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See detailNew approach to quantitative analysis of benzo[a]pyrene in food supplements by an immunochemical column test
Beloglazova, Natalia; Goryacheva, Irina; De Saeger, Sarah et al

in Talanta (2011), 85

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See detailA new approach to the qualitative evaluation of functional disability in dementia
Kurz, Xavier; Scuvée-Moreau, Jacqueline ULg; Rive, B. et al

in International Journal of Geriatric Psychiatry (2003), 18

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See detailNew approach to vascular injection in fresh cadaver dissection.
Heymans, Olivier Y; Nelissen, Xavier P; Peters, Stephane et al

in Journal of Reconstructive Microsurgery (2004), 20(4), 311-5

Vascular injection techniques for anatomic studies are often complementary. Use of colored gelatinous mixtures with methylene blue provides precious data about descriptive anatomy by the contrast that it ... [more ▼]

Vascular injection techniques for anatomic studies are often complementary. Use of colored gelatinous mixtures with methylene blue provides precious data about descriptive anatomy by the contrast that it produces in the tissues. The introduction of radiopaque medium, such as lead oxide, into the gelatinous mixture can be used as a complement by means of x-ray examination, in order to facilitate and to reduce the time of investigation. Addition of rhodamine B to the radiopaque mixture keeps the advantages of the contrast medium, but also permits further dissection to demonstrate some details shown by prior x-ray examination. This article compares these different injection techniques in the study of the nasal vascular network. Moreover, it depicts a new injection approach that allows the investigation of vascular territories depending on thin caliber arteries by selective reinjection, defining microangiosomes. Each above-cited technique was used in ten facial territories of fresh cadavers. The patterns of the vessels shown by these techniques were identical, with a constant visualization of infra-millimetric arteries. However, selective reinjection was the only method that permitted characterization of the proper vascular territory of the lateral nasal artery. [less ▲]

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See detailNew approaches and neglected areas
Richelle, Marc ULg

in Zbinden, X. (Ed.) Applications of behavioral pharmacology and toxicology (1983)

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See detailNew approaches and old controversies to postoperative pain control following cardiac surgery
Roediger, Laurence ULg; Larbuisson, Robert ULg; Lamy, Maurice ULg

in European Journal of Anaesthesiology (2006), 23(7), 539-550

Objective: To evaluate the effect of postoperative pain control in cardiac surgical patients on morbidity, mortality and other outcome measures. Background: New approaches in pain control have been ... [more ▼]

Objective: To evaluate the effect of postoperative pain control in cardiac surgical patients on morbidity, mortality and other outcome measures. Background: New approaches in pain control have been introduced over the past decade. The impact of these interventions, either alone or in combination, on perioperative outcome was evaluated in cardiac surgical patients. Methods: We searched Medline for the period of 1980 to the present using the key terms analgesics, opioid, non-steroidal anti-inflammatory drugs, cardiac surgery, regional analgesia, spinal, epidural, fast-track cardiac anaesthesia, fast-track cardiac surgery, myocardial ischaemia, myocardial infarction, postoperative care, accelerated care programmes, postoperative complications, and we examined and discussed the articles that were identified to be included in this review. Results: Pain management in cardiac surgery is becoming more important with the establishment of minimally invasive direct coronary artery bypass surgery and fast-track management of conventional cardiac surgery patients. Advances have been made in this area and encompass specific techniques, such as central neuraxial blockade or selective nerve blocks, and drugs (opioids, sedative-hypnotics and non-steroidal anti-inflammatory drugs). Ideally, these therapies provide not only patient comfort but also mitigate untoward cardiovascular responses, pulmonary responses, and other inflammatory and secondary sympathetic responses. The introduction of these newer approaches to perioperative care has reduced morbidity, but not mortality, in cardiac surgical patients. Conclusions: Understanding perioperative pathophysiology and implementation of care regimes to reduce the stress of cardiac surgery, will continue to accelerate rehabilitation associated with decreased hospitalization and increased satisfaction and safety after discharge. Reorganization of the perioperative team (anaesthesiologists, surgeons, nurses and physical therapists) will be essential to achieve successful fast-track cardiac surgical programmes. Developments and improvements of multimodal interventions within the context of 'fast-track' cardiac surgery programmes represents the major challenge for the medical professionals working to achieve a 'pain and risk free' perioperative course. [less ▲]

