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See detailA new precise ultrasonic range sensor based on the emission of two coded FSK signals combined to a ping-pong strategy
Pierlot, Vincent ULg; Tassin, Pierre; Van Droogenbroeck, Marc ULg

in Conference on Research in Information and communication Technology (2010, November)

Ultrasonic range sensors are widely used in robotic applications mainly for obstacle avoidance or environment map generation. They are attractive because of the low cost of the transducers, associated ... [more ▼]

Ultrasonic range sensors are widely used in robotic applications mainly for obstacle avoidance or environment map generation. They are attractive because of the low cost of the transducers, associated electronics and implementation facilities. On the other hand, they suffer from several limitations inherent to the underlying principle. Most of these systems send a short pulse at an ultrasonic frequency, that reflects on some object in the environment and then that returns back to the emitter. The propagation time in conjunction with the knowledge of the speed of sound in the air are used to compute the distance between the emitter and the object. The main drawbacks are multipaths, echos, diffraction, etc, resulting in unreliable range measurements. This paper present a new ultrasonic range sensor using ping-pong strategy, FSK modulation and coded signals to overcome those main limitations. [less ▲]

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See detailNew Primers For The Polymerase Chain Amplification Of Cpdna Intergenic Spacers In Phaseolus Phylogeny
Fofana, B.; Harvengt, L.; Baudoin, Jean-Pierre ULg et al

in Belgian Journal of Botany (1997), 129(2),

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See detailNew pro-death function of NIK downstream of TNFR1
Boutaffala, Layla ULg

Doctoral thesis (2013)

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See detailA new process for the synthesis of alkoxyamines active in controlled radical polymerization
Detrembleur, Christophe ULg; Gross, Thomas; Meyer, Rolf-Volker

Patent (2004)

The present invention relates to a new process for the preparation of alkoxyamine initiators and to a process of radical polymerization using the alkoxyamine initiators as intermediates.

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See detailNew process for X-ray mirror image quality improvement
Gailly, Patrick ULg; de Chambure, Daniel; Collette, Jean-Paul et al

in Freund, Andreas K. (Ed.) X-Ray Mirrors, Crystals, and Multilayers II (Proceedings Volume) (2002, December 24)

A new technique to improve the image quality of Ni replicated X-ray mirror is presented. During the manufacturing of XMM Mirror Module between 1994 to 1999, the classical manufacturing process showed its ... [more ▼]

A new technique to improve the image quality of Ni replicated X-ray mirror is presented. During the manufacturing of XMM Mirror Module between 1994 to 1999, the classical manufacturing process showed its limits. In 1995, the XMM Mirror Module Qualification Model HEW was around 20 arcsec. In 1998, the fifth Flight Model Mirror Module reached 11 arcsec HEW, with a single mirror shell achieving 8 arcsec HEW. The performance of this technology is namely limited by the integration process of the shells. The new technique is based on the following philosophy : • Firstly, an accurate measurement of each mirror shell after integration. A dedicated metrology system has been built and allows a precise metrology of the actual surface. • Secondly, a modification of the mirror shell and of the support to transfer the stress to a non optical active area. • Finally, an ion figuring run to correct the residual shape error of the mirror. The control and evaluation of the process is assured by EUV PSF assessment achieved in the FOCAL X facility developed for XMM. The advantages of this new process are to shape the mirrors in their final hardware configuration and the versality of the process enabling improvement of other kinds of high accuracy mirrors. [less ▲]

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See detailNew Professions in the Socio-Legal Field: An Incomplete Institutionalisation?
Bastard, Benoit; Dubois, Christophe ULg

Conference (2011, September 10)

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See detailA new proposal of a simple model for the lateral-torsional buckling of unrestrained steel I-beams in case of fire: experimental and numerical validation
Vila Real, Paolo; Piloto, Paolo; Franssen, Jean-Marc ULg

in Journal of Constructional Steel Research (2003), 59(2), 179-199

The behaviour of Steel I-Beams exhibiting lateral-torsional buckling at elevated temperature has been studied by means of experimental and numerical analysis. The authors in an earlier paper have ... [more ▼]

