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See detailNew insights in auditory organ development: the inner pillar cell goes it own way
Thelen, Nicolas; Malgrange, B; Thiry, Marc ULg

Poster (2008)

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See detailNew insights in mammalian auditory organ development
Thelen, Nicolas ULg; Malgrange, Brigitte ULg; Thiry, Marc

Conference (2008, October 30)

Although the structure of the auditory organ in mature mammals, the organ of Corti, is clearly established, its development is far from being elucidated. Using cytochemical and immunohistochemical methods ... [more ▼]

Although the structure of the auditory organ in mature mammals, the organ of Corti, is clearly established, its development is far from being elucidated. Using cytochemical and immunohistochemical methods at the light and electron microscope levels, we examined its spatiotemporal development in rats from embryonic day 16 (E16) to E19. At E16, whatever the region of the cochlear studied (base, middle, apex), the organ of Corti was not present. We demonstrate that the organ of Corti develops from a non-proliferative cell zone that is located in the junctional region between the greater epithelial ridge and the lesser epithelial ridge of the cochlear duct and that is characterized by the presence of numerous microvilli. Using the periodic acid-thiocarbohydrazide-silver proteinate method, we revealed that the first cells to develop in this zone are the inner pillar cells, a particular type of nonsensory supporting cells. They arise in the base of the cochlear duct at the boundary between the two ridges at E16. The cell differentiation in this prosensory region continues according to a base-to-apex gradient, the inner hair cells appearing in the greater epithelial ridge at E17 and the outer hair cells in the lesser epithelial ridge at E18. At E19, all the different cell types of the organ of Corti are well in place. We also showed that the development of the inner pillar cells within the prosensory region does not involve Notch1 signaling. These results highlight the central role that the inner pillar cells could play in the development of the organ of Corti. [less ▲]

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See detailNew Insights in the History of the First International Congress of Geography (Antwerp, 1871).
Vandersmissen, Jan ULg

Conference (2004, August)

The internationalisation of geography gained its full strength after World War I. But this phenomenon originated in the third quarter of the nineteenth century, encouraged by the public attention for ... [more ▼]

The internationalisation of geography gained its full strength after World War I. But this phenomenon originated in the third quarter of the nineteenth century, encouraged by the public attention for exploration, the gradual professionalisation of geography at universities, and the organisation of international congresses. The first congres of this type was organised in Antwerp, Belgium, in 1871. The meeting set standards for all other pre-War international congresses of geography. In this contribution we give new insights in the realization of the Antwerp Congress. We focuss on the initiators Charles Ruelens, Jan-Hubert Van Raemdonck and Pierre Génard, their motives for action, the challenges and difficulties they found on their way. We discuss the collaboration between the Belgian organising committee and the European geographical societies, in particular the “Société de Géographie de Paris”. We discover how the first programme was drawn up en give a detailed image of the participants, paying attention to their origins and fields of interests. Finally we show the results of their debates and try to evaluate the lasting results of the encounter. This paper is based on the recently discovered archives of the first Congress in the City Archives of Antwerp. [less ▲]

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See detailNew insights in the thermomechanical modelling of soils
Laloui, Lyesse; François, Bertrand ULg

Conference (2007)

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See detailNew insights in the toxicology and health status of marine marine mammals: Use of free-ranging harbour seals from the Wadden Sea
Das, Krishna ULg; Seibel, Henrike; Hasseilmeier, Ilka et al

Conference (2011, March 20)

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See detailNew insights in toxic epidermal necrolysis (Lyell's syndrome): clinical considerations, pathobiology and targeted treatments revisited.
Paquet, Philippe ULg; Pierard, Gérald ULg

in Drug Safety : An International Journal of Medical Toxicology & Drug Experience (2010), 33(3), 189-212

Drug-induced toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, is a life-threatening drug reaction characterized by extensive destruction of the epidermis and mucosal epithelia. The eyes ... [more ▼]

