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See detailN-REM sleep slow oscillations amplitude and density in the young and middle-aged men and women
Viens, I; Lafortune, M; Poirier, G et al

Poster (2009, April)

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See detailN-REM sleep slow oscillations amplitude and density in the young and middle-aged men and women
Viens, I; Lafortune, M; Poirier, G et al

in Sleep (2009), 32(Suppl. 1),

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See detailThe N-terminal 12 residue long peptide of HIV gp41 is the minimal peptide sufficient to induce significant T-cell-like membrane destabilization in vitro.
Charloteaux, Benoît ULg; Lorin, A.; Crowet, Jean-Marc ULg et al

in Journal of molecular biology (2006), 359(3), 597-609

Here, we predicted the minimal N-terminal fragment of gp41 required to induce significant membrane destabilization using IMPALA. This algorithm is dedicated to predict peptide interaction with a membrane ... [more ▼]

Here, we predicted the minimal N-terminal fragment of gp41 required to induce significant membrane destabilization using IMPALA. This algorithm is dedicated to predict peptide interaction with a membrane. We based our prediction of the minimal fusion peptide on the tilted peptide theory. This theory proposes that some protein fragments having a peculiar distribution of hydrophobicity adopt a tilted orientation at a hydrophobic/hydrophilic interface. As a result of this orientation, tilted peptides should disrupt the interface. We analysed in silico the membrane-interacting properties of gp41 N-terminal peptides of different length derived from the isolate BRU and from an alignment of 710 HIV strains available on the Los Alamos National Laboratory. Molecular modelling results indicated that the 12 residue long peptide should be the minimal fusion peptide. We then assayed lipid-mixing and leakage of T-cell-like liposomes with N-terminal peptides of different length as first challenge of our predictions. Experimental results confirmed that the 12 residue long peptide is necessary and sufficient to induce membrane destabilization to the same extent as the 23 residue long fusion peptide. In silico analysis of some fusion-incompetent mutants presented in the literature further revealed that they cannot insert into a modelled membrane correctly tilted. According to this work, the tilted peptide model appears to explain at least partly the membrane destabilization properties of HIV fusion peptide. [less ▲]

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See detailThe N-Terminal Juxtamembranous Domain Of Kcnq1 Is Critical For Channel Surface Expression - Implications In The Romano-Ward Lqt1 Syndrome
Dahimene, S.; Alcolea, S.; Naud, P. et al

in Circulation Research (2006), 99(10), 1076-83

arrhythmias in newborn children and adolescents but the cellular mechanisms involved in this dramatic issue remain, however, to be discovered. Here, we analyzed the trafficking of a series of N-terminal ... [more ▼]

arrhythmias in newborn children and adolescents but the cellular mechanisms involved in this dramatic issue remain, however, to be discovered. Here, we analyzed the trafficking of a series of N-terminal truncation mutants and identified a critical trafficking motif of KCNQ1. This determinant is located in the juxtamembranous region preceding the first transmembrane domain of the protein. Three mutations (Y111C, L114P and P117L) implicated in inherited Romano-Ward LQT1 syndrome, are embedded within this domain. Reexpression studies in both COS-7 cells and cardiomyocytes showed that the mutant proteins fail to exit the endoplasmic reticulum. KCNQ1 subunits harboring Y111C or L114P exert a dominant negative effect on the wild-type KCNQ1 subunit by preventing plasma membrane trafficking of heteromultimeric channels. The P117L mutation had a less pronounced effect on the trafficking of heteromultimeric channels but altered the kinetics of the current. Furthermore, we showed that the trafficking determinant in KCNQ1 is structurally and functionally conserved in other KCNQ channels and constitutes a critical trafficking determinant of the KCNQ channel family. Computed structural predictions correlated the potential structural changes introduced by the mutations with impaired protein trafficking. In conclusion, our studies unveiled a new role of the N-terminus of KCNQ channels in their trafficking and its implication in severe forms of LQT1 syndrome. [less ▲]

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See detailN-tert-butyl-N'-[5-cyano-2-(4-methylphenoxy)phenylsulfonyl]urea, a new TXA₂ receptor antagonist
Bambi Nyanguile, S.M.; Mangwala Kimpende, P.; Pirotte, Bernard ULg et al

in Acta Crystallographica Section C-Crystal Structure Communications (2013), 69

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See detailN-type and p-type ultra shallow junctions by atomic layer epitaxy and laser anneal
Nguyen, Ngoc Duy ULg; Souriau, Laurent; Shimizu, Yasuo et al

Conference (2011)

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See detail"N-VA wil federale staat uitkleden" (interview de presse)
Behrendt, Christian ULg

Article for general public (2011)

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See detailThe n-Zipf analysis of financial data series and biased data series
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physica A: Statistical Mechanics and its Applications (1999), 268(1-2), 240-249

The Zipf analysis of n-words in random sequences and financial data series like the stock prices of a company has been performed. The bias as well as the resulting staircase structure of the Zipf plots ... [more ▼]

The Zipf analysis of n-words in random sequences and financial data series like the stock prices of a company has been performed. The bias as well as the resulting staircase structure of the Zipf plots are taken into account in the subsequent analysis. It is found that correlations for the sign of the fluctuations as well as for the amplitude of the fluctuations can be found in financial time series. The relevance of the n-Zipf analysis to financial sequences is underlined to be only weakly predictive for a "binary transformation level", but could be more interesting for "higher translation levels". [less ▲]

