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See detailNew dibenzazepine derivatives with disinhibitory and/or antidepressant potential: neurochemical and behavioural study in the open-field and forced swimming tests.
Bruhwyler, J.; Liégeois, Jean-François ULg; Lejeune, C. et al

in Behavioural pharmacology (1995), 6(8), 830-838

Original bioisosteric analogues of clozapine were evaluated for potential disinhibitory and/or antidepressant effects using the open-field test in the rat and Porsolt's forced swimming test in the mouse ... [more ▼]

Original bioisosteric analogues of clozapine were evaluated for potential disinhibitory and/or antidepressant effects using the open-field test in the rat and Porsolt's forced swimming test in the mouse. Attempts to relate the behavioural results to the binding affinities for dopamine (D1, D2), serotonin (5-HT(2)) and muscarinic (M) receptors were also undertaken. In the open-field test, two main profiles were observed. The first profile corresponded to disinhibitory molecules resembling diazepam and ritanserin. The second profile corresponded to antipsychotic compounds resembling either typical (haloperidol, clothiapine) or atypical (clozapine) neuroleptics. The results obtained in the forced swimming test confirmed the neuroleptic-like activity of the second group of compounds, while two compounds of the first group (JL 3 and JL 26) showed an antidepressant-like activity, JL 3 being as active as imipramine. While it was not possible to relate the first profile to any binding interaction, a relation could be established among the second group of compounds between the typical or atypical antipsychotic behavioural profile and the 5-HT(2)/D2 ratio. [less ▲]

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See detailNew digestive symbiosis in the hydrothermal vent amphipoda Ventiella sulfuris
Corbari, L.; Durand, L.; Cambon-Bonavita, M.-A. et al

in Comptes Rendus Biologies (2012), 335(2), 142-154

Ventiella sulfuris Barnard and Ingram, 1990 is the most abundant amphipod species inhabiting the Eastern Pacific Rise (EPR 9°N) vent fields. This vent-endemic species is frequently encountered near ... [more ▼]

Ventiella sulfuris Barnard and Ingram, 1990 is the most abundant amphipod species inhabiting the Eastern Pacific Rise (EPR 9°N) vent fields. This vent-endemic species is frequently encountered near colonies of Pompeii worms Alvinella pompejana. V. sulfuris specimens were collected during the oceanographic cruise LADDER II at the Bio9 (9°50.3′ N, 2508 m depth) hydrothermal vent site. Main objectives were to highlight the occurrence of bacterial symbiosis in V. sulfuris and to hypothesise their implications in nutrition. Observations in light and electron microscopy (SEM, TEM) showed that the outer body surface and appendages are free of microorganisms. In contrast, the digestive system revealed two major microbial communities settled in the midgut and in the hindgut. Gut contents showed bacterial traces together with abundant fragments of Alvinellid cuticle and setae, from A. pompejana, suggesting that V. sulfuris could directly feed on Alvinellids and/or on their bacterial epibionts. Molecular analyses based on the 16S rRNA genes revealed the diversity of bacterial communities in the digestive system, of which, the Epsilonproteobacteria phylum, could be considered as one of the major bacterial group. Hypotheses were proposed on their symbiotic features and their implications in V. sulfuris nutrition. © 2011 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved. [less ▲]

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See detailThe new digitized geological map of Wallonia and its applications
Barchy, Laurent; Marion, Jean-Marc ULg

Poster (2003, June)

Objectives: understanding of geological phenomena, development of new methodologies and techniques, to produce and disseminate pertinent, high-quality data and to provide for public authorities: - Surface ... [more ▼]

Objectives: understanding of geological phenomena, development of new methodologies and techniques, to produce and disseminate pertinent, high-quality data and to provide for public authorities: - Surface, subsurface and natural-ressource management - Preventing natural risks and pollution - Regional planning and developmentthe necessary tools [less ▲]

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See detailNew dihydrocoumarine derivatives as potential mechanism-based inactivators of serine proteinases
Schynts, M.; Boggetto, N.; Masereel, B. et al

Poster (1992, November 06)

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See detailNew dihydrocoumarine derivatives as potential mechanism-based inactivators of serine proteinases
Schynts, M.; Boggetto, N.; Masereel, B. et al

in Pharmaceutisch Weekblad (1992), 14

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See detailNew dimensions in tumor immunology: what does 3D culture reveal?
Feder-Mengus, Chantal; Ghosh, Sourabh; Reschner, Anca ULg et al

in Trends in Molecular Medicine (2008), 14(8), 333-40

Experimental models indicate that tumor cells in suspension, unlike solid tumor fragments, might be unable to produce life-threatening cancer outgrowth when transferred to animal models, irrespective of ... [more ▼]

