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See detailNew features in SAFIR: Transient Creep in Eurocode Concrete Model
Gernay, Thomas ULg; Franssen, Jean-Marc ULg

Scientific conference (2011, November 15)

A new formulation of the Eurocode 2 concrete model at elevated temperature has been implemented in which the transient creep strain is treated by an explicit term in the strain decomposition. This new ... [more ▼]

A new formulation of the Eurocode 2 concrete model at elevated temperature has been implemented in which the transient creep strain is treated by an explicit term in the strain decomposition. This new model gives the same answer as the Eurocode model when the load and the temperature increase, but the new model is better than the Eurocode model at capturing the concrete behavior when the load or the temperature decrease owing to the explicit transient creep term. This new concrete model, called Explicit Transient Creep Eurocode model (ETC), has been implemented in the software SAFIR. [less ▲]

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See detailNew features in the treatment of androgen-independent prostate cancer.
Closset, Jean ULg; Ammar, Hayet; Nguyen, Viet-Ha et al

in Current Pharmaceutical Design (2004), 10(5), 513-22

Prostate cancer develops from clones that are already present as early as thirty-five years of age, when circulating concentrations of androgens are high. The progression of the disease is low and the ... [more ▼]

Prostate cancer develops from clones that are already present as early as thirty-five years of age, when circulating concentrations of androgens are high. The progression of the disease is low and the cancer is diagnosed at a more advanced age. Prostate cancer evolves from an androgen dependant stage to stage where it escapes from all anti-androgenic treatments. The patient usually dies within two years following the diagnosis of advanced cancer. Therefore, it is of great interest to develop new therapies for androgen independent prostate cancer. The androgen independent evolution of prostate cancer is a complex phenomenon at the cellular and molecular levels. It includes an increased sensitivity to growth factors, the control of proliferation pathways, apoptotic and survival pathways as well as the control of angiogenesis. Epidemiological studies have also suggested that certain vitamins or phyto-oestrogens could protect against prostate cancer development. The present review attempts to present an overview of the fundamental research in cellular signalling which could be interesting as target for the treatment of androgen independent prostate cancer. Also the potential interest of non-androgenic steroids was reviewed for the same goal. [less ▲]

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See detailNew features of the INCL4 model for spallation reactions
Cugnon, Joseph ULg; Boudard, A; Leray, S et al

in Journal of Korean Physical Society (2011), 59(2), 955-958

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See detailNew findings on selenium related mercury detoxification processes.
Holsbeek, Ludo; Das, Krishna ULg; Bouquegneau, Jean-Marie ULg et al

Poster (2002)

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See detailNew findings on the prototypical Of?p stars
Nazé, Yaël ULg; Ud-Doula, Asif; Spano, Maxime et al

in Astronomy and Astrophysics (2010), 520

<BR /> Aims: In recent years several in-depth investigations of the three prototypical Of?p stars were undertaken. These multiwavelength studies revealed the peculiar properties of these objects (in the X ... [more ▼]

<BR /> Aims: In recent years several in-depth investigations of the three prototypical Of?p stars were undertaken. These multiwavelength studies revealed the peculiar properties of these objects (in the X-rays as well as in the optical): magnetic fields, periodic line profile variations, recurrent photometric changes. However, many questions remain unsolved. <BR /> Methods: To clarify some of the properties of the Of?p stars, we have continued their monitoring. A new xmm-Newton observation and two new optical datasets were obtained. <BR /> Results: Additional information about the prototypical Of?p trio has been found. HD 108 has now reached its quiescent, minimum-emission state for the first time in 50-60 yr. The échelle spectra of HD 148937 confirm the presence of the 7d variations in the Balmer lines and reveal similar periodic variations (though of lower amplitudes) in the He i λ 5876 and He ii λ 4686 lines, underlining its similarities with the other two prototypical Of?p stars. The new xmm-Newton observation of HD 191612 was taken at the same phase in the line modulation cycle, but at a different orbital phase from previous data. It clearly shows that the X-ray emission of HD 191612 is modulated by the 538d period and not by the orbital period of 1542d - it is thus not of colliding-wind origin. The phenomenon responsible for the optical changes appears also at work in the high-energy domain. There are problems however: our MHD simulations of the wind magnetic confinement predict both a harder X-ray flux of a much larger strength than what is observed (the modelled differential emission measure peaks at 30-40 MK, whereas the observed one peaks at 2 MK) and narrow lines (hot gas moving with velocities of 100-200 km s[SUP]-1[/SUP], whereas the observed full width at half maximum is ~2000 km s[SUP]-1[/SUP]). Based on observations collected at the Haute-Provence Observatory, at the La Silla and San Pedro Mártir Observatories, and with XMM-Newton, an ESA Science Mission with instruments and contributions directly funded by ESA Member States and the USA (NASA). [less ▲]

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See detailA new finite element integration scheme. Application to a simple shear test of anisotropic material
de Montleau, P.; Habraken, Anne ULg; Duchene, Laurent ULg

in International Journal for Numerical Methods in Engineering (2008)

