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See detailNavigating polyfunctionality in the lexicon. Semantic maps and Ancient Egyptian lexical semantics
Grossman, Eitan; Polis, Stéphane ULg

in Grossman, Eitan; Polis, Stéphane; Winand, Jean (Eds.) Lexical Semantics in Ancient Egyptian (2012)

In lexical semantic descriptions of Ancient Egyptian, there is a tendency to search for a single basic meaning or Grundbedeutung, even if the element in question has a wide range of meanings or functions ... [more ▼]

In lexical semantic descriptions of Ancient Egyptian, there is a tendency to search for a single basic meaning or Grundbedeutung, even if the element in question has a wide range of meanings or functions. The actual functions of these elements — as they occur in texts — are usually explained as contextual or combinatory, derived from the interaction of the basic meaning with environmental cues or triggers. While there are certainly lexical items for which this is appropriate, there are nonetheless other ways of describing polyfunctionality, a generic term for situations in which multiple functions (or meanings or senses) are associated with a single signifier. The goal of the present article is to demonstrate that other kinds of analyses are possible, and can be equally interesting and useful for describing the facts of Ancient Egyptian and for relating them to cross-linguistic research. Moreover we show that Ancient Egyptian linguistic data allow us to test — corroborate, extend, or revise — hypotheses that have been proposed in the typological literature. The paper is structured as follows: Part 1 raises the problem of polyfunctionality and possible approaches to this pervasive linguistic phenomenon; Part 2 presents the (classical) semantic map model developed by typologists in order to account for the cross-linguistically recurrent relationships between two or more meanings of single linguistic forms; Part 3 examines the applicability and usefulness of this model in Ancient Egyptian with two small-scale case studies dealing with specific semantic areas ([a] instrument-companion and [b] allative). In each case, the semantic map provides a principled method for the analysis of polyfunctionality in both synchrony and diachrony. [less ▲]

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See detailLa navigation fluviale et l'avenir de la région liègeoise
Marchal, Jean ULg

in Revue Etudes et Expansion, Demain (1982), (293), 9

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See detailNavigation neurochirurgicale basée sur des modèles biomécaniques
Vigneron; Boman, Romain C.; Ponthot, Jean-Philippe et al

Conference (2007)

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See detailNawoord
Spinoy, Erik ULg; Buelens, Geert

in Borgers, Gerrit (Ed.) Paul van Ostaijen. Een documentatie (1996)

This is an afterword to a reprint of the main biographical work on Paul van Ostaijen, which was first published in 1971.

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See detailNazinga
Delvingt, W.; Vermeulen, Cédric ULg

Book published by Presses Agronomiques de Gembloux (2007)

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See detailNazinga
Delvingt, W.; Vermeulen, Cédric ULg; Doucet, Jean-Louis ULg

Conference given outside the academic context (2008)

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See detailUna nazione ricostruita: musica e feste delle confraternite tedesche e fiamminghe a Roma
Corswarem, Emilie ULg

in Goulet, Anne-Madelaine; zur Nieden (Eds.) Europäische Musiker in Venedig, Rom, und Neapel. 1650-1750 (in press)

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See detailNbVO5 Mesoporous Thin Films by Evaporation Induced Micelles Packing: Pore Size Dependence of the Mechanical Stability upon Thermal Treatment and Li Insertion/Extraction
Krins, Natacha ULg; Bass, John D; Grosso, David et al

in Chemistry Of Materials (2011), 23(18), 4124-4131

Mesoporous thin films (MTFs) appear as an interesting architecture for positive electrodes in Li-ion energy storage systems because they offer high specific area and interconnected porosity presenting ... [more ▼]

