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See detailNasal calcitonin in prevention of early postmenopausal bone loss. A 18-month study
Reginster, Jean-Yves ULg; Franchimont, P

in Journal of Bone and Mineral Research (1988), 3(S1), 163

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See detailNasal salmon calcitonin for prevention of early postmenopausal bone loss: a dose-ranging placebo controlled study
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; Lecart, MP et al

in Journal of Bone and Mineral Research (1993), 8(S1), 340

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See detailNasal salmon calcitonin in prevention of postmenopausal osteoporosis
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; Sarlet, N et al

in Revista Clinica Espanola (1991), 188

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See detailNash equilibria and reinforcement learning for active decision maker modelling in power markets
Krause, Thilo; Andersson, Goran; Ernst, Damien ULg et al

in Proceedings of the 6th IAEE European Conference: Modelling in Energy Economics and Policy (2004)

In this paper, we study the behavior of power suppliers who submit their bids to the market place in order to maximize their payoffs. The market clearing mechanism is based on the locational marginal ... [more ▼]

In this paper, we study the behavior of power suppliers who submit their bids to the market place in order to maximize their payoffs. The market clearing mechanism is based on the locational marginal price. To study the interaction of the power suppliers, we rely on two different approaches and compare the results obtained. One approach consists of computing the Nash equilibria of the market, and the other models each player’s behavior by using reinforcement learning algorithms. Simulations are carried out on a five node power system. [less ▲]

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See detailNash equilibrium as the minimum of a function. Application to electricity markets with large number of actors
Beck, Elena Vdovina; Cherkaoui, Rachid; Minoia, Anna et al

in Proceedings of the 2007 Power Tech (2007)

We introduce in this paper a new approach for efficiently identifying Nash equilibria for games composed of large numbers of players having discrete and not too large strategy spaces. The approach is ... [more ▼]

We introduce in this paper a new approach for efficiently identifying Nash equilibria for games composed of large numbers of players having discrete and not too large strategy spaces. The approach is based on a characterization of Nash equilibria in terms of minima of a function and relies on stochastic optimization algorithms to find these minima. The approach is applied to compute Nash equilibria of some electricity markets and, based on the simulation results, its performances are discussed. [less ▲]

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See detailNASS Congress
Martin, Didier ULg

Conference (2008, October 14)

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See detailNatalizumab induced freedom from disease activity after failure to previous therapy in relapsing remitting multiple sclerosis.
Belachew, Shibeshih ULg; Bartholome E.; DELVAUX, Valérie ULg et al

Conference (2009, June)

Objectives: To analyze the efficacy of natalizumab after switching relapsing-remitting multiple sclerosis (RRMS) patients from other disease modifying treaments (DMTs). Background: Natalizumab (Tysabri ... [more ▼]

Objectives: To analyze the efficacy of natalizumab after switching relapsing-remitting multiple sclerosis (RRMS) patients from other disease modifying treaments (DMTs). Background: Natalizumab (Tysabri) is a monoclonal antibody directed against VLA4 that was recently approved for the treatment of RRMS. Due to safety concerns, the use should be restricted to highly active patients and/or patients with insufficient response to other DMTs. The pivotal trials were not designed to examine the effect of natalizumab as an escalation monotherapy. Methods: Prospective, open label, observational study. All patients initiating natalizumab had experienced at least 1 relapse in the previous year under DMTs and had at least 1 Gd-enhancing lesion on their brain MRI. Previous treatment with interferon-beta (IFN-beta) or glatiramer acetate (GA) were stopped at least one week and azathioprine or mitoxantrone at least 3 months before switching. The minimum therapy duration with natalizumab was 6 months for all patients. 21 RRMS patients were included in this analysis. The mean age of the patients was 25,5 yo with mean disease duration of 6,8 years. All patients were under IFN-beta (17) or GA (4) during at least the previous year before starting natalizumab therapy. Four patients had also received azathioprine and 1 patient mitoxantrone. Results: The mean relapse rate in the previous year was 2.15 (1-4), the mean EDSS at baseline was 3.3 (1,0-6.0), the mean number of Gd+ lesions at baseline 2,58 (1-6). Under tysabri treatment the annualized relapse rate dropped to 0,20. Eleven patients improved their EDSS (0,5 to 1,5 steps down), others remained stable at 6 months. The mean number of Gd+ T1 lesions dropped to 0,23 and the mean number of new T2 lesions was 0.25 on the control MRI at 6 months. 55% of patients were free from disease activity, i.e. had no relapses, no EDSS progression, no new T2 lesion and no Gd+ T1 lesions after 6 months of Tysabri. 5 patients experienced minor adverse events (1 zona, 2 flu-like symptoms, 1 gastroenteritis, 1 allergic reaction). Conclusion: Natalizumab was well tolerated and safe as escalation therapy when previous DMTs had failed to control disease progression in this group of highly active RRMS patients. These results suggest comparable efficacy to the phase III AFFIRM trial of natalizumab when the drug is used in a context of breakthrough disease. Although data from preliminary analyses are promising, long term investigations are warranted. [less ▲]

