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See detailNews on antifungal drugs registered in Belgium for the treatment of dermatophytosis in domestic carnivores.
Hamoir, J.; Goret, M.; Mignon, Bernard ULg et al

in Annales de Médecine Vétérinaire (2001), 145

This note gives a progress report on the various molecules registered in Belgium which can be used for the treatment of dermatophytosis in domestic carnivores. Its purpose is not to develop the ... [more ▼]

This note gives a progress report on the various molecules registered in Belgium which can be used for the treatment of dermatophytosis in domestic carnivores. Its purpose is not to develop the therapeutic protocols used in this type of diseases but rather to describe these compounds according to their pharmacological and toxicological characteristics as well as to define their status in the current legal framework. [less ▲]

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See detailNewsletter N° 3 - DACEFI
Meunier, Quentin ULg; Moumbogou, Carl; Ndoutoume, C. et al

E-print/Working paper (2011)

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See detailNewsletter n° 5 - DACEFI 2
Meunier, Quentin; Moumbogou, Carl; Angwé, A. et al

E-print/Working paper (2012)

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See detailNewsletter n°1 - DACEFI
Meunier, Quentin; Vermeulen, Cédric ULg

E-print/Working paper (2011)

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See detailNewsletter N°2-DACEFI
Meunier, Quentin; Grégoire, Bruno; Moumbogou, Carl et al

E-print/Working paper (2011)

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See detailNewsletter n°4 - DACEFI
Meunier, Quentin; Moumbogou, Carl; Ibinga, S. et al

E-print/Working paper (2011)

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See detailNewsletter n°6 - DACEFI
Meunier, Quentin; Moumbogou, Carl; Morin, Amélie et al

E-print/Working paper (2012)

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See detailNewt decline in Western Europe: highlights from relative distribution changes within guilds
Denoël, Mathieu ULg

in Biodiversity & Conservation (2012), 21(11), 2887-2898

The recent increase in the number of monitoring schemes has formed the basis for high quality distribution atlases. This provides the opportunity of estimating global and specific decline patterns across ... [more ▼]

The recent increase in the number of monitoring schemes has formed the basis for high quality distribution atlases. This provides the opportunity of estimating global and specific decline patterns across regional and national borders. In this framework, this study focused on four sympatric newt species—including the great crested newt (Triturus cristatus), an Annex 2 European Habitats Directive species, over six geographic areas (five countries) in Western Europe. A relative comparison of distribution maps across time is used here and is based on more than twelve thousands occupied grid cells. It benefits from the definition of a guild, as these species are simultaneously detectable in wetlands. T. cristatus and the alpine newt (Mesotriton alpestris) were the most and the least threatened newt species, respectively, whereas the palmate (Lissotriton helveticus) and smooth newt (Lissotriton vulgaris) had an intermediate decline level at both coarse and fine grain resolutions. However, regional variations across Europe and scale effects were also found. On one hand, these results show that T. cristatus is not only regionally threatened but suffers from a global decline in Western Europe. On another hand, the results indicate that patterns of decline are not uniform within Europe and that species often considered as common and not threatened are, in fact, declining more than others. Finally, the proposed methodology, i.e. using guilds to assess relative decline, would be useful as a complement to other standardized methods in correctly advising conservation managers and policy makers, particularly for species with more subtle declines. [less ▲]

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See detailNewton, précurseur de l'analyse non standard
Bair, Jacques ULg; Henry, Valérie

in Tangente (2010), 137

En analysant un extrait des travaux de Newton, nous montrons que ce dernier avait une conception pratique du concept d'infiniment petit en comparant divers angles de contact.

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See detailNext-generation phase-mask coronagraphy for extrasolar planetary system imaging
Mawet, D.; Riaud, Pierre ULg; Surdej, Jean ULg

Conference (2006, March 16)

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See detailNext-Generation Sequencing for Rodent Barcoding: Species Identification from Fresh, Degraded and Environmental Samples
Galan, Maxime; Pagès, Marie ULg; Cosson, Jean-François

in PLoS ONE (2012), 7(11), 48374

Rodentia are one of the most diverse orders among mammals, with more than 2,000 species currently described. Species assignation based on morphological data alone can present enormous challenges. In this ... [more ▼]

