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See detailNew results on the variability of some WN stars
Gosset, Eric ULg; Vreux, Jean-Marie ULg; Manfroid, Jean ULg et al

in Davidson, K.; Moffat, A. F. J.; Lamers, H.J.G.L.M. (Eds.) Physics of Luminous Blue Variables (1989)

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See detailNew ribonucleotide reductase inhibitor, (E)-2′-deoxy-(fluromethylene) cytidine, acts as a radiosensitizer on human colon and cervix cancer cell lines
Coucke, Philippe ULg; LI, XY; Cottin, E et al

in Radiotherapy & Oncology (1996), 40(Supplément 1), 135

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See detailNew role for Emerin, a key inner nuclear membrane protein, as an enhancer of the autophagosome formation in the C16-ceramide autophagy pathway.
Deroyer, Céline ULg; Renert, Anne-Françoise; Merville, Marie-Paule ULg et al

in Autophagy (2014)

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in ... [more ▼]

To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in the regulation of cell growth, differentiation or cell death. However, the mechanisms by which they mediate these pathways are not fully understood. We found that C16-ceramide induces EMD phosphorylation on its LEM domain through PRKACA. Upon ceramide treatment, phosphorylated EMD binds LC3 leading to an increase of the autophagosomes formation. These data suggest a new role of EMD as an enhancer of autophagosomes formation in the C16-ceramide autophagy pathway in colon cancer cells. [less ▲]

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See detailA new role for histone deacetylase 5 in the maintenance of long telomeres.
Novo, Clara Lopes; Polese, Catherine ULg; Matheus, Nicolas ULg et al

in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2013), 27

Telomeres are major regulators of genome stability and cell proliferation. A detailed understanding of the mechanisms involved in their maintenance is of foremost importance. Of those, telomere chromatin ... [more ▼]

Telomeres are major regulators of genome stability and cell proliferation. A detailed understanding of the mechanisms involved in their maintenance is of foremost importance. Of those, telomere chromatin remodeling is probably the least studied; thus, we intended to explore the role of a specific histone deacetylase on telomere maintenance. We uncovered a new role for histone deacetylase 5 (HDAC5) in telomere biology. We report that HDAC5 is recruited to the long telomeres of osteosarcoma- and fibrosarcoma-derived cell lines, where it ensures proper maintenance of these repetitive regions. Indeed, depletion of HDAC5 by RNAi resulted in the shortening of longer telomeres and homogenization of telomere length in cells that use either telomerase or an alternative mechanism of telomere maintenance. Furthermore, we present evidence for the activation of telomere recombination on depletion of HDAC5 in fibrosarcoma telomerase-positive cancer cells. Of potential importance, we also found that depletion of HDAC5 sensitizes cancer cells with long telomeres to chemotherapeutic drugs. Cells with shorter telomeres were used to control the specificity of HDAC5 role in the maintenance of long telomeres. HDAC5 is essential for the length maintenance of long telomeres and its depletion is required for sensitization of cancer cells with long telomeres to chemotherapy. -Novo, C. L., Polese, C., Matheus, N., Decottignies, A., Londono-Vallejo, A., Castronovo, V., Mottet, D. A new role for histone deacetylase 5 in the maintenance of long telomeres. [less ▲]

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See detailNew Role For Hpar-1 Kinases Emk And C-Tak1 In Regulating Localization And Activity Of Class Iia Histone Deacetylases
Dequiedt, Franck ULg; Martin, Maud ULg; Von Blume, Julia et al

in Molecular and Cellular Biology (2006), 26(19), 7086-102

Class IIa histone deacetylases (HDACs) are found both in the cytoplasm and in the nucleus where they repress genes involved in several major developmental programs. In response to specific signals, the ... [more ▼]