Finite element simulations involving large strains and large displacements imply the setting up of a precise kinematics for the integration scheme. Moreover, anisotropic mechanical behaviours have to be ... [more ▼]

Finite element simulations involving large strains and large displacements imply the setting up of a precise kinematics for the integration scheme. Moreover, anisotropic mechanical behaviours have to be expressed in an appropriate local reference frame. In the present paper, a computational procedure is derived from a particular velocity gradient definition. Its implementation in a finite element code is described. Application to a simple shear test is proposed. For anisotropic materials, a sinusoidal behaviour of the shear stress component is emphasized. This is due to the anisotropic yield locus and appears in the case of a saturated isotropic hardening law. [less ▲]

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See detailNew firm property and regional and local service development
Merenne-Schoumaker, Bernadette ULg

in GeolNova (2006), (12), 381-395

In less than ten years, a corporate property market has emerged in Wallonia. This market first covered offices and retail units and recently extended to semi-industrial establishments. Its development is ... [more ▼]

In less than ten years, a corporate property market has emerged in Wallonia. This market first covered offices and retail units and recently extended to semi-industrial establishments. Its development is largely related to the creation of a new type of demand resulting from the growth of new service activities and from new expectations regarding physical units, environment, accessibility and location choices – on both sub-regional and local scales. It has been favoured by the appearance of new property stakeholders, Belgians as well as foreigners (developers, investors and estate agents), but also by public authorities (the Walloon Region and economic development supra-communal agencies). This market’s emergence is related to the deepening of territorial contrasts as property development projects usually reinforce strong areas. [less ▲]

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See detailNew Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors
Francotte, Pierre ULg; Goffin, Eric ULg; Fraikin, Pierre ULg et al

in Journal of Medicinal Chemistry (2010), 53

In the search of a potent cognitive enhancer, a series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as positive allosteric modulators of the AMPA receptors. In ... [more ▼]

In the search of a potent cognitive enhancer, a series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as positive allosteric modulators of the AMPA receptors. In the present work, we focused our efforts on the insertion of mono- or polyfluoro- substituted alkyl chains at the 4-position of the thiadiazine ring in an attempt to enhance the pharmacokinetic behavior of previously described compounds. Among all the described compounds, 7-chloro-4-(2-fluoroethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, 12b, was shown to exert a strong activity on AMPA receptors in vitro and a marked cognitive-enhancing effect in vivo after oral administration to Wistar rats. Considering its in vivo activity, the metabolic degradation of 12b was studied and compared to that of its nonfluorinated analogue 9b. Taken together, results of this study clearly validated the positive impact of the fluorine atom on the alkyl chain at the 4-position of benzothiadiazine dioxides on activity and metabolic stability. [less ▲]

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See detailNew fluorinated surfactant for nanogels preparation
Alaimo, David ULg; Rieger, Jutta; Beigbeder, Alexandre et al

Conference (2009, March 19)

A series of novel fluorinated amphiphilic stabilizers of different architecture (diblock, grafted, or palm tree copolymers) were successfully prepared by reversible addition-fragmentation chain transfer ... [more ▼]

A series of novel fluorinated amphiphilic stabilizers of different architecture (diblock, grafted, or palm tree copolymers) were successfully prepared by reversible addition-fragmentation chain transfer and used as stabilizers for the dispersion polymerization of 2-hydroxyethyl methacrylate (HEMA) in fluorinated solvent, namely alpha,alpha,alpha-trifluorotoluene (TFT). The effect of the amount and the architecture of the copolymer on the size and the stabilization of the particles was studied. Whatever the experimental conditions, scanning electron microscopy showed the formation of submicronic (typically about 300 nm) spherical particles, with a narrow size distribution. The principal difference emerges from the concentration of surfactant. Indeed, at higher copolymer concentration, smaller and less aggregated particles were produced. These results were confirmed by dynamic light scattering but these measurements also revealed the presence of larger aggregates (1,5 micrometer). Furthermore, the surfactant properties of the copolymers were investigated by measuring the interfacial tension at the H2O/TFT interface, and the results were correlated to their stabilizing efficiency in the dispersion polymerization of HEMA. [less ▲]

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See detailNew fluorinated surfactant for nanogels preparation in supercritical CO2
Alaimo, David ULg; Beigbeder, Alexandre; Dubois, Philippe et al

Poster (2011, April 29)

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See detailNew fluorinated surfactants for nanogels preparation
Alaimo, David ULg; Rieger, Jutta; Beigbeder, Alexandre et al

Conference (2009, June 18)

A series of novel fluorinated amphiphilic stabilizers of different architecture (diblock, grafted, or palm tree copolymers) were successfully prepared by reversible addition-fragmentation chain transfer ... [more ▼]

