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See detailAssessment of glucose metabolism in humans with the simultaneous use of indirect calorimetry and tracer techniques.
Tappy, L.; Paquot, Nicolas ULg; Tounian, P. et al

in Clinical Physiology (1995), 15(1), 1-12

Concomitant measurements of sytemic glucose delivery and carbohydrate oxidation are frequently performed in human investigations. Systemic glucose delivery (SGD) is usually determined using dilution of ... [more ▼]

Concomitant measurements of sytemic glucose delivery and carbohydrate oxidation are frequently performed in human investigations. Systemic glucose delivery (SGD) is usually determined using dilution of infused glucose tracers; net carbohydrate oxidation rate (net CHOOX) can be calculated from respiratory gas exchanges and urinary nitrogen excretion (indirect calorimetry); alternatively, glucose oxidation can be measured from labelled CO2 production during infusion of carbon-labelled glucose tracers. In this paper, the theory underlying the use of each of these techniques is briefly reviewed and qualitative differences are outlined. SGD represents the sum of hepatic glucogenolysis, gluconeogenesis from amino acids or glycerol, and, according to the glucose tracer used, glucose cycles (glucose-phosphate cycle, fructose-phosphate cycle, Cori and glucose-alanine cycles); systemic delivery of exogenous glucose after oral or i.v. glucose administration is also measured. Net CHOOX represents oxidation of glucose arising from hepatic or muscle glycogen or from exogenous glucose; it does not take into account oxidation of glucose formed from amino acids or glycerol, which is included in net protein or lipid oxidation. In contrast, isotopic determination of glucose oxidation corresponds to oxidation of glucose originating from hepatic glycogen breakdown, of exogenously administered glucose, and of glucose formed from amino acids and glycerol. Non-oxidative glucose disposal, calculated as SGD-net CHOOX, corresponds to the sum of gluconeogenesis from amino acids or glycerol (which are included in net protein and lipid oxidation), glucose cycles, and glycogen synthesis. [less ▲]

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See detailAssessment of grazing rates in Daphnia galeata
Thys, Isabelle; Pandolfini, Eliana; Darchambeau, François ULg et al

Conference (1999, September 14)

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See detailAssessment of hallucinations
Bell, Vaughan; Raballo, Andrea; Laroi, Frank ULg

in Laroi, Frank; Aleman, André (Eds.) Hallucinations: A guide to treatment and management (2010)

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See detailAssessment of health claims in the field of bone: a view of the Group for the Respect of Ethics and Excellence in Science (GREES)
Bruyère, Olivier ULg; Rizzoli, René; Coxam, V. et al

in Osteoporosis International (2012), 23

Health claims for food products in Europe are permitted if the nutrient has been shown to have a beneficial nutritional or physiological effect. This paper defines health claims related to bone health and ... [more ▼]

Health claims for food products in Europe are permitted if the nutrient has been shown to have a beneficial nutritional or physiological effect. This paper defines health claims related to bone health and provides guidelines for the design and the methodology of clinical studies to support claims. [less ▲]

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See detailAssessment of high sensitive troponin T and I immunoassays in patients with acute chest
Le Goff, Caroline ULg; Garweg, Christophe ULg; Laurent, Terry et al

in Clinical Chemistry (2010, July), 56(S6), 127

Introduction: Cardiac troponin I and T are specific markers of myocardial injury that are widely used for the diagnosis of acute coronary syndrome (ACS). In acute chest pain without ST-segment elevation ... [more ▼]