Class IIa histone deacetylases (HDACs) are found both in the cytoplasm and in the nucleus where they repress genes involved in several major developmental programs. In response to specific signals, the repressive activity of class IIa HDACs is neutralized through their phosphorylation on multiple N-terminal serine residues and 14-3-3-mediated nuclear exclusion. Here, we demonstrate that class IIa HDACs are subjected to signal-independent nuclear export that relies on their constitutive phosphorylation. We identify EMK and C-TAK1, two members of the microtubule affinity-regulating kinase (MARK)/Par-1 family, as regulators of this process. We further show that EMK and C-TAK1 phosphorylate class IIa HDACs on one of their multiple 14-3-3 binding sites and alter their subcellular localization and repressive function. Using HDAC7 as a paradigm, we extend these findings by demonstrating that signal-independent phosphorylation of the most N-terminal serine residue by the MARK/Par-1 kinases, i.e., Ser155, is a prerequisite for the phosphorylation of the nearby 14-3-3 site, Ser181. We propose that this multisite hierarchical phosphorylation by a variety of kinases allows for sophisticated regulation of class IIa HDACs function. [less ▲]

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See detailA new role for NF-kappaB in angiogenesis inhibition.
Tabruyn, Sébastien ULg; Griffioen, A. W.

in Cell Death & Differentiation (2007), 14(8), 1393-7

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See detailA new role for the PP2A regulatory subunit Balpha in angiogenesis
Martin, Maud ULg

Conference (2010)

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See detailNEW ROTATIONAL ANALYSIS OF THE ALPHA-1-PI-CHI-1-SIGMA+ TRANSITION OF ALBR
BREDOHL, Harald; DUBOIS, Iwan; Mahieu, Emmanuel ULg et al

in Journal of Molecular Spectroscopy (1991), 145(1), 12-17

Twenty-eight bands of the A1Π-X1Σ+ transition have been fully analyzed. The vibrational constants obtained for the A1Π state do not agree with earlier data. On the other hand the observations suggest that ... [more ▼]

Twenty-eight bands of the A1Π-X1Σ+ transition have been fully analyzed. The vibrational constants obtained for the A1Π state do not agree with earlier data. On the other hand the observations suggest that the conclusion about the predissociation ought to be revised. [less ▲]

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See detailA New Route for the Synthesis of [18f]Fluoroaromatic Substituted Amino Acids: No Carrier Added L-P-[18f]Fluorophenylalanine
Lemaire, Christian ULg; Guillaume, M.; Christiaens, Léon ULg et al

in International Journal of Radiation Applications and Instrumentation. Part A : Applied Radiation and Isotopes (1987), 38(12), 1033-8

L-p-[18F]fluorophenylalanine was designed as a potential marker for probing protein synthesis in the human brain by positron emission tomography. This radiotracer has been synthesized using nucleophilic ... [more ▼]

L-p-[18F]fluorophenylalanine was designed as a potential marker for probing protein synthesis in the human brain by positron emission tomography. This radiotracer has been synthesized using nucleophilic displacement of the activated nitro group of p-nitrobenzaldehyde by NCA 18F- obtained from the 18O (p, n) reaction on enriched water. The L-form of the [18F]fluoroamino acid can be separated on an analytical scale chiral column. A typical production run of 22.2 GBq (600 mCi) of 18F obtained after a 10 microA.h bombardment of 18 MeV protons on 99.8% 18O-enriched water leads to a batch of 1.11 GBq (30 mCi) of NCA L-p-[18F]fluorophenylalanine after a total synthesis time of 120 min. [less ▲]

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See detailNew Rules, New Political Class? Analysis of the Impact of the Electoral Reforms in Belgium on the 2014 Elections and Aftermath
Dodeigne, Jérémy ULg; Vandeleene, Audrey

Conference (2013, October 18)

At the eve of the 2014 “mammoth elections”, the Belgian electoral systems are in question. According to the eight parties having contributed to the sixth State reform, it is time for a “political renewal” ... [more ▼]

At the eve of the 2014 “mammoth elections”, the Belgian electoral systems are in question. According to the eight parties having contributed to the sixth State reform, it is time for a “political renewal”. The agreement of October 2011 plans that the Senate will cease to be a permanent institution composed of directly elected senators. The latter will be instead replaced by regional MPs with dual offices. The agreement also provides the (principle of) vertical simultaneity between the regional, federal and European elections while it bans dual candidature and forces candidates to seat where they get elected. In the meantime, the Walloon Parliament has adopted the “anti-cumul” Decree, which limits the accumulation of local and parliamentary offices. This research note proposes therefore a global reflexion on the potential consequences resulting from these electoral reforms on the Belgian political class. We proceed in two steps. First, we detail which reforms could affect the political class. Second, we seek to evaluate which impact the reforms may have on the political class. We argue that the electoral reforms adopted for the 6th State reforms but also by the Walloon Parliament confirm and furthermore enhance an already pre-existing trend towards a territorial distinctiveness between the federal and the regional levels. The 2014 elections might become one of the key points of crystallization when political actors become aware of the existence of two distinct political arenas. Overall, the article anticipates the reshaping of Belgian politics in the run-up to 2014 and aftermath. [less ▲]