The behaviour of Steel I-Beams exhibiting lateral-torsional buckling at elevated temperature has been studied by means of experimental and numerical analysis. The authors in an earlier paper have presented an analytical formula for the buckling resistance moment in the fire design situation. This new proposal, different from the actual proposal of the Eurocode 3 Part 1.2 has been validated in this work by comparison with the results from a set of 120 experimental and numerical tests performed on IPE 100 beams, submitted to temperatures varying from room temperature to 600 degreesC. The numerical simulations have been based on the measured geometrical dimensions of the cross-sections, the longitudinal imperfections, i.e. the out of straightness of the beams, the residual stresses and the yield strength. The Eurocode simple model promotes ultimate loads that depend mainly on the non-dimensional slenderness of the beams. The analytical results provided by the Eurocode 3, for a certain range of the slenderness, appear to be unsafe when compared with the numerical and experimental results. It is shown that the new proposal is safer than the Eurocode 3 formulas. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailNew proposals for the design of Steel-Beam-Colums under fire conditions
Lopes, Nuno; Vila Real, P. M. M.; Simoes da Silva, Luis et al

in Franssen, Jean-Marc; Benichou; Kodur (Eds.) et al Proceedings of SiF'04: Third International Structures in Fire workshop (2004)

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See detailNew prospects for the grafting of functional groups onto aliphatic polyesters. Ring-opening polymerization of alpha- or gamma-substituted epsilon-caprolactone followed by chemical derivatization of the substituents
Lecomte, Philippe ULg; Riva, Raphaël ULg; Schmeits, Stephanie ULg et al

in Macromolecular Symposia (2006), 240

Recent progress in the synthesis of aliphatic polyesters, substituted by pendent functional groups, has been reviewed. Two main strategies have to be distinguished. The first route consists of the ring ... [more ▼]

Recent progress in the synthesis of aliphatic polyesters, substituted by pendent functional groups, has been reviewed. Two main strategies have to be distinguished. The first route consists of the ring-opening polymerization of F,caprolactone substituted by various functional groups, protected if needed, in alpha- or gamma-position. In a second strategy, the functional groups are grafted onto preformed polyesters chains in alpha-position of the carbonyl groups. alpha-chloro-epsilon-caprolactone is quite an interesting monomer because, after polymerization, the activated chloride can be easily derivatized by atom transfer radical addition and "click" chemistry, respectively. Similarly, gamma-acrylic-epsilon-caprolactone is precursor of (co)polyesters wellsuited to derivatization of the pendent double bonds by Michael addition. [less ▲]

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See detailNew prospects in flame retardant polymer materials: From fundamentals to nanocomposites
Laoutid, Fouad; Bonnaud, Leïla; Alexandre, Michaël ULg et al

in Materials Science & Engineering : R (2009), 63(3), 100-125

The objective of this review is to make the field of “flame retardants for polymer materials” more accessible to the materials science community, i.e. chemists, physicists and engineers. We present the ... [more ▼]

The objective of this review is to make the field of “flame retardants for polymer materials” more accessible to the materials science community, i.e. chemists, physicists and engineers. We present the fundamentals of polymer combustion theory, the main flame retardant properties and tests used to describe fire behavior, together with the nature and modes of action of the most representative flame retardants and the synergistic effects that can be achieved by combining them. We particularly focus on polymer nanocomposites, i.e. polymer matrices filled with specific, finely dispersed nanofillers, which will undoubtedly pave the way for future materials combining physicochemical and thermo-mechanical performances with enhanced flame retardant behavior. [less ▲]

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See detailNew prospects in the roles of the C-terminal domains of VEGF-A and their cooperation for ligand binding, cellular signaling and vessels formation.
Delcombel, Romain ULg; Janssen, Lauriane ULg; Vassy, Roger et al

in Angiogenesis (2013), 16(2), 353-71

VEGF-A is a crucial growth factor for blood vessel homeostasis and pathological angiogenesis. Due to alternative splicing of its pre-mRNA, VEGF-A is produced under several isoforms characterized by the ... [more ▼]