Introduction: Cardiac troponin I and T are specific markers of myocardial injury that are widely used for the diagnosis of acute coronary syndrome (ACS). In acute chest pain without ST-segment elevation, they are used to differentiate unstable angina from non ST-segment elevation myocardial infarction (NSTEMI). Recently, troponin assays with higher analytical sensitivities became available to enable the detection of minor myocardial damage and identify individuals at higher risk for ACS. As a result of its high tissue-specificity, cardiac troponin T and I are cardio-specific, highly sensitive markers for myocardial damage. The aim of this study was to evaluate the new higher sensitive troponin (T and I) in patients with stable angina and acute chest pain without ST-segment elevation. Methods: Sixty subjects (mean age : 65.5± 11 years), were included: 20 healthy controls, 20 patients with stable angina, 9 with unstable angina (troponin-) and 18 patients with NSTEMI myocardial infarction (troponin+). The protocol was approved by the ethic committee of the University of Liège (Belgium). High sensitive troponin T (hsTnT) determination was realized on heparin plasma by electrochemiluminescence immunoassay on Modular E (Roche Diagnostic). Troponin I II (TnI II) is a chemiluminescent microparticle immunoassay for the quantitative determination of cardiac troponin-I in heparine plasma on the ARCHITECT i System (Abbott Diagnostic). The lower detection limit of these assays was 0.005μg/L for hsTnT and 0.01μg/L for TnI II. Stastistical analysis was performed using t test. P value <0.05 was considered significant. Results: HsTNT levels were 0.003(0.003, 0.004) [median baseline (1st, 3rd quartile)]ng/ml in controls, 0.0075 (0.00475, 0.014) ng/ml in stable angina, 0.011(0.006, 0.012) ng/ml in unstable angina and 0.3715 (0.1795, 1.00725) ng/ml in NSTEMI ACS. TnI II levels were 0 (0, 0.001) ng/ml in controls and in patients with stable angina, 0.07 (0.005, 0.014) ng/ml in unstable angina and 1.4475 (0.0407, 2.656) ng/ml in NSTEMI. HsTNT and TnI II levels were significantly increased in NSTEMI as compared to control subjects, patients with stable and unstable angina. TnI II levels were also increased in unstable angina as compared to controls. Conclusion: In our population, TnI II was more sensitive than hsTNT to detect minor myocardial damage in patients with unstable angina as compared to controls. Therefore, future studies will have to determine whether TnI II might contribute to better risk stratification and treatment strategy in this group of patients. [less ▲]

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See detailAssessment of insulin resistance in vivo: application to the study of type 2 diabetes.
Scheen, André ULg; Lefebvre, Pierre ULg

in Hormone Research (1992), 38(1-2), 19-27

Besides insulin secretion, insulin sensitivity plays a key role in the feedback glucose-insulin closed loop. It can be altered in numerous physiological, pathological and pharmacological conditions. It ... [more ▼]

Besides insulin secretion, insulin sensitivity plays a key role in the feedback glucose-insulin closed loop. It can be altered in numerous physiological, pathological and pharmacological conditions. It can be estimated in vivo using methods that open the feedback loop (insulin suppression test, glucose clamp) or that analyze the closed loop by employing mathematical models of glucose kinetics. The most popular method is the euglycemic hyperinsulinemic glucose clamp. This test should be ideally coupled with a priming-constant infusion of a glucose tracer together with indirect calorimetry. This combination allows to study the glucose kinetics (Ra and Rd, and thus endogenous-mainly hepatic-glucose production) and its metabolism (oxidation or storage as glycogen), respectively. One alternative approach is the frequently sampled intravenous glucose tolerance test where the dynamic changes in plasma insulin and glucose levels are analyzed using the so-called 'minimal model' method. Noninsulin-dependent or type 2 diabetes is characterized by a significant defect in both insulin secretion and action. The insulin resistance is located at the liver site (increased glucose production) and at the peripheral tissues (decreased oxidation and, even more, defective storage of glucose in the muscles). This insulin resistance, which predominates at the postreceptor level, seems to be genetically determined but is worsened by weight excess and by hyperglycemia itself. This contributes to a vicious circle which aggravates progressively the severity of the disease. [less ▲]

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See detailAssessment of joint space narrowing in knee osteoarthritis has good long-term intercentre reproducibility when read in pairs with a semi-automated device
Gensburger, Deborah; DEROISY, Rita ULg; Arlot, Monique et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 247-248

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See detailAssessment of joint space narrowing with conventional standing antero-posterior radiographs: relief in mild-to-moderate pain is not a confounder in recent osteoarthritis structure-modifying drug trials
Rovati, L. C.; Pavelka, K.; Giacovelli, G. et al

in Osteoarthritis and Cartilage (2006), 14(Suppl. A), 14-18

Objective: Knee pain relief has been suggested to potentially alter radioanatomic positioning in conventional standing antero-posterior knee radiographs. This study was performed to determine whether this ... [more ▼]