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See detailNew ruthenium catalysts bearing N-heterocyclic carbene ligands for ATRA and ATRP
Sauvage, Xavier ULg; Richel, Aurore ULg; Delfosse, Sébastien et al

in e-polymers (2003)

This study provides a glimpse of the synthetic possibilities arising from the use of NHC􀀀 s complexes in radical reactions, and illustrates how the fine tuning of the steric and electronic parameters of ... [more ▼]

This study provides a glimpse of the synthetic possibilities arising from the use of NHC􀀀 s complexes in radical reactions, and illustrates how the fine tuning of the steric and electronic parameters of this class of ruthenium complexes affect their catalytic activity. [less ▲]

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See detailNew ruthenium catalysts bearing N-heterocyclic carbene ligands for ATRP
Sauvage, Xavier ULg; Richel, Aurore ULg; Delfosse, Sébastien et al

Poster (2003, May)

Stable nucleophilic N-heterocyclic carbenes (NHCs) are neutral, two-electron ligands with a negligible p-back-bonding tendency. They behave as phosphine mimics, yet they are better s- donors and they form ... [more ▼]

Stable nucleophilic N-heterocyclic carbenes (NHCs) are neutral, two-electron ligands with a negligible p-back-bonding tendency. They behave as phosphine mimics, yet they are better s- donors and they form stronger bonds to metal centers than most phosphines. Their electronic and steric properties are liable to ample modification simply by varying the substituents on the nitrogen atoms. Therefore, NHCs constitute a promising new class of ligands available for catalyst engineering and fine-tuning. We found that the 18-electron complex RuCl2(p-cymene)(PCy3) was a versatile and efficient promoter for ring-opening metathesis polymerization of both strained and low-strain cyclic olefins when activated by a suitable precursor such as trimethylsilyldiazomethane. This complex was also an excellent catalyst for ATRP (Atom Transfer Radical Polymerization) of MMA and styrene. In this poster, we present preliminary results obtained in olefin metathesis and in radical reactions (ATRP and Kharasch addition) when tricyclohexylphosphine was substituted by an N-heterocylic carbene ligand. [less ▲]

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See detailNew ruthenium catalysts bearing N-heterocyclic carbene ligands for ATRP
Tudose, Adriana; Delfosse, Sébastien; Richel, Aurore ULg et al

in e-polymers (2003)

New ruthenium catalysts bearing N-heterocyclic carbene ligands in Kharasch chemistry

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See detailNew ruthenium catalysts bearing N-heterocyclic carbene ligands in Kharasch chemistry
Tudose, Adriana; Delfosse, Sébastien; Richel, Aurore ULg et al

Poster (2003)

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See detailThe "New Science" and the Sea - Academies, Learned Societies and Marine Knowledge in the Seventeenth and Eighteenth Centuries
Vandersmissen, Jan ULg

Conference (2012, July 05)

Academies and learned societies were the main tools for the application of the “new science” in the seventeenth and eighteenth centuries. This paper aims to contribute to the research on marine science ... [more ▼]

Academies and learned societies were the main tools for the application of the “new science” in the seventeenth and eighteenth centuries. This paper aims to contribute to the research on marine science, nautical knowledge and empire building by studying academies and learned societies in their role of bureaus of investigation of the colonial reality. As a fact, institutions such as the Académie Royale des Sciences in Paris and the Royal Society of London played an important role as mediators in the development of various models of “science policies”. This paper focuses on the implication of these institutions in overseas scientific exploration in the seventeenth and eighteenth centuries. It stresses the specific importance of “academic” voyages for the development of navigational techniques, from Huygens and Hooke to Maskelyne and Harrison. This comparative study thus tries to show how through these new centers of knowledge production a scholarly interest for day-to-day nautical practices influenced the scientized perfection of navigational techniques. [less ▲]