Mesoporous thin films (MTFs) appear as an interesting architecture for positive electrodes in Li-ion energy storage systems because they offer high specific area and interconnected porosity presenting homogeneous pore size and wall thickness. However, it must be ascertained that the mesostructure survives template removal or/and crystallization and is retained on electrochemical cycling. In order to investigate the potentialities and limits of the soft-templating approach in the case of complex transition metal oxide networks, we deliberately selected a "difficult" compound: NbVO5 was chosen because it combines a challenging synthesis with reported severe structural distortions during the first lithium insertion in the bulk material. In this work, NbVO5 MTFs with different pore sizes were synthesized using the evaporation induced micelles packing (EIMP) method. PS-b-PEO diblock copolymers of different molar weights were used as structure directing agent in order to obtain wormlike porous networks with pore size and wall thickness ranging from 15 to 100 nm. Thermal ellipsometry analysis, used to track surfactant removal and crystallization of the layer, reveals that partial crystallization is possible while retaining the mesoporous architecture. Electron tomography complements result from environmental ellipsometric porosimetry, atomic force microscopy, and transmission electron microscopy to provide a comprehensive description of the structure. A multilayer process is also proposed to build crack-free thick mesoporous films. The mechanical stability of MTFs presenting three different pore sizes is tested by inserting Li(+) in amorphous NbVO5 MTFs using cyclic voltammetry. Capacity retention data show that the mechanical stresses associated with Li+ insertion are better accommodated by MTFs compared to nonporous films, and this ability is enhanced as the pore size decreases. [less ▲]

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See detailNC100100, a new echo contrast agent for the assessment of myocardial perfusion--safety and comparison with technetium-99m sestamibi single-photon emission computed tomography in a randomized multicenter study.
Binder, T.; Assayag, P.; Baer, F. et al

in Clinical cardiology (1999), 22(4), 273-82

BACKGROUND AND HYPOTHESIS: Myocardial contrast echocardiography using second-generation agents has been proposed to study myocardial perfusion. A placebo-controlled, multicenter trial was conducted to ... [more ▼]

BACKGROUND AND HYPOTHESIS: Myocardial contrast echocardiography using second-generation agents has been proposed to study myocardial perfusion. A placebo-controlled, multicenter trial was conducted to evaluate the safety, optimal dose, and imaging mode for NC100100, a novel intravenous second-generation echo contrast agent, and to compare this technique with technetium-99m sestamibi (MIBI) single-photon emission computed tomography (SPECT). METHODS: In a placebo-controlled, multicenter trial, 203 patients with myocardial infarction > 5 days and < 1 year previously underwent rest SPECT and MCE. Fundamental and harmonic imaging modes combined with continuous and electrocardiogram-- (ECG) triggered intermittent imaging were used. Six dose groups (0.030, 0.100, and 0.300 microliter particles/kg body weight for fundamental imaging; and 0.006, 0.030, and 0.150 microliter particles/kg body weight for harmonic imaging) were tested. A saline group was also included. Safety was followed for 72 h after contrast injection. Myocardial perfusion by MCE was compared with myocardial rest perfusion imaging using MIBI as a tracer. RESULTS: NC100100 was well tolerated. No serious adverse events or deaths occurred. No clinically relevant changes in vital signs, laboratory parameters, and ECG recordings were noted. There was no significant difference between adverse events in the NC100100 (25.7%) and in the placebo group (17.9%, p = 0.3). Intermittent harmonic imaging using the intermediate dose was superior to all other modalities, allowing the assessment of perfusion in 76% of all segments. Eighty segments (96%) with normal perfusion by SPECT imaging also showed myocardial perfusion with MCE. However, a substantial percentage of segments (61-80%) with perfusion defects by SPECT imaging also showed opacification by MCE. This resulted in an overall agreement of 66-81% and a high specificity (80-96%), but in low sensitivity (20-39%) of MCE for the detection of perfusion defects. CONCLUSION: NC100100 is safe in patients with myocardial infarction. Intermittent harmonic imaging with a dose of 0.03 microliter particles/kg body weight can be proposed as the best imaging protocol. Myocardial contrast echocardiography with NC 100100 provides perfusion information in approximately 76% of segments and results in myocardial opacification in the vast majority of segments with normal perfusion as assessed by SPECT. Although the discrepancies between MCE and SPECT with regard to the definition of perfusion defects requires further investigation, MCE with NC 100100 is a promising technique for the noninvasive assessment of myocardial perfusion. [less ▲]

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See detailNCA asymmetric synthesis of 2-[18F]fluoro-L-tyrosine.
Lemaire, Christian ULg; Plenevaux, Alain ULg; Damhaut, Ph. et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1993), 32

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See detailNCA asymmetric synthesis of 6-[18F]fluoro-L-dopa.
Lemaire, Christian ULg; Guillaume, M.; Cantineau, R. et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1991), 30

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See detailNCA synthesis of an N-w-[18F]fluoroethyl analog of altanserine, a serotonine S2 receptor ligand.
Lemaire, Christian ULg; Damhaut, Ph.; Cantineau, R. et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1991), 30