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See detailNew approaches in light/laser therapies and photodynamic treatment of acne.
Pierard-Franchimont, Claudine; PAQUET, Philippe ULg; PIERARD, Gérald ULg

in Expert Opinion on Pharmacotherapy (2011), 12(4), 493-501

Acne is a domain in which the technology and understanding of light/laser therapeutic procedures have advanced considerably. The aim of the paper was to revisit adjunctive physical treatments of acne ... [more ▼]

Acne is a domain in which the technology and understanding of light/laser therapeutic procedures have advanced considerably. The aim of the paper was to revisit adjunctive physical treatments of acne, including light/laser treatments and photodynamic therapy. This review summarizes findings about such treatment modalities with particular emphasis on efficacy and safety. A number of laser/light-based modalities have been developed to meet the increasing demand for new acne treatments. The current devices correspond, on the one hand, to light-emitting diode therapy and, on the other hand, to the 532-nm potassium titanyl phosphate laser, the 585- and 595-nm pulsed dye laser, the 1450-nm diode laser, the 1320-nm Nd:YAG laser and intense pulsed light. Photodynamic therapy is also available. It is claimed that light/laser treatments might induce a faster response compared with the 1-3 months needed for response to traditional oral and topical treatments. In conclusion, pulsed dye laser shows efficacy in some patients with mild to moderate acne. The relative effectiveness compared with other treatments is unconfirmed; from the published information, evidence-based efficacy assessment of light/laser therapies in acne remains almost impossible. [less ▲]

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See detailNew Approaches in Text Linguistics
Longrée, Dominique ULg; Mellet, Sylvie

Book published by John Benjamins (2009)

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See detailNew arguments supporting the intrinsic origin of BAL QSOs - Formation of the complex Ly-alpha+NV line profile
Hutsemekers, Damien ULg; Surdej, Jean ULg

in Bianchi, L.; Gilmozzi, R. (Eds.) Proceedings of the Second Torino Workshop "Mass Outflows from Stars and Galactic Nuclei" (1988)

A study is presented to further elucidate the question of whether or not all quasars are affected by the BAL phenomenon. The possibility that observed BAL profiles are formed in spherically symmetric ... [more ▼]

A study is presented to further elucidate the question of whether or not all quasars are affected by the BAL phenomenon. The possibility that observed BAL profiles are formed in spherically symmetric expanding atmospheres is investigated. [less ▲]

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See detailNew assessment of bovine tuberculosis risk factors in Belgium based on nationwide molecular epidemiology.
Humblet, M.-F.; Gilbert, M.; Govaerts, M. et al

in Journal of Clinical Microbiology (2010), 48(8), 2802-8

This assessment aimed to elaborate a statistical nationwide model for analyzing the space-time dynamics of bovine tuberculosis in search of potential risk factors that could be used to better target ... [more ▼]

This assessment aimed to elaborate a statistical nationwide model for analyzing the space-time dynamics of bovine tuberculosis in search of potential risk factors that could be used to better target surveillance measures. A database comprising Mycobacterium bovis molecular profiles from all isolates obtained from Belgian outbreaks during the 1995-to-2006 period (n = 415) allowed the identification of a predominant spoligotype (SB0162). Various databases compiling 49 parameters to be tested were queried using a multiple stepwise logistic regression to assess bovine tuberculosis risk factors. Two isolate datasets were analyzed: the first included all Mycobacterium bovis isolates, while the second included only data related to the SB0162 type strain. When all Mycobacterium bovis isolates were included in the model, several risk factors were identified: history of bovine tuberculosis in the herd (P < 0.001), proximity of an outbreak (P < 0.001), cattle density (P < 0.001), and annual amplitude of mean middle-infrared temperature (P < 0.001). The approach restricted to the predominant SB0162 type strain additionally highlighted the proportion of movements from an infected area during the current year as a main risk factor (P = 0.009). This study identified several risk factors for bovine tuberculosis in cattle, highlighted the usefulness of molecular typing in the study of bovine tuberculosis epidemiology, and suggests a difference of behavior for the predominant type strain. It also emphasizes the role of animals' movements in the transmission of the disease and supports the importance of controlling trade movements. [less ▲]

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See detailNew assessment of dependency in demented patients : impact on the quality of life in informal caregivers.
Andrieu, Sandrine; Rive, Benoït; Guilhaume, Chantal et al

in Psychiatry & Clinical Neurosciences (2007), 61(3), 234-242

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See detailNew asthma biomarkers: lessons from murine models of acute and chronic asthma.
Di Valentin, Emmanuel ULg; Crahay, Céline; Garbacki, Nancy ULg et al

in American Journal of Physiology - Lung Cellular and Molecular Physiology (2009), 296(2), 185-97

