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See detailNegative purifying selection drives prion and doppel protein evolution
Tsangaras, K.; Kolokotronis, S.-O.; Ulrich, R. G. et al

in Journal of Molecular Evolution (2014), 79(1-2), 12-20

The prion protein (PrP) when misfolded into the pathogenic conformer PrPSc is the major causative agent of several lethal transmissible spongiform encephalopathies in mammals. Studies of evolutionary ... [more ▼]

The prion protein (PrP) when misfolded into the pathogenic conformer PrPSc is the major causative agent of several lethal transmissible spongiform encephalopathies in mammals. Studies of evolutionary pressure on the corresponding gene using different datasets have yielded conflicting results. In addition, putative PrP or PrP interacting partners with strong similarity to PrP such as the doppel protein have not been examined to determine if the same evolutionary mechanisms apply to prion paralogs or if there are coselected sites that might indicate how and where the proteins interact. We examined several taxonomic groups that contain model organisms of prion diseases focusing on primates, bovids, and an expanded dataset of rodents for selection pressure on the prion gene (PRNP) and doppel gene (PRND) individually and for coevolving sites within. Overall, the results clearly indicate that both proteins are under strong selective constraints with relaxed selection on amino acid residues connecting α-helices 1 and 2. © 2014 Springer Science+Business Media New York. [less ▲]

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See detailNegative refraction: theory and application to thin metal layer superlens
Lecler, Sylvain; Frere, Benjamin; Habraken, Serge ULg et al

in Proceedings of SPIE (2008), 6987

The main concepts dealing with negative refraction are clarified in order to understand if a high conductive metal layer thinner than the wavelength can really be considered as a metamaterial with a ... [more ▼]

The main concepts dealing with negative refraction are clarified in order to understand if a high conductive metal layer thinner than the wavelength can really be considered as a metamaterial with a negative refraction index. The theoretical method to find the direction of phase velocity is clearly explained. The use of the causality principle is presented. We discuss why the negative refractive metamaterial has to be regarded as a dispersive one. Discussions are illustrated by means of FDTD simulations. The superlens application is presented. We explain why it is not obvious to consider a thin metal layer as a negative refractive material. [less ▲]

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See detailNegative valence affects false working memories too
Dehon, Hedwige ULg; Martial, Charlotte ULg

Poster (2013, May 28)

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See detailNegative wind anomalies generated a diminution of productivity in the North Atlantic in 2010
Troupin, Charles ULg; Machín, Francis

Poster (2012, April 27)

The weakening of the wind intensity in winter 2010, related to a low NAO index, generated unseen temperature anomalies and a significant decrease of biological activity in the Canary Current upwelling ... [more ▼]

The weakening of the wind intensity in winter 2010, related to a low NAO index, generated unseen temperature anomalies and a significant decrease of biological activity in the Canary Current upwelling system. [less ▲]

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See detailNegative wind anomalies generated a diminution of productivity of in the North Atlantic in 2010
Troupin, Charles ULg; Machín, Francisco

Poster (2012, November 14)

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See detailNégativité et finitude de l'élan vital
Caeymaex, Florence ULg

in Annales bergsoniennes (2008), IV

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See detailThe neglected intrinsic resistome of bacterial pathogens.
Fajardo, Alicia; Martinez-Martin, Nadia; Mercadillo, Maria et al

in PloS one (2008), 3(2), 1619

Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular ... [more ▼]

Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular impermeability and activity of efflux pumps. However, the analysis of transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows that this phenotype emerges from the action of numerous proteins from all functional categories. Mutations in some genes make P. aeruginosa more susceptible to antibiotics and thereby represent new targets. Mutations in other genes make P. aeruginosa more resistant and therefore define novel mechanisms for mutation-driven acquisition of antibiotic resistance, opening a new research field based in the prediction of resistance before it emerges in clinical environments. Antibiotics are not just weapons against bacterial competitors, but also natural signalling molecules. Our results demonstrate that antibiotic resistance genes are not merely protective shields and offer a more comprehensive view of the role of antibiotic resistance genes in the clinic and in nature. [less ▲]

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See detailA Neglected Reservoir of Mamluk Literature: al-Ṣafadī and his Tadhkira
Bauden, Frédéric ULg

Scientific conference (2010, April 16)

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See detailLas negociaciones UE-Mercosur: un juego con pocas cartas en la mesa?
Santander, Sébastian ULg

in Revista de Derecho Internacional y del Mercosur (2003), 2

L'UE et le Mercosur sont engagé depuis de nombreuses années dans des négociations commerciales dans l'objectif de sceller un accord d'association devant intégrer une zone de libre-échange interrégionale ... [more ▼]

L'UE et le Mercosur sont engagé depuis de nombreuses années dans des négociations commerciales dans l'objectif de sceller un accord d'association devant intégrer une zone de libre-échange interrégionale. Plusieurs obstacles affectent les négociations. Pour l'UE l'agriculture reste un domaine très sensible d'autant que les pays d'Amérique du Sud ont d'importants avantages comparatifs dans ce secteur. Pour les économies des pays du Mercosur, l'industrie et les services constituent de véritables sujets sensibles. [less ▲]

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See detailNegociation and Transaction in the Context of Restructuring: Ethics, Trust and Social Responsability
Robert, Jocelyne ULg

in Harrisson, Denis; Szell, György; Bourque, Reynald (Eds.) Social Innovation,the Social Economy and World Economic Development (2009)

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See detailLa négociation collective d’une maladie professionnelle : la pneumoconiose des ouvriers mineurs en Belgique (c. 1937- c. 1970)
Geerkens, Eric ULg

in Rainhorn, Judith (Ed.) Santé et travail à la mine XIXe-XXIe siècle (2014)

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See detailLa négociation des contrats publics en cours d'exécution et le droit communautaire
Durviaux, Ann-Lawrence ULg

in Jaarboek Overheidsopdrachten (2011)

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See detailLa négociation immobilière après l'arrêt de la cour d'appel de Mons du 15 juin 2009
Kohl, Benoît ULg

in Leleu, Yves-Henri (Ed.) Chroniques Notariales (2009)

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See detailNégociation immobilière: bref propos sur le "retrait" et la caducité de l'offre de vente. Note sous Liège, 12 décembre 2006
Kohl, Benoît ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2009)

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See detailLa négociation internationale comme mode de résolutions de conflits politiques
Kabamba, Bob ULg

Learning material (2009)

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See detailLes négociations du GATT et le Marché unique
Burny, Philippe ULg

Conference (1990)

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See detailNégociations identitaires et comportementales à l'adolescence
Born, Michel ULg; Gavray, Claire ULg

in Vrancken, Didier; Dubois, C.; Schoenaers, Frédéric (Eds.) Penser la négociation. Mélanges en hommmage à Olgierd Kuty (2008)

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See detailNégociations identitaires et comportements déviants à l'adolescence
Born, Michel ULg; Gavray, Claire ULg

in Vrancken, D.; Dubois, C.; Schoenaers, F. (Eds.) Penser la négociation (2008)

Detailed reference viewed: 95 (25 ULg)