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See detailMinocycline attenuates HIV-1 infection and suppresses chronic immune activation in humanized NOD/LtsZ-scidIL-2Rgamma(null) mice.
Singh, Maneesh; Singh, Pratibha; Vaira, Dolores et al

in Immunology (2014), 142(4), 562-72

More than a quarter of a century of research has established chronic immune activation and dysfunctional T cells as central features of chronic HIV infection and subsequent immunodeficiency. Consequently ... [more ▼]

More than a quarter of a century of research has established chronic immune activation and dysfunctional T cells as central features of chronic HIV infection and subsequent immunodeficiency. Consequently, the search for a new immunomodulatory therapy that could reduce immune activation and improve T-cell function has been increased. However, the lack of small animal models for in vivo HIV study has hampered progress. In the current study, we have investigated a model of cord blood haematopoietic progenitor cells (CB-HPCs) -transplanted humanized NOD/LtsZ-scidIL-2Rgamma(null) mice in which progression of HIV infection is associated with widespread chronic immune activation and inflammation. Indeed, HIV infection in humanized NSG mice caused up-regulation of several T-cell immune activation markers such as CD38, HLA-DR, CD69 and co-receptor CCR5. T-cell exhaustion markers PD-1 and CTLA-4 were found to be significantly up-regulated on T cells. Moreover, increased plasmatic levels of lipopolysaccharide, sCD14 and interleukin-10 were also observed in infected mice. Treatment with minocycline resulted in a significant decrease of expression of cellular and plasma immune activation markers, inhibition of HIV replication and improved T-cell counts in HIV-infected humanized NSG mice. The study demonstrates that minocycline could be an effective, low-cost adjunctive treatment to regulate chronic immune activation and replication of HIV. [less ▲]

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See detailMinor contributions and notes: an absorption line of C IV in stellar spectra
Mack, J.-E.; Swings, Polydore ULg; Struve, Otto

in Astrophysical Journal (1932), 76

An absorption line at λ 4658.41, observed in O-type stars, is probably identical with C IV 4658.64. This line has the distinction of requiring the greatest energy of excitation of any line yet observed in ... [more ▼]

An absorption line at λ 4658.41, observed in O-type stars, is probably identical with C IV 4658.64. This line has the distinction of requiring the greatest energy of excitation of any line yet observed in stellar absorption spectra. [less ▲]

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See detailMinorité et tutelle
Deguel, François ULg

in Leleu, Yves-Henri (Ed.) Chroniques notariales (2010)

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See detailMinorité prolongée, interdiction et conseil judiciaire: les dernières années
Leleu, Yves-Henri ULg

in Leleu, Yves-Henri (Ed.) Les incapacités (2003)

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See detailMinorités deleuziennes et politiques linguistiques
Petteni, Oriane ULg

Conference (2011, February)

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See detailMinorities in European Cities: The Dynamics of Social Integration and Social Exclusion at the Neighbourhood Level
Martiniello, Marco ULg; Body-Gendrot, Sophie

Book published by MacMillan & St. Martin's Press (2000)

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See detailMinority Nationalism and European Integration - P. Lynch
Martiniello, Marco ULg

in Nations & Nationalism (1997), 4(3), 476-478

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See detailMinority Rights in Europe de H. Miall (ed)
Martiniello, Marco ULg

in Ethnic and Racial Studies (1996), 19(2), 446-447

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See detailA miospore assemblage at the Siluro-Devonian boundary from the Tawil Formation, Qatif Field, Saudi Arabia
Steemans, Philippe ULg; Al-Ruwaili, M.; Filatoff, J. et al

Conference (2001)

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See detailMiospore assemblages from the Silurian-Devonian boundary, in borehole A1-61, Ghadamis Basin, Libya
Rubinstein, C.; Steemans, Philippe ULg

in Review of Palaeobotany and Palynology (2002, April), 118(1-avr Sp. Iss. SI), 397-421

