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See detailNatural antibodies to BLV gp51 are reactive against the carbohydrate moiety of the glycoprotein.
Portetelle, Daniel ULg; Bruck, Claudine; Mammerickx, Marc et al

in Neth, R. (Ed.) Modern Trends in Human Leukemia IV (1981)

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See detailNatural antibody--complement dependent neutralization of bovine herpesvirus 4 by human serum
Machiels, Bénédicte ULg; Gillet, Laurent ULg; Brito, Sieberth Do Nascimento et al

in Microbes & Infection (2007), 9(14-15), 1530-1537

In contrast to most gammaherpesviruses, Bovine herpesvirus 4 (BoHV-4) has a broad range of host species both in vitro and in vivo. Several in vitro studies demonstrated that some human cell lines are ... [more ▼]

In contrast to most gammaherpesviruses, Bovine herpesvirus 4 (BoHV-4) has a broad range of host species both in vitro and in vivo. Several in vitro studies demonstrated that some human cell lines are sensitive or even permissive to BoHV-4. These observations led to the hypothesis that cross-species transmission of BoHV-4 could lead to human infections. In the present study, we investigate the sensitivity of BoHV-4 to neutralization by naïve human sera in order to determine if humans exhibit innate anti-viral activities against this virus. Our results demonstrate that human sera from naïve individuals, in contrast to the sera of naïve subjects from various animal species, neutralize BoHV-4 efficiently. A series of complementary experiments were performed to unravel the mechanism(s) of this neutralization. The data obtained in this study demonstrates that human serum neutralizes BoHV-4 in a complement dependent manner activated by natural antibodies raised against the Galalpha1-3Galbeta1-4GlcNAc-R epitope expressed by bovine cells [less ▲]

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See detailNatural case of bovine herpesvirus 1 meningoencephalitis in an adult cow.
Roels, S.; Charlier, G.; Letellier, C. et al

in Veterinary Record : Journal of the British Veterinary Association (2000), 146(20), 586-8

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See detailNatural clinoptiolite in contaminated soil and effluent handling
Gaydardzhiev, Stoyan ULg

in Salatic, D. (Ed.) Proceedings of the 8th Balkan Conference on Mineral Processing, Belgrade, Yugoslavia (1999)

Natural zeolite has been used as adsorbent for heavy metals from effluents and as soil ammendment for imobilzation of phytotoxic heavy metals. The principal technological factors being investigated were ... [more ▼]

Natural zeolite has been used as adsorbent for heavy metals from effluents and as soil ammendment for imobilzation of phytotoxic heavy metals. The principal technological factors being investigated were pH, soil/zeolite ratio and zeolite granulometry. A second order regression analysis has been used to outline their influence on th degree of metal immobilisation. [less ▲]

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See detailA natural dominant negative P2X1 receptor due to deletion of a single amino acid residue.
Oury, Cécile ULg; Toth-Zsamboki, Emese; Van Geet, Chris et al

in Journal of Biological Chemistry (2000)

We describe a naturally occurring dominant negative P2X1 mutant. This mutant lacks one leucine within a stretch of four leucine residues in its second transmembrane domain (TM2) (amino acids 351-354 ... [more ▼]

We describe a naturally occurring dominant negative P2X1 mutant. This mutant lacks one leucine within a stretch of four leucine residues in its second transmembrane domain (TM2) (amino acids 351-354). Confocal microscopy revealed proper plasma membrane localization of the mutant in stably transfected HEK293 cells. Nevertheless, voltage-clamped HEK293 cells expressing mutated P2X1 channels failed to develop an ATP or ADP-induced current. Furthermore, when co-expressed with the wild type receptor in Xenopus oocytes, the mutated protein exhibited a dose-dependent dominant negative effect on the normal ATP or ADP-induced P2X1 channel activity. These data indicate that deletion of a single apolar amino acid residue at the inner border of the P2X1 TM2 generates a nonfunctional channel. [less ▲]