Many patients suffering from asthma are not fully controlled by currently available treatments, and some of them display an airway remodeling leading to exaggerated lung function decline. The aim of the ... [more ▼]

Many patients suffering from asthma are not fully controlled by currently available treatments, and some of them display an airway remodeling leading to exaggerated lung function decline. The aim of the present study was to unveil new mediators in asthma to better understand pathophysiology and propose or validate new potential therapeutic targets. A mouse model of asthma mimicking acute or chronic asthma disease was used to select genes undergoing a modulation in both acute and chronic conditions. Mice were exposed to ovalbumin or PBS for 1, 5, and 10 wk [short-, intermediate-, and long-term model (ST, IT, and LT)], and gene expression in the lung was studied using an Affymetrix 430 2.0 genome-wide microarray and further confirmed by RT-PCR and immunohistochemistry for selected targets. We report that 598, 1,406, and 117 genes were upregulated and 490, 153, 321 downregulated at ST, IT, and LT, respectively. Genes related to mucous secretion displayed a progressively amplified expression during the allergen exposure protocol, whereas genes corresponding to growth and differentiation factors, matrix metalloproteinases, and collagens were mainly upregulated at IT. By contrast, genes related to cell division were upregulated at ST and IT and were downregulated at LT. In this study, besides confirming that Arg1, Slc26a4, Ear11, and Mmp12 genes are highly modulated throughout the asthma pathology, we show for the first time that Agr2, Scin, and Cd209e genes are overexpressed throughout the allergen exposure and might therefore be considered as suitable new potential targets for the treatment of asthma. [less ▲]

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See detailA new automatic video multitracking system able to follow a large school
Delcourt, Johann ULg; Becco, Christophe ULg; Vandewalle, Nicolas ULg et al

in Noldus, L.P.P.J.; Grieco, F.; Loijens, L. W. S. (Eds.) et al Proceedings of Measuring Behavior 2005 (2005)

The study of shoaling behaviours is tackled by scientists by three approaches: the field, laboratory and computer modelling approach. The field studies are complicated and permit rarely an analysis of ... [more ▼]

The study of shoaling behaviours is tackled by scientists by three approaches: the field, laboratory and computer modelling approach. The field studies are complicated and permit rarely an analysis of individual positions. The third approach, consisting of development of mathematic models, is artificial. It requires a comparison with empiric results to validate and to determine the explications’ degree of each model. Thanks to the developments of digital imaging techniques, the laboratory studies on fish are able to measure the behavioural parameters with precision, impossible to realize with manual recording. Multitracking systems are rare and of recent development. These are insufficient to study the real size of shoals, often composed of hundreds of .shes. We have developed a new system of multitracking thanks to collaboration with the G.R.A.S.P. The G.R.A.S.P. has before realised other multitracking systems to follow some hundreds physical objects. Our video multitracking system is able to detect and to track more than a hundred unmarked fishes by gray scaling technique during some minutes. It permits an analysis as well at the group level as at the individual level. The multitraking program is able to attribute a number at each fish and to follow each one during the whole duration of the track. Our system permits the analysis of the movement of each individual, even if the trajectories of two fishes cross each other. It is possible thanks to the theoretical estimation of trajectory of each fish, compared with the real trajectory (analysis with feedback). The human eye is always necessary to detect the errors in identification but reediting is possible. However, if the fishes don’t move too rapidly, a rate of 25 images /s gives very good results, without too much visual expertise from the experimenter. If the fishes are too fast (i.e. escape response), it is better to use a high speed camera. [less ▲]

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See detailA new Barremian (Early Cretaceous) ichthyosaur from western Russia
Fischer, Valentin ULg; Masure, Edwige; Arkhangelsky, Maxim et al

in Journal of Vertebrate Paleontology (2011), 31(5), 1010-1025

A new ophthalmosaurid ichthyosaur, Sveltonectes insolitus gen. et sp. nov., is described from a sub-complete and three-dimensionally preserved specimen from the late Barremian of western Russia. This new ... [more ▼]