Objective: Knee pain relief has been suggested to potentially alter radioanatomic positioning in conventional standing antero-posterior knee radiographs. This study was performed to determine whether this is always the case and in particular if it applied to two recent randomised, placebo-controlled trials showing both symptom- and structure-modification with glucosamine sulfate in knee osteoarthritis. Design: Patients in the two studies were selected if they completed the 3-year evaluations and, irrespectively of treatment, (1) were pain-improvers in that they underwent Western Ontario and McMaster Universities (WOMAC) osteoarthritis index (WOMAC) pain decrease at least equal to the mean improvement observed with glucosamine sulfate, or (2) if their baseline standing knee pain (item #5 of the WOMAC pain scale) was "severe" or "extreme" and improved by any degree at the end of the trials. Changes in minimum joint space width were then compared between treatments. Results: Knee pain was of mild-to-moderate severity in the two original studies and in all patient subsets identified here. Obviously, there were more pain-improvers in the glucosamine sulfate than in the placebo subsets (N 76 vs 57 in pooling the two studies), but WOMAC pain scores improved to the same extent (over 50% relative to baseline). Notwithstanding such a major pain relief, patients in the placebo subsets of both studies suffered a definite mean (SE) joint space narrowing, that was of -0.22 (0.15) mm in the pooled analysis, and that was not observed with glucosamine sulfate: +0.15 (0.07) mm; P= 0.003. Similar evidence was found in the smaller subsets with at least severe baseline standing knee pain improving after 3 years. Conclusions: Knee pain relief did not bias the report of a structure-modifying effect of glucosamine sulfate in two recent long-term trials, possibly due to the mild-to-moderate patient characteristics. Consensus deliverables should acknowledge that the potential limitations of conventional standing antero-posterior radiographs should not be overestimated since they may not apply to all patient populations and to all studies using this gold standard technique. (C) 2006 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved. [less ▲]

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See detailThe assessment of kidney function
cohen, Eric P.; Krzesinski, Jean-Marie ULg

in Cohen, Eric P (Ed.) Cancer and the Kidney - The frontier of nephrology and oncology (2010)

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See detailAssessment of kidney function: estimating GFR in children.
DELANAYE, Pierre ULg; Ebert, Natalie

in Nature Reviews Nephrology (2012), 8(9), 503-504

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See detailAssessment of Lake Sediment Sensitivity along the North Anatolian Fault
Boes, Xavier; Ulas, Avsar; King, J et al

Conference (2007, October)

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See detailAssessment of Lake Sediment Sensitivity to Earthquakes and Climate Cycles along the North Anatolian Fault,
Boes, Xavier; Avsar, Ulas; King, J et al

in Geophysical Research Abstracts (2007, April), 9

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See detailAssessment of Lake Sediment Sensitivity to Earthquakes and Climate Cycles along the North Anatolian Fault,
Boes, Xavier; Avsar, Ulas; Doner, L. et al

Conference (2007, July)

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See detailAssessment of landslides activity in Maily‐Say Valley, Kyrgyz Tien Shan
Schlögel, Romy; Fernandez-Steeger, Tomas; Braun, Anika et al

in Landslide Science and Practice (2013)

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See detailAssessment of lipoxygenase activity in seed extracts from 35 plant species
Fauconnier, Marie-Laure ULg; Vanzeveren, E.; Marlier, Michel et al

in Grasas y Aceites (1995), 46(1), 6-10

Lipoxyganase activity in 35 seed extracts was determined an the basis of hydroperoxide synthesis using linoleic acid as substrate. The results referring to the extracted protein content show that several ... [more ▼]

Lipoxyganase activity in 35 seed extracts was determined an the basis of hydroperoxide synthesis using linoleic acid as substrate. The results referring to the extracted protein content show that several species of Vigna (V. unguiculata, V. radiata and V. mungo) and one of Trifolium exhibit stronger lipoxygenase activity than soybean enzyme extracts. The pH-activity relationship was also established for 4 very active samples. GCMS analysis revealed equal amounts of 9- and 13 hydroperoxides of linoleic acid In these seed extracts, indicating no enzyme positional specificity. [less ▲]

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See detailAssessment of long-term safety and efficacy of etanercept in a 5-year extension study in patients with rheumatoid arthritis.
Klareskog, L.; Gaubitz, M.; Rodriguez-Valverde, V. et al

in Clin Exp Rheumatol. 2011 Mar-Apr (2011)