VEGF-A is a crucial growth factor for blood vessel homeostasis and pathological angiogenesis. Due to alternative splicing of its pre-mRNA, VEGF-A is produced under several isoforms characterized by the combination of their C-terminal domains, which determines their respective structure, availability and affinity for co-receptors. As controversies still exist about the specific roles of these exon-encoded domains, we systematically compared the properties of eight natural and artificial variants containing the domains encoded by exons 1-4 and various combinations of the domains encoded by exons 5, 7 and 8a or 8b. All the variants (VEGF(111)a, VEGF(111)b, VEGF(121)a, VEGF(121)b, VEGF(155)a, VEGF(155)b, VEGF(165)a, VEGF(165)b) have a similar affinity for VEGF-R2, as determined by Surface plasmon resonance analyses. They strongly differ however in terms of binding to neuropilin-1 and heparin/heparan sulfate proteoglycans. Data indicate that the 6 amino acids encoded by exon 8a must be present and cooperate with those of exons 5 or 7 for efficient binding, which was confirmed in cell culture models. We further showed that VEGF(165)b has inhibitory effects in vitro, as previously reported, but that the shortest VEGF variant possessing also the 6 amino acids encoded by exon 8b (VEGF(111)b) is remarkably proangiogenic, demonstrating the critical importance of domain interactions for defining the VEGF properties. The number, size and localization of newly formed blood vessels in a model of tumour angiogenesis strongly depend also on the C-terminal domain composition, suggesting that association of several VEGF isoforms may be more efficient for treating ischemic diseases than the use of any single variant. [less ▲]

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See detailNew proteins involved in cellular invasion
Paupert, Jenny ULg; Monferran, Sylvie; Dauvillier, Stéphanie et al

Conference (2005)

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See detailNew pyridinic analogues of nimesulide as potent COXs inhibitors.
Renard, Jean-François ULg; Garbacki, Nancy ULg; de Leval, Xavier et al

Poster (2008)

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See detailNew Pyridobenzodiazepine Derivatives as Potential Antipsychotics: Synthesis and Neurochemical Study
Liégeois, Jean-François ULg; Bruhwyler, J.; Damas, Jacques ULg et al

in Journal of Medicinal Chemistry (1993), 36(15), 2107-14

The discovery of a new, safe, atypical antipsychotic remains an important challenge. To achieve this goal, a series of N-methylpiperazinopyrido[2,3-b] [1,4]- and -[1,5]- and -pyrido[4,3-b][1,4]- and -[1,5 ... [more ▼]

The discovery of a new, safe, atypical antipsychotic remains an important challenge. To achieve this goal, a series of N-methylpiperazinopyrido[2,3-b] [1,4]- and -[1,5]- and -pyrido[4,3-b][1,4]- and -[1,5]- benzodiazepines were synthesized. The dopaminergic (D1, D2), serotonergic (5-HT2), and cholinergic (M) affinities, frequently remarked in the action mechanisms of antipsychotic drugs, were determined using their respective in vitro receptor binding assays. All affinities were reduced for each compound. Optimal substituents were found to be in the 2- or 8-position for the retention of affinities, while substitution at the 5-position by acyl or alkyl groups dramatically diminished binding affinities. Pyridobenzodiazepine derivatives, such as clozapine, were found to be inactive or only weakly effective against apomorphine-mediated stereotypes in rats. In an original and complex behavioral model developed in dogs and successfully used to differentiate distinct classes of psychotropic drugs and to discriminate between typical and atypical neuroleptic drugs, 8-chloro-6-(4-methyl-1-piperazinyl)-11H-pyrido[2,3-b] [1,4]benzodiazepine (9), 8-methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido [2,3-b][1,4]benzodiazepine (12), and 5-(4-methyl-1-piperazinyl)-11H-pyrido[2,3-b][1,5]benzodiazepine (16) showed most of the behavioral characteristics previously described for neuroleptics. Their neurochemical profiles, particularly their 5-HT2/D2 pKi ratios, were compatible with an atypical antipsychotic effect. These compounds were selected for further investigation. The proposed modulations could lead to new possibilities for the pharmacochemistry of diarylazepines. [less ▲]

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See detailNew pyridobenzodiazepine derivatives: Modifications of the basic side chain differentially modulate binding to dopamine (D-4.2, D-2L) and serotonin (5-HT2A) receptors
Liégeois, Jean-François ULg; Eyrolles, L.; Ellenbroek, B. A. et al

in Journal of Medicinal Chemistry (2002), 45(23), 5136-5149

A series of new pyridobenzodiazepines with variation of the basic side chain were synthesized and evaluated for their binding to D-4.2, D-2L, and 5-HT2A receptors in comparison with clozapine, haloperidol ... [more ▼]