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See detailNatalizumab induces a rapid improvement of disability status and ambulation after failure of previous therapy in relapsing-remitting multiple sclerosis.
Belachew, Shibeshih ULg; Phan-Ba, Rémy ULg; Bartholome, Emmanuel et al

in European Journal of Neurology (2010), 18(2), 240-245

Background: Natalizumab (Tysabri) is a monoclonal antibody that was recently approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). Our primary objective was to analyse the efficacy ... [more ▼]

Background: Natalizumab (Tysabri) is a monoclonal antibody that was recently approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). Our primary objective was to analyse the efficacy of natalizumab on disability status and ambulation after switching patients with RRMS from other disease-modifying treatments (DMTs). Methods: A retrospective, observational study was carried out. All patients (n = 45) initiated natalizumab after experiencing at least 1 relapse in the previous year under interferon-beta (IFNB) or glatiramer acetate (GA) treatments. The patients also had at least 1 gadolinium-enhancing (Gd+) lesion on their baseline brain MRI. Expanded Disability Status Scale (EDSS) scores, and performance on the Timed 25-Foot Walk Test and on the Timed 100-Metre Walk Test were prospectively collected every 4 weeks during 44 weeks of natalizumab treatment. Brain MRI scans were performed after 20 and 44 weeks of treatment. Results: Sixty-two per cent of patients showed no clinical and no radiological signs of disease activity, and 29% showed a rapid and confirmed EDSS improvement over 44 weeks of natalizumab therapy. Patients with improvement on the EDSS showed similar levels of baseline EDSS and active T1 lesions, but had a significantly higher number of relapses, and 92% of them had experienced relapse-mediated sustained EDSS worsening in the previous year. A clinically meaningful improvement in ambulation speed was observed in approximately 30% of patients. Conclusions: These results indicate that natalizumab silences disease activity and rapidly improves disability status and walking performance, possibly through delayed relapse recovery in patients with RRMS who had shown a high level of disease activity under other DMTs. [less ▲]

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See detailNatalizumab to kill two birds with one stone: A case of celiac disease and multiple sclerosis.
Phan-Ba, Rémy ULg; LAMBINET, Nadine ULg; Louis, Edouard ULg et al

in Inflammatory Bowel Diseases (2011), 17(6), 62-63

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See detailLa natation à l’école: participation des élèves en primaire et au secondaire
Cloes, Marc ULg

Conference (2013, May 15)

Swimming represents one of the most popular physical activities that are practiced by the children and the adolescents in Wallonia and Brussels. Paradoxically, their participation to the school swimming ... [more ▼]

Swimming represents one of the most popular physical activities that are practiced by the children and the adolescents in Wallonia and Brussels. Paradoxically, their participation to the school swimming lessons is clearly lower. Is it still necessary to maintain swimming courses at school? This presentation underlines that it would be unreasonable to remove the swimming courses from the school curricula. However, it would be essential to implement some dispositions in order to enrich the experiences lived by the students. [less ▲]

