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See detailA new treatment for the reduction of vertebral and non-vertebral fractures in post-menopausal women with osteoporosis
Reginster, Jean-Yves ULg; Brixen, Kim; Bianchi, Gerolamo et al

in Arthritis and Rheumatism (2004, September), 50(number 9 (suppl.)), 291

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See detailNew trends in anti-malarial agents
Frederich, Michel ULg; Dogné, Jean-Michel ULg; Angenot, Luc ULg et al

in Current Medicinal Chemistry (2002), 9(15), 1435-1456

Malaria is the major parasitic infection in many tropical and subtropical regions, leading to more than one million deaths (principally young African children) out of 400 million cases each year (WHO ... [more ▼]

Malaria is the major parasitic infection in many tropical and subtropical regions, leading to more than one million deaths (principally young African children) out of 400 million cases each year (WHO world health report 2000). More than half of the world's population live in areas where they remain at risk of malaria infection. During last years, the situation has worsened in many ways, mainly due to malarial parasites becoming increasingly resistant to several antimalarial drugs. Furthermore, the control of malaria is becoming more complicated by the parallel spread of resistance of the mosquito vector to currently available insecticides. Discovering new drugs in this field is therefore a health priority. Several new molecules are under investigation. This review describes the classical treatments of malaria and the latest discoveries in antimalarial agents, especially artemisinin and its recent derivatives as well as the novel peroxidic compounds. [less ▲]

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See detailNew trends in clinical toxicology
Charlier, Corinne ULg; Plomteux, Guy ULg

Conference (1996, October)

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See detailNew Trends in Computing Anticipatory Systems : Emergence of Artificial Conscious Intelligence with Machine Learning Natural Language
Dubois, Daniel ULg

in Dubois, Daniel (Ed.) COMPUTING ANTICIPATORY SYSTEMS (2008)

This paper deals with the challenge to create an Artificial Intelligence System with an Artificial Consciousness. For that, an introduction to computing anticipatory systems is presented, with the ... [more ▼]

This paper deals with the challenge to create an Artificial Intelligence System with an Artificial Consciousness. For that, an introduction to computing anticipatory systems is presented, with the definitions of strong and weak anticipation. The quasi-anticipatory systems of Robert Rosen are linked to open-loop controllers. Then, some properties of the natural brain are presented in relation to the triune brain theory of Paul D. MacLean, and the mind time of Benjamin Libet, with his veto of the free will. The theory of the hyperincursive discrete anticipatory systems is recalled in view to introduce the concept of hyperincursive free will, which gives a similar veto mechanism: free will as unpredictable hyperincursive anticipation The concepts of endo-anticipation and exo-anticipation are then defined. Finally, some ideas about artificial conscious intelligence with natural language are presented, in relation to the Turing Machine, Formal Language, Intelligent Agents and Mutli-Agent System. [less ▲]

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See detailNew trends in dual 5-LOX/COX inhibition
De Leval, X.; Julémont, F.; Delarge, J. et al

in Current Medicinal Chemistry (2002), 9

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See detailNew trends in flood risk analysis: working with 2D flow models, laser DEM and a GIS environment
Archambeau, Pierre ULg; Dewals, Benjamin ULg; Erpicum, Sébastien ULg et al

in Greco, M.; Carravetta, A.; Della Morte, R. (Eds.) Proceedings of the 2nd International Conference on Fluvial Hydraulics: River Flow 2004 (2004)

This paper outlines the integration of new and accurate laser DEM into the determination of floodplains. Global and robust GIS environment is absolutely necessary to manage this very large amounts of ... [more ▼]

This paper outlines the integration of new and accurate laser DEM into the determination of floodplains. Global and robust GIS environment is absolutely necessary to manage this very large amounts of topographic data. The development and interaction of 2D flow models, simplified or not, ensures to offer more accurate and flexible physically based tools to the decision-makers. [less ▲]

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See detailNew Trends in Hot Strip Mill Roughing Mills: Characterization of High Chromium Steel and Semi-HSS Grades
Lecomte-Beckers, Jacqueline ULg; Sinnaeve, Mario; Tchuindjang, Jérôme Tchoufack ULg

in Proceedings of the Iron & Steel Technology Conference (AISTech 2011) (2011)

Two alloys grades for work rolls used in the roughing stand of Hot Strip Mill (HSM) are compared. The first grade known as High Chromium Steel (HCS) is presently the most widely used alloy for such an ... [more ▼]