Drug-induced toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, is a life-threatening drug reaction characterized by extensive destruction of the epidermis and mucosal epithelia. The eyes are typically involved in TEN. At present, the disease has a high mortality rate. Conceptually, TEN and the Stevens-Johnson syndrome are closely related, although their severity and outcome are different. Distinguishing TEN from severe forms of erythema multiforme relies on consideration of aetiological, clinical and histological characteristics. The current understanding of the pathomechanism of TEN suggests that keratinocytes are key initiator cells. It is probable that the combined deleterious effects on keratinocytes of both the cytokine tumour necrosis factor (TNF)-alpha and oxidative stress induce a combination of apoptotic and necrotic events. As yet, there is no evidence indicating the superiority of monotherapy with corticosteroids, ciclosporin (cyclosporine) or intravenous immunoglobulins over supportive care only for patients with TEN. However, the current theory of TEN pathogenesis supports the administration of a combination of antiapoptotic/antinecrotic drugs (e.g. anti-TNF-alpha antibodies plus N-acetylcysteine) targeting different levels of the keratinocyte failure machinery. [less ▲]

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See detailNew Insights Into Aortic Diseases A Report From the Third International Meeting on Aortic Diseases (IMAD3)
KUIVANIEMI, Helena; SAKALIHASAN, Natzi ULg; LEDERLE, Franck et al

in AORTA (2013), 1

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See detailNew insights into aphid isoprenoid pathway
Vandermoten, Sophie ULg; Cusson, Michel; Haubruge, Eric ULg et al

Conference (2010, August)

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See detailNew insights into peripherin expression in cochlear neurons
Lallemend, François; Vandenbosch, Renaud ULg; Hadjab, S. et al

in Neuroscience (2007), 150(1), 212-222

Peripherin is an intermediate filament protein that is expressed in peripheral and enteric neurons. In the cochlear nervous system, peripherin expression has been extensively used as a differentiation ... [more ▼]

Peripherin is an intermediate filament protein that is expressed in peripheral and enteric neurons. In the cochlear nervous system, peripherin expression has been extensively used as a differentiation marker by preferentially labeling the type II neuronal population at adulthood, but yet without knowing its function. Since the expression of peripherin has been associated in time with the process of axonal extension and during regeneration of nerve fibers in other systems, it was of interest to determine whether peripherin expression in cochlear neurons was a static phenotypic trait or rather prone to modifications following nerve injury. In the present study, we first compared the expression pattern of peripherin and beta III-tubulin from late embryonic stages to the adult in rat cochlea. The staining for both proteins was seen before birth within all cochlear neurons. By birth, and for 2 or 3 days, peripherin expression was gradually restricted to the type II neuronal population and their projections. In contrast, from postnatal day (P) 10 onwards, while the expression of beta III-tubulin was still found in projections of all cochlear neurons, only the type I population had beta III-tubulin immunoreactivity in their cell bodies. We next investigated the expression of peripherin in axotomized cochlear neurons using an organotypic explant model. Peripherin expression was surprisingly re-expressed in a vast majority of neurons after axotomy. In parallel, the expression and localization of beta III-tubulin and peripherin in dissociated cultures of cochlear neurons were studied. Both proteins were distributed along the entire neuronal length but exhibited complementary distribution, especially within the projections. Moreover, peripherin immunoreactivity was still abundant in the growth cone, whereas that of beta III-tubulin was decreasing at this compartment. Our findings are consistent with a model in which peripherin plays an important structural role in cochlear neurons and their projections during both development and regenerative processes and which is compatible with the assumption that frequently developmentally regulated factors are reactivated during neuronal regeneration. [less ▲]

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See detailNew Insights into Pervaporation Mass Transport under Increasing Downstream Pressure Conditions: Critical Role of Inert Gas Entrance.
Vallières, Cécile; Favre, Eric; Roizard, Denis et al

in Industrial & Engineering Chemistry Research (2001), 40

The influence of the total downstream pressure on the pervaporation flux of a pure compound through a dense polymer membrane has been the subject to controversial debates recently. Experimental arguments ... [more ▼]

The influence of the total downstream pressure on the pervaporation flux of a pure compound through a dense polymer membrane has been the subject to controversial debates recently. Experimental arguments in favor of either the solution−diffusion model or the newly proposed pore-flow model are alternatively reported on different systems. To critically reexamine this debate, an experimental study under controlled downstream conditions has been performed for pure methanol and pure 2-propanol pervaporation through a poly(dimethylsiloxane) film, the latter having been previously reported to follow pore-flow model predictions. It is shown that a rational analysis of the effects of the downstream pressure on the results can be achieved according to the classical solution−diffusion model, provided that the influence of air leaks in the installation is properly taken into account. Based on this observation, the implications of an inert gas contribution, generally speaking, on pervaporation operation are discussed. [less ▲]

