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See detailAs/zteken. Gedichtendagessay
Spinoy, Erik ULg

Book published by Poëziecentrum / De Bezige Bij Antwerpen (2012)

This essay discusses the changing nature of (Flemish) poetry at the beginning of the 21ste century: the genre appears to become increasingly obsolete and unpopular; on the other hand, it continues to show ... [more ▼]

This essay discusses the changing nature of (Flemish) poetry at the beginning of the 21ste century: the genre appears to become increasingly obsolete and unpopular; on the other hand, it continues to show an unexpected vitality. This may be explained by the fact that both poetry and the inescapable frailty of human identifications are two faces of the same coin. [less ▲]

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See detailL'asbestose pleuro-parenchymateuse. Interet de l'analyse du liquide de lavage broncho-alveolaire.
CORHAY, Jean-Louis ULg; Hotermans, G; Biquet, J F et al

in Revue Médicale de Liège (1989), 44(6), 218-28

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See detailLes ASBL belges: Principes et Constitution
Gol, Déborah ULg

in Benoit, Nathalie; Caprasse, Olivier; Thirion, Nicolas (Eds.) A.S.B.L., Fondations et Associations internationales (2004)

La loi du 27 juin 1921 relative aux associations sans but lucratif a été modifiée par une loi du 2 mai 2002 relative aux associations sans but lucratif, aux fondations et aux associations internationales ... [more ▼]

La loi du 27 juin 1921 relative aux associations sans but lucratif a été modifiée par une loi du 2 mai 2002 relative aux associations sans but lucratif, aux fondations et aux associations internationales sans but lucratif. Cette partie de l'ouvrage rappelle les principes qui gouvernent la notion d'association sans but lucratif (définition, absence de but de lucre et comparaison de l'ASBL avec d'autres groupements tels que la société à finalité sociale ou l'association de fait) ainsi que les règles relatives à la constitution des ASBL telles que modifiées par la loi de 2002 (acte constitutif, acquisition de la personnalité juridique, engagements pris au nom d'une ASBL en formation et formalités de publicité). [less ▲]

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See detailASBL et activités commerciales : le fil d'Ariane
Pasteger, David ULg

in Gol, Déborah; T'kint, Philippe (Eds.) Les personnes morales sans but lucratif : questions choisies (2012)

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See detailASBL, Fondations et Associations internationales
Thirion, Nicolas ULg; Caprasse, Olivier ULg

Book published by La Charte (2004)

Ouvrage collectif visant à présenter dans son ensemble le régime juridiques des ASBL, des fondations et des associations internationale après la réforme de 2002

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See detailASCA spectroscopy of the hard X-ray emission from the colliding wind interaction in gamma[SUP]2[/SUP] Velorum
Rauw, Grégor ULg; Stevens, I. R.; Pittard, J. M. et al

in Monthly Notices of the Royal Astronomical Society (2000), 316

We discuss an ASCA observation of the eccentric WC8+O7.5III binary gamma[SUP]2[/SUP]Velorum near apastron. The X-ray spectrum is compared with two previous observations obtained when the system was near ... [more ▼]

We discuss an ASCA observation of the eccentric WC8+O7.5III binary gamma[SUP]2[/SUP]Velorum near apastron. The X-ray spectrum is compared with two previous observations obtained when the system was near periastron. All three spectra display a hard-emission component that undergoes strong variability over the orbital cycle. The properties of the hard X-ray emission of gamma[SUP]2[/SUP]Vel are constrained by taking into account the contribution from contaminating soft X-ray sources in the vicinity of gamma[SUP]2[/SUP]Vel. We find that the observed variations are in qualitative agreement with the predictions of colliding wind models. We investigate for the first time the effect of uncertainties in the chemical composition of the X-ray emitting plasma on our understanding of the high-energy properties of the wind interaction region. Our results indicate that these uncertainties significantly affect the derived shock temperature and absorption column, but play a smaller role in determining the intrinsic X-ray luminosity of the colliding wind zone. We further find that the intrinsic luminosity from the hard X-ray component in gamma[SUP]2[/SUP]Vel does not follow the 1/D distance relation expected from simple models of adiabatic shocks. [less ▲]