Two alloys grades for work rolls used in the roughing stand of Hot Strip Mill (HSM) are compared. The first grade known as High Chromium Steel (HCS) is presently the most widely used alloy for such an application, while the second one known as semi-High-speed Steel (semi-HSS) is the new grade developed to improve the overall performance of the work roll in the roughing stands of the HSM. In the present paper, the new semi-HSS grade is studied starting from three chemical compositions closed one to another, the variation in the alloying elements is intended to assess, on one hand the effect of a small increase of the carbon content, and on the other hand the influence of the addition of a strong MC carbide forming element. The comparison of HCS and semi-HSS grades involves many fields. Regarding the metallurgical aspect, such a comparison led to the enhancement of the solidification range, the crystallization behavior and the microstructure in the as-cast condition for both grades. Furthermore, corrosion behavior and performances of the work rolls in service are compared. Various techniques are used in order to characterize both grades, such as Differential Thermal Analysis (to determine phase transformations temperatures, the crystallization behavior and the interval of solidification), hardness measurements, optical microscopy, scanning electron microscopy associated with energy dispersive X-ray spectroscopy (to determine the nature and the composition of phases, especially matrix and carbides). Finally micro-macro relations between the nature of the microstructure and the properties of HCS and semi-HSS rolls grades in service conditions could be established. [less ▲]

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See detailNew trends in selenium-labeled compounds synthesis.
Christiaens, L.; Guillaume, M.; Luxen, André ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1982), 19

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See detailNew trends in the design of drugs against Alzheimer's disease
Francotte, Pierre ULg; De Tullio, Pascal ULg; Fraikin, Pierre ULg et al

in Frontiers in Medicinal Chemistry (2006), 3

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See detailNew trends in the design of drugs against Alzheimer's disease
Francotte, Pierre ULg; Graindorge, Emmanuel; Boverie, Stéphane et al

in Current Medicinal Chemistry (2004), 11(13), 1757-1778

First described by Alois Alzheimer in 1907, Alzheimer's disease (AD) is the most common dementia type, affecting approximately 20 million people worldwide. As the population is getting older, AD is a ... [more ▼]

First described by Alois Alzheimer in 1907, Alzheimer's disease (AD) is the most common dementia type, affecting approximately 20 million people worldwide. As the population is getting older, AD is a growing health problem. AD is currently treated by symptomatic drugs, the acetylcholinesterase inhibitors. based on the cholinergic hypothesis (1976). During the past decade, advances in neurobiology have conducted to the identification of new targets. Although some of these innovative approaches tend to delay onset of AD, others are still symptomatic. In this review, we present an overview of the several strategies and new classes of compounds against AD. [less ▲]

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See detailNew trends in the development of positive allosteric modulators of AMPA receptors
Graindorge, E.; Francotte, Pierre ULg; Boverie, S. et al

in Current Medicinal Chemistry - Central Nervous System Agents (2004), 4

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See detailNew trends in the diagnosis and treatment of recurrent inflammation in competition horses
Lekeux, Pierre ULg; Thomas, A.; Art, Tatiana ULg et al

in Pferdeheilkunde (2006)

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See detailNEW TRENDS IN VALIDATION OF ANALYTICAL METHODS
Rozet, Eric ULg; Hubert, Philippe ULg

Conference (2011, September 08)

Analytical method validation is a mandatory step to evaluate the ability of developed methods to provide accurate results for their routine application in order to trust the critical decisions that will ... [more ▼]

Analytical method validation is a mandatory step to evaluate the ability of developed methods to provide accurate results for their routine application in order to trust the critical decisions that will be made with them. Even if several guidelines exist to help perform analytical method validations (ICH Q2R1 [1], USP <1225> [2], …) there is still the need to clarify the meaning and interpretation of analytical method validation criteria and methodology. Indeed, actually method validation is mostly realised as the traditional check list implementation of e.g. the ICH Q2R1 or USP <1225> method validation requirements. However, within the trend of Quality by Design [3], there is the need to switch from this traditional vision to an analytical method validation really adding value and providing a high level of assurance of analytical methods results reliability. Yet, different interpretations can be made of the validation guidelines as well as for the definitions of the validation criteria. This will lead to diverse experimental designs implemented to try fulfilling these criteria. Finally, different decision methodologies can also be interpreted from these guidelines. Therefore, the risk that a validated analytical method may be unfit for its future purpose will depend on a personal interpretation of these guidelines. The objective of this presentation is thus to show that analytical method validation should be planned and performed by first starting with the end in mind: what is the objective of the analytical methods under study? In such a way analytical method validation is coherent with the actual Quality by Design regulatory expectations. The risk of having validated an analytical method unfit for its purpose is strongly reduced as well as the risk of generating Out of Specification (OOS) results due to an unfit method. References [1] International Conference on Harmonisation (ICH) of Technical Requirements for registration of Pharmaceuticals for Human Use, Topic Q2 (R1): Validation of Analytical Procedures: Text and Methodology, Geneva, 2005. [2] USP 33 NF 28 S1, U.S. Pharmacopeia, 2007. USP–NF General Chapter <1225>. [3] International Conference on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use, Topic Q8(R2): Pharmaceutical development, Geneva, 2009. [less ▲]