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See detailNation und Publikum in der spanischen Literatur des 19. Jahrhunderts
Ceballos Viro, Alvaro ULg

Conference (2007, June 02)

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See detailA nation-wide pilot project for early rehabilitation of low back pain workers
Mairiaux, Philippe ULg; DELARUELLE D.; STRAUSS, Patrick

in IEA 2006 Proccedings (2006, July)

As a result of both a political and a scientific thinking, the Belgian Fund for Occupational Diseases (FOD) has launched, starting March 1st 2005, a pilot project for the nursing staff in the health care ... [more ▼]

As a result of both a political and a scientific thinking, the Belgian Fund for Occupational Diseases (FOD) has launched, starting March 1st 2005, a pilot project for the nursing staff in the health care sector in order to prevent the transition of low back pain (LBP) to chronicity through a program promoting an early return to work. Target workers are those being off work due to LBP for at least 4 weeks and maximum 3 months. The program involves a standardised multidisciplinary back rehabilitation program on the one hand, and on the other hand an ergonomics intervention in the health care institution. Depending on the context, the workplace intervention may involve an ergonomic analysis with the participation of the sicklisted worker, a larger group-based ergonomics redesign, or temporary change in the worker duty or work time in order to facilitate his/her return to work. The employer gets a financial incentive from the FOD when he agrees to such an intervention. Due to a lack of communication among the target population, this pilot project has had a slow start; the presentation gives a qualitative overview of the first 100 cases having entered the program. [less ▲]

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See detailA nation-wide project for early rehabilitation of low back pain workers : an implementation study
Mairiaux, Philippe ULg; CREYTENS, Guido; DELARUELLE, Dirk et al

in Book of Abstracts: Sixth International Scientific Conference on Prevention of Work-related musculoskeletal disorders. PREMUS 2007 (2007, August)

Aims Based on a new policy for managing work-related diseases, the Belgian government has launched, starting March 1st 2005, an evidence-based program to promote an early return to work and to prevent ... [more ▼]

Aims Based on a new policy for managing work-related diseases, the Belgian government has launched, starting March 1st 2005, an evidence-based program to promote an early return to work and to prevent chronic low back pain (LBP). Target workers belong to the health care sector and must be off work due to LBP for at least 4 weeks and maximum 3 months. Considering the challenge in applying an innovative program on such a large scale, its implementation was carefully monitored by a task force created within the Fund for Occupational Diseases (FOD) and various process and impact evaluations carried out to identify barriers to its possible extension to other categories of workers. Methods The program can be defined as a “return to work” (RTW) program and involves a multidisciplinary back rehabilitation program available through more than 40 rehabilitation centres across the country, and an ergonomics intervention in the health care institutions to be carried out by the OH prevention service. Financial incentives are allowed to both the patient and the employer to stimulate participation. For every worker included in the project, data are systematically retrieved both by the rehabilitation centre and the prevention service using standardized forms. Questions arising from the various stakeholders (workers, trade unions, employers, general practitioners, OH physicians) about the program are systematically recorded by the task force. In addition, a phone survey has been conducted among the first 83 participants (out of 91 accepted applications) to know the managing path followed by each worker, and to identify the strengths and weaknesses of the designed program. Results One year after its official launch, the program was found to have reached 5.1% to 14.6% of the target population depending on the estimation basis chosen. Only 18.5% of the participants had seen or read the information leaflet edited by the FOD in the two national languages (in 20.000 exemplars). The main access criterion (>= 4 weeks sick leave), even supported by a solid scientific evidence, has been considered too severe by many stakeholders; the possibility to access the program during a relapse of a pain episode was not properly understood. Arising from wrong beliefs about back pain and its treatment, some patients but also their treating physicians were not keen to participate to such an active program. Entering the program also implied a visit by the OH physician during the sick leave, a new procedure still rarely used in the enterprises. Some employers worried about the program becoming a stimulus for extending the sick leave period instead of shortening it, but the collected data did not support this assumption. Potential concurrence between health professionals had also a negative influence in some areas. Regarding its content, the program was consistently applied in its medical component, well formalized within the Belgian health care system, but much less in its ergonomics component that was highly dependent on each institution own dynamic for prevention. As regard the program impact at short term, 98% of the participants did return to work and for 79% of them well before the end of the rehabilitation treatment in the centre; subjective improvements were recorded in 85% to 91% of the workers depending on the variable considered. Discussion and conclusions Informing about 90.000 workers in hundreds of health care institutions was a challenge and would have needed an ambitious media campaign. The project being completely innovative in the Belgian context, it implies deep changes in the traditional interactions between different health professionals and it requests altering very common beliefs about back pain. Such beliefs or behaviours cannot be changed in a few months! More fundamentally this project shows that there is long way to go before implementing with success at a national scale, interventions originally developed and tested in well controlled conditions and in a selected number of settings: return to work research has yet to evolve from establishing efficacy to proving effectiveness. References See FOD web site : www.fmp-fbz.fgov.be (“prevention dos” or “rugpreventie”) [less ▲]