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See detailASCID : le noyau centrral de douze facteurs expliquant la conduite en éducation thérapeutique du patient
Leclercq, Dieudonné ULg

in Education Thérapeutique du Patient [=ETP] = Therapeutic Patient Education [=TPE] (2010), 2(2), 213-221

Abstract – ASCID: the core of 12 factors that explain behavior in patient education. Introduction: Professionals involved in Patient Education need to have a good understanding of the (numerous) factors ... [more ▼]

Abstract – ASCID: the core of 12 factors that explain behavior in patient education. Introduction: Professionals involved in Patient Education need to have a good understanding of the (numerous) factors that affect, in a person, her becoming aware, then her decision, then her putting it into practice in a lasting and efficient way. For this purpose, we propose a model we have developed during several years in CERES (University of Liège) as well as in DPSS (University of Paris 13), named “Factors of production and perseveration in actions”. If these factors are designated by the first letters of their names, at the heard of the model stands the acronym ASCID (Attitudes, Skills, Cognition, Identity, Decision). Objectives: This model, conceived for health and environment education is not limited to therapeutic patient education, but it fits it very well. The interest and the fecundity of this model have been put to test during more than 25 years with cohorts of students and professionals involved in TPE to analyze situations, cases, and to conceive relevant course of action for the educator and the patient. Description: Methods of diagnostic and of action in TPE superimposed themselves to the model of patient functioning. To help readers assimilate this complex model, we start with a familiar case (AIDS) and we will use frequently cases to illustrate theoretical concepts. [less ▲]

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See detailAscididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro
Guittat, Lionel; De Cian, Anne; Rosu, Frédéric ULg et al

in Biochimica et Biophysica Acta - General Subjects (2005), 1724(3), 375-384

Ascididemin and Meridine are two marine compounds with pyridoacridine skeletons known to exhibit interesting antitumour activities. These molecules have been reported to behave like DNA intercalators. In ... [more ▼]

Ascididemin and Meridine are two marine compounds with pyridoacridine skeletons known to exhibit interesting antitumour activities. These molecules have been reported to behave like DNA intercalators. In this study, dialysis competition assay and mass spectrometry experiments were used to determine the affinity of ascididemin and meridine for DNA structures among duplexes, triplexes, quadruplexes and single-strands. Our data confirm that ascididemin and meridine interact with DNA but also recognize triplex and quadruplex structures. These molecules exhibit a significant preference for quadruplexes over duplexes or single-strands. Meridine is a stronger quadruplex ligand and therefore a stronger telomerase inhibitor than ascididemin (IC50= 11 and > 80 mu M, respectively in a standard TRAP assay). (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailAscl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish
Flasse, Lydie; Pirson, Justine; Stern, David ULg et al

in BMC Biology (2013), 11

Background NEUROG3 is a key regulator of pancreatic endocrine cell differentiation in mouse, essential for the generation of all mature hormone producing cells. It is repressed by Notch signaling that ... [more ▼]

Background NEUROG3 is a key regulator of pancreatic endocrine cell differentiation in mouse, essential for the generation of all mature hormone producing cells. It is repressed by Notch signaling that prevents pancreatic cell differentiation by maintaining precursors in an undifferentiated state. Results We show herein that, in zebrafish, neurog3 is not expressed in the pancreas and null neurog3 mutant embryos do not display any apparent endocrine defects. The control of endocrine cell fate is instead fulfilled by a couple of bHLH factors, Ascl1b and Neurod1, that are both repressed by Notch signaling. ascl1b is transiently expressed in the mid-trunk endoderm just after gastrulation and is required for the generation of the first pancreatic endocrine precursor cells. Neurod1 is expressed afterwards in the pancreatic anlagen and pursues the endocrine cell differentiation program initiated by Ascl1b. Their complementary role in endocrine differentiation of the dorsal bud is demonstrated by the loss of all hormone-secreting cells following their simultaneous inactivation. This defect is due to a blockage of the initiation of endocrine cell differentiation. Conclusions This study demonstrates that NEUROG3 is not the unique pancreatic endocrine cell fate determinant in vertebrates. A general survey of endocrine cell fate determinants in the whole digestive system among vertebrates indicates that they all belong to the ARP/ASCL family but not necessarily to the Neurog3 subfamily. The identity of the ARP/ASCL factor involved depends not only on the organ but also on the species. One could therefore consider differentiating stem cells into insulin-producing cells without the involvement of NEUROG3 but via another ARP/ASCL factor. [less ▲]