Rodentia are one of the most diverse orders among mammals, with more than 2,000 species currently described. Species assignation based on morphological data alone can present enormous challenges. In this study, we compared the applicability of 100 bp mini-barcodes from cytochrome b and cytochrome c oxidase 1 genes to enable rodent species identification. Based on GenBank sequence datasets of 115 rodent species, a 136 bp fragment of cytochrome b combined with universal rodent primers was selected as the most discriminatory mini-barcode. The efficacy of this new molecular tool was assessed on 946 samples including rodent tissues, feces, museum samples and feces/pellets from predators known to ingest rodents. Utilizing next generation sequencing technologies able to sequence multiple DNAs, 1,140 amplicons were tagged, multiplexed and sequenced together in one single 454 GS-FLX run. Our method was initially validated on a reference sample set including 265 clearly identified rodent tissues, corresponding to 103 different species. Following validation, 85.6% of 555 rodent samples from Europe, Asia and Africa whose species identity was unknown were able to be identified using the BLASTN program and GenBank reference sequences. In addition, our method proved effective even on degraded rodent DNA samples: 91.8% and 75.9% of samples from feces and museum specimens respectively were correctly identified. Finally, we succeeded in determining the diet of 66.7% of the investigated carnivores from their feces and 81.8% of owls from their pellets. Non-rodent species were also identified suggesting that our method is sensitive enough to investigate complete predator diets. This study demonstrates how this molecular identification method combined with high throughput sequencing can open new realms of possibilities in achieving fast, accurate and inexpensive species identification. [less ▲]

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See detailNext-to-leading-order QCD corrections to the yields and polarisations of J/Psi and Upsilon directly produced in association with a Z boson at the LHC
Gong, Bin; Lansberg, Jean-Philippe ULg; Lorce, Cédric ULg et al

in Journal of High Energy Physics [=JHEP] (2013), 1303

We update the study of the production of direct $J/\Psi$ in association with a $Z$ boson at the Next-to-Leading Order (NLO) in $\alpha_S$ by evaluating both the yield differential in $P_T$ and the $J/\Psi ... [more ▼]

We update the study of the production of direct $J/\Psi$ in association with a $Z$ boson at the Next-to-Leading Order (NLO) in $\alpha_S$ by evaluating both the yield differential in $P_T$ and the $J/\Psi$ polarisation in the QCD-based Colour-Singlet Model (CSM). Contrary to an earlier claim, QCD corrections at small and mid $P_T$ are small if one assumes that the factorisation and the renormalisation scales are commensurate with the $Z$ boson mass. As it can be anticipated, the t-channel gluon-exchange (t−CGE) topologies start to be dominant only for $P_T > m_Z/2$. The polarisation pattern is not altered by the QCD corrections. This is thus far the first quarkonium-production process where this is observed in the CSM. Along the same lines, our predictions for direct $\Upsilon + Z$ are also given. [less ▲]

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See detailNez électronique adapté aux odeurs de sucrerie, Rapport final
Romain, Anne-Claude ULg; Nicolas, Jacques ULg

Report (1998)

Au terme de cette convention FIRST, un savoir faire en matière de mesure d'odeur environnementale a été développé à sur le campus d'Arlon. Ce savoir faire étoffe ainsi l'acquis de l'équipe de recherche ... [more ▼]

Au terme de cette convention FIRST, un savoir faire en matière de mesure d'odeur environnementale a été développé à sur le campus d'Arlon. Ce savoir faire étoffe ainsi l'acquis de l'équipe de recherche "Surveillance de l'Environnement". Un détecteur de nuisances olfactives a été développé en laboratoire. Ce système s'avère au moins aussi performant que les instruments proposés sur le marché. Dans notre cas, la technologie des nez artificiels a été adaptée au monitoring des odeurs dans l'environnement : notamment les influences des facteurs externes, comme la température et l'humidité ambiantes ont été étudiées. Les quelques odeurs environnementales (prélevées sur le terrain ou reconstituées artificiellement) testées sur le détecteur ont pu être identifiées par des techniques de reconnaissance de formes. Couplé à l'acquisiteur de données VIGIL de C2MS, un détecteur de terrain a été placé sur le terrain, aux alentours des bassins de décantation de la sucrerie "Tirlemont" de Genappe. Moyennant une calibration des algorithmes utilisés, il va donc servir à la surveillance continue des émissions olfactives sur le site considéré, notamment dans le but de mettre en évidence un indicateur d'alarme ou de délivrer un signal capable de contrôler un aérateur de bassin. A l'issue des 3 années de recherche, on peut donc considérer que l'instrument de laboratoire et le détecteur de terrain fonctionnent de manière satisfaisante et, en tout état de cause, suffisamment bien que pour être transposés à d'autres applications environnementales, au-delà de celle du monitoring des odeurs de sucrerie. Il est notamment projeté d'adapter une technique similaire à celle du détecteur de terrain au suivi des émissions olfactives aux alentours de décharges d'ordures, l'objectif étant le contrôle des dispositifs anti-odeurs. Chaque émission d'odeur est un cas spécifique : il sera donc difficilement envisageable, dans l'avenir, de commercialiser un appareil universel. Une perspective intéressante serait d'adapter le détecteur de terrain, au cas par cas, à d'autres suivis d'odeurs environnementales, en se servant des acquis de cette première expérience et de l'instrument de laboratoire comme banc d'essais préliminaires. [less ▲]