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See detailA new seismic analysis of Alpha Centauri
Thoul, Anne ULg; Scuflaire, Richard ULg; Noels-Grötsch, Arlette ULg et al

in Astronomy and Astrophysics (2003), 402(1), 293-297

Models of alpha Cen A & B have been computed using the masses determined by Pourbaix et al. (\cite{Po2002}) and the data derived from the spectroscopic analysis of Neuforge & Magain (\cite{Ne1997}). The ... [more ▼]

Models of alpha Cen A & B have been computed using the masses determined by Pourbaix et al. (\cite{Po2002}) and the data derived from the spectroscopic analysis of Neuforge & Magain (\cite{Ne1997}). The seismological data obtained by Bouchy & Carrier (\cite{Bo2001}, \cite{Bo2002}) do help improve our knowledge of the evolutionary status of the system. All the constraints are satisfied with a model which gives an age of about 6 Gyr for the binary. [less ▲]

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See detailA new semi-selective agar medium for recovery and enumeration of antagonistic yeast, Pichia guilliermondii strain Z1 from orange fruit surface
Lahlali, Rachid; Hamadi, Younes; El Guilli, Mohamed et al

in African Journal of Microbiology Research [=AJMR] (2013), 7(25), 3209-3216

The aim of this work was to develop a semi-selective medium for recovery and enumeration of Pichia guilliermondii strain Z1, a reliable biocontrol agent against postharvest pathogens of citrus fruit, and ... [more ▼]

The aim of this work was to develop a semi-selective medium for recovery and enumeration of Pichia guilliermondii strain Z1, a reliable biocontrol agent against postharvest pathogens of citrus fruit, and to assess the population dynamic of this antagonistic yeast on orange fruit in relation to incubation temperature and time of incubation. PDA is the basal medium used in this study which allows the antagonistic strain Z1 source of carbon and nutrients. Different chemicals (thiophanate-methyl, thiabendazole, thiram and imazalil) and antibiotics (hygromycin, tetracyclin, ampicillin and chloramphenicol) have been tested individually and based on the plating efficiency up to 90%, 40 combinations have been assayed between antibiotics and fungicides. Ten combinations proved to be highly selective against citrus pathogens and laboratory microflora, but only one consisting of tetracyclin (1 g/L) and thiabendazole (60 mg/L) was retained based on plating efficiency up to 99%, total selectivity against laboratory microflora, epiphytic microflora from washed orange fruit and lower cost. The semi-selective medium TET-TBZ-PDA has been used to assess the impact of temperature and incubation time on the survival of strain Z1. It appears that population density was significantly influenced by both factors and the highest population size was recorded at 25°C followed by 5 and 35°C, respectively. This strain required a time of adaptation before entering the exponential growth phase with a maximum growth observed at 25°C relative to others. The semi-selective medium TETTBZ- PDA could be an efficient and valuable way to track the population density of this strain on the surface of orange when applied pre-or postharvest. This semi-selective medium may also aid in reaching a population density allowing a better efficiency in relation to environmental conditions. [less ▲]

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See detailA New Separable Approximation Scheme for Topological Problems and Optimization Problems Characterized by a Large Number of Design Variables
Duysinx, Pierre ULg; Zhang, Weihong; Fleury, Claude ULg et al

in Olhoff, Niels; Rozvany, Georges I.N. (Eds.) Proceedings of the First World Congress of Structural and Multidisciplinary Optimization (WCSMO1) (1995, May)

This paper is dedicated to a new convex separable approximation for solving optimization problems characterized by a very large number of design variables as in topology design. For such problems, the ... [more ▼]

This paper is dedicated to a new convex separable approximation for solving optimization problems characterized by a very large number of design variables as in topology design. For such problems, the convergence speed can be accelerated if one uses high quality approximation schemes for structural responses. To achieve this task, we propose, here, a new approximation procedure that belongs to the GMMA family. The originality of this new scheme is to rely on an automatic selection procedure of the asymptotes, using only first and zero order information accumulated during the previous iterations. This is possible owing to a diagonal Quasi-Newton update technique. Firstly, the new approximation procedure is validated on classical "benchmarks" of structural optimization. Then, it is compared to other schemes on a typical topology optimization problem. [less ▲]

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