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See detailAsclépios et les médecins d’après les inscriptions grecques : des relations cultuelles
Nissen, Cécile ULg

in Medicina nei Secoli : Arte e Scienza (2007), 19(3), 721-744

The Greek inscriptions afford several examples of the relationship between Asklepios, the god of medicine, and the human doctors, in Graeco-Roman Antiquity. Many dedications of steles, statues, altars and ... [more ▼]

The Greek inscriptions afford several examples of the relationship between Asklepios, the god of medicine, and the human doctors, in Graeco-Roman Antiquity. Many dedications of steles, statues, altars and even sanctuaries were consecrated to Asklepios by doctors. Other physicians have undertaken the offices of zacorate or priesthood in the worship of Asklepios. In some cities, notably at Athens and Ephesos, the doctors sacrificed collectively to the physician-god. The aim of this paper is to explain these cult relations between Asklepios and the doctors. After the Asklepiads, doctors at Kos and Knidos, who were believed to be the descendants of Asklepios, all the ancient doctors were connected with Asklepios by their techne; the physician-god was the divine patron of the physicians. Furthermore although the doctors rejected the divine origin of the diseases, they acknowledged the healing power of the gods, especially Asklepios, and could seek his help. [less ▲]

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See detailAsclépios et les médecins en Asie Mineure
Nissen, Cécile ULg

E-print/Working paper (2010)

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See detailAscorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death
Verrax, Julien; Cadrobbi, Julie; Marques, Carole et al

in Apoptosis : An International Journal on Programmed Cell Death (2004), 9(2), 223-233

Hepatocarcinoma cells (TLT) were incubated in the presence of ascorbate and menadione, either alone or in combination. Cell death was only observed when such compounds were added simultaneously, most ... [more ▼]

Hepatocarcinoma cells (TLT) were incubated in the presence of ascorbate and menadione, either alone or in combination. Cell death was only observed when such compounds were added simultaneously, most probably due to hydrogen peroxide (H2O2) generated by ascorbate-driven menadione redox cycling. TLT cells were particularly sensitive to such an oxidative stress due to its poor antioxidant status. DNA strand breaks were induced by this association but this process did not correspond to oligosomal DNA fragmentation (a hallmark of cell death by apoptosis). Neither caspase-3-like DEVDase activity, nor processing of procaspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP) were observed in the presence of ascorbate and menadione. Cell death induced by such an association was actively dependent on protein phosphorylation since it was totally prevented by preincubating cells with sodium orthovanadate, a tyrosine phosphatase inhibitor. Finally, while H2O2, when administered as a bolus, strongly enhances a constitutive basal NF-kappaB activity in TLT cells, their incubation in the presence of ascorbate and menadione results in a total abolition of such a constitutive activity. [less ▲]

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See detailAscorbate-induced fibroblast cell matrix: reaction of antibodies to procollagen I and III and fibronectin in an axial periodic fashion.
Furcht, L. T.; Wendelschafer-Crabb, G.; Mosher, D. F. et al

in Progress in Clinical & Biological Research (1980), 41

Fibronectin and procollagen types I and III are constituents of the extracellular matrix of human fibroblasts. Ultrastructural immunocytochemistry using the peroxidase anti-peroxidase method showed ... [more ▼]

