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Peer Reviewed
See detailLes karsts siliceux d'Afrique
Vicat, Jean-Paul; Willems, Luc ULg

in Géosciences au Cameroun @ collection Géocam (1998), 1

Detailed reference viewed: 15 (1 ULg)
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See detailDe Kartonfabriek Winderickx
Gantois, Gisele ULg

Article for general public (1990)

The Cardboardfactory Winderickx or Papermill of Herissem. On the border between Alsemberg and Dworp, situated south of Brussels, along the Molenbeek, a wonderful former rural industrial site is located ... [more ▼]

The Cardboardfactory Winderickx or Papermill of Herissem. On the border between Alsemberg and Dworp, situated south of Brussels, along the Molenbeek, a wonderful former rural industrial site is located, called the Papermill of Herissem, founded in 1763. This paper factory is owned by the family Winderickx uo till today. The whole chain of old machines, needed for the paper production is still present and well conserved. Today the cardboard factory is restored and a museum is installed showing the fabrication process of paper, illustrating how an industry functioned in a rural area by combining rural and industrial activities. [less ▲]

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See detailKaryotype of dormice Eliomys quercinus from Tirol (Austria)
Ramalhinho, M. D.; Libois, Roland ULg

in Acta Theriologica (2005), 50(1), 133-136

A karyotype of 2n = 52 chromosomes was found in two Eliomys quercinus (Linnaeus, 1766) specimens from two different localities of Tirol (Austria). The karyotype is similar to the one described in the ... [more ▼]

A karyotype of 2n = 52 chromosomes was found in two Eliomys quercinus (Linnaeus, 1766) specimens from two different localities of Tirol (Austria). The karyotype is similar to the one described in the Italian Alps, suggesting that these mountains were not a barrier to the northern expansion of this chromosomal race. [less ▲]

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See detailThe karyotype of the Formentera island garden dormouse, Eliomys quercinus ophiusae
Ramalhinho, Graça; Libois, Roland ULg

in Belgian Journal of Zoology (2001), 131(1), 83-85

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See detailKashin-Beck Disease: evaluation of mineral intake in young Tibetan children from endemic areas
DERMIENCE, Michael ULg; Maesen, Philippe ULg; Mathieu, Françoise et al

Poster (2010, October 26)

Kashin-Beck disease is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People’s Republic of China. Although many ... [more ▼]

Kashin-Beck disease is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People’s Republic of China. Although many studies have already been conducted and many others are still underway, its ethiology remains unknown. A multifactorial hypothesis has been proposed: selenium deficiency, high concentration of organic matters in drinking water (fulvic acids) and mycotoxin poisoning by fungi infecting cereals. This original study aimed to measure the mineral contents of the food most often consumed in severe endemic regions and then to evaluate the daily intake of minerals in young Tibetan children from endemic areas. The mineral elements were selected in relation to their implications in bone metabolism. A sampling campaign split up into two time periods (winter and spring) was carried out. Ten families from two distinct regions were selected based on three criteria: they live in endemic areas; they include a 3 to 5 year-old child; this child has a KBD brother or sister. At the same time, a nutritional survey was made by the means of a prospective questionnaire in order to list the 24h food intake of the 3 to 5 year-old child. This survey highlighted the extremely monotonous cereal-based Tibetan diet. An analytical method for the minerals was developed as follows: mineralization of samples performed by microwave-assisted wet process; mineralized solutions measured by several atomic absorption or emission spectrometric methods and molecular absorption spectrometric methods. The analytical method was validated by mean of certified reference materials. Mean food contents were calculated and compared to food composition reference tables. High iron contents and selenium deficiencies were highlighted in several foods. Daily intakes were estimated combining mineral measurements and nutritional survey results. These were compared to dietary reference intakes from reference tables. This estimation reveals some crucial points: we confirm a marked deficiency in calcium; Ca/P ratios are always low; iron and copper intakes are excessive; zinc is the most probably deficient; while selenium could be deficient; manganese intakes often exceed toxicity thresholds. Nevertheless, this study encounters some limits. The bioavailability of minerals is a critical point that deserves further investigations. Moreover, a larger study over a longer term covering both endemic and non-endemic regions is required for definite conclusions to be reached. [less ▲]