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See detailNatural dualities for varieties generated by a set of subalgebras of a semi-primal algebra
Mathonet, Pierre ULg; Niederkorn, Philippe; Teheux, Bruno ULg

in Algebra and Discrete Mathematics (2007), (1), 67--85

The main contribution of this paper is the construction of a strong duality for the varieties generated by a set of subalgebras of a semi-primal algebra. We also obtain an axiomatization of the objects of ... [more ▼]

The main contribution of this paper is the construction of a strong duality for the varieties generated by a set of subalgebras of a semi-primal algebra. We also obtain an axiomatization of the objects of the dual category and develop some algebraic consequences (description of the dual of the finite structures and algebras, construction of finitely generated free algebras,. . . ). Eventually, we illustrate this work for the finitely generated varieties of MV-algebras. [less ▲]

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See detailNatural durability of black locust ( Robinia pseudoacacia L.) wood grown in Wallonia, Belgium
Pollet, Caroline; Jourez, Benoît ULg; Hebert, Jacques ULg

in Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (2008), 38(6), 1366-1372

The decay resistance of black locust (Robinia pseudoacacia L.) heartwood was evaluated on standardised test specimens taken from mature and juvenile wood in 25 trees distributed over 5 sites in Wallonia ... [more ▼]

The decay resistance of black locust (Robinia pseudoacacia L.) heartwood was evaluated on standardised test specimens taken from mature and juvenile wood in 25 trees distributed over 5 sites in Wallonia, Belgium. The percentage mass losses caused by the wood-destroying fungi Coriolus versicolor CTB 863 A and Coniophora puteana BAM Ebw.15 were evaluated according to CEN/TS 15083-1 (CEN/TS 15083-1. 2005. Durability of wood and wood-based products – determination of the natural durability of solid wood against wood-destroying fungi, test methods – Part 1 : basidiomycetes. European Comm. For Standardization, Brussels). Black locust is classified as a “very durable” wood (Class 1), while the juvenile heartwood (located near the pith) showed classes 1 to 2. The statistical analysis does not reveal any significant differences among the sites, suggesting that the growth environment of the trees has no effect on their natural durability. However, statistical analysis shows very highly significant differences among trees and between the two radial positions in the tree, mature wood being more resistant than juvenile wood. Using such a naturally very durable species could reduce reliance on preservative treatment and the use of tropical species generally recommended for outdoor woodwork. [less ▲]

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See detailNatural Element Method for the Simulation of Structures and Processes
Chinesta, Francisco; Cescotto, Serge ULg; Cueto, Elías et al

Book published by John Wiley & Sons, Inc. / ISTE Ltd (2011)

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See detailNatural equivariant quantizations
Radoux, Fabian ULg

Conference (2008, November 12)

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See detailNatural expression technology to identify bioactive compounds of medical relevance
Craig, Matthias ULg

Diverse speeche and writing (2009)

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See detailNatural fire safety concept
Franssen, Jean-Marc ULg

in Proceedings of the International Seminar on Steel Structures in Fire (2001)

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See detailNatural functions of cyclic lipopeptides from Bacillus and Pseudomonas: more than surfactants and antibiotics
Raaijmakers, Jos; De Bruin, Irene; Nybroe, Ole et al

in FEMS Microbiology Reviews (2010), 34

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See detailNatural Gas as an Alternative Fuel for Spark Ignition Engines
Sartor, Kevin ULg; Ngendakumana, Philippe ULg

Scientific conference (2010, May)

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See detailThe natural history, including orofacial features of three patients with Ehlers-Danlos syndrome, dermatosparaxis type (EDS type VIIC).
Malfait, Fransiska; De Coster, Peter; Hausser, Ingrid et al

in American Journal of Medical Genetics. Part A (2004), 131(1), 18-28

Ehlers-Danlos syndrome (EDS) dermatosparaxis type (type VIIC) and the related disease of cattle dermatosparaxis, are recessively inherited connective tissue disorders, caused by a deficient activity of ... [more ▼]

