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See detailNeural Correlates of Ongoing Conscious Experience: Both Task-Unrelatedness and Stimulus-Independence Are Related to Default Network Activity
Stawarczyk, David ULg; Majerus, Steve ULg; Maquet, Pierre ULg et al

in PLoS ONE (2011), 6(2), 16997

The default mode network (DMN) is a set of brain regions that consistently shows higher activity at rest compared to tasks requiring sustained focused attention toward externally presented stimuli. The ... [more ▼]

The default mode network (DMN) is a set of brain regions that consistently shows higher activity at rest compared to tasks requiring sustained focused attention toward externally presented stimuli. The cognitive processes that the DMN possibly underlies remain a matter of debate. It has alternately been proposed that DMN activity reflects unfocused attention toward external stimuli or the occurrence of internally generated thoughts. The present study aimed at clarifying this issue by investigating the neural correlates of the various kinds of conscious experiences that can occur during task performance. Four classes of conscious experiences (i.e., being fully focused on the task, distractions by irrelevant sensations/perceptions, interfering thoughts related to the appraisal of the task, and mind-wandering) that varied along two dimensions (“task-relatedness” and “stimulus-dependency”) were sampled using thought-probes while the participants performed a go/no-go task. Analyses performed on the intervals preceding each probe according to the reported subjective experience revealed that both dimensions are relevant to explain activity in several regions of the DMN, namely the medial prefrontal cortex, posterior cingulate cortex/precuneus, and posterior inferior parietal lobe. Notably, an additive effect of the two dimensions was demonstrated for midline DMN regions. On the other hand, lateral temporal regions (also part of the DMN) were specifically related to stimulus-independent reports. These results suggest that midline DMN regions underlie cognitive processes that are active during both internal thoughts and external unfocused attention. They also strengthen the view that the DMN can be fractionated into different subcomponents and reveal the necessity to consider both the stimulus-dependent and the task-related dimensions of conscious experiences when studying the possible functional roles of the DMN. [less ▲]

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See detailNeural Correlates of Performance Variabilty during Motor Sequence Acquisition
Albouy, Geneviève ULg; Sterpenich, V.; Vandewalle, Gilles ULg et al

in NeuroImage (2012), 60(1), 324-331

Detailed reference viewed: 62 (14 ULg)
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See detailNeural correlates of personal goal processing when envisioning future events
D'Argembeau, Arnaud ULg

Conference (2009, December 10)

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See detailThe Neural Correlates of Re-cancellation Behaviors in Unilateral Neglect: A Neuropsychological Approach
Wansard, Murielle ULg; Bastin, Christine ULg; Meulemans, Thierry ULg

Poster (2014, April)

The present study focused on re-cancellation behaviors in unilateral neglect (i.e., the tendency to search repeatedly items located on the right side in visual search tasks), and used a neuropsychological ... [more ▼]

The present study focused on re-cancellation behaviors in unilateral neglect (i.e., the tendency to search repeatedly items located on the right side in visual search tasks), and used a neuropsychological approach to identify the cerebral correlates of this deficit. Fourteen patients suffering from left neglect and 14 elderly age-matched controls performed a cancellation task without visual feedback. Neglect patients cancelled fewer targets than controls, and re-cancelled an abnormally high number of targets. Lesion maps were used to compare the location of brain damage in neglect patients with the highest versus the lowest percentage of re-cancellations. Anatomical data revealed that the right insula is commonly damaged in 5 out of 6 patients with the highest re-cancellation percentage, but is spared in the subgroup of patients with the lowest re-cancellation percentage. These results suggest that damage to the right insula may contribute to pathological visual search in spatial neglect, possibly by reducing interaction between the ventral and dorsal attention network (the latter being more directly involved in spatial processes). [less ▲]

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See detailThe neural correlates of recollection and familiarity during aging
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

in Journal of Psychophysiology (2013), 27(Suppl 1), 48

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See detailThe neural correlates of recollection and familiarity during aging
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

Poster (2013)

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See detailThe neural correlates of recollection and familiarity during aging
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

in Proceedings of the XII Colloque International sur le Vieillissement Cognitif (2012)

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See detailThe neural correlates of recollection and familiarity during aging
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

in Frontiers in Human Neuroscience (2012)

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See detailThe neural correlates of recollection and familiarity during aging
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

Poster (2012, June)