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See detailA nation-wide project for the revision of the Belgian Nursing Minimum Data Set : from concept to implementation
SERMEUS, Walter; VAN DEN HEEDE, Koen; MICHIELS, Dominik et al

in OUD, Nico; SERMEUS, Walter; EHNFORS, Margareta (Eds.) Proceedings of the fifth biennial European Conference of the Association for Common European Nursing Diagnoses, Interventions and Outcomes (2005, April)

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See detailA nation-wide project for the revision of the Belgian Nursing Minimum Dataset: from concept to implementation
THONON, Olivier ULg

in Proceedings of the Saudi International Conference of Excellence in Patient Care -Saudi Organizer Co. (2013, April)

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See detailA nation-wide project for the revision of the Belgian Nursing Minimum Dataset: from concept to implementation
THONON, Olivier ULg; CODOGNOTTO, Jean ULg; GILLET, Pierre ULg et al

in EfCCNa (Ed.) Proceedings of the 2nd Congress of the EfCCNa (2005, November)

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See detailA nation-wide project for the revision of the Belgian nursing minimum dataset: from concept to implementation.
SERMEUS, Walter; VAN DEN HEEDE, Koen; MICHIELS, Dominik et al

in Studies in Health Technology & Informatics (2004), 110

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See detailA national cohort of HIV-infected patients in Belgium: design and main characteristics.
Van Beckhoven, D.; Buve, A.; Ruelle, J. et al

in Acta Clinica Belgica (2012), 67(5), 333-7

In Belgium, individual laboratory and treatment data of all HIV-infected patients seen in the 9 AIDS Reference Centres and 7 AIDS Reference Laboratories are collected prospectively since 2006. We present ... [more ▼]

In Belgium, individual laboratory and treatment data of all HIV-infected patients seen in the 9 AIDS Reference Centres and 7 AIDS Reference Laboratories are collected prospectively since 2006. We present here an analysis of patients recorded in the cohort database between 1st of January 2006 and 31st of December 2008. During that period, 11982 patients were under medical follow-up in Belgium. Sixty-one percent of the patients were male and the median age was 39.8 at the time of first recorded viral load. Among the patients whose nationality or probable mode of transmission was recorded, nearly half (48.0%) were Belgian and 38.3% originated from Sub-Saharan Africa; heterosexual contacts were reported in the majority of cases (56.0%) followed by homosexual contacts (35.3%). A total of 145 deaths were reported. Around three quarters of the patients were on ART. The median CD4 cell count rose from 470 cells/mm3 in 2006 to 501 cells/mm3 in 2008. This cohort enabled us to obtain comprehensive information on the numbers and characteristics of HIV-infected patients currently being followed up in Belgium, and on trends in antiretroviral therapy and biological results. This will serve for planning purposes, evaluation of access to care and as a source of information for further studies. [less ▲]