Ehlers-Danlos syndrome (EDS) dermatosparaxis type (type VIIC) and the related disease of cattle dermatosparaxis, are recessively inherited connective tissue disorders, caused by a deficient activity of procollagen I N-proteinase, the enzyme that excises the N-terminal propeptide in procollagen type I, type II, and type III. Although well documented in cattle, to date only seven human cases have been recorded, most of them aged under 2 years. We document the natural history of three patients with EDS dermatosparaxis type, two of whom have been reported before the age of 2 years, and one new patient. The phenotype of the patients, and especially the facial resemblance, is striking, making this a clinically recognizable condition. The most consistent anomalies during the first years of life are premature rupture of the membranes, extreme skin fragility and easy bruising, large fontanels, blue sclerae, puffy eyelids, micrognathia, umbilical hernia, and short fingers. Joint hypermobility becomes more important with age. The children are at risk for rupture of internal organs due to soft tissue fragility, as is illustrated by different internal events in two of the three patients described here. Orofacial features include micrognathia, a frontal open bite, and gingival hyperplasia with varying degrees of hyperkeratosis. The deciduous dentition shows abnormal morphology of the molars, obliteration of the tooth pulp, and severe enamel attrition. The permanent dentition shows agenesis and microdontia of several teeth. Tooth discoloration, dysplastic roots, and tooth pulp obliteration are present in a restricted number of permanent teeth. [less ▲]

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See detailNatural infection of Swiss mice by the Mouse Mammary Tumor Virus (MMTV). 2. Studies on the pathway of infection
Hainaut, P.; Vaira, Dolorès ULg; Calberg-Bacq, Claire Michelle et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1984), 92(1), 28

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See detailNatural intrauterine infection with Schmallenberg virus in malformed newborn calves: pathology and distribution of viral RNA
Bayrou, Calixte ULg; Garigliany, Mutien-Marie ULg; Sarlet, Michaël ULg et al

in Emerging Infectious Diseases (2014), 20(8),

We comprehensively surveyed morphologic alterations in calves naturally infected in utero by Schmallenberg virus (SBV) and born deformed. SBV-specific RNA was distributed unevenly in different tissues ... [more ▼]

We comprehensively surveyed morphologic alterations in calves naturally infected in utero by Schmallenberg virus (SBV) and born deformed. SBV-specific RNA was distributed unevenly in different tissues. Implications for diagnosic procedures are highlighted. [less ▲]

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See detailNatural killer and dendritic cells collaborate in the immune response induced by the vaccine against uterine cervical cancer.
Langers, Inge ULg; Renoux, Virginie; Reschner, Anca et al

in European journal of immunology (in press)

Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since ... [more ▼]

Virus-like particles (VLPs) of human papillomavirus (HPV) are used as a vaccine against HPV-induced cancer, and recently we have shown that these VLPs are able to activate natural killer (NK) cells. Since NK cells collaborate with dendritic cells (DCs) to induce an immune response against viral infections and tumors, we studied the impact of this crosstalk in the context of HPV vaccination. NK cells in the presence of HPV-VLPs enhanced DC maturation as shown by an upregulation of CD86 and HLA-DR and an increased production of IL-12p70, but not of the immunosuppressive cytokine IL-10. This activation was bi-directional. Indeed, in the presence of HPV-VLPs, DCs further activated NK cells by inducing the upregulation of cell surface activation markers (CD69 and HLA-DR). The function of NK cells was also improved as shown by an increase in IFN-gamma secretion and cytotoxic activity against an HPV+ cell line. This crosstalk between NK cells and DCs needed CD40 interaction and IL-12p70 secretion, whereas NKG2D was not implicated. Our results provide insight into how VLPs interact with innate immune cells and how NK cells and DCs play a role in the immune response induced by this vaccine agent. This article is protected by copyright. All rights reserved. [less ▲]

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