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See detailLa non-observance therapeutique: probleme majeur pour la prevention des maladies cardio-vasculaires.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(12), 914-20

The prevention of cardiovascular diseases relies upon the correction of risk factors and, more particularly, the optimal management of various metabolic abnormalities such as obesity, dyslipidaemias ... [more ▼]

The prevention of cardiovascular diseases relies upon the correction of risk factors and, more particularly, the optimal management of various metabolic abnormalities such as obesity, dyslipidaemias, diabetes mellitus and arterial hypertension. Such an approach first requires the adherence to life-style habits (healthy diet, physical activity and no smoking) and, in case of failure, the use of lipid-lowering drugs, antidiabetic agents and/or antihypertensive medications. Sometimes, a monotherapy may be sufficient but, in most cases, a drug combination is mandatory because of the need to reach tight therapeutic targets and of the presence of a polypathology, especially within the frame of the metabolic syndrome. Unfortunately, all surveys indicate that therapeutic compliance to non-pharmacological advice and even to drug prescriptions is far from being excellent. Such a non-compliance limits the efficacy of the prevention strategies and contributes to markedly increase the cost of metabolic diseases and associated complications. [less ▲]

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See detailA non-parametric probabilistic model for ground-borne vibrations in buildings
Arnst, Maarten ULg; Clouteau, Didier; Chebli, Hamid et al

in Probabilistic Engineering Mechanics (2006), 21(1), 18-34

This paper studies the prediction accuracy of models for ground-borne vibrations in buildings based on a three-dimensional coupled FE–BE formulation in the frequency range relevant for traffic induced ... [more ▼]

This paper studies the prediction accuracy of models for ground-borne vibrations in buildings based on a three-dimensional coupled FE–BE formulation in the frequency range relevant for traffic induced vibrations. In structural dynamics, the prediction accuracy at relatively high frequencies is known to be problematic since the sensitivity of the predicted response to modelling errors and parameter uncertainties increases with the frequency. To estimate the prediction accuracy, this paper incorporates the parameter uncertainties and the modelling errors into the analysis using the non-parametric probabilistic approach, introduced by Soize. The methodology is applied to a case history. The results of a prediction model for the transmission of vibrations from a shallow cut-and-cover tunnel to a six storey reinforced concrete frame structure in Paris are considered and compared with in situ measurements. The results demonstrate that a single dispersion parameter allows fitting the data. The sensitivity of the response to uncertainties is shown to increase as vibrations propagate inside the building. [less ▲]

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See detailThe non-penicillin-binding module of the tripartite penicillin-binding protein 3 of Escherichia Coli is required for folding and/or stability of the penicillin-binding module and the membrane-anchoring module confers cell septation activity on the folded structure
Goffin, Colette ULg; Fraipont, Claudine ULg; Ayala, Juan et al

in Journal of Bacteriology (1996), 178(18), 5402-5409

The ftsI-encoded multimodular class B penicillin-binding protein 3 (PBP3) is a key element of the cell septation machinery of Escherichia coli. Altered ftsI genes were overexpressed, and the gene products ... [more ▼]

The ftsI-encoded multimodular class B penicillin-binding protein 3 (PBP3) is a key element of the cell septation machinery of Escherichia coli. Altered ftsI genes were overexpressed, and the gene products were analyzed with respect to the level of production, stability, penicillin affinity, and cell septation activity. In contrast to the serine beta-lactamases and low-molecular-mass PBPs which are autonomous folding entities, the S-259-to-V-577 penicillin-binding module of M-1-to-V-577 PBP3 lacks the amino acid sequence information for correct folding. The missing piece of information is provided by the associated G-57-to-E-258 non-penicillin-binding module which functions as a noncleaved, pseudointramolecular chaperone. Key elements of the folding information reside within the motif 1-containing R-60-to-W-110 polypeptide segment and within G-188-to-D-197 motif 3 of the n-PB module. The intermodule interaction is discussed in the light of the known three-dimensional structure (at 3.5-A [0.35-nm] resolution) of the analogous class B PBP2x of Streptococcus pneumoniae (S. Pares, N. Mouz, Y. Petillot, R. Hakenbeck, and O. Dideberg, Nature Struct. Biol. 3:284-289, 1996). Correct folding and adoption of a stable penicillin-binding conformation are necessary but not sufficient to confer cell septation activity to PBP3 in exponentially growing cells. The in vivo activity of PBP3 also depends on the M-1-to-E-56 amino-terminal module which encompasses the cytosol, the membrane, and the periplasm and which functions as a noncleaved pseudo-signal peptide. [less ▲]