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See detailNeural correlates of sleep spindles as revealed by simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (FMRI)
Schabus, M.; Dang-Vu, T.; Balteau, Evelyne ULg et al

in Journal of Sleep Research (2006, September), 15(Suppl. 1), 50-51

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See detailNeural correlates of tic generation in Tourette syndrome: an event-related functional MRI study.
Bohlhalter, Stephan; Goldfine, Andrew; Matteson, S. et al

in Brain : A Journal of Neurology (2006), 129(Pt 8), 2029-37

Little is known about the neural correlates of tics and associated urges. In the present study, we aimed to explore the neural basis of tics in patients with Tourette syndrome by using event-related ... [more ▼]

Little is known about the neural correlates of tics and associated urges. In the present study, we aimed to explore the neural basis of tics in patients with Tourette syndrome by using event-related functional MRI (fMRI). Ten patients (6 women, 4 men; age: mean +/- SD = 31 +/- 11.2) were studied while spontaneously exhibiting a variety of motor and vocal tics. On the basis of synchronized video/audio recordings, fMRI activities were analysed 2 s before and at tic onset irrespective of the clinical phenomenology. We identified a brain network of paralimbic areas such as anterior cingulate and insular cortex, supplementary motor area (SMA) and parietal operculum (PO) predominantly activated before tic onset (P < 0.05, corrected for multiple comparisons). In contrast, at the beginning of tic action, significant fMRI activities were found in sensorimotor areas including superior parietal lobule bilaterally and cerebellum. The results of this study indicate that paralimbic and sensory association areas are critically implicated in tic generation, similar to movements triggered internally by unpleasant sensations, as has been shown for pain or itching. [less ▲]

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See detailThe neural correlates of updating information in verbal working memory
Van der Linden, Martial ULg; Collette, Fabienne ULg; Salmon, Eric ULg et al

in Memory (1999), 7(5-6), 549-560

The aim of the present study was to re-examine cerebral areas subserving the updating function of the central executive with a running span task requiring subjects to watch strings of consonants of ... [more ▼]

The aim of the present study was to re-examine cerebral areas subserving the updating function of the central executive with a running span task requiring subjects to watch strings of consonants of unknown length and then to recall serially a specific number of recent items. In order to dissociate more precisely the updating process from the storage function, a four-item instead of a six-item memory load was used, contrary to our previous study (Salmon et al., 1996). In addition, a serial recall procedure was preferred to a recognition procedure in order to suppress the use of visuospatial strategies. The most significant increase of rCBF occurred in the left frontopolar cortex (Brodmann's area 10), spreading to the left middle frontal (Brodmann's area 46). Results suggest that frontopolar activation underlies an updating process in working memory. [less ▲]

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See detailThe neural correlates of verbal short-term memory in Alzheimer's disease: an fMRI study.
Peters, Fréderic; Collette, Fabienne ULg; Degueldre, Christian ULg et al

in Brain : A Journal of Neurology (2009), 132(7), 1833-1846

Although many studies have shown diminished performance in verbal short-term memory tasks in Alzheimer's disease, few studies have explored the neural correlates of impaired verbal short-term memory in ... [more ▼]

Although many studies have shown diminished performance in verbal short-term memory tasks in Alzheimer's disease, few studies have explored the neural correlates of impaired verbal short-term memory in Alzheimer's disease patients. In this fMRI study, we examined alterations in brain activation patterns during a verbal short-term memory recognition task, by differentiating encoding and retrieval phases. Sixteen mild Alzheimer's disease patients and 16 elderly controls were presented with lists of four words followed, after a few seconds, by a probe word. Participants had to judge whether the probe matched one of the items of the memory list. In both groups, the short-term memory task elicited a distributed fronto-parieto-temporal activation that encompassed bilateral inferior frontal, insular, supplementary motor, precentral and postcentral areas, consistent with previous studies of verbal short-term memory in young subjects. Most notably, Alzheimer's disease patients showed reduced activation in several regions during the encoding phase, including the bilateral middle frontal and the left inferior frontal gyri (associated with executive control processes) as well as the transverse temporal gyri (associated with phonological processing). During the recognition phase, we found decreased activation in the left supramarginal gyrus and the right middle frontal gyrus in Alzheimer's disease patients compared with healthy seniors, possibly related to deficits in manipulation and decision processes for phonological information. At the same time, Alzheimer's disease patients showed increased activation in several brain areas, including the left parahippocampus and hippocampus, suggesting that Alzheimer's disease patients may recruit alternative recognition mechanisms when performing a short-term memory task. Overall, our results indicate that Alzheimer's disease patients show differences in the functional networks underlying memory over short delays, mostly in brain areas known to support phonological processing or executive functioning. [less ▲]