A series of new pyridobenzodiazepines with variation of the basic side chain were synthesized and evaluated for their binding to D-4.2, D-2L, and 5-HT2A receptors in comparison with clozapine, haloperidol, and two parent compounds previously described, 8-chloro-6-(4-methyl-1-piperazinyl)-11H-pyrido[2,3-b][1,4]benzodiazepine (8) and 8-methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido[2,3-b][1,4]benzodiazepine (9). In the piperazine series, replacing the N-methyl group by a N-phenyl moiety (15-17, 30-32) provided a dramatic decrease of affinity for all receptors (K-i > 1000 nM). A N-cyclohexyl group (20, 35) restored some affinity. Compounds with a N-benzyl (18, 33) or N-phenethyl side chain (19, 34) had significant affinities at D-4.2 and 5-HT2A receptors. Homologation of the piperazine nucleus (29, 44) led to a significant decrease of the affinity at all receptors investigated. In the 4-aminopiperidine series, N-methyl derivatives (21, 36) possessed less affinity in comparison with the N-metbylpiperazine analogues (8, 9) while the N-benzyl congeners (22, 37) showed similar affinities. The rigidification of piperidine nucleus as obtained in azabicyclo [3.2.1] octane derivatives (23, 38) involved a slight reduction of the affinity at D-4.2 and 5-HT2A receptors while the affinity at D-2L receptors was dramatically increased. The introduction of N-substituted aminoalkylamines to replace N-methylpiperazine generally led to a significant decrease in the affinity for D-4.2 receptors but some of these molecules (24, 25, 41) presented a significant 5-HT2A binding affinity. The presence of a more flexible side chain induced an increased conformational freedom. Consequently, the preferential position of the distal nitrogen or its basicity in piperazine derivatives was greatly modified. 19 with a high D-4.2 and 5-HT2A affinity (K-i = 40 and 103 nM, respectively) did not induce cataleptic phenomenon in the paw test in rats but significantly reduced the immobility time in Porsolt's test in mice suggesting antidepressant properties. [less ▲]

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See detailNew pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation
Liégeois, Jean-François ULg; Deville, Marine; Dilly, Sébastien ULg et al

in Journal of Medicinal Chemistry (2012), 55(1572), 1582

A series of new pyridobenzoxazepine derivatives with various heterocyclic amine side chains were synthesized in order to explore two main parameters related to the distal basic nitrogen. These compounds ... [more ▼]

A series of new pyridobenzoxazepine derivatives with various heterocyclic amine side chains were synthesized in order to explore two main parameters related to the distal basic nitrogen. These compounds were tested for their affinity for dopamine D2L, D4, serotonin 5-HT1A, 5-HT2A and adrenergic 2A receptors in comparison with 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine, JL13 (1) and other diarylazepine derivatives. In terms of multi-receptor target strategy, 2 and 5 present the most promising in vitro binding profile. Bulky, polar and more flexible side chains are not favourable in this context. 2 and 5 were tested in adult rats to evaluate their long-term effects on dopamine and serotonin receptors density in different brain areas. Similar to 1 and other second-generation antipsychotic drugs, repeated treatment with 2 significantly increased D1 and D4 receptors in nucleus accumbens and caudate putamen, and D2 receptors in medial prefrontal cortex and hippocampus while 5 significantly increased D2 and D4 receptors in nucleus accumbens. In addition, 2 increased 5-HT1A and decreased 5-HT2A receptors in cerebral cortex. In contrast, 5 did not alter levels of any 5-HT receptor subtype in any brain region examined. These results encourage further development of 2 as a novel second-generation antipsychotic agent. [less ▲]

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See detailNew quadrangular shell element in SAFIR
Talamona, Didier; Franssen, Jean-Marc ULg

in Franssen, Jean-Marc (Ed.) Proceedings of the 1st International Structures in Fire workshop (2000)

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See detailA New Quicklook Optical Processor with Digital Input/Output
Litovchenko, Konstantin Ts.; Lemaire, Philippe; Barbier, Christian ULg

in Proceedings IGARSS'96 Symposium (1996)

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See detailNew quinazolinones structurally related to diazoxide and pinacidil as potential KATP channel openers
Somers, F.; Ouedraogo, R.; De Tullio, Pascal ULg et al

Conference (1998, February 14)

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See detailNew quinazolinones structurally related to diazoxide and pinacidil as potential KATP channel openers
Somers, F.; Ouedraogo, R.; De Tullio, Pascal ULg et al

in Fundamental & Clinical Pharmacology (1998), 12

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