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See detailLa non-performativité de l'art performance
Hagelstein, Maud ULg

Conference (2013, March 08)

Objectif : Identifier le rapport critique de la performativité à l’imagination (ou plutôt de la non-performativité à l’imagination) à travers le médium de l’art performance (pour élaborer une nouvelle ... [more ▼]

Objectif : Identifier le rapport critique de la performativité à l’imagination (ou plutôt de la non-performativité à l’imagination) à travers le médium de l’art performance (pour élaborer une nouvelle théorie de la réception). Trois arguments sont développés dans cette intervention : (1) La théorie du performatif elle-même (en tout cas telle qu’énoncée par Austin) évacue la possibilité d’une performativité artistique (d’une performativité qui s’exercerait dans le domaine de l’art ou de la fiction) ; (2) La performance artistique se distingue de l’« objet performatif » - c’est-à-dire de l’objet artistique qui incite le spectateur à des actes et à un comportement spécifiques. Dans le champ de l’art contemporain, l’idée de « performativité » a un tel succès, que l’on parle désormais d’œuvre performative à chaque fois qu’un objet artistique entretient un lien quelconque à l’action, soit qu’il réclame d’être activé par la présence physique de l’artiste ou du spectateur, soit qu’il renvoie directement à une action ou un processus dans lequel il est inscrit ou dont il est issu. En ce sens, la performativité constitue une valeur ajoutée à un objet ou une image – c’est-à-dire à une représentation. Tandis que l’art performance présente de pures actions (dont il serait vain/redondant de rappeler le lien à l’action). (3) L’art performance refuse radicalement (position esthétique radicale) d’exercer un pouvoir sur l’imagination du spectateur. La réaction de ce dernier aux actions visuelles qui lui sont présentées lui appartient en propre, n’est pas guidée/influencée par les intentions de l’artiste. L’essence même de ce genre artistique est d’appeler des lectures toujours/nécessairement subjectives. Souligner la non-performativité de l’art performance reviendrait à montrer qu’elle déjoue par avance toute prise de pouvoir, toute autorité exercée sur le spectateur. Cela reviendrait par conséquent à jeter les bases d’une théorie renouvelée de la réception. [less ▲]

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See detailNon-perturbative effect of rotation on dipolar mixed modes in red giant stars
Ouazzani, R.-M.; Goupil, M. J.; Dupret, Marc-Antoine ULg et al

in Astronomy and Astrophysics (2013), 554

Context. The space missions CoRoT and Kepler provide high-quality data that allow us to test the transport of angular momentum in stars by the seismic determination of the internal rotation profile. <BR ... [more ▼]

Context. The space missions CoRoT and Kepler provide high-quality data that allow us to test the transport of angular momentum in stars by the seismic determination of the internal rotation profile. <BR /> Aims: Our aim is to test the validity of seismic diagnostics for red giant rotation that are based on a perturbative method and to investigate the oscillation spectra when the validity does not hold. <BR /> Methods: We use a non-perturbative approach implemented in the ACOR code that accounts for the effect of rotation on pulsations and solves the pulsation eigenproblem directly for dipolar oscillation modes. <BR /> Results: We find that the limit of the perturbation to first order can be expressed in terms of the rotational splitting compared to the frequency separation between consecutive dipolar modes. Above this limit, non-perturbative computations are necessary, but only one term in the spectral expansion of modes is sufficient as long as the core rotation rate remains significantly smaller than the pulsation frequencies. Each family of modes with different azimuthal symmetry, m, has to be considered separately. In particular, in case of rapid core rotation, the density of the spectrum differs significantly from one m-family of modes to another, so that the differences between the period spacings associated with each m-family can constitute a promising guideline toward a proper seismic diagnostic for rotation. [less ▲]