A new ophthalmosaurid ichthyosaur, Sveltonectes insolitus gen. et sp. nov., is described from a sub-complete and three-dimensionally preserved specimen from the late Barremian of western Russia. This new taxon is supported by 11 cranial, dental, and postcranial autapomorphies, and is also characterized by features previously considered as autapomorphic for some other Ophthalmosauridae, such as a processus narialis on the prefrontal and relatively long hindfins with pre- and postaxial accessory digits. We conducted a new phylogenetic analysis of Thunnosauria, which supports a ‘Stenopterygius-origin’ for Ophthalmosauridae. Sveltonectes is regarded as the sister taxon of Aegirosaurus, which shares a similar skull roof construction. Contrary to most other Cretaceous ichthyosaurs, Sveltonectes is characterized by delicate and sharply pointed teeth, confirming that the Ophthalmosauridae were ecologically highly diversified during the Early Cretaceous [less ▲]

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See detailNew Basic Membrane-Destabilizing Peptides For Plasmid-Based Gene Delivery In Vitro And In Vivo
Rittner, K.; Benavente, A.; Bompard-Sorlet, A. et al

in Molecular Therapy (2002), 5(2), 104-14

We have designed new basic amphiphilic peptides, ppTG1 and ppTG20 (20 amino acids), and evaluated their efficiencies in vitro and in vivo as single-component gene transfer vectors. ppTG1 and ppTG20 bind ... [more ▼]

We have designed new basic amphiphilic peptides, ppTG1 and ppTG20 (20 amino acids), and evaluated their efficiencies in vitro and in vivo as single-component gene transfer vectors. ppTG1 and ppTG20 bind to nucleic acids and destabilize liposomes consisting of 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) and cholesterol (3:1 mol/mol) at pH 5 and pH 7. Complexes of plasmid DNA and ppTG1 gave rise to efficient transfection in a variety of human and murine cell lines at low charge ratios ([+/-] between 1 and 2). In cell culture experiments, such vectors were superior to the membrane-destabilizing peptide KALA. In comparison with cationic lipid-, dendrimer-, and polymer-based transfection agents like Superfect, polyethylenimine (PEI), and Lipofectin, ppTG1 vectors showed good transfection efficiencies, especially at low DNA doses. Moreover, we demonstrated for the first time successful gene transfer in living animals with a single-component peptide vector. In the mouse, intravenous injection of a luciferase expression plasmid complexed with ppTG1 or ppTG20 led to significant gene expression in the lung 24 hours after injection. Structure-function studies with ppTG1, ppTG20, and sequence variants suggest that the high gene transfer activity of these peptides is correlated with their propensity to exist in alpha-helical conformation, which seems to be strongly influenced by the nature of the hydrophobic amino acids. [less ▲]

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See detailA new benzotriazole-mediated stereoflexible gateway to hetero-2,5-diketopiperazines
Monbaliu, Jean-Christophe ULg; Hansen, Finn; Beagle, Lucas et al

in Chemistry : A European Journal (2011), 18

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See detailNew Biological Investigations on 3-Bromophenyl 6-Acetoxymethyl-2-oxo-2H-1-Benzopyran-3-Carboxylate as Anti-angiogenic Agent
Hemmer, M.; Kempen, Isabelle; De Tullio, Pascal ULg et al

in Drug Development Research (2010), 71

The development of blood vessels inside tumors is required to provide the nutrients and oxygen needed for tumor growth and to allow the spread of cancer cells at a distance to form metastasis ... [more ▼]

The development of blood vessels inside tumors is required to provide the nutrients and oxygen needed for tumor growth and to allow the spread of cancer cells at a distance to form metastasis. Angiogenesis is also implicated in ocular diseases like age-related macular degeneration. The present work describes the potential anti-angiogenic properties of a coumarinic derivative, 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate (IK9), previously described as a potent inhibitor of HT 1080 fibrosarcoma cell invasion in vitro and tumor growth in vivo. In vivo, ex vivo, and in vitro models were used to delineate the anti-angiogenic properties of IK9. The anti-angiogenic effect of IK9 was demonstrated in vivo in a choroidal neovascularization mice model and additionally ex vivo in a rat aortic ring assay where it was more active than the known matrix metalloproteinase inhibitor Ro 28-2653. IK9 did not affect apoptosis, proliferation, or endothelial cell invasiveness in vitro. These findings suggest a complex mechanism of action of the compound via direct or indirect effects on endothelial cell properties. This study identifies IK9 as a new potent inhibitor of angiogenesis and suggests its potential use as a therapeutic agent. [less ▲]

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