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See detailKashin-Beck Disease: evaluation of mineral intake in young Tibetan children from endemic areas
Dermience, Michael ULg

Master's dissertation (2010)

Kashin-Beck disease is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People’s Republic of China. Although many ... [more ▼]

Kashin-Beck disease is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People’s Republic of China. Although many studies have already been conducted and many others are still underway, its ethiology remains unknown. A multifactorial hypothesis has been proposed: selenium deficiency, high concentration of organic matters in drinking water (fulvic acids) and mycotoxin poisoning by fungi infecting cereals. This original study aimed to measure the mineral contents of the food most often consumed in severe endemic regions and then to evaluate the daily intake of minerals in young Tibetan children from endemic areas. The mineral elements were selected in relation to their implications in bone metabolism. A sampling campaign split up into two time periods (winter and spring) was carried out. Ten families from two distinct regions were selected based on three criteria: they live in endemic areas; they include a 3 to 5 year-old child; this child has a KBD brother or sister. At the same time, a nutritional survey was made by the means of a prospective questionnaire in order to list the 24h food intake of the 3 to 5 year-old child. This survey highlighted the extremely monotonous cereal-based Tibetan diet. An analytical method for the minerals was developed as follows: mineralization of samples performed by microwave-assisted wet process; mineralized solutions measured by several atomic absorption or emission spectrometric methods and molecular absorption spectrometric methods. The analytical method was validated by mean of certified reference materials. Mean food contents were calculated and compared to food composition reference tables. High iron contents and selenium deficiencies were highlighted in several foods. Daily intakes were estimated combining mineral measurements and nutritional survey results. These were compared to dietary reference intakes from reference tables. This estimation reveals some crucial points: we confirm a marked deficiency in calcium; Ca/P ratios are always low; iron and copper intakes are excessive; zinc is the most probably deficient; while selenium could be deficient; manganese intakes often exceed toxicity thresholds. Nevertheless, this study encounters some limits. The bioavailability of minerals is a critical point that deserves further investigations. Moreover, a larger study over a longer term covering both endemic and non-endemic regions is required for definite conclusions to be reached. [less ▲]

Detailed reference viewed: 170 (29 ULg)
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See detailKatanga Business - Pale Peko Bantu: Notes sur deux moments de cinéma postcolonial belge
Hamers, Jérémy ULg

in French Forum (2011), 35(n°2-3, Spring Fall 2010), 95-113

Detailed reference viewed: 206 (81 ULg)
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See detailKategorie und Formbegriff. Von Lask zu Heidegger
Gauvry, Charlotte ULg

in International Yearbook for Hermeneutics/ Internationales Jahrbuch für Hermeneutik (2014), 13

L’article examine la réception heideggérienne de la philosophie d’Emil Lask, dans ses premiers écrits logiques de 1912-1915 puis dans les cours de Freiburg de 1919-1923. Il accorde une attention spéciale ... [more ▼]

L’article examine la réception heideggérienne de la philosophie d’Emil Lask, dans ses premiers écrits logiques de 1912-1915 puis dans les cours de Freiburg de 1919-1923. Il accorde une attention spéciale à la distinction introduite par Lask entre les « catégories constitutives » et les « catégories réflexives » et explore en conséquence la connexion entre cette reformulation de la notion de catégorie et l’introduction heideggérienne de la notion de concept formel et d’anticipation (Vorgriff) formelle, afin de montrer que, malgré la rupture engagée par la phénoménologie herméneutique de la facticité, Heidegger reste profondément influencé par le néokantisme dans ces cours et écrits de jeunesse. [less ▲]

Detailed reference viewed: 21 (0 ULg)
See detailKatharsis
Pontzen, Alexandra ULg; Göritz, Anja

in Kiesow; Korte (Eds.) EGB. Emotionales Gesetzbuch. Dekalog der Gefühle (2005)

Detailed reference viewed: 29 (3 ULg)
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See detailKATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1 -dioxides
Lebrun, P.; Becker, B.; Morel, N. et al

in Biochemical Pharmacology (2008), 75

Detailed reference viewed: 14 (3 ULg)
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See detailKBD is an agro-environmental disease: The south central Tibet input
Haubruge, Eric ULg; Chasseur, Camille; Lognay, Georges ULg et al

Conference (2008, August)