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See detailNon-Perturbative Effect of Rotation on Dipolar Mixed-Modes in Red Giants
Ouazzani, R.-M.; Goupil, M.-J.; Dupret, Marc-Antoine ULg et al

in Astronomical Society of the Pacific Conference Series (2013, December 01)

The space missions CoRoT (Convection Rotation and Planetary Transits) and Kepler provide high quality data that allows the transport of angular momentum in stars to be investigated by the seismic ... [more ▼]

The space missions CoRoT (Convection Rotation and Planetary Transits) and Kepler provide high quality data that allows the transport of angular momentum in stars to be investigated by the seismic determination of the internal rotation profile. In a former study (Ouazzani et al. 2013b) we test the validity of seismic diagnostics for red giant rotation that are based on a perturbative method. Our aim here is to investigate oscillation spectra when that validity no longer holds. We use a non-perturbative approach implemented in the Adiabatic Code of Oscillations including Rotation (ACOR code) (Ouazzani et al. 2012) that accounts for the eff [less ▲]

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See detailNon-perturbative momentum dependence of the coupling constant and hadronic models
Courtoy, Aurore ULg; Scopetta, S.; Vento, V.

in European Physical Journal A -- Hadrons & Nuclei (2011), 47(4), 1-7

Models of hadron structure are associated with a hadronic scale which allows by perturbative evolution to calculate observables in the deep inelastic region. The resolution of Dyson-Schwinger equations ... [more ▼]

Models of hadron structure are associated with a hadronic scale which allows by perturbative evolution to calculate observables in the deep inelastic region. The resolution of Dyson-Schwinger equations leads to the freezing of the QCD running coupling (effective charge) in the infrared, which is best understood as a dynamical generation of a gluon mass function, giving rise to a momentum dependence which is free from infrared divergences. We use this new development to understand why perturbative treatments are working reasonably well despite the smallness of the hadronic scale. © 2011 SIF, Springer-Verlag Berlin Heidelberg. [less ▲]

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See detailNon-pharmacological management of osteoporosis: a consensus of the Belgian Bone Club
Body, J. J.; Bergmann, P.; Boonen, S. et al

in Osteoporosis International (2011), 22(11), 2769-88

This consensus article reviews the various aspects of the non-pharmacological management of osteoporosis, including the effects of nutriments, physical exercise, lifestyle, fall prevention, and hip ... [more ▼]

This consensus article reviews the various aspects of the non-pharmacological management of osteoporosis, including the effects of nutriments, physical exercise, lifestyle, fall prevention, and hip protectors. Vertebroplasty is also briefly reviewed. Non-pharmacological management of osteoporosis is a broad concept. It must be viewed as an essential part of the prevention of fractures from childhood through adulthood and the old age. The topic also includes surgical procedures for the treatment of peripheral and vertebral fractures and the post-fracture rehabilitation. The present document is the result of a consensus, based on a systematic review and a critical appraisal of the literature. Diets deficient in calcium, proteins or vitamin D impair skeletal integrity. The effect of other nutriments is less clear, although an excessive consumption of sodium, caffeine, or fibres exerts negative effects on calcium balance. The deleterious effects of tobacco, excessive alcohol consumption and a low BMI are well accepted. Physical activity is of primary importance to reach optimal peak bone mass but, if numerous studies have shown the beneficial effects of various types of exercise on bone mass, fracture data as an endpoint are scanty. Fall prevention strategies are especially efficient in the community setting, but less evidence is available about their effectiveness in preventing fall-related injuries and fractures. The efficacy of hip protectors remains controversial. This is also true for vertebroplasty and kyphoplasty. Several randomized controlled studies had reported a short-term advantage of vertebroplasty over medical treatment for pain relief, but these findings have been questioned by recent sham-controlled randomized clinical studies. [less ▲]