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See detailNational differences in ulcerative colitis experience and management among patients from five European countries and Canada: An online survey.
Schreiber, Stefan; Panes, Julian; LOUIS, Edouard ULg et al

in Journal of Crohn’s and Colitis (2013), 7

BACKGROUND AND AIMS: Patients' and physicians' perceptions of ulcerative colitis and its management are important for developing and guiding appropriate therapies. This study explored national differences ... [more ▼]

BACKGROUND AND AIMS: Patients' and physicians' perceptions of ulcerative colitis and its management are important for developing and guiding appropriate therapies. This study explored national differences in patients' and physicians' experiences, expectations, and beliefs about ulcerative colitis. METHODS: Structured, cross-sectional, online surveys evaluating various indices were completed by 775 adult patients with ulcerative colitis and 475 physicians actively managing ulcerative colitis patients from France, Germany, Ireland, Spain, the United Kingdom, and Canada. RESULTS: Patients' classification of their symptom severity differed across countries (mild, 16%-45%; moderate, 46%-58%; severe, 4%-36%). Expectations of disease control also varied, with 26% (Ireland) to 65% (Spain) describing that remission realistically involves "living without symptoms." Within each country, more patients (45%-69%) than physicians (28%-45%) considered ulcerative colitis symptoms to affect patients' quality of life. Mean number of patient-reported flares during the past year ranged from 2.5 in Ireland to 8.0 in France. Self-reported adherence with oral 5-aminosalicylic acid (during remission) was highest in Spain (91% vs 50%-73% across other countries). Spanish patients were more likely to self-adjust their medications (54% vs 2%-5%), but reported the most dissatisfaction with therapy (42% vs 9%-27%). Irish patients were least likely to arrange physician/specialist nurse visits (14% vs 36%-49%) and least open to discussion of their condition. CONCLUSIONS: Important national differences in ulcerative colitis patients' attitudes and perceptions were observed, which may help physicians improve patient care based on country-specific needs and influence self-assessments in clinical trials. The results suggest a need for structured patient education to improve adherence and outcomes. [less ▲]

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See detailNational Forest Inventory contributions to forest biodiversity monitoring
Chirici, Gherardo; McRoberts, Ronald E.; Winter, Susanne et al

in Forest Science (2012), 58(3), 257-268

Forests are the most biodiverse terrestrial ecosystems. National forest inventories (NFIs) are the main source of information on the status and trends of forests, but they have traditionally been designed ... [more ▼]

Forests are the most biodiverse terrestrial ecosystems. National forest inventories (NFIs) are the main source of information on the status and trends of forests, but they have traditionally been designed to assess land coverage and the production value of forests rather than forest biodiversity. The primary international processes dealing with biodiversity and sustainable forest management, the convention on Biological Diversity (CBD), Forest Europe, Streamlining European Biodiversity Indicators 2010 of the European Environmental Agency, and the Montréal Process, all include indicators related to forest biodiversity. The scope of this article is to review and present possibilities offered by NFIs to harmonize estimation of indicators useful for international forest and present possibilities offered by NFIs to harmonize estimation of indicators useful for international forest biodiversity monitoring and reporting. We summarize key findings from Working Group 3 of Action E43 (« Harmonization of National Forest Inventories in Europe : Techniques for Common Reporting ») of the European program Cooperation in Science and Technology (COST). We discuss definitions and techniques for harmonizing estimates of possible biodiversity indicators based on data from NFIs in Europe and the United States. We compare these possible indicators with indicators selected by international processes. The results demonstrate that NFIs can report comparable or harmonized estimates of indicators for multiple biodiversity features (forest categories, deadwood, forest age, forest structure, and forest naturalness), but for others (ground vegetation and regeneration) NFIs should invest more in harmonization efforts. On the basis of these key findings, we recommend that NFIs should represent a main component of a future global biodiversity monitoring network as urgently requested by the CBD. [less ▲]

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