Well preserved and diversified miospore assemblages have been recorded from a relatively continuous sequence in borehole A1-61 which spans the Silurian-Devonian boundary in the northwestern part of the ... [more ▼]

Well preserved and diversified miospore assemblages have been recorded from a relatively continuous sequence in borehole A1-61 which spans the Silurian-Devonian boundary in the northwestern part of the Ghadamis Basin, Libya. The sequence is represented by early Devonian Lochkovian beds of the Tadrart Formation that transgress onto the Silurian Ludlow-Pridoli beds of the upper part of the 'Alternances Argilo-greseuses' Formation. The present work demonstrates a succession of miospore assemblages from closely sampled layers that have been stratigraphically dated as Ludlow-middle Pridoli and early Lochkovian by chitinozoans and acritarchs. Over 80 species of cryptospores and trilete spores have been identified. Modified detailed morphological interpretations are given. The miospore assemblages are correlated with miospore zonation schemes established for the type sequences of the Welsh Borderland, and those previously described from Libya. Early occurrences of some species as Streelispora newportensis on the western Gondwana plate, are put forward by comparison with the Old Red Sandstone continent. Phytogeographic and palaeobotanic implications based on these observations are discussed. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailMiospore Biozonation in the Middle Devonian - Lower Carboniferous of Europe : its application to Western Gondwana
Loboziak, S.; Streel, Maurice ULg

in Anais da Academia Brasileira de Ciencias (1995), 67(3), 311-312

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See detailMiospore contribution to the Upper Famennian-Strunian event stratigraphy
Streel, Maurice ULg

in Annales de la Société Géologique de Belgique (1986), 109(1), 75-92

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See detailMiospore evidence for pre-Emsian and latest Famennian sedimentation in the Devonian of the Paraná Basin, South Brazil
Loboziak, S; Goncalves De Melo, JH; Steemans, Philippe ULg et al

Conference (1995)

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See detailMiospore Evolution from the Ordovician to the Silurian
Steemans, Philippe ULg

in Review of Palaeobotany and Palynology (2000, December), 113(1-3), 189-196

The definition of the term cryptospore is amended to include only spores thought to be produced by embryophytes and to exclude all enigmatic palynomorphs. Cryptospores are included here in the miospore ... [more ▼]

The definition of the term cryptospore is amended to include only spores thought to be produced by embryophytes and to exclude all enigmatic palynomorphs. Cryptospores are included here in the miospore group.The oldest published assemblage of typical cryptospores is Llanvirn in age. The evolution of cryptospore assemblages is very slow from the Llanvirn to the early Llandovery. The Telychian and Sheinwoodian stages are periods of drastic impoverishment in cryptospore biodiversity, followed by an important modification in miospore assemblages. This step in the evolution of the vegetation is correlated with the rapid transgression of seas on the continent during the early Llandovery. On the other hand, the Hirnantian glaciation does not affect diversity of the miospore assemblages. [less ▲]

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See detailMiospore lateral distribution in Upper Famennian alluvial lagoonal to tidal facies from eastern United States and Belgium.
Streel, Maurice ULg; Schlecker, S.E.

in Review of Palaeobotany and Palynology (1990), 64

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See detailMiospore ranges near the D/C Boundary and extinction events.
Streel, Maurice ULg

in Newsletter. Subcommission on Devonian Stratigraphy (1996), 12

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See detailMiospore systematics and stratigraphic correlation of Devonian-Carboniferous Boundary deposits in the European part of the USSR and Western Europe.
Avchimovitch, V.I.; Byvsheva, T.V.; Higgs, K et al

in Courier Forschungsinstitut Senckenberg (1988), 100

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See detailMiospores and the emergence of land plants
Steemans, Philippe ULg; Wellman, C. H.

in Webby, B.; Paris, F.; Droser, M.L. (Eds.) et al The Great Ordovician Biodiversification Event (2004)

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