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See detailNon-pharmacological strategy to decrease risk of fall in the elderly
Bruyère, Olivier ULg

Conference (2009, March 28)

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See detailNon-photoperiodic factors and timing of breeding in blue tits: Impact of environmental and social influences in semi-natural conditions
Caro, S. P.; Lambrechts, M. M.; Balthazart, Jacques ULg et al

in Behavioural Processes (2007), 75(1), 1-7

The seasonal development of life-history traits is influenced by many environmental factors. The impact of photoperiodic and non-photoperiodic factors on nest building and egg laying has been rarely ... [more ▼]

The seasonal development of life-history traits is influenced by many environmental factors. The impact of photoperiodic and non-photoperiodic factors on nest building and egg laying has been rarely investigated in non-domesticated avian species for which long term field data sets are available. Former investigations showed that blue tits originating from geographically close populations in the Mediterranean region do not respond in the same way to photoperiodic factors in semi-natural outdoor conditions. Here we show experimentally that nest building and onset of egg laying in captive blue tits is also proximately influenced by non-photoperiodic factors, including aspects related to aviary characteristics and social interactions between birds of the two sexes originating from different local Mediterranean study populations. In two successive experiments, we show that (1) increasing the volume of the aviary advanced the egg laying period of one specific population by almost I month, and (2) crossing pairs of birds from different origins strongly reduced the nest building and egg laying behaviours. These results indicate that obtaining biologically relevant breeding results in captivity with wild birds requires the control and experimental manipulation of a wide array of complex environmental cues. (c) 2007 Elsevier B.V All rights reserved. [less ▲]

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See detailNon-radial oscillations in the red giant HR 7349 measured by CoRoT
Carrier, F.; De Ridder, J.; Baudin, F. et al

in Astronomy and Astrophysics (2010), 509

Context. Convection in red giant stars excites resonant acoustic waves whose frequencies depend on the sound speed inside the star, which in turn depends on the properties of the stellar interior ... [more ▼]

Context. Convection in red giant stars excites resonant acoustic waves whose frequencies depend on the sound speed inside the star, which in turn depends on the properties of the stellar interior. Therefore, asteroseismology is the most robust available method for probing the internal structure of red giant stars. <BR /> Aims: Solar-like oscillations in the red giant HR 7349 are investigated. <BR /> Methods: Our study is based on a time series of 380 760 photometric measurements spread over 5 months obtained with the CoRoT satellite. Mode parameters were estimated using maximum likelihood estimation of the power spectrum. <BR /> Results: The power spectrum of the high-precision time series clearly exhibits several identifiable peaks between 19 and 40 μHz showing regularity with a mean large and small spacing of Πν = 3.47 ± 0.12 μHz and δν[SUB]02[/SUB] = 0.65 ± 0.10 μHz. Nineteen individual modes are identified with amplitudes in the range from 35 to 115 ppm. The mode damping time is estimated to be 14.7[SUP]+4.7[/SUP][SUB]-2.9[/SUB] days. The CoRoT space mission has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA, Germany and Spain. [less ▲]

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See detailNon-radial, non-adiabatic solar-like oscillations in RGB and HB stars
Grosjean, Mathieu ULg; Dupret, Marc-Antoine ULg; Belkacem, K. et al

in EPJ Web of Conferences (2013, March 01), 43

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. We compare the theoretical spectrum of two red giants in ... [more ▼]

CoRoT and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. We compare the theoretical spectrum of two red giants in the same region of the HR diagram but in different evolutionary phases. We present here our first results on the inertia, lifetimes and amplitudes of the oscillations and discuss the differences between the two stars. [less ▲]

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See detailNon-radial, non-adiabatic solar-like oscillations in RGB and HB stars
Grosjean, Mathieu ULg; Dupret, Marc-Antoine ULg; Belkacem, Kevin et al

Poster (2012, July)

