroscopy. Moreover, we demonstrate that the I59T variant can readily form fibrils in vitro, similar in nature to those of the amyloidogenic I56T variant, under significantly milder conditions than are needed for the wild-type protein. [less ▲]

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See detailNon-neoplastic surgical diseases of the vagina and vulva
Hamaide, Annick ULg

in Proceedings du 1st Surgical Forum ECVS (2001, July)

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See detailNon-O157 Shiga toxin-producing Escherichia coli isolated from diarrhoeic calves in Argentina.
Mercado, E. C.; Gioffre, A.; Rodriguez, Sabrina ULg et al

in Journal of Veterinary Medicine. B, Infectious Diseases & Veterinary Public Health (2004), 51(2), 82-8

Faecal samples from 76 diarrhoeic calves belonging to 36 farms located in the Pampas plain, Argentina, were examined for Shiga toxin-producing Escherichia coli (STEC). A total of 15 STEC strains were ... [more ▼]

Faecal samples from 76 diarrhoeic calves belonging to 36 farms located in the Pampas plain, Argentina, were examined for Shiga toxin-producing Escherichia coli (STEC). A total of 15 STEC strains were isolated from 12 (15.8%) calves which came from six different farms. All stx positive strains assayed by PCR were also positives in the Vero cell cytotoxicity test. The majority (60.0%) of the STEC strains carried the stx(1) gene. Twelve (80.0%) of the STEC isolates which belonged to serotypes O5:H- (n = 4), O26:H11 (n = 4), O26:H- (n = 1), O111:H- (n = 2), and O123:H38 (n = 1) were also enterohaemolysin (EHly) positive and carried the gene encoding for intimin (eae). All the stx positive strains were negative for the bfpA gene. Localized adherence to HEp-2 cells were observed in 83.3% of the eae+ STEC strains. STEC belonging to serotype O5:H- showed atypical biochemical properties, including urease production. Urease was also produced by two strains belonging to serotypes O153:H? and non-typeable, respectively. Resistance to three or more antibiotics was observed in 12 (80.0%) of the STEC isolates. Most of the serotypes of STEC recovered in this survey carried virulence traits that are associated with increased human and bovine pathogenicity. The present study shows that highly virulent STEC strains are being shed by diarrhoeic calves from farms located in a high incidence area of human STEC infections. [less ▲]

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See detailNon-observance thérapeutique: causes, conséquences, solutions.
Scheen, André ULg; Giet, Didier ULg

in Revue Médicale de Liège (2010), 65(5-6), 239-45

Compliance is defined as the extent to which a patient's behaviour coincides with medical or health advice. Medication adherence seems to be rather low as 30 to 60% of patients with chronic disease may be ... [more ▼]

Compliance is defined as the extent to which a patient's behaviour coincides with medical or health advice. Medication adherence seems to be rather low as 30 to 60% of patients with chronic disease may be categorised as being poorly or not adherent to drug therapy. Numerous factors may influence compliance among which patient's characteristics, disease peculiarities, drug treatment modalities, physician's attitudes and health system organisation. The consequences of non-compliance to drug therapy may not only be harmful for patient's health, but could also negatively impact the financial cost of public health services. Thus, all efforts should be focused to improve drug compliance, if possible by targeting all causes responsible for poor adherence to medications. [less ▲]

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See detailLa non-observance therapeutique: probleme majeur pour la prevention des maladies cardio-vasculaires.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(12), 914-20

The prevention of cardiovascular diseases relies upon the correction of risk factors and, more particularly, the optimal management of various metabolic abnormalities such as obesity, dyslipidaemias ... [more ▼]

The prevention of cardiovascular diseases relies upon the correction of risk factors and, more particularly, the optimal management of various metabolic abnormalities such as obesity, dyslipidaemias, diabetes mellitus and arterial hypertension. Such an approach first requires the adherence to life-style habits (healthy diet, physical activity and no smoking) and, in case of failure, the use of lipid-lowering drugs, antidiabetic agents and/or antihypertensive medications. Sometimes, a monotherapy may be sufficient but, in most cases, a drug combination is mandatory because of the need to reach tight therapeutic targets and of the presence of a polypathology, especially within the frame of the metabolic syndrome. Unfortunately, all surveys indicate that therapeutic compliance to non-pharmacological advice and even to drug prescriptions is far from being excellent. Such a non-compliance limits the efficacy of the prevention strategies and contributes to markedly increase the cost of metabolic diseases and associated complications. [less ▲]

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See detailA non-overlapping quasi-optimal optimized Schwarz domain decomposition algorithm for the Helmholtz equation
Boubendir, Yassine; Antoine, Xavier; Geuzaine, Christophe ULg

in Proceedings of Domain Decomposition Methods in Science and Engineering XX (2013)