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See detailThe KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat
Hansen, H. H.; Ebbesen, C.; Mathiesen, C. et al

in Journal of Pharmacology and Experimental Therapeutics (The) (2006), 318(3), 1006-1019

Homo- and heteromeric complexes of KCNQ channel subunits are the molecular correlate of the M-current, a neuron-specific voltage-dependent K+ current with a well established role in control of neural ... [more ▼]

Homo- and heteromeric complexes of KCNQ channel subunits are the molecular correlate of the M-current, a neuron-specific voltage-dependent K+ current with a well established role in control of neural excitability. We investigated the effect of KCNQ channel modulators on the activity of dopaminergic neurons in vitro and in vivo in the rat ventral mesencephalon. The firing of dopaminergic neurons recorded in mesencephalic slices was robustly inhibited in a concentration-dependent manner by the KCNQ channel opener N-(2-amino-4-(4-fluorobenzylamino)phenyl) carbamic acid ethyl ester ( retigabine). The effect of retigabine persisted in the presence of tetrodotoxin and simultaneous blockade of GABA A receptors, small-conductance calcium-activated K+ ( SK) channels, and hyperpolarization-activated (I-h) channels, and it was potently reversed by the KCNQ channel blocker 4- pyridinylmethyl-9(10H)-anthracenone (XE991), indicating a direct effect on KCNQ channels. Likewise, in vivo single unit recordings from dopaminergic neurons revealed a prominent reduction in spike activity after systemic administration of retigabine. Furthermore, retigabine inhibited dopamine synthesis and c-Fos expression in the striatum under basal conditions. Retigabine completely blocked the excitatory effect of dopamine D-2 auto-receptor antagonists. Again, the in vitro and in vivo effects of retigabine were completely reversed by preadministration of XE991. Dual immunocytochemistry revealed that KCNQ4 is the major KCNQ channel subunit expressed in all dopaminergic neurons in the mesolimbic and nigrostriatal pathways. Collectively, these observations indicate that retigabine negatively modulates dopaminergic neurotransmission, likely originating from stimulation of mesencephalic KCNQ4 channels. [less ▲]

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See detailKCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum.
Singh, Nanda A; Westenskow, Peter; Charlier, Carole ULg et al

in Brain : A Journal of Neurology (2003), 126(Pt 12), 2726-37

Benign familial neonatal convulsions (BFNC) is a rare autosomal dominant generalized epilepsy of the newborn infant. Seizures occur repeatedly in the first days of life and remit by approximately 4 months ... [more ▼]

Benign familial neonatal convulsions (BFNC) is a rare autosomal dominant generalized epilepsy of the newborn infant. Seizures occur repeatedly in the first days of life and remit by approximately 4 months of age. Previously our laboratory cloned two novel potassium channel genes, KCNQ2 and KCNQ3, and showed that they are mutated in patients with BFNC. In this report, we characterize the breakpoints of a previously reported interstitial deletion in the KCNQ2 gene and show that only KCNQ2 is deleted. We identify 11 novel mutations in KCNQ2 and one novel mutation in the KCNQ3 potassium channel genes. In one family, the phenotype extends beyond neonatal seizures and includes rolandic seizures, and a subset of families has onset of seizures in infancy. In the Xenopus oocyte expression system, we characterize five KCNQ2 and one KCNQ3 disease-causing mutations. These mutations cause a variable loss of function, and selective effects on the biophysical properties of KCNQ2/KCNQ3 heteromultimeric channels. We report here the first dominant negative mutation in KCNQ2 that has a phenotype of neonatal seizures without permanent clinical CNS impairment. [less ▲]

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See detailKCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases
Bayón, Yolanda; Trinidad, Antonio G.; de la Puerta, María L et al

in FEBS Journal (2008), 275(15), 3900-3910

Potassium channel tetramerization domain (KCTD) proteins contain a bric-a-brac, tramtrak and broad complex (BTB) domain that is most similar to the tetramerization domain (T1) of voltage-gated potassium ... [more ▼]

