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See detailKleist-Rezeption 1811-1880
Gerrekens, Louis ULg

in Breuer, Ingo (Ed.) Kleist-Handbuch (2009)

Detailed reference viewed: 31 (5 ULg)
See detailKlemtoon in het Nederlands van Franstalige immersie- en niet-immersieleerlingen
Hiligsmann, Philippe; Bui-Anh, Vu ULg; Jouniaux, Anthony et al

Scientific conference (2014, April 16)

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See detailKlemtoon in het Nederlands van Franstalige immersie- en niet-immersieleerlingen
Rasier, Laurent ULg; Bui-Anh, Vu ULg; Jouniaux, Anthony et al

in Degand, Liesbeth; Hiligsmann, Philippe; Rasier, Laurent (Eds.) et al In het teken van identiteit. Taal en cultuur van de Nederlanden (2014)

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See detailHet klemtoonpatroon in de tussentaal van Franstalige leerders van het Nederlands
Michaux, Marie-Catherine; Hiligsmann, Philippe; Rasier, Laurent ULg

in Grucza, F. (Ed.) Vielheit und Einheit der Germanistik weltweit. Akten des XII. Internationalen Germanistenkongress 2010 (2012)

Detailed reference viewed: 108 (10 ULg)
See detailDe kleur van armoede : Armoede bij personen van buitenlandse herkomst
Martiniello, Marco ULg; Perrin, Nathalie ULg; Vranken, Jan et al

Book published by ACCO (2007)

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See detailKLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression.
Ali, Amjad ULg; Zhang P; Liangfang Y et al

in cell death and disease (2015)

Inhibition of tumor suppressive signaling is linked to cancer progression, metastasis and epithelial-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β)/Smad signaling plays an important ... [more ▼]

Inhibition of tumor suppressive signaling is linked to cancer progression, metastasis and epithelial-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β)/Smad signaling plays an important role in tumor suppression. Kruppel-like-factor 17 (KLF17) is a negative regulator of metastasis and EMT. However, underlying mechanisms leading to tumor suppressive and anti-metastatic function of KLF17 still remains unknown. Here, we show that KLF17 plays an integral role in potentiating TGF-β/Smad signaling via Smad3-dependent pathway to suppress tumor progression. Intriguingly, TGF-β/Smad3 signaling induces KLF17 expression, generating a positive feedback loop. TGF-β/Smad3-KLF17 loop is critical for anti-metastasis and tumor inhibition in cancer cells. Mechanistically, silencing KLF17 reduced Smad3-DNA complex formation on Smad binding element (SBE) and affects the expression of TGF-β/Smad target genes. Moreover, KLF17 alters Smad3 binding pattern on chromatin. KLF17 regulates TGF-β target genes that are Smad3-dependent. Smad3 and KLF17 physically interact with each other via KLF17 responsive elements/SBE region. Intriguingly, TGF-β stimulates the recruitment of KLF17 on chromatin to subsets of metastasis-associated genes. Functionally, depletion of KLF17 enhanced tumorigenic features in cancer cells. KLF17 is critical for full cytostatic function of TGF-β/Smad signaling. Clinically, KLF17 expression significantly decreases during advance HCC. KLF17 shows positive correlation with Smad3 levels in cancer samples. Our data shows that enhance KLF17 activity has important therapeutic implications for targeted-therapies aimed at TGF-β/Smad3 pathway. These findings define novel mechanism by which TGF-β/Smad-KLF17 pathway mutually affect each other during cancer metastasis, provide a new model of regulation of TGF-β/Smad signaling by KLF17 and defines new insights into anti-metastatic function of KLF17. [less ▲]

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See detailDe klinkers in het Nederlands van Franstalige leerders
Williquet, Emilie; Hiligsmann, Philippe; Rasier, Laurent ULg

Conference (2011, November 19)

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See detail'Klinkt helder op, gebeeldhouwde sonnetten'. Een vers van Jacques Perk als het startsein van Tachtig
Steyaert, Kris ULg

in Nederlandse Letterkunde (2004), 9(2), 155-174

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See detailKluge, Adorno et l’indomptable Leni Peickert
Hamers, Jérémy ULg; Cormann, Grégory ULg

in Cahiers du GRM (2014), 5

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See detailKluyveromyces marxianus mutants affected in protein secretion.
Rikir, R.; Roblain, D.; Thonart, Philippe ULg

Poster (1988, July)

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See detailKnee model using articular shape knowledge
Schwartz, Cédric ULg; de Zee, Mark; Rasmussen, John et al

Conference (2010, July)

In motion capture, a standard procedure to obtain the bone motion is the use of skin markers. However, because of the relative motion of the skin and the bones, so-called soft tissue artefacts (STA), the ... [more ▼]