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See detailN.B.
Lecocq, Pascale ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2011), (24), 1134-1137-1138

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See detailN.C.A. asymmetric syntheses of a-methyl and b-hydroxy a-amino acid labelled with fluorine-18 for probing enzymatic function.
Damhaut, Ph.; Lemaire, Christian ULg; Plenevaux, Alain ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1994), 35

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See detailN1,N2,N3-trisisopentenyl guanidine and N1,N2-diisopentenyl guanidine, two cytotoxic alkaloids from Alchornea cordifolia (Schumach.& Thonn.) Mull. Arg. (Euphorbiaceae) root barks.
Mavar-Manga, H.; Chapon, David; Hoet, Sara et al

in Natural Product Communications [=NPC] (2006), 1(12), 1097-1100

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See detailN2-cyano-N1-isopropyl-N3-[4-(3-methylphenylamino)-3-pyridylsulfonyl]guanidine
Dupont, L.; Masereel, B.; De Tullio, Pascal ULg et al

in Acta Crystallographica (1995), C51

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See detailNa channel purification by ion exchange and affinity chromatography
Bontemps, J; Grandfils, Christian ULg; Dandrifosse, Guy ULg et al

Poster (1984, May 30)

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See detailNa et K anormaux : A quoi faut-il penser?
Krzesinski, Jean-Marie ULg

Conference (2008, October 23)

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See detailNa(1.50)Mn(2.48)Al(0.85)(Po4)3, a New Synthetic Alluaudite-Type Compound
Hatert, Frédéric ULg

in Acta Crystallographica Section C-Crystal Structure Communications (2006), 62(Pt 1), 1-2

The first hydrothermal synthesis of an Al-rich alluaudite-type compound, namely disodium dimanganese aluminium tris(phosphate), which has been obtained at 1073 K and 0.1 GPa starting from the composition ... [more ▼]

The first hydrothermal synthesis of an Al-rich alluaudite-type compound, namely disodium dimanganese aluminium tris(phosphate), which has been obtained at 1073 K and 0.1 GPa starting from the composition Na2Mn2Al(PO4)(3), is reported. The crystal structure, which has been refined in the monoclinic C2/c space group, is identical to that of natural alluaudite. The structure consists of kinked chains of edge-sharing M1 and M2 octahedra, which contain Mn2+ and Al3+ ions. The chains are stacked parallel to {101} and are connected in the b direction by the P1 and P2 tetrahedra. These interconnected chains produce channels parallel to c, which contain the large A1 and AT sites occupied by Na+ and Mn2+ ions. [less ▲]

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See detailNa+,2Cl-,K+ cotransport system as a marker of antihypertensive activity of new torasemide derivatives
Masereel, B.; Ferrari, P.; Ferrandi, M. et al

in European Journal of Pharmacology (1992), 219

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See detailThe Na+/PO4 cotransporter SLC20A1 gene labels distinct restricted subdomains of the developing pronephros in Xenopus and zebrafish embryos.
Nichane, Massimo; Van Campenhout, Claude; Pendeville, Helene et al

in Gene Expression Patterns (2006), 6(7), 667-72

The embryonic pronephric kidneys of Xenopus and zebrafish serve as models to study vertebrate nephrogenesis. Recently, multiple subdomains within the Xenopus pronephros have been defined based on the ... [more ▼]

The embryonic pronephric kidneys of Xenopus and zebrafish serve as models to study vertebrate nephrogenesis. Recently, multiple subdomains within the Xenopus pronephros have been defined based on the expression of several transport proteins. In contrast, very few studies on the expression of renal transporters have been conducted in zebrafish. We have recently shown that the anterior and posterior segments of the zebrafish pronephric duct may correspond to the proximal tubule and distal tubule/duct compartments of the Xenopus and higher vertebrate pronephros, respectively. Here, we report the embryonic expression pattern of the Na(+)/PO(4) cotransporter SLC20A1 (PiT1/Glvr-1) gene encoding a type III sodium-dependent phosphate cotransporter in Xenopus and zebrafish. In Xenopus, SLC20A1 mRNA is expressed in the somitic mesoderm and lower level of expression is detected in the neural tube, eye, and neural crest cells. From stage 25, SLC20A1 is also detectable in the developing pronephros where expression is restricted to the late portion of the distal pronephric tubules. In zebrafish, SLC20A1 is transcribed from mid-somitogenesis in the anterior part of the pronephros where its expression corresponds to the rostral portion of the expression of other proximal tubule-specific markers. Outside the pronephros, lower level of SLC20A1 expression is also observed in the posterior cardinal and caudal veins. Based on the SLC20A1 expression domain and that of other transporters, four segments have been defined within the zebrafish pronephros. Together, our data reveal that the zebrafish and Xenopus pronephros have non-identical proximo-distal organizations. [less ▲]

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See detailNa-23 2D 3QMAS NMR and Si-29, Al-27 MAS NMR investigations of Laponite and synthetic saponites of variable interlayer charge
Delevoye, Laurent; Robert, Jean-Louis; Grandjean, Jean ULg

in Clay Minerals (2003), 38

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