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See detailNaturalisme et pragmatisme
Leclercq, Bruno ULg

Conference (2001, November 13)

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See detailA naturalistic study of the determinants of health related quality of life improvement in osteoarthritic patients treated with non-specific non-steroidal antiinflammatory drugs
Rabenda, Véronique ULg; Burlet, N.; Ethgen, Olivier ULg et al

in Annals of the Rheumatic Diseases (2005), 64(5), 688-693

OBJECTIVES: To capture changes in the quality of life (QoL) occurring in patients with osteoarthritis (OA) during treatment with non-specific non-steroidal anti-inflammatory drugs (NSAIDs) and to identify ... [more ▼]

OBJECTIVES: To capture changes in the quality of life (QoL) occurring in patients with osteoarthritis (OA) during treatment with non-specific non-steroidal anti-inflammatory drugs (NSAIDs) and to identify factors that predict such changes. METHODS: A naturalistic, prospective follow up of 783 patients with OA in whom primary care physicians decided to start treatment with non-selective NSAIDs. Short Form-36 (SF-36) and the Western Ontario and McMaster Universities OA index (WOMAC) were assessed at baseline and after 3 months. Baseline results were compared with QoL values in 4800 subjects randomly selected from the general population. Multiple regression analysis was performed to identify determinants of QoL at baseline and measures influencing changes in SF-36 or WOMAC during follow up. RESULTS: All QoL dimensions were significantly (p<0.01) decreased in patients with OA compared with controls. Significant improvement (p<0.05) in four dimensions of the SF-36 (vitality, role emotional, role physical, bodily pain) and in all components of the WOMAC was seen between baseline and month 3. Older age, female sex, longer duration of OA, and a higher number of comorbidities were the major determinants of a poor QoL at baseline. Maximal benefit from non-specific NSAIDs was seen in patients with the most severe impairment in QoL and the shortest duration of OA. CONCLUSION: OA negatively impacts all dimensions of the QoL. Non-specific NSAIDs improve the QoL in patients with OA treated in a "real life setting". The profile of patients receiving maximal benefit from such treatment may be of interest for health providers, enabling them to decide who should preferentially be given cytoprotective treatments or coxibs. [less ▲]

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See detailNaturalization and impact of a horticultural species, Cotoneaster horizontalis (Rosaceae) in biodiversity hotspots in Belgium
Piqueray, Julien ULg; Mahy, Grégory ULg; Vanderhoeven, Sonia

in Belgian Journal of Botany (2008), 141

Cultivation of ornamental plant species has been recognized to foster plant naturalization of exotics by counteracting environmental stochasticity and continuously providing propagules. As a preliminary ... [more ▼]

Cultivation of ornamental plant species has been recognized to foster plant naturalization of exotics by counteracting environmental stochasticity and continuously providing propagules. As a preliminary attempt to describe the invasion status of C horizontalis, we gathered information on the occurrence of the species in Belgium by compiling various databases. We assessed the naturalization status of C. horizontalis in Belgian calcareous grasslands, high-value habitats recognized as biodiversity hotspots, by characterizing its occurrence, population status, preferred habitats, invaded communities, growth rate and fruiting capacity. We also assessed the impact of the species on calcareous grasslands communities and on individual species. Cotoneaster occurred in seven of the nine investigated sites, with densities varying from 0.34 to 10 individuals/ha. In the most invaded sites, the high proportion of small individuals suggests an important ongoing colonization process, emphasized by the fact that fruiting capacities were demonstrated for 3-year-old individuals. Invaded habitats were typically Mosan Xerobromion habitats, which are priority Natura 2000 habitats. The presence of C horizontalis was associated with changes in both the structure and composition of the community by decreasing species richness and diversity, and affecting grassland specialist species. These impacts are expected to intensify over time with population age and increasing propagule pressure due to close urbanization. [less ▲]