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See detailNCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia
Jeffs, G. J.; Meloni, B.; Sokolow, S. et al

in Experimental Neurology (2008), 210

There is uncertainty as to whether the plasma membrane Na(+)/Ca(2+)exchanger (NCX) has a neuroprotective or neurodamaging role following cerebral ischemia. To address this issue we compared hippocampal ... [more ▼]

There is uncertainty as to whether the plasma membrane Na(+)/Ca(2+)exchanger (NCX) has a neuroprotective or neurodamaging role following cerebral ischemia. To address this issue we compared hippocampal neuronal injury in NCX3 knockout mice (Ncx3(-/-)) and wild-type mice (Ncx3(+/+)) following global cerebral ischemia. Using a bilateral common carotid artery occlusion (BCCAO) model of global ischemia we subjected NCX3 knockout and wild-type mice to 17 and 15 minutes of ischemia. Following the 17 minute period of ischemia, wild-type mice exhibited approximately 80% CA1 neuronal loss and approximately 40% CA2 neuronal loss. In contrast, NCX3 knockout mice displayed >95% CA1 neuronal loss and approximately 95% CA2 neuronal loss. Following the 15 minute period of ischemia, wild-type mice did not exhibit any significant hippocampal neuronal loss. In contrast, NCX3 knockout mice displayed approximately 45% CA1 neuronal loss and approximately 25% CA2 neuronal loss. The results clearly demonstrate that mice deficient in the NCX3 protein are more susceptible to global cerebral ischemia than wild-type mice. Our findings suggest NCX3 has a positive role in maintaining neuronal intracellular calcium homeostasis following ischemia, and that when exchanger function is compromised neurons are more susceptible to calcium deregulation and cell death [less ▲]

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See detailNd and Pb isotope signatures of the clay-size fraction of Labrador Sea sediments during the Holocene: Implications for the inception of the modern deep circulation pattern
Fagel, Nathalie ULg; Hillaire-Marcel, Claude ULg; Humblet, Marc et al

in Paleoceanography (2004), 19(3),

Nd and Pb isotopes were measured on the fine fraction of one sediment core drilled off southern Greenland. This work aims to reconstruct the evolution of deep circulation patterns in the North Atlantic ... [more ▼]

Nd and Pb isotopes were measured on the fine fraction of one sediment core drilled off southern Greenland. This work aims to reconstruct the evolution of deep circulation patterns in the North Atlantic during the Holocene on the basis of sediment supply variations. For the last 12 kyr, three sources have contributed to the sediment mixture: the North American Shield, the Pan-African and Variscan crusts, and the Mid-Atlantic Ridge. Clay isotope signatures indicate two mixtures of sediment sources. The first mixture (12.2-6.5 ka) is composed of material derived from the North American shield and from a "young'' crustal source. From 6.5 ka onward the mixture is characterized by a young crustal component and by a volcanic component characteristic of the Mid-Atlantic Ridge. Since the significant decrease in proximal deglacial supplies, the evolution of the relative contributions of the sediment sources suggests major changes in the relative contributions of the deep water masses carried by the Western Boundary Undercurrent over the past 8.4 kyr. The progressive intensification of the Western Boundary Undercurrent was initially associated mainly with the transport of the Northeast Atlantic Deep Water mass until 6.5 ka and with the Denmark Strait Overflow Water thereafter. The establishment of the modern circulation at 3 ka suggests a reduced influence of the Denmark Strait Overflow Water, synchronous with the full appearance of the Labrador Seawater mass. Our isotopic data set emphasizes several changes in the relative contribution of the two major components of North Atlantic Deep Water throughout the Holocene. [less ▲]

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See detailNd and Pb isotopic signatures of detrital fractions from Labrador Sea and Iceland Basin sediments: Deep oceanic circulation changes over the Holocene
Fagel, Nathalie ULg; Brasseur; Mattielli, N. et al

in Geochimica et Cosmochimica Acta (2008), 72(12), 251-251

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See detailThe Nd-123 superconducting system: From single crystal to top-seeded large grain. Physical and chemical parameters influence
Auguste, F.; Vandewalle, Nicolas ULg; Ausloos, Marcel ULg et al

in Applied Superconductivity (1998), 6(2-5), 77-85

Nd-123 signle crystals have been produced via the Aux method in alumina crucibles by controlling the chemical composition of the flux. For so doing, quenched materials have been prepared and analyzed in ... [more ▼]

