Autobiographical remediation therapy in schizophrenia: results from an exploratory clinical training

Poster (2005, September)

Autobiographie d'Antoine Galland

in Le Journal d'Antoine Galland (1646-1715). La période parisienne. Vol. II (1710-1711) (2012)

L’Autobiographie polyphonique : Trois livres fondateurs

in Dejasse, Erwin; Habrand, Tanguy; Meesters, Gert (Eds.) L'Association : Une utopie éditoriale et esthétique (2011)

Cross-over study of three autobiographical comics: "Journal d'un album" by Dupuy and Berberian, "Approximativement" by Lewis Trondheim and "Livret de Phamille" by JC Menu.

Autobiopoésie, Cliff, Verheggen, Delaive

in de la Torre, Estrella; Renouprez, Martine (Eds.) L'Autobiographie dans l'espace francophone I-la Belgique (2003)

La définition de l'autobiographie proposée par Lejeune restreint celle-ci à la prose. Qu'en est-il de ces trois poètes belges qui se racontent volontiers dans leurs écrits (Cliff, Verheggen, Delaive)?

An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.

in Cell Metabolism (2010), 11(4), 311-9

Lactate is an important metabolic intermediate released by skeletal muscle and other organs including the adipose tissue, which converts glucose into lactate under the influence of insulin. Here we show ... [more ▼]

Lactate is an important metabolic intermediate released by skeletal muscle and other organs including the adipose tissue, which converts glucose into lactate under the influence of insulin. Here we show that lactate activates the G protein-coupled receptor GPR81, which is expressed in adipocytes and mediates antilipolytic effects through G(i)-dependent inhibition of adenylyl cyclase. Using GPR81-deficient mice, we demonstrate that the receptor is not involved in the regulation of lipolysis during intensive exercise. However, insulin-induced inhibition of lipolysis and insulin-induced decrease in adipocyte cAMP levels were strongly reduced in mice lacking GPR81, although insulin-dependent release of lactate by adipocytes was comparable between wild-type and GPR81-deficient mice. Thus, lactate and its receptor GPR81 unexpectedly function in an autocrine and paracrine loop to mediate insulin-induced antilipolytic effects. These data show that lactate can directly modulate metabolic processes in a hormone-like manner, and they reveal a new mechanism underlying the antilipolytic effects of insulin. [less ▲]

Autocrine/paracrine activation of the GABA(A) receptor inhibits the proliferation of neurogenic polysialylated neural cell adhesion molecule-positive (PSA-NCAM+) precursor cells from postnatal striatum.

in Journal of Neuroscience (2003), 23(8), 3278-94

GABA and its type A receptor (GABA(A)R) are present in the immature CNS and may function as growth-regulatory signals during the development of embryonic neural precursor cells. In the present study, on ... [more ▼]

GABA and its type A receptor (GABA(A)R) are present in the immature CNS and may function as growth-regulatory signals during the development of embryonic neural precursor cells. In the present study, on the basis of their isopycnic properties in a buoyant density gradient, we developed an isolation procedure that allowed us to purify proliferative neural precursor cells from early postnatal rat striatum, which expressed the polysialylated form of the neural cell adhesion molecule (PSA-NCAM). These postnatal striatal PSA-NCAM+ cells were shown to proliferate in the presence of epidermal growth factor (EGF) and formed spheres that preferentially generated neurons in vitro. We demonstrated that PSA-NCAM+ neuronal precursors from postnatal striatum expressed GABA(A)R subunits in vitro and in situ. GABA elicited chloride currents in PSA-NCAM+ cells by activation of functional GABA(A)R that displayed a typical pharmacological profile. GABA(A)R activation in PSA-NCAM+ cells triggered a complex intracellular signaling combining a tonic inhibition of the mitogen-activated protein kinase cascade and an increase of intracellular calcium concentration by opening of voltage-gated calcium channels. We observed that the activation of GABA(A)R in PSA-NCAM+ neuronal precursors from postnatal striatum inhibited cell cycle progression both in neurospheres and in organotypic slices. Furthermore, postnatal PSA-NCAM+ striatal cells synthesized and released GABA, thus creating an autocrine/paracrine mechanism that controls their proliferation. We showed that EGF modulated this autocrine/paracrine loop by decreasing GABA production in PSA-NCAM+ cells. This demonstration of GABA synthesis and GABA(A)R function in striatal PSA-NCAM+ cells may shed new light on the understanding of key extrinsic cues that regulate the developmental potential of postnatal neuronal precursors in the CNS. [less ▲]