Potassium channel tetramerization domain (KCTD) proteins contain a bric-a-brac, tramtrak and broad complex (BTB) domain that is most similar to the tetramerization domain (T1) of voltage-gated potassium channels. Some BTB-domain-containing proteins have been shown recently to participate as substrate-specific adaptors in multimeric cullin E3 ligase reactions by recruiting proteins for ubiquitination and subsequent degradation by the proteasome. Twenty-two KCTD proteins have been found in the human genome, but their functions are largely unknown. In this study, we have characterized KCTD5, a new KCTD protein found in the cytosol of cultured cell lines. The expression of KCTD5 was upregulated post-transcriptionally in peripheral blood lymphocytes stimulated through the T-cell receptor. KCTD5 interacted specifically with cullin3, bound ubiquitinated proteins, and formed oligomers through its BTB domain. Analysis of the interaction with cullin3 showed that, in addition to the BTB domain, some amino acids in the N-terminus of KCTD5 are required for binding to cullin3. These findings suggest that KCTD5 is a substrate-specific adaptor for cullin3-based E3 ligases. [less ▲]

Detailed reference viewed: 43 (9 ULg)
See detailKDIGO a guidelines for bone turnover management in dialysis patients
CAVALIER, Etienne ULg

Conference (2015, November 20)

Detailed reference viewed: 11 (3 ULg)
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See detailKDIGO Guidelines and Kidney Transplantation: Is the cystatin-C Based Recommendation relevant?
Masson, I; Maillard, N; CAVALIER, Etienne ULg et al

in American Journal of Transplantation (2015), 15(8), 2211-4

The KDIGO guidelines propose a new approach to diagnose chronic kidney disease (CKD) based on estimated glomerular ®ltration rate (GFR). In patients with a GFR value comprised between 45 and 59 mL/ min/1 ... [more ▼]

The KDIGO guidelines propose a new approach to diagnose chronic kidney disease (CKD) based on estimated glomerular ®ltration rate (GFR). In patients with a GFR value comprised between 45 and 59 mL/ min/1.73m2 as estimated by the CKD-EPI creatinine equation (eGFRcreat), it is suggested to con®rm the diagnosis with a second estimation using the CKD-EPI cystatin C-based equations (eGFRcys/eGFRcreat-cys). We sought to determine whether this new diagnostic strategy might extend to kidney transplant recipients (KTR) and help to identify those with decreased GFR. In 670 KTR for whom a measured GFR was available, we simulated the detection of CKD using the two-steps approach recommended by the guidelines in comparison to the conventional approach relying on creatinine equation. One hundred forty-®ve patients with no albuminuria had eGFRcreat between 45 and 59 mL/ min/1.73m2. Among them, 23% had inulin clearance over 60 mL/min/1.73m2 and were thus incorrectly classi®ed as CKD patients. When applying the Kidney Disease: Improving Global Outcomes (KDIGO) strategy, 138 patients were con®rmed as having a GFR below 60 mL/min with eGFRcreat-cys. However, 21% of them were misclassi®ed in reference to measured GFR. Our data do no not support the use of cystatin C as a con®rmatory test of stage 3A CKD in KTR. [less ▲]

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See detailKDIGO – prise en charge de l’hypertension artérielle en dialyse
Krzesinski, Jean-Marie ULg

Conference (2013, March 28)

1. A lower target may be chosen in CKD patients with proteinuria but after individualized risk-benefit assessment. The price to pay is a need for a higher number of antiHTA drugs and a risk of more ... [more ▼]

1. A lower target may be chosen in CKD patients with proteinuria but after individualized risk-benefit assessment. The price to pay is a need for a higher number of antiHTA drugs and a risk of more frequent side-effects. 2. Confirmation of a high BP level is necessary through out-of-the clinic BP measurement In CKD, ABPM offers night-time BP information useful for CV and renal risk evaluation. BP variability is a new point to be considered in the future. Proteinuria but also other specific risk factors (Phosphate, anemia, inflammation,..) should be integrated in the management of hypertension in CKD [less ▲]

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See detailKeep bacteria under control: Dietary modulation of gut microflora in farm animals by use of hen egg yolk antibodies
Marcq, Christopher ULg; Thewis, André ULg; Portetelle, Daniel ULg et al

E-print/Working paper (2010)

This review article focuses on the use of IgY in therapy or prophylaxis of diseases in veterinary medicine as well as in the context of functional foods to modulate microflora in animal.

Detailed reference viewed: 189 (38 ULg)