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See detailA non-parametric probabilistic model for ground-borne vibrations in buildings
Arnst, Maarten ULg; Clouteau, Didier; Chebli, Hamid et al

in Probabilistic Engineering Mechanics (2006), 21(1), 18-34

This paper studies the prediction accuracy of models for ground-borne vibrations in buildings based on a three-dimensional coupled FE–BE formulation in the frequency range relevant for traffic induced ... [more ▼]

This paper studies the prediction accuracy of models for ground-borne vibrations in buildings based on a three-dimensional coupled FE–BE formulation in the frequency range relevant for traffic induced vibrations. In structural dynamics, the prediction accuracy at relatively high frequencies is known to be problematic since the sensitivity of the predicted response to modelling errors and parameter uncertainties increases with the frequency. To estimate the prediction accuracy, this paper incorporates the parameter uncertainties and the modelling errors into the analysis using the non-parametric probabilistic approach, introduced by Soize. The methodology is applied to a case history. The results of a prediction model for the transmission of vibrations from a shallow cut-and-cover tunnel to a six storey reinforced concrete frame structure in Paris are considered and compared with in situ measurements. The results demonstrate that a single dispersion parameter allows fitting the data. The sensitivity of the response to uncertainties is shown to increase as vibrations propagate inside the building. [less ▲]

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See detailThe non-penicillin-binding module of the tripartite penicillin-binding protein 3 of Escherichia Coli is required for folding and/or stability of the penicillin-binding module and the membrane-anchoring module confers cell septation activity on the folded structure
Goffin, Colette ULg; Fraipont, Claudine ULg; Ayala, Juan et al

in Journal of Bacteriology (1996), 178(18), 5402-5409

The ftsI-encoded multimodular class B penicillin-binding protein 3 (PBP3) is a key element of the cell septation machinery of Escherichia coli. Altered ftsI genes were overexpressed, and the gene products ... [more ▼]

The ftsI-encoded multimodular class B penicillin-binding protein 3 (PBP3) is a key element of the cell septation machinery of Escherichia coli. Altered ftsI genes were overexpressed, and the gene products were analyzed with respect to the level of production, stability, penicillin affinity, and cell septation activity. In contrast to the serine beta-lactamases and low-molecular-mass PBPs which are autonomous folding entities, the S-259-to-V-577 penicillin-binding module of M-1-to-V-577 PBP3 lacks the amino acid sequence information for correct folding. The missing piece of information is provided by the associated G-57-to-E-258 non-penicillin-binding module which functions as a noncleaved, pseudointramolecular chaperone. Key elements of the folding information reside within the motif 1-containing R-60-to-W-110 polypeptide segment and within G-188-to-D-197 motif 3 of the n-PB module. The intermodule interaction is discussed in the light of the known three-dimensional structure (at 3.5-A [0.35-nm] resolution) of the analogous class B PBP2x of Streptococcus pneumoniae (S. Pares, N. Mouz, Y. Petillot, R. Hakenbeck, and O. Dideberg, Nature Struct. Biol. 3:284-289, 1996). Correct folding and adoption of a stable penicillin-binding conformation are necessary but not sufficient to confer cell septation activity to PBP3 in exponentially growing cells. The in vivo activity of PBP3 also depends on the M-1-to-E-56 amino-terminal module which encompasses the cytosol, the membrane, and the periplasm and which functions as a noncleaved pseudo-signal peptide. [less ▲]

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See detailLa non-performativité de l'art performance
Hagelstein, Maud ULg

Conference (2013, March 08)

Objectif : Identifier le rapport critique de la performativité à l’imagination (ou plutôt de la non-performativité à l’imagination) à travers le médium de l’art performance (pour élaborer une nouvelle ... [more ▼]