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See detailLe nez électronique, un nouvel outil diagnostique pour les maladies respiratoires du cheval ?
Salinas, Emmanuelle; Ramery, Eve ULg; Fraipont, Audrey ULg et al

in Proceedings: AVEF, Versailles, France (2006)

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See detailNF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression.
Drew, P. D.; Franzoso, G.; Becker, K. G. et al

in Journal of Interferon & Cytokine Research (1995), 15(12), 1037-45

Major histocompatibility (MHC) class I gene expression is synergistically induced by the cytokines TNF-alpha and IFN-gamma. However, the mechanism that results in synergistic activation of these genes has ... [more ▼]

Major histocompatibility (MHC) class I gene expression is synergistically induced by the cytokines TNF-alpha and IFN-gamma. However, the mechanism that results in synergistic activation of these genes has remained unclear. We demonstrated here that TNF-alpha induced binding of NF kappa B p50 and p65 to the NF kappa B-like element of the MHC class I promoter termed region I and IFN-gamma induced binding of IRF-1 to the adjacent interferon consensus sequence (ICS). We further demonstrated that NF kappa B and IRF-1 physically interacted with each other and cooperatively induced MHC class I gene expression when cotransfected into CHP-126 neuroblastomas. These results provide a molecular mechanism by which TNF-alpha and IFN-gamma synergistically induce the expression of a variety of genes involved in immune responses, including MHC class I. [less ▲]

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See detailNf- Kappa B and Chemoresistance: Could Nf- Kappa B Be an Antitumor Target?
Bentires-Alj, Mohamed; Merville, Marie-Paule ULg; Bours, Vincent ULg

in Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy (1999), 2(4), 274-276

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See detailNF-kappa B activation by double-strand breaks
Habraken, Yvette ULg; Piette, Jacques ULg

in Biochemical Pharmacology (2006), 72(9), 1132-1141

Cellular response to DNA damage is complex and relies on the simultaneous activation of different networks. It involves DNA damage recognition, repair, and induction of signalling cascades leading to cell ... [more ▼]

Cellular response to DNA damage is complex and relies on the simultaneous activation of different networks. It involves DNA damage recognition, repair, and induction of signalling cascades leading to cell cycle checkpoint activation, apoptosis, and stress related responses. The fate of damaged cells depends on the balance between pro- and antiapoptotic signals. in this decisive life or death choice, the transcription factor NF-kappa B has emerged as a prosurvival actor in most cell types. As corollary, it appears to be associated with tumorigenic process and resistance to therapeutic strategies as it protects cancerous cells from death. in this review, we will focus on NF-kappa B activation by double-strand breaks inducing agents, such as ionizing radiation and DNA topoisomerase I and II inhibitors routinely used in cancer therapy. Coinciding with the 20th anniversary of the NF-kappa B discovery, major steps of the DSB-triggered cascade have been recently identified. Two parallel cascades are necessary for NF-kappa B activation. The first one depends on ATM (activated by double-strand breaks) and the second on PIDD (activated by an unknown stress signal). The phosphorylation of NEMO by ATM is the point of convergence of these two cascades. The identification of ATM/NEMO complex as the long searched "nuclear to cytoplasm" signal leading to IKK activation is also a major piece of the puzzle. The knowledge of the precise steps leading to DSB-initiated NF kappa B activation will allow the development of specific blocking compounds reducing its prosurvival function. (c) 2006 Elsevier Inc. All rights reserved. [less ▲]

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See detailNF-kappa B activation by reactive oxygen species: Fifteen years later
Gloire, Geoffrey ULg; Legrand-Poels, Sylvie ULg; Piette, Jacques ULg

in Biochemical Pharmacology (2006), 72(11), 1493-1505

The transcription factor NF-kappa B plays a major role in coordinating innate and adaptative immunity, cellular proliferation, apoptosis and development. Since the discovery in 1991 that NF-kappa B maybe ... [more ▼]