In motion capture, a standard procedure to obtain the bone motion is the use of skin markers. However, because of the relative motion of the skin and the bones, so-called soft tissue artefacts (STA), the recorded motion does not accurately describe the movement of the bones. To compute joint reaction forces and perhaps limit STA, most musculo-skeletal models use underlying joint models. The knee is usually modeled as a simple hinge joint. However such approaches do not lead to a better estimation of the real motion1. In this work the hinge joint is improved by taking into account the morphological features of the joint surfaces. [less ▲]

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See detailKnee whole-organ MRI score (WORMS) as a surrogate marker for X-ray joint space narrowing
Bruyère, Olivier ULg; Kothari, M.; Zaim, S. et al

in Osteoporosis International (2005, March), 16(Suppl.3), 6

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See detailKnelpunten bouwpromotieovereenkomst
Kohl, Benoît ULg; Somers, M.

in Tilleman, B.; Verbeke, A. (Eds.) Knelpunten Vastgoedpromotor, vastgoedexpert en architect (2011)

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See detailKNIŽEVNI ANGAŽMAN I MORAL KNJIŽEVNOSTI
Denis, Benoît ULg

in NOVI IZRAZ (2014), (61-62), 35-44

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See detailKnock-down of the COX3 and COX17 gene expression of cytochrome c oxidase in the unicellular green alga Chlamydomonas reinhardtii.
Remacle, Claire ULg; Coosemans, Nadine ULg; Jans, Frédéric ULg et al

in Plant Molecular Biology (2010), 74(3), 223-2363

The COX3 gene encodes a core subunit of mitochondrial cytochrome c oxidase (complex IV) whereas the COX17 gene encodes a chaperone delivering copper to the enzyme. Mutants of these two genes were isolated ... [more ▼]

The COX3 gene encodes a core subunit of mitochondrial cytochrome c oxidase (complex IV) whereas the COX17 gene encodes a chaperone delivering copper to the enzyme. Mutants of these two genes were isolated by RNA interference in the microalga Chlamydomonas. The COX3 mRNA was completely lacking in the cox3-RNAi mutant and no activity and assembly of complex IV were detected. The cox17-RNAi mutant presented a reduced level of COX17 mRNA, a reduced activity of the cytochrome c oxidase but no modification of its amount. The cox3-RNAi mutant had only 40% of the wild-type rate of dark respiration which was cyanide-insensitive. The mutant presented a 60% decrease of H(2)O(2) production in the dark compared to wild type, which probably accounts for a reduced electron leakage by respiratory complexes III and IV. In contrast, the cox17-RNAi mutant showed no modification of respiration and of H(2)O(2) production in the dark but a two to threefold increase of H(2)O(2) in the light compared to wild type and the cox3-RNAi mutant. The cox17-RNAi mutant was more sensitive to cadmium than the wild-type and cox3-RNAi strains. This suggested that besides its role in complex IV assembly, Cox17 could have additional functions in the cell such as metal detoxification or Reactive Oxygen Species protection or signaling. Concerning Cox3, its role in Chlamydomonas complex IV is similar to that of other eukaryotes although this subunit is encoded in the nuclear genome in the alga contrary to the situation found in all other organisms. [less ▲]

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See detailKnock-out. Tres historias de boxeo.
London, Jack; Willson, Patricia ULg

Book published by Libros del Zorro Rojo (2011)

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See detailKnowing the past to anticipate the future: soil charcoal as a proxy to model forest evolution
Morin, Julie ULg; Biwolé, Achille; Bourland, Nils et al

Poster (2014, October)

Tropical forests of Central Africa constitute the second most important block of moist forest of the world. However little is known about their past evolution. Indeed, determining the past specific ... [more ▼]

Tropical forests of Central Africa constitute the second most important block of moist forest of the world. However little is known about their past evolution. Indeed, determining the past specific composition of these forests could allow modeling their evolution over time and providing data about their resilience capacity facing global change. To do this, we performed a pedoanthracological analysis in the semi-deciduous forests of southeastern Cameroon. We excavated test pits in 53 plots of botanical inventory along a gradient of vegetation, quantified wood charcoals by layers of 10 cm, identify the species present in charcoals, dated the charcoals by the radiocarbon method, then built up sequences including present forest composition. Results show that repeated fire events occurred across the study area during the last 2500 years. These disturbances are likely human-induced regarding evidence of anthropogenic activities (e.g. potsherds). Nonetheless the past specific composition does not strongly differ from the current one except for the oldest layers related to the major dry climatic event of 2500 BP. We conclude that moist forests have a good resilience capacity regarding moderate disturbances but were and will be deeply impacted by climate change. [less ▲]

Detailed reference viewed: 10 (2 ULg)