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See detailNew insights into short-chain prenyltransferases: structural features, evolutionary history and potential for selective inhibition.
Vandermoten, Sophie ULg; Haubruge, Eric ULg; Cusson, M.

in Cellular and Molecular Life Sciences : CMLS (2009), 66

Isoprenoids form an extensive group of natural products involved in a number of important biological processes. Their biosynthesis proceeds through sequential 1'-4 condensations of isopentenyl diphosphate ... [more ▼]

Isoprenoids form an extensive group of natural products involved in a number of important biological processes. Their biosynthesis proceeds through sequential 1'-4 condensations of isopentenyl diphosphate (C(5)) with an allylic acceptor, the first of which is dimethylallyl diphosphate (C(5)). The reactions leading to the production of geranyl diphosphate (C(10)), farnesyl diphosphate (C(15)) and geranylgeranyl diphosphate (C(20)), which are the precursors of mono-, sesqui- and diterpenes, respectively, are catalyzed by a group of highly conserved enzymes known as short-chain isoprenyl diphosphate synthases, or prenyltransferases. In recent years, the sequences of many new prenyltransferases have become available, including those of several plant and animal geranyl diphosphate synthases, revealing novel mechanisms of product chain-length selectivity and an intricate evolutionary path from a putative common ancestor. Finally, there is considerable interest in designing inhibitors specific to short-chain prenyltransferases, for the purpose of developing new drugs or pesticides that target the isoprenoid biosynthetic pathway. [less ▲]

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See detailNew insights into the development pf ATP-sensitive potassium channel openers
Pirotte, Bernard ULg; De Tullio, Pascal ULg; Antoine, M.-H. et al

in Expert Opinion on Therapeutic Patents (2005), 15

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See detailNEW INSIGHTS INTO THE Early EVOLUTION OF LiFe: EVIDENCE FROM THE pilbara craton
Sugitani, Ken; Grey, Kath; Van Kranendonk, Martin et al

Conference (2010, September)

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See detailNew insights into the effect of amorolfine nail lacquer.
Flagothier, Caroline ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Mycoses (2005), 48(2), 91-4

Despite improvements in antifungal strategies, the outcome of treating onychomycoses often remains uncertain. Several factors account for treatment failure, of which the pharmacokinetics and ... [more ▼]

Despite improvements in antifungal strategies, the outcome of treating onychomycoses often remains uncertain. Several factors account for treatment failure, of which the pharmacokinetics and pharmacodynamics of the antifungal are of importance. The taxonomic nature and ungual location of the fungus cannot be neglected, besides the type of nail and its growth rate. In addition, the biological cycle of the fungus and the metabolic activity of the pathogen likely play a marked influence in drug response. The presence of natural antimicrobial peptides in the nail is also probably a key feature controlling the cure rates. There are many outstanding publications that cover the full spectrum of the field. The purpose of this review is to put in perspective some facets of activity of the topical treatment using amorolfine nail laquer. The antifungal activity of the drug is likely less pronounced in onychomycosis than that expected from conventional in vitro studies. However, the nail laquer formulation should reduce the propensity to form antifungal-resistant spores and limit the risk of reinfection. [less ▲]

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See detailNew insights into the metastasis-associated 67 kD laminin receptor.
Menard, S.; Castronovo, Vincenzo ULg; Tagliabue, E. et al

in Journal of Cellular Biochemistry (1997), 67(2), 155-65

The interactions between tumor cells and laminin or other components of the extracellular matrix have been shown to play an important role in tumor invasion and metastasis. These interactions are mediated ... [more ▼]

The interactions between tumor cells and laminin or other components of the extracellular matrix have been shown to play an important role in tumor invasion and metastasis. These interactions are mediated by different cell surface molecules, including the monomeric 67 kD laminin receptor. This molecule appears to be very peculiar since so, far only a full-length gene encoding a 37 kD precursor protein has been isolated and the mechanism by which the precursor reaches the mature form is not understood. Based on clinical data, which clearly demonstrate the importance of the receptor in tumor progression, studies were conducted to define the structure, expression, and function of this laminin receptor as a step toward developing therapeutic strategies that target this molecule. The data suggest that acylation of the precursor is the key mechanism in maturation of the 67 kD form. The function of the membrane receptor is to stabilize the binding of laminin to cell surface integrins, acting as an integrin-accessory molecule, although homology of the gene encoding the receptor precursor with other genes suggests additional functions. Downregulation of the receptor expression on tumor cells might open new therapeutic approaches to decrease tumor aggressiveness. [less ▲]