Corot and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. We compare the theoretical spectrum (amplitudes and life ... [more ▼]

Corot and Kepler observations of red giants reveal rich spectra of non-radial solar-like oscillations allowing to probe their internal structure. We compare the theoretical spectrum (amplitudes and life- times) of two red giants in the same region of the HR diagram but in different evolutionary phases. The lifetimes are obtained by computing theoretical non-adiabatic non-radial solar-like oscillations for mixed modes in the two models. Thanks to this, we have been able to compute the oscillation amplitudes through a stochastic excitation model. We present here our first results on the inertia, damping rates and amplitudes of the oscillations in the two stars and discuss the trapping, the visibilities and the am- plitudes of the different modes. The differences in the spectra of the two stars are also investigated. As already known, the period spacings in the two models are very different. Moreover, we find significant differences in amplitudes and lifetimes between the two models. [less ▲]

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See detailNon-random genomic integration - an intrinsic property of retrogenes in Drosophila?
Metta, Muralidhar ULg; Schlotterer, C.

in BMC Evolutionary Biology (2010), 10(1), 114

ABSTRACT: BACKGROUND: The Drosophila X-chromosome shows a significant underrepresentation of genes with male-biased gene expression (demasculinization). This trend is matched by retrogenes, which ... [more ▼]

ABSTRACT: BACKGROUND: The Drosophila X-chromosome shows a significant underrepresentation of genes with male-biased gene expression (demasculinization). This trend is matched by retrogenes, which typically have a male biased gene expression pattern and show a significant movement bias from X-chromosomes to autosomes. It is currently assumed that these patterns are best explained by selection, either mediated by male meiotic sex chromosome inactivation (MSCI) or sexually antagonistic forces. We scrutinized the evolutionary dynamics of retroposition by focusing on retrogenes for which the parental copy has degenerated. RESULTS: Consistent with a functional substitution of the degenerated gene by the retrogene, patterns of sequence evolution and gene expression were similar between retroposed and parental genes. Like previous studies, our set of retrogenes showed a significant movement off the X-chromosome. In contrast to data sets where retroposition caused gene duplication, the genes in our study showed primarily female-biased or unbiased gene expression. CONCLUSIONS: Based on our results, the biased transposition pattern cannot be explained by MSCI and probably not by sexual antagonism. Rather, we propose that the movement away from the X-chromosome represents a general property of retroposition in Drosophila. [less ▲]

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See detailLes non-recommandations dans le traitement de l'arthrose et de la polyarthrite rhumatoïde, ou pourquoi la médecine basée sur le niveau de preuve ne s'applique pas (encore) à la rhumatologie
Malaise, Michel ULg

in Revue Médicale de Liège (2000), 55(5), 466-475

The speed with which the phrase "Evidence-Based Medicine" has entered our language has been astonishing. Virtually all medical areas are concerned, but it probably applies best when clearcut diagnosis can ... [more ▼]

The speed with which the phrase "Evidence-Based Medicine" has entered our language has been astonishing. Virtually all medical areas are concerned, but it probably applies best when clearcut diagnosis can be made or when mortality or well-defined morbidity are the outcomes, two conditions not really frequently encountered in rheumatology. We will discuss why rheumatology is probably not ready yet for the concept and will systematically review why "Evidence-Based Medicine" could in fact be "evidence-biased medicine". We will emphasize why evidence-based medicine can not replace the personal experience and knowledge of patients, two major corner-stones in the clinician's daily work, but should simply be an access to scientific data for the benefit of both patient and physician. [less ▲]

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See detailLa non-représentation d'enfants et les moyens de défense
Kefer, Fabienne ULg

in Annales de la Faculté de droit de l'Université de Liège (1988)

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See detailNon-responsive generalised bacterial infection associated with systemic lupus erytematous in a beauceron
Clercx, Cécile ULg; Mc Entee, Katleen; Gilbert, Sophie et al

in Journal of Veterinary Internal Medicine (1997)

Detailed reference viewed: 5 (1 ULg)