Nd-123 signle crystals have been produced via the Aux method in alumina crucibles by controlling the chemical composition of the flux. For so doing, quenched materials have been prepared and analyzed in order to get information about the optimum barium: copper ratio for an unchanged neodymium concentration. Non corrosive fluxes with a low viscosity have been put into evidence and can thus be used for single crystal production. Experiments have been performed with three different chemical compositions of the Aux and by considering various amounts of neodymium oxide for each system. The single crystals have been analyzed by energy dispersive X-ray microanalysis and used for the synthesis of large Dy-123 single-domains? [less ▲]

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See detailND3 and ND4L subunits of mitochondrial complex I, both nucleus encoded in Chlamydomonas reinhardtii, are required for activity and assembly of the enzyme
Cardol, Pierre ULg; Lapaille, Marie ULg; Minet, P. et al

in Eukaryotic Cell (2006), 5(9), 1460-1467

Made of more than 40 subunits, the rotenone-sensitive NADH:ubiquinone oxidoreductase (complex I) is the most intricate membrane-bound enzyme of the mitochondrial respiratory chain. In vascular plants ... [more ▼]

Made of more than 40 subunits, the rotenone-sensitive NADH:ubiquinone oxidoreductase (complex I) is the most intricate membrane-bound enzyme of the mitochondrial respiratory chain. In vascular plants, fungi, and animals, at least seven complex I subunits (ND1, -2, -3, -4, -4L, -5, and -6; ND is NADH dehydrogenase) are coded by mitochondrial genes. The role of these highly hydrophobic subunits in the enzyme activity and assembly is still poorly understood. In the unicellular green alga Chlamydomonas reinhardtii, the ND3 and ND4L subunits are encoded in the nuclear genome, and we show here that the corresponding genes, called NUO3 and NUO11, respectively, display features that facilitate their expression and allow the proper import of the corresponding proteins into mitochondria. In particular, both polypeptides show lower hydrophobicity compared to their mitochondrion-encoded counterparts. The expression of the NUO3 and NUO11 genes has been suppressed by RNA interference. We demonstrate that the absence of ND3 or ND4L polypeptides prevents the assembly of the 950-kDa whole complex I and suppresses the enzyme activity. The putative role of hydrophobic ND subunits is discussed in relation to the structure of the complex I enzyme. A model for the assembly pathway of the Chlamydomonas enzyme is proposed. [less ▲]

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See detailNDS27 combines the effect of curcumin lysinate and hydroxypropyl-β-cyclodextrin to inhibit equine PKCδ and NADPH oxidase involved in the oxidative burst of neutrophils
Derochette, Sandrine ULg; Mouithys-Mickalad, Ange ULg; Franck, Thierry ULg et al

in FEBS Open Bio (2014)

Polymorphonuclear neutrophils (PMNs) are involved in host defence against infections by the production of reactive oxygen species (ROS), but excessive PMN stimulation is associated with the development of ... [more ▼]

Polymorphonuclear neutrophils (PMNs) are involved in host defence against infections by the production of reactive oxygen species (ROS), but excessive PMN stimulation is associated with the development of inflammatory diseases. After appropriate stimuli, protein kinase C (PKC) triggers the assembly of NADPH oxidase (Nox2) which produces superoxide anion (O2●-), from which ROS derive. The therapeutic use of polyphenols is proposed to lower ROS production by limiting Nox2 and PKC activities. The purpose of this study was to compare the antioxidant effect of NDS27 and NDS28, two water-soluble forms of curcumin lysinate respectively complexed with hydroxypropyl-β-cyclodextrin (HPβCD) and γ-cyclodextrin (γ-CD), on the activity of Nox2 and PKCδ, involved in the Nox2 activation pathway. Our results, showed that NDS27 is the best inhibitor for Nox2 and PKCδ. This was illustrated by the combined effect of HPβCD and curcumin lysinate: HPβCD, but not γ-CD, improved the release of curcumin lysinate and its exchange against lipid or cholesterol as demonstrated by the lipid coloration with Oil red O, the extraction of radical lipophilic probes recorded by ESR and the HPLC measurements of curcumin. HPβCD not only solubilised and transported curcumin, but also indirectly enhanced its action on both PKC and Nox2 activities. The modulatory effect of NDS27 on the Nox2 activation pathway of neutrophils may open therapeutic perspectives for the control of pathologies with excessive inflammatory reactions. [less ▲]

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