A series of novel fluorinated amphiphilic stabilizers of different architecture (diblock, grafted, or palm tree copolymers) were successfully prepared by reversible addition-fragmentation chain transfer and used as stabilizers for the dispersion polymerization of 2-hydroxyethyl methacrylate (HEMA) in fluorinated solvent, namely alpha,alpha,alpha-trifluorotoluene (TFT). The effect of the amount and the architecture of the copolymer on the size and the stabilization of the particles was studied. Whatever the experimental conditions, scanning electron microscopy showed the formation of submicronic (typically about 300 nm) spherical particles, with a narrow size distribution. The principal difference emerges from the concentration of surfactant. Indeed, at higher copolymer concentration, smaller and less aggregated particles were produced. These results were confirmed by dynamic light scattering but these measurements also revealed the presence of larger aggregates (1,5 micrometer). Furthermore, the surfactant properties of the copolymers were investigated by measuring the interfacial tension at the H2O/TFT interface, and the results were correlated to their stabilizing efficiency in the dispersion polymerization of HEMA. [less ▲]

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See detailNew fluorinated surfactants for nanogels preparation in supercritical CO2
Alaimo, David ULg; Beigbeder, Alexandre; Dubois, Philippe et al

Poster (2010, November 29)

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See detailNew format of the quality of life systemic inventory for children (QLSI-C): preliminary results
Toucheque, Malorie ULg; Tilkin, Caroline; Etienne, Anne-Marie ULg

Poster (2013, July)

Background: This study assesses the test-retest reliability of the QLSI-C iPad version. Methods: Sample consisted of 40 children aged 8 to 12 years which completed QLSI-C twice over a two-week delay ... [more ▼]

Background: This study assesses the test-retest reliability of the QLSI-C iPad version. Methods: Sample consisted of 40 children aged 8 to 12 years which completed QLSI-C twice over a two-week delay. Participants were divided into 3 groups: 13 participants completed iPad (T0) – paper (T1) version, 13 others filled paper (T0) – iPad (T1) and 14 answered iPad (T0) – iPad (T1). Findings: Analysis of variance indicates that group effect (F(2,37) = 1,27, p = 0,29) and time effect (F(2,37) = 0,04, p= 0,84) is not statistically significant nor the interaction effect (F(2,37) = 0,08 p = 0,92). Correlations for the 5 global scores between iPad – iPad version is from .63 to .91 and between the 2 different formats is from .40 to .87. Discussion: QLSI-C test-retest stability and paper – iPad version equivalence are good. This new format is more attractive for children, decreases time for administration and makes easier the encoding. [less ▲]

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See detailA new formulation of internal forces for non-linear hypoelastic constitutive models verifying conservation laws
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg et al

in Bathe, K. J. (Ed.) Second MIT Conference on Fluid and Solid Mechanics (2003)

This paper proposes a new formulation of the internal forces for hypoelastic constitutive models ensuring that the elastic work of deformation can be restored by the scheme. Moreover, we demonstrate that ... [more ▼]

This paper proposes a new formulation of the internal forces for hypoelastic constitutive models ensuring that the elastic work of deformation can be restored by the scheme. Moreover, we demonstrate that the work of the plastic deformation is positive and consistent with the material model. [less ▲]

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See detailNew fossils at the “Troisième caverne” of Goyet (Belgium) and the mortuary practices of late Neandertals
Rougier, H.; Crevecoeur, I.; Beauval, C. et al

Conference (2014, March 21)

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See detailNew Functional Aliphatic Polyesters by Chemical Modification of Copolymers of ε-Caprolactone with γ-(2-Bromo-2-methylpropionate)- ε-caprolactone, γ-Bromo- ε-caprolactone, and a Mixture of β-and γ-Ene- ε-caprolactone
Detrembleur, Christophe ULg; Mazza, Michaël; Lou, Xudong et al

in Macromolecules (2000), 33(17), 7751-7760

New functional aliphatic polyesters were prepared by chemical modification of brominated copolyesters. Poly(epsilon-caprolactone)-co-poly(gamma-(2-bromo-2-methylpropionate)-epsilon-caprolactone) copolymer ... [more ▼]

New functional aliphatic polyesters were prepared by chemical modification of brominated copolyesters. Poly(epsilon-caprolactone)-co-poly(gamma-(2-bromo-2-methylpropionate)-epsilon-caprolactone) copolymer was prepared and successfully converted into copolyester bearing methacrylate double bonds by dehydrohalogenation of the pendant tertiary alkyl bromides, thus leading to cross-linkable polyester. The tertiary alkyl bromide groups of the original copolyester were also quaternized by reaction with pyridine, although some side reactions occurred which Limited the reaction yield. Nevertheless, quaternization of the bromide groups of the poly(epsilon-caprolactone)-co-poly(gamma-bromo-epsilon-caprolactone) copolymer proved to be quantitative and to occur without degradation of the polyester chains. This general strategy paves the way to either amphiphilic copolyesters or water-soluble polyesters. The poly(epsilon -caprolactone)-co-poly(gamma -bromo-epsilon-caprolactone) lactone) copolymer was also quantitatively converted into unsaturated copolyester by dehydrohalogenation with formation of double bonds including acrylic-type double bonds. As an alternative, gamma-bromo-epsilon-caprolactone was first dehydrohalogenated, and the unsaturated cyclic monomer was copolymerized with epsilon-caprolactone. Finally, the nonconjugated double bonds of the copolyesters were oxidized into epoxides, except for the acrylic-type unsaturations which remained unchanged. [less ▲]

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