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See detailNaturally occurring BLV- LTR variants show differential binding with transcriptional regulator E2F-4
Rodriguez, Sabrina ULg; Varone, C.; Cánepa, E. et al

in AIDS Research and Human Retroviruses (2007, April 23), 23(4), 657

Naturally occurring BLV- LTR variants show differential binding with transcriptional regulator E2F-4. Sabrina M. Rodríguez1, Cecilia Varone2, Eduardo Cánepa2, Karina Trono1. srodriguez@cnia.inta.gov.ar ... [more ▼]

Naturally occurring BLV- LTR variants show differential binding with transcriptional regulator E2F-4. Sabrina M. Rodríguez1, Cecilia Varone2, Eduardo Cánepa2, Karina Trono1. srodriguez@cnia.inta.gov.ar 1Instituto de Virología. CICVyA. INTA-Castelar. Castelar. Buenos Aires. Argentina 2Catedra de Biología Molecular. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Buenos Aires. Argentina The proviral Long Terminal Repeats (LTR) of retroviruses constitute a critical element involved in the regulation of viral and cellular gene expression. It is well known for some viruses within the Retroviridae family that minimal changes in this region can influence tropism, virulence and pathogenicity. The aim of this work was to elucidate if there is any association between the binding capacity of the Bovine Leukemia Virus (BLV) LTR region with cellular transcription factors and the pathogenic evolution of natural infection. The complete 5´LTR sequence amplified from mononuclear cells and tumour tissues of 40 naturally infected cattle was analyzed. Sequence analysis revealed the presence of two LTR variants associated with the different BLV pathogenic phenotypes: aleukemic (AL), persistent lymphocitosis (PL) and lymphosarcoma (LS). Analysis by EMSA showed a clearly weaker specific binding pattern when a LS-derived sequence was used as probe. Together with this finding, we also demonstrated by gel shift and supershift assays that the cellular transcription factor E2F-4 specifically interacts with a putative E2F binding motif within the U5 region of BLV 5`LTR unveiled by “in sillico” analysis. The results of this work demonstrates for the first time the presence of differential binding capacity of BLV natural derived variants to cellular nuclear proteins, together with physical characterization of an E2F-4 binding site in the U5 region of BLV-LTR that shows preferential binding to AL/PL derived sequences. These findings can contribute to the knowledge of LTR-driven regulation of viral and cellular gene expression. [less ▲]

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See detailNature and distribution of pulmonary vascular resistance during endotoxin insult in intact dogs
D'Orio, Vincenzo ULg; FATEMI, M; MARNETTE, JM et al

in American Review of Respiratory Disease (1992), 4

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Peer Reviewed
See detailThe nature and evolution of working memory deficits in multiple sclerosis
DELRUE, Gaël ULg; Caps, Emilie; Gryglewicz, Céline et al

Poster (2007, October 12)

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See detailLa nature de l'acte juridique attesté par l'O. Mich. III 1098
Straus, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1997), LXXII(143), 128-129

O. Mich. III 1098 attests the delivery of a slave as a surety of a loan.

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See detail"Nature des fonctions en grammaire"; "Fonctions des natures en grammaire"
Defays, Jean-Marc ULg

Scientific conference (2011, February 22)

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See detailNature des traitements morphologiques chez les dyslexiques : une étude en amorçage masqué
Quemart, Pauline ULg; Casalis, Séverine

Conference (2010, September)

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See detailNature du phosphore dans deux échantillons de gypse Imacid
Bastin, David ULg

Report (2000)

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See detailNature et qualités de spatiocartes
Donnay, Jean-Paul ULg

in Bulletin de la Société Géographique de Liège (2000), 38

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See detailNature et sanction(s) de l'article 701 du Code judiciaire
Boularbah, Hakim ULg

in Journal des Tribunaux (2009)

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See detailNature et tendances de la cartographie assistée par ordinateur
Donnay, Jean-Paul ULg

in Nouvelles tendances de la géographie en Belgique (1994)

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