Objectif : Identifier le rapport critique de la performativité à l’imagination (ou plutôt de la non-performativité à l’imagination) à travers le médium de l’art performance (pour élaborer une nouvelle théorie de la réception). Trois arguments sont développés dans cette intervention : (1) La théorie du performatif elle-même (en tout cas telle qu’énoncée par Austin) évacue la possibilité d’une performativité artistique (d’une performativité qui s’exercerait dans le domaine de l’art ou de la fiction) ; (2) La performance artistique se distingue de l’« objet performatif » - c’est-à-dire de l’objet artistique qui incite le spectateur à des actes et à un comportement spécifiques. Dans le champ de l’art contemporain, l’idée de « performativité » a un tel succès, que l’on parle désormais d’œuvre performative à chaque fois qu’un objet artistique entretient un lien quelconque à l’action, soit qu’il réclame d’être activé par la présence physique de l’artiste ou du spectateur, soit qu’il renvoie directement à une action ou un processus dans lequel il est inscrit ou dont il est issu. En ce sens, la performativité constitue une valeur ajoutée à un objet ou une image – c’est-à-dire à une représentation. Tandis que l’art performance présente de pures actions (dont il serait vain/redondant de rappeler le lien à l’action). (3) L’art performance refuse radicalement (position esthétique radicale) d’exercer un pouvoir sur l’imagination du spectateur. La réaction de ce dernier aux actions visuelles qui lui sont présentées lui appartient en propre, n’est pas guidée/influencée par les intentions de l’artiste. L’essence même de ce genre artistique est d’appeler des lectures toujours/nécessairement subjectives. Souligner la non-performativité de l’art performance reviendrait à montrer qu’elle déjoue par avance toute prise de pouvoir, toute autorité exercée sur le spectateur. Cela reviendrait par conséquent à jeter les bases d’une théorie renouvelée de la réception. [less ▲]

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See detailNon-perturbative effect of rotation on dipolar mixed modes in red giant stars
Ouazzani, R.-M.; Goupil, M. J.; Dupret, Marc-Antoine ULg et al

in Astronomy and Astrophysics (2013), 554

Context. The space missions CoRoT and Kepler provide high-quality data that allow us to test the transport of angular momentum in stars by the seismic determination of the internal rotation profile. <BR ... [more ▼]

Context. The space missions CoRoT and Kepler provide high-quality data that allow us to test the transport of angular momentum in stars by the seismic determination of the internal rotation profile. <BR /> Aims: Our aim is to test the validity of seismic diagnostics for red giant rotation that are based on a perturbative method and to investigate the oscillation spectra when the validity does not hold. <BR /> Methods: We use a non-perturbative approach implemented in the ACOR code that accounts for the effect of rotation on pulsations and solves the pulsation eigenproblem directly for dipolar oscillation modes. <BR /> Results: We find that the limit of the perturbation to first order can be expressed in terms of the rotational splitting compared to the frequency separation between consecutive dipolar modes. Above this limit, non-perturbative computations are necessary, but only one term in the spectral expansion of modes is sufficient as long as the core rotation rate remains significantly smaller than the pulsation frequencies. Each family of modes with different azimuthal symmetry, m, has to be considered separately. In particular, in case of rapid core rotation, the density of the spectrum differs significantly from one m-family of modes to another, so that the differences between the period spacings associated with each m-family can constitute a promising guideline toward a proper seismic diagnostic for rotation. [less ▲]

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See detailNon-Perturbative Effect of Rotation on Dipolar Mixed-Modes in Red Giants
Ouazzani, R.-M.; Goupil, M.-J.; Dupret, Marc-Antoine ULg et al

in Astronomical Society of the Pacific Conference Series (2013, December 01)

The space missions CoRoT (Convection Rotation and Planetary Transits) and Kepler provide high quality data that allows the transport of angular momentum in stars to be investigated by the seismic ... [more ▼]

The space missions CoRoT (Convection Rotation and Planetary Transits) and Kepler provide high quality data that allows the transport of angular momentum in stars to be investigated by the seismic determination of the internal rotation profile. In a former study (Ouazzani et al. 2013b) we test the validity of seismic diagnostics for red giant rotation that are based on a perturbative method. Our aim here is to investigate oscillation spectra when that validity no longer holds. We use a non-perturbative approach implemented in the Adiabatic Code of Oscillations including Rotation (ACOR code) (Ouazzani et al. 2012) that accounts for the eff [less ▲]

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See detailNon-perturbative momentum dependence of the coupling constant and hadronic models
Courtoy, Aurore ULg; Scopetta, S.; Vento, V.

in European Physical Journal A -- Hadrons & Nuclei (2011), 47(4), 1-7

Models of hadron structure are associated with a hadronic scale which allows by perturbative evolution to calculate observables in the deep inelastic region. The resolution of Dyson-Schwinger equations ... [more ▼]

Models of hadron structure are associated with a hadronic scale which allows by perturbative evolution to calculate observables in the deep inelastic region. The resolution of Dyson-Schwinger equations leads to the freezing of the QCD running coupling (effective charge) in the infrared, which is best understood as a dynamical generation of a gluon mass function, giving rise to a momentum dependence which is free from infrared divergences. We use this new development to understand why perturbative treatments are working reasonably well despite the smallness of the hadronic scale. © 2011 SIF, Springer-Verlag Berlin Heidelberg. [less ▲]

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