Fibronectin and procollagen types I and III are constituents of the extracellular matrix of human fibroblasts. Ultrastructural immunocytochemistry using the peroxidase anti-peroxidase method showed fibronectin and procollagen antibodies reacting in continuous fashion on 10 nm diameter extracellular fibrils on human fibroblasts. Intracellular localization showed an intense accumulation of procollagen within cells cultured under routine conditions. This accumulation appeared almost as if there were a blockade in secretion of procollagen under routine culture conditions. Cells treated with ascorbic acid do not have the dense intracellular accumulation of procollagens seen with the apparent blockade of secretion in cells cultured under routine conditions. Ascorbate treated cells also have a more pronounced extracellular accumulation of matrix fibronectin and procollagen constituents. At the electromicroscopic level a new 40 nm diameter fibril is formed after ascorbic acid treatment of human fibroblasts. Antibody to fibronectin and procollagen I and III are seen binding to the 40 nm diameter fibrils in a periodic or stuttered appearance. The fibronectin and procollagen antibodies react with a 70 nm axial repeat along these 40 nm fibrils formed after ascorbate treatment. These studies suggest that under routine culture conditions "precursor" fibrils of fibronectin and procollagen are formed. Ascorbic acid treatment leads to enhanced matrix formation. Ultrastructural studies clearly show antibodies to fibronectin bind to fibronectin on native collagen fibrils formed by human fibroblasts cultured with ascrobic acid. Lastly there is an asymmetric or 70 nm axial periodic distribution of fibronectin along these definitive or mature collagen fibrils formed after ascorbic acid treatment. [less ▲]

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See detailAscorbic acid, Phenolic acid, Flavonoid and Carotenoid profiles of selected extracts from Ribes nigrum
Tabart, Jessica ULg; Kevers, Claire ULg; Evers, Danièle et al

in Journal of Agricultural and Food Chemistry (2011), 59

Small fruits such as berries have low energy contents, but high content of vitamins, micronutrients, and dietary fibres and constitute a good source of natural antioxidant compounds that are important ... [more ▼]

Small fruits such as berries have low energy contents, but high content of vitamins, micronutrients, and dietary fibres and constitute a good source of natural antioxidant compounds that are important constituents of the human diet. This study allowed to identify a large number of compounds in an extract of blackcurrant showing high antioxidant activity and to compare their profile in various parts of the plants (leaves, buds and berries). If it was known that berries contained very high levels of natural phenolic compounds, here we showed that leaves and buds could also be considered as a good sources of natural antioxidants. Indeed, they contained high amount of ascorbic acid, phenolic acids, flavonoids and carotenoids. An acetone mixture can extract several classes of phenolic compounds with a good yield of ascorbic acid, flavonols, flavan-3-ols and anthocyanins. For phenolic acids, it extracted fewer compounds than a specific extraction solution. [less ▲]

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See detailAseptic and automatable vitrification of human embryonic stem cells using defined media
Ectors, Fabien ULg

Conference (2012, October 22)

Aseptic and automatable vitrification of human embryonic stem cells using defined media Efficient recovery of biologically safe and undifferentiated hESCs is a major challenge after cryobanking ... [more ▼]

Aseptic and automatable vitrification of human embryonic stem cells using defined media Efficient recovery of biologically safe and undifferentiated hESCs is a major challenge after cryobanking, especially when their use for human therapy is foreseen. One drawback of actual cryopreservation protocols is the direct contact of the cells with liquid nitrogen, therefore cells can be in contact with heavy metals, bacteria, viruses or fungi during cooling and storage. We describe a novel cryopreservation method which uses aseptic vitrification1 (no direct contact with LN2) and only chemically defined materials and media, and is automatable. 1: Vitrification is a cryopreservation method based on the conversion of a liquid into a glass-like state by an infinite enhancement of its viscosity and without formation of ice crystals. [less ▲]

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See detailAseptic vitrification of blastocysts from infertile patients, egg donors and after IVM
Vanderzwalmen, Pierre ULg; Ectors, Fabien ULg; Grobet, Luc ULg et al

in Reproductive Biomedicine Online (2009), 19(5), 700-707

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