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See detailAssessment of lumbopelvic movement control in tennis players with and without low back pain
GROSDENT, Stéphanie ULg; Demoulin, Christophe ULg; Lemaire, Vincent et al

Poster (2012, October)

Relevance: LBP is common among tennis players. More than one third of professional tennis players reported LBP as reason for missing at least one tournament. As impaired lumbar motor functions have been ... [more ▼]

Relevance: LBP is common among tennis players. More than one third of professional tennis players reported LBP as reason for missing at least one tournament. As impaired lumbar motor functions have been associated with LBP, it appears particularly relevant to assess lumbopelvic movement control in tennis players. Methods: Twenty amateur tennis players (male, 22.9 ± 3.0 years) were included. Subjects were pooled into two groups: 10 players with chronic LBP (mean pain duration: 3.1 ± 2.6 years, pain severity score: 3.5/10 on a pain visual analogue scale) and 10 players without LBP. The Bent Knee Fall Out (BKFO) test was used to assess the players’ ability to control movement of lumbopelvic region. BKFO was performed in supine position and monitored by means of two pressure biofeedback units inflated to 40 mmHg and positioned under the lumbar spine of the participant. The reliability of this test has been previously assessed. Players were instructed to make an active abduction-external rotation movement of the hip (45°) without concomitant lumbopelvic movement of the pelvis and low back. Pressure modification (mmHg) was recorded, each side was assessed. Results: Tennis players with LBP had a worse lumbopelvic movement control than players without LBP both for dominant (9.0 mm Hg vs 3.4 mmHg, P<0.05) as well for the non-dominant side (9.1 mmHg vs 4.6 mmHg, P<0.05). Conclusions: Tennis players with LBP experience similar alterations of motor control as those observed in sedentary people with LBP. However, it remains unclear if these alterations are the cause of the consequence of chronic LBP. Implications: Further prospective studies should assess the cause or effect relationship and should determine whether motor control exercises are effective in tennis players with chronic LBP. [less ▲]

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See detailAssessment of mechanobiological models for the numerical simulation of tissue differentiation around immediately loaded implants.
Geris, Liesbet ULg; Van Oosterwyck, H.; Vander Sloten, J. et al

in Computer Methods in Biomechanics & Biomedical Engineering (2003), 6(5-6), 277-88

Nowadays, there is a growing consensus on the impact of mechanical loading on bone biology. A bone chamber provides a mechanically isolated in vivo environment in which the influence of different ... [more ▼]

Nowadays, there is a growing consensus on the impact of mechanical loading on bone biology. A bone chamber provides a mechanically isolated in vivo environment in which the influence of different parameters on the tissue response around loaded implants can be investigated. This also provides data to assess the feasibility of different mechanobiological models that mathematically describe the mechanoregulation of tissue differentiation. Before comparing numerical results to animal experimental results, it is necessary to investigate the influence of the different model parameters on the outcome of the simulations. A 2D finite element model of the tissue inside the bone chamber was created. The differentiation models developed by Prendergast, et al. ["Biophysical stimuli on cells during tissue differentiation at implant interfaces", Journal of Biomechanics, 30(6), (1997), 539-548], Huiskes et al. ["A biomechanical regulatory model for periprosthetic fibrous-tissue differentiation", Journal of Material Science: Materials in Medicine, 8 (1997) 785-788] and by Claes and Heigele ["Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing", Journal of Biomechanics, 32(3), (1999) 255-266] were implemented and integrated in the finite element code. The fluid component in the first model has an important effect on the predicted differentiation patterns. It has a direct effect on the predicted degree of maturation of bone and a substantial indirect effect on the simulated deformations and hence the predicted phenotypes of the tissue in the chamber. Finally, the presence of fluid also causes time-dependent behavior. Both models lead to qualitative and quantitative differences in predicted differentiation patterns. Because of the different nature of the tissue phenotypes used to describe the differentiation processes, it is however hard to compare both models in terms of their validity. [less ▲]

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See detailAssessment of microbiological criteria for regular checks of faecal contamination and general hygiene in Belgian establishments producing meat
Ghafir, Yasmine; Daube, Georges ULg; Dierick, Katleen et al

in Sciences des Aliments (2003), 23(1), 104-106

Detailed reference viewed: 40 (3 ULg)