Experimental models indicate that tumor cells in suspension, unlike solid tumor fragments, might be unable to produce life-threatening cancer outgrowth when transferred to animal models, irrespective of the number of cells transferred, although they induce specific immune responses. Human tumor cells cultured in three dimensions display increased pro-angiogenic capacities and resistance to interferons, chemotherapeutic agents or irradiation, as compared with cells cultured in two-dimensional (2D) monolayers. Tumor cells cultured in three dimensions were also shown to be characterized by defective immune recognition by cytotoxic T lymphocytes (CTLs) specific for tumor-associated antigens (TAAs) and by a capacity to inhibit CTL proliferation and dendritic cell (DC) functions. Downregulation of human leukocyte antigen (HLA) or TAA expression and high production of lactic acid might play a role in the elicitation of these effects. Here, we propose that growth in 3D architectures might provide new insights into tumor immunology and could represent an integral missing component in pathophysiological tumor immune escape mechanisms. [less ▲]

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See detailA New Dimethyl Sulfoxide-Based Method for Gene Promoter Methylation Detection
Kholod, Natalia ULg; Boniver, Jacques ULg; Delvenne, Philippe ULg

in Journal of Molecular Diagnostics (2007), 9(5), 574-81

The identification of gene promoter methylation is a useful tool for the molecular diagnosis of human diseases. We have developed a new PCR-based technique for detecting the methylation status of CpG ... [more ▼]

The identification of gene promoter methylation is a useful tool for the molecular diagnosis of human diseases. We have developed a new PCR-based technique for detecting the methylation status of CpG islands of gene promoters. This new method, named methyl-sensitive dimethyl sulfoxide-PCR (Ms-DMSO-PCR), is based on the finding that methylated and unmethylated DNAs show a different sensitivity to the amount of DMSO used in the PCR reaction. For the amplification of methylated DNA, more DMSO is required in comparison to unmethylated DNA. This finding resulted in the development of a simple PCR screening of CpG islands with addition of DMSO in the range from 0 to 8% (v/v), and the same pair of primers is sufficient for distinguishing hyper- or hypomethylated gene promoters from normally methylated sequences. This new technique is a one-step procedure and does not require any modifications of DNA or expensive equipment. Therefore, Ms-DMSO-PCR has the potential to be widely used for clinical applications as well in basic research. [less ▲]

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See detailA New Discontinuous Galerkin Formulation for Kirchhoff-Love Shells
Noels, Ludovic ULg; Radovitzky, Raul

Conference (2007)

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See detailA New Discontinuous Galerkin Formulation for Non-Linear Elasticity
Noels, Ludovic ULg; Chandran, Ram B; Radovitzky, Raul

Conference (2006)

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See detailA new discontinuous Galerkin method for Kirchhoff-Love shells
Noels, Ludovic ULg; Radovitzky, Raúl

in Computer Methods in Applied Mechanics & Engineering (2008), 197

Discontinuous Galerkin methods (DG) have particular appeal in problems involving high-order derivatives since they provide a means of weakly enforcing the continuity of the unknown-field derivatives. This ... [more ▼]

Discontinuous Galerkin methods (DG) have particular appeal in problems involving high-order derivatives since they provide a means of weakly enforcing the continuity of the unknown-field derivatives. This paper proposes a new discontinuous Galerkin method for Kirchhoff–Love shells considering only the membrane and bending response. The proposed one-field method utilizes the weak enforcement in such a way that the displacements are the only unknowns, while the rotation continuity is weakly enforced. This work presents the formulation of the new discontinuous Galerkin method for linear elastic shells, demonstrates the consistency and stability of the proposed framework, and establishes the method’s convergence rate. After a description of the formulation implementation into a finite-element code, these properties are demonstrated on numerical applications. [less ▲]

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See detailA new discontinuous Galerkin method for non-linear Mechanics
Noels, Ludovic ULg; Radovitzky, Raúl

(2006)

A discontinuous Galerkin framework for large deformations of solids is established. The method is based on a general Hu-Washizu-de Veubeke functional allowing for displacement and stress discontinuities ... [more ▼]

A discontinuous Galerkin framework for large deformations of solids is established. The method is based on a general Hu-Washizu-de Veubeke functional allowing for displacement and stress discontinuities in the domain interior. The focus of this paper is on the treatment of large elasto-plastic deformations. The method is shown to possess the required numerical properties: consistency in the non-linear range and linearized stability. In order to demonstrate the versatility, accuracy and robustness of the method examples of application and convergence studies in three dimensions are provided. Further developments of the method will lead to applications where physical discontinuities must be modeled like fragmentation or failure. [less ▲]