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See detailNew insights into the nature of the peculiar star theta Carinae
Hubrig, S.; Briquet, Maryline ULg; Morel, Thierry ULg et al

in Astronomy and Astrophysics (2008), 488

Context: θ Carinae belongs to a group of peculiar early-type stars (OBN) with enhanced nitrogen and carbon deficiency. It is also known as a binary system, but it is not clear yet whether the chemical ... [more ▼]

Context: θ Carinae belongs to a group of peculiar early-type stars (OBN) with enhanced nitrogen and carbon deficiency. It is also known as a binary system, but it is not clear yet whether the chemical anomalies can be explained by mass transfer between the two components. On the basis of the previously reported spectral variability of a few metal lines it may be expected that θ Car possesses a weak magnetic field. <BR />Aims: A study of the physical nature of this hot massive binary which is furthermore a well-known blue straggler lying ~2 mag above the turnoff of the young open cluster IC 2602 is important to understand the origin of its strong chemical anomalies. <BR />Methods: We acquired high resolution spectroscopic and low resolution spectropolarimetric observations to achieve the following goals: a) to improve the orbital parameters to allow a more in-depth discussion on the possibility of mass transfer in the binary system; b) to carry out a non-local thermodynamic equilibrium (NLTE) abundance analysis; and c) to search for the presence of a magnetic field. <BR />Results: The study of the radial velocities using CORALIE spectra allowed us to significantly improve the orbital parameters. A comparative NLTE abundance analysis was undertaken for θ Car and two other early B-type stars with recently detected magnetic fields, Ï Sco and ξ[SUP]1[/SUP] CMa. The analysis revealed significantly different abundance patterns: a one-order-of-magnitude nitrogen overabundance and carbon depletion was found in θ Car, while the oxygen abundance is roughly solar. For the stars ξ[SUP]1[/SUP] CMa and Ï Sco the carbon abundance is solar and, while an N excess is also detected, it is of much smaller amplitude (0.4-0.6 dex). Such an N overabundance is typical of the values already found for other slowly-rotating (magnetic) B-type dwarfs. For θ Car, we attribute instead the chemical peculiarities to a past episode of mass transfer between the two binary components. The results of the search for a magnetic field using FORS 1 at the VLT consisting of 26 measurements over a time span of ~1.2 h are rather inconclusive: only few measurements have a significance level of 3Ï . Although we detect a periodicity of the order of ~8.8 min in the dataset involving the measurements on all hydrogen Balmer lines with the exception of the Hα and Hβ lines, these results have to be confirmed by additional time-resolved magnetic field observations. Based on observations collected with the CORALIE spectrograph attached to the Euler Telescope of the Geneva Observatory located at La Silla (Chile), at the European Southern Observatory, Paranal, Chile (ESO programmes 67.D-0239(A), 072.D-0377(A), 078.D-0080(A) and 278.D-5056(A)), and at the Complejo Astronómico El Leoncito (CASLEO), Argentina. [less ▲]

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See detailNew insights into the nature of the SMC WR/LBV binary HD 5980
Foellmi, C.; Koenigsberger, G.; Georgiev, L. et al

in Revista Mexicana de Astronomía y Astrofísica (2008), 44(1), 3-27

We present the results of optical wavelength observations of the unusual SMC eclipsing binary system HD 5980 obtained in 1999 and 2004-2005. Radial velocity curves for the erupting LBV/WR object (star A ... [more ▼]

We present the results of optical wavelength observations of the unusual SMC eclipsing binary system HD 5980 obtained in 1999 and 2004-2005. Radial velocity curves for the erupting LBV/WR object (star A) and its close WR-like companion (star B) are obtained by deblending the variable emission-line profiles of NIV and NV lines. The derived masses M-A = 58 - 79 M-circle dot and M-B = 51 - 67 M-circle dot, are more consistent with the the stars' location near the top of the HRD than previous estimates. The presence of a wind-wind interaction region is inferred from the orbital phase-dependent behavior of He I P Cygni absorption components. The emission-line intensities continued with the declining trend previously seen in UV spectra. The behavior of the photospheric absorption lines is consistent with the results of Schweickhardt (2000) who concludes that the third object in the combined spectrum, star C, is also a binary system with P-starC similar to 96.5 days, e=0.83. [less ▲]

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