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See detailThe neural correlates of visual self-recognition
Devue, Christel ULg; Brédart, Serge ULg

in Consciousness and Cognition (2011), 20

This paper presents a review of studies that were aimed at determining which brain regions are recruited during visual self-recognition, with a particular focus on self-face recognition. A complex ... [more ▼]

This paper presents a review of studies that were aimed at determining which brain regions are recruited during visual self-recognition, with a particular focus on self-face recognition. A complex bilateral network, involving frontal, parietal and occipital areas, appears to be associated with self-face recognition, with a particularly high implication of the right hemisphere. Results indicate that it remains difficult to determine which specific cognitive operation is reflected by each recruited brain area, in part due to the variability of used control stimuli and experimental tasks. A synthesis of the interpretations provided by previous studies is presented. The relevance of using self-recognition as an indicator of self-awareness is discussed. We argue that a major aim of future research in the field should be to identify more clearly the cognitive operations induced by the perception of the self-face, and search for dissociations between neural correlates and cognitive components. [less ▲]

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See detailNeural crest stem cells from adult bone marrow: a new source for cell replacement therapy?
Glejzer, Aneta; Neirinckx, Virginie ULg; Rogister, Bernard ULg et al

in Wislet, Sabine (Ed.) Advance in Regenerative Medicine (2011)

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See detailNeural differentiation potential of human bone marrow-derived mesenchymal stromal cells: misleading marker gene expression
MONTZKA, Katrin; Lassonczyk, Nina; Tschöke, Beate et al

in BMC Neuroscience (2009), 10

Background: In contrast to pluripotent embryonic stem cells, adult stem cells have been considered to be multipotent, being somewhat more restricted in their differentiation capacity and only giving rise ... [more ▼]

Background: In contrast to pluripotent embryonic stem cells, adult stem cells have been considered to be multipotent, being somewhat more restricted in their differentiation capacity and only giving rise to cell types related to their tissue of origin. Several studies, however, have reported that bone marrow-derived mesenchymal stromal cells (MSCs) are capable of transdifferentiating to neural cell types, effectively crossing normal lineage restriction boundaries. Such reports have been based on the detection of neural-related proteins by the differentiated MSCs. In order to assess the potential of human adult MSCs to undergo true differentiation to a neural lineage and to determine the degree of homogeneity between donor samples, we have used RT-PCR and immunocytochemistry to investigate the basal expression of a range of neural related mRNAs and proteins in populations of non-differentiated MSCs obtained from 4 donors. Results: The expression analysis revealed that several of the commonly used marker genes from other studies like nestin, Enolase2 and microtubule associated protein 1b (MAP1b) are already expressed by undifferentiated human MSCs. Furthermore, mRNA for some of the neural-related transcription factors, e.g. Engrailed-1 and Nurr1 were also strongly expressed. However, several other neural-related mRNAs (e.g. DRD2, enolase2, NFL and MBP) could be identified, but not in all donor samples. Similarly, synaptic vesicle-related mRNA, STX1A could only be detected in 2 of the 4 undifferentiated donor hMSC samples. More significantly, each donor sample revealed a unique expression pattern, demonstrating a significant variation of marker expression. Conclusion: The present study highlights the existence of an inter-donor variability of expression of neuralrelated markers in human MSC samples that has not previously been described. This donor-related heterogeneity might influence the reproducibility of transdifferentiation protocols as well as contributing to the ongoing controversy about differentiation capacities of MSCs. Therefore, further studies need to consider the differences between donor samples prior to any treatment as well as the possibility of harvesting donor cells that may be inappropriate for transplantation strategies. [less ▲]

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See detailNeural fate of Mesenchymal Stem Cells and Neural Crest Stem Cells : Which ways to get neurons for cell therapy purpose ?
Neirinckx, Virginie ULg; Coste, Cécile ULg; Rogister, Bernard ULg et al

in Trends in cell signaling pathways in neuronal fate decision (2013)

Detailed reference viewed: 54 (12 ULg)