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See detailNew trends on real time measurement on power lines : application to ampacity, aeolian vibrations and others
Lilien, Jean-Louis ULg

Conference given outside the academic context (2008)

new trends in real time monitoring onpower lines using mycrosystems

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See detailNew tripodal iminophosphorane-based ethylene oligomerization catalysts - Part II. Catalytic behavior
Beaufort, Laurence; Benvenuti, Federica; Delaude, Lionel ULg et al

in Journal of Molecular Catalysis A : Chemistry (2008), 283(1-2), 77-82

Seven transition-metal complexes of general formula RC(CH2NPR'(3))(3))MX2 based on new tripodal iminophosphorane ligands were investigated as initiators for the oligomerization of ethylene in the presence ... [more ▼]

Seven transition-metal complexes of general formula RC(CH2NPR'(3))(3))MX2 based on new tripodal iminophosphorane ligands were investigated as initiators for the oligomerization of ethylene in the presence of aluminum co-catalysts using high-throughput techniques. In all cases, ethylene consumption peaked at ca. 30 degrees C and was not drastically affected by varying the nature of the metal (M = Ni, Fe, Pd, Cu), the aluminum co-catalyst (MMAO, Et2AlCl, or EtAlCl2) or the substituents of the tris(iminophosphorane) ligand (R = Me, Ph; R'= cyclopentyl, Ph). Structural modifications of the organometallic complexes, either at the metal center or within the tripodal ligand, however, had a significant impact on the oligomer distribution obtained. In particular, Pd-based catalyst (PhC(CH2NPPh3)(3))PdCl2 displayed an excellent selectivity toward hexene formation. (c) 2007 Elsevier B.V. All rights reserved. [less ▲]

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See detailA new tripodal ligand system based on the iminophosphorane functional group. Part 1: Synthesis and characterization
Beaufort, Laurence; Delaude, Lionel ULg; Noels, Alfred ULg

in Tetrahedron (2007), 63(30), 7003-7008

Two tripodal alcohols, viz., 1,1,1-tris(hydroxymethyl) ethane and alpha, alpha, alpha-tris(hydroxymethyl) toluene were converted by an efficient multi-step pathway involving azide formation into the ... [more ▼]

Two tripodal alcohols, viz., 1,1,1-tris(hydroxymethyl) ethane and alpha, alpha, alpha-tris(hydroxymethyl) toluene were converted by an efficient multi-step pathway involving azide formation into the corresponding tris(iminophosphorane) scaffolds bearing cyclopentyl (Cp) or phenyl groups on their phosphorus atoms, R-C(CH2-N] PR'(3))(3) (R Me or Ph, R'=Cp or Ph). The synthesis of some representative transition-metal complexes of Cu(I), Cu(II), Ni(II), and Pd(II) bearing these new tridentate ligands is also reported. (C) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailA new two-level algorithm for large power systems estimation
Van Cutsem, Thierry ULg; Horward, J-L; Ribbens-Pavella, Mania

in Proc. 7th Power Systems Computation Conference (1981)

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See detailA New Type of Ambiguity in the Planet and Binary Interpretations of Central Perturbations of High-magnification Gravitational Microlensing Events
Choi, J.-Y.; Shin, I.-G.; Han, C. et al

in Astrophysical Journal (2012), 756

High-magnification microlensing events provide an important channel to detect planets. Perturbations near the peak of a high-magnification event can be produced either by a planet or a binary companion ... [more ▼]

High-magnification microlensing events provide an important channel to detect planets. Perturbations near the peak of a high-magnification event can be produced either by a planet or a binary companion. It is known that central perturbations induced by both types of companions can be generally distinguished due to the essentially different magnification pattern around caustics. In this paper, we present a case of central perturbations for which it is difficult to distinguish the planetary and binary interpretations. The peak of a lensing light curve affected by this perturbation appears to be blunt and flat. For a planetary case, this perturbation occurs when the source trajectory passes the negative perturbation region behind the back end of an arrowhead-shaped central caustic. For a binary case, a similar perturbation occurs for a source trajectory passing through the negative perturbation region between two cusps of an astroid-shaped caustic. We demonstrate the degeneracy for two high-magnification events of OGLE-2011-BLG-0526 and OGLE-2011-BLG-0950/MOA-2011-BLG-336. For OGLE-2011-BLG-0526, the χ[SUP]2[/SUP] difference between the planetary and binary model is ~3, implying that the degeneracy is very severe. For OGLE-2011-BLG-0950/MOA-2011-BLG-336, the stellar binary model is formally excluded with Δχ[SUP]2[/SUP] ~ 105 and the planetary model is preferred. However, it is difficult to claim a planet discovery because systematic residuals of data from the planetary model are larger than the difference between the planetary and binary models. Considering that two events observed during a single season suffer from such a degeneracy, it is expected that central perturbations experiencing this type of degeneracy is common. [less ▲]

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