The transcription factor NF-kappa B plays a major role in coordinating innate and adaptative immunity, cellular proliferation, apoptosis and development. Since the discovery in 1991 that NF-kappa B maybe activated by H(2)o(2), several laboratories have put a considerable effort into dissecting the molecular mechanisms underlying this activation. Whereas early studies revealed an atypical mechanism of activation, leading to I kappa B alpha Y42 phosphorylation independently Of I kappa B kinase (IKK), recent findings suggest that H2O2 activates NF-kappa B mainly through the classical IKK-dependent pathway. The molecular mechanisms leading to IKK activation are, however, cell-type specific and will be presented here. In this review, we also describe the effect of other ROS (HOCl and O-1(2)) and reactive nitrogen species on NF-kappa B activation. Finally, we critically review the recent data highlighting the role of ROS in NF-kappa B activation by proinflammatory cytokines (TNF-alpha and IL-1 beta) and lipopolysaccharide (LPS), two major components of innate immunity. (c) 2006 Elsevier Inc. All rights reserved. [less ▲]

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See detailThe Nf-Kappa B Transcription Factor and Cancer: High Expression of Nf-Kappa B- and I Kappa B-Related Proteins in Tumor Cell Lines
Bours, Vincent ULg; Dejardin, Emmanuel ULg; Goujon-Letawe, F. et al

in Biochemical Pharmacology (1994), 47(1), 145-9

NF-kappa B is a pleiotropic transcription factor which controls the expression of many genes and viruses. To date, there is good evidence, but no definitive proof, for its role in tumor formation and ... [more ▼]

NF-kappa B is a pleiotropic transcription factor which controls the expression of many genes and viruses. To date, there is good evidence, but no definitive proof, for its role in tumor formation and development of metastasis. To investigate the possibility that members of the NF-kappa B family could participate in the molecular control of the transformed and invasive phenotype, we examined the expression of these proteins in a variety of human tumor cell lines. The expression of p50, p65, p52 and I kappa B was quantified at the protein level using western immunoblot and mobility shift assay and at the RNA level by northern blot. We observed high expression of the NF-kappa B inhibitor I kappa B in the ovarian carcinoma cell line OVCAR-3 together with constitutive nuclear NF-kappa B activity. We also studied the colon carcinoma cell line HT-29 and its metastatic counterpart HTM-29 and we observed specific expression of the p52 NF-kappa B-related protein in the metastatic cells. Our data confirm that NF-kappa B could be involved in the genesis of a variety of cancers including solid tumors and provide us with interesting models to explore the exact role of these transcription factors in cancer. [less ▲]

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See detailNF-kappa B2/p100 induces Bcl-2 expression
Viatour, Patrick ULg; Bentires-Alj, Mohamed; Chariot, Alain ULg et al

in Leukemia (2003), 17(7), 1349-1356

The NF-kappaB2/p100 and bcl-3 genes are involved in chromosomal translocations described in chronic lymphocytic leukemias (CLL) and non-Hodgkin's lymphomas, and nuclear factor kappaB (NF-kappaB) protects ... [more ▼]

The NF-kappaB2/p100 and bcl-3 genes are involved in chromosomal translocations described in chronic lymphocytic leukemias (CLL) and non-Hodgkin's lymphomas, and nuclear factor kappaB (NF-kappaB) protects cancer cells against apoptosis. Therefore, we investigated whether this transcription factor could modulate the expression of the Bcl-2 antiapoptotic protein. Bcl-2 promoter analysis showed multiple putative NF-kappaB binding sites. Transfection assays of bcl-2 promoter constructs in HCT116 cells showed that NF-kappaB can indeed transactivate bcl-2. We identified a kappaB site located at position -180 that can only be bound and transactivated by p50 or p52 homodimers. As p50 and p52 homodimers are devoid of any transactivating domains, we showed that they can transactivate the bcl-2 promoter through association with Bcl-3. We also observed that stable overexpression of p100 and its processed product p52 can induce endogenous Bcl-2 expression in MCF7AZ breast cancer cells. Finally, we demonstrated that, in breast cancer and leukemic cells ( CLL), high NF-kappaB2/p100 expression was associated with high Bcl-2 expression. Our data suggest that Bcl-2 could be an in vivo target gene for NF-kappaB2/p100. [less ▲]

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