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See detailNew disruption cassettes for rapid gene disruption and marker rescue in the yeast Yarrowia lipolytica
Fickers, Patrick ULg; Le Dall, M. T.; Gaillardin, C. et al

in Journal of Microbiological Methods (2003), 55(3), 727-737

Yarrowia lipolytica is one of the most extensively studied nonconventional yeasts. Unfortunately, few methods for gene disruption have been reported for this yeast, and all of them are time-consuming and ... [more ▼]

Yarrowia lipolytica is one of the most extensively studied nonconventional yeasts. Unfortunately, few methods for gene disruption have been reported for this yeast, and all of them are time-consuming and laborious. The functional analysis of unknown genes requires powerful disruption methods. Here, we describe such a new method for rapid gene disruption in Y lipolytica. This knockout system combines SEP method and the Cre-lox recombination system, facilitating efficient marker rescue. Versatility was increased by using both auxotrophic markers like ylURA3 and ylLEU2, as well as the antibiotic resistance marker hph. The hph marker, which confers resistance to hygromycin-B, allows gene disruption in a strain lacking any conventional auxothrophic marker. The disruption cassette was shown to integrate at the correct locus at an average frequency of 45%. Upon expression of Cre recombinase, the marker was excised at a frequency of 98%, by recombination between the two lox sites. This new method for gene disruption is an ideal tool for the functional analysis of gene families, or for creating large-scale mutant collections in general. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailA new distribution of vegetation types and its inclusion in a global biosphere model
Warnand; François, Louis ULg; Nemry, B. et al

Poster (1995, August)

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See detailA new diterpene enone from the soldier beetle Cantharis livida (Coleoptera : Cantharidae)
Durvaux, Christophe; Laurent, Pascal ULg; Daloze, Désiré et al

in ARKIVOC (2007), 10

Cantharenone, a new diterpene structurally related to the prenylbisabolane skeleton, has been isolated from the beetle Cantharis livida (Cantharidae). Its structure has been determined on the basis of its ... [more ▼]

Cantharenone, a new diterpene structurally related to the prenylbisabolane skeleton, has been isolated from the beetle Cantharis livida (Cantharidae). Its structure has been determined on the basis of its spectral properties. This is the first report of such a type of diterpenoid from an insect. [less ▲]

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See detailNew drugs and nutraceuticals in the treatment of osteoarthritis
Henrotin, Yves ULg; Reginster, Jean-Yves ULg

in Cox Gad, Shayne (Ed.) Development of Therapeutic Agents Handbook (2012)

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See detailA new easy method for specific measurement of active myeloperoxidase in human biological fluids and tissue extracts
Franck, Thierry ULg; Kohnen, Stephan; Zouaoui Boudjeltia, Karim et al

in Talanta (2009), 80

The SIEFED (“Specific Immunological Extraction Followed by Enzymatic Detection”) method already developed for the specific detection of the activity of equine myeloperoxidase (MPO) was adapted for the ... [more ▼]

The SIEFED (“Specific Immunological Extraction Followed by Enzymatic Detection”) method already developed for the specific detection of the activity of equine myeloperoxidase (MPO) was adapted for the specific measurement of active human MPO in biological fluids or tissue extracts. [less ▲]

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See detailNew Economy, New Myths ? The American Media Industry in Perspective
Geuens, Geoffrey ULg

Scientific conference (2008, October 16)

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See detailA new elastic-visco-plastic damage model for annealed aluminium: theory, calibration and validation
Habraken, Anne ULg; Zhang, Lihong ULg; Wang, X. C. et al

in Benallal, A. (Ed.) Proceedings of the Continuous Damage and Fracture Symposium (2000)

This article describes an energy based, two variables, isotropic damage model merged with Bodner's elasto-visco-plastic model and implemented in a non-linear finite element code. The procedure to identify ... [more ▼]

This article describes an energy based, two variables, isotropic damage model merged with Bodner's elasto-visco-plastic model and implemented in a non-linear finite element code. The procedure to identify the parameters of the model and its experimental validation are presented and applied to an annealed aluminium. [less ▲]

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See detailNew emission lines in Mira Ceti
Swings, Polydore ULg

in Publications of the Astronomical Society of the Pacific [=PASP] (1940), 52

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See detailNew Energy Levels in Ne II deduced from FTS spectra in the Infrared Region (1800-9000 cm-1)
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg

in Physica Scripta (1994), 49

Detailed reference viewed: 9 (2 ULg)