Autofill remote storage form on the OPAC holdings page

Conference (2012, September 13)

A big part of our library collections are located in a remote storage which is about 12 km from its managing library. Until recently, the only way to request a volume was by filling in a paper form at a ... [more ▼]

A big part of our library collections are located in a remote storage which is about 12 km from its managing library. Until recently, the only way to request a volume was by filling in a paper form at a library desk. The form was then faxed to the remote storage whose staff treated the request and delivered the ordered item to the pickup library. This workflow forced patrons to go to the library desk, no remote request was allowed. In order to modernize the workflow, we wanted to implement Aleph remote storage functionalities. We found it not so easy to set up and were faced moreover with two additional problems: we wanted to allow patrons to request (1) some items which are not in a remote storage and (2) serial issues from older collections which had never been itemized and so could not be requested through the traditional Aleph functionalities. Therefore, we set up a PHP form that any registered patron can call from the OPAC holding page (item-global) and that automatically contains patron information, bibliographic information and item details (location, call number, description, status, barcode). The patron just needs to select the appropriate pickup library before the form is sent by e-mail to the remote storage. That form can be used for any location (not necessarily for volumes located in a remote storage) and for serial holdings with few itemized volumes (a Z30 is not required to make a request). [less ▲]

Gli autografi di Francesco Guicciardini, in Autografi della letteratura italiana

in Motolese, Matteo; Procaccioli, Paolo; Russo, Emilio (Eds.) Il Cinquecento (2009)

Autoimmune angioneurotic edema in a patient with Helicobacter pylori infection.

in Helicobacter (2009), 14(1), 9-11

Association of acquired autoimmune angioneurotic edema with other diseases is increasing. However, the precise mechanism by which antibodies to C1-esterase inhibitor (C1-INH) are produced, is not ... [more ▼]

Association of acquired autoimmune angioneurotic edema with other diseases is increasing. However, the precise mechanism by which antibodies to C1-esterase inhibitor (C1-INH) are produced, is not elucidated. We describe a patient with IgA antibodies against C1-INH without other autoimmune markers. Our patient had gastritis and Helicobacter pylori infection, proven by biopsy. This case suggests that H. pylori infection can act as triggering factor for acquired autoimmune angioneurotic edema. [less ▲]

Autoimmune Pancreatitis Mimicking Cancer of the Head of Pancreas: Report of Two Cases

in Acta Gastro-Enterologica Belgica (2001), 64(2, Apr-Jun), 227-30

Autoimmune pancreatitis has been characterised in 1995, but only a few cases have been published since then, most of them from Japan. This report describes the cases of two Belgian male patients who ... [more ▼]

Autoimmune pancreatitis has been characterised in 1995, but only a few cases have been published since then, most of them from Japan. This report describes the cases of two Belgian male patients who presented with isolated obstructive jaundice. Radiological imaging studies were highly suggestive of carcinoma of the head of pancreas and both patients underwent uneventful cephalic pancreaticoduodenectomy with portal vein resection. Pathological analysis of the removed tissues suggested an autoimmune process in both cases. Both patients had hyper-gammaglobulinemia and antinuclear antibodies, but failed to show evidence of any other autoimmune disease or cause of chronic pancreatitis. In both cases final diagnosis was autoimmune pancreatitis. Preoperative clinical suspicion of this diagnosis is mandatory and may avoid unnecessary surgery in future cases. [less ▲]