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See detailA multidisciplinary approach to understanding the sea ice system: implications on gas. Gordon Research Seminars
Zhou, Jiayun ULg; Tison, Jean-Louis; Eicken, Hajo et al

Conference (2011, March)

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See detailMultidisciplinary approaches and fractionations to study lower termite symbiotic system and ligno-cellulose digestion
Bauwens, Julien ULg; Brasseur, Catherine ULg; Tarayre, Cédric ULg et al

Poster (2014, August)

Wood-feeding termites are a considerable source of enzymes active on ligno-cellulosic compounds. These enzymes are produced by the termite host and some representatives of its symbiotic microbial ... [more ▼]

Wood-feeding termites are a considerable source of enzymes active on ligno-cellulosic compounds. These enzymes are produced by the termite host and some representatives of its symbiotic microbial community, and are of particular interest in regard second generation biofuel. However, the complexity of microbial interactions renders micro-organisms isolation very difficult. Culture-independent methods permitted to gather a large amount of data and to understand a little more the role of each microbial population, particularly the prokaryotes. Proteomics allows working on the final product of gene expression, and corresponds more to the real operation of the digestive system. In order to investigate such a complex system, it is necessary to use multidisciplinary approaches and to fractionate this system. Zymography or affinity chromatography are used in parallel of routine proteomics techniques such as two-dimensional gel electrophoresis associated to MALDI-TOF mass spectrometry and nano-LC ESI-MS/MS. We used an artificial-diet based rearing to induce changes in microbial population balance. We performed preliminary assay to investigate the glycosylated proteome in the hindgut of a lower termite, using Multi-Lectin Affinity Chromatography (M-LAC) and enzymatic activity of harvested fractions was assessed on cellulosic substrates. [less ▲]

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See detailMultidisciplinary rehabilitation program after breast cancer : potential benefits analysis on physical function and quality of life
LECLERC, Anne-France ULg; FOIDART-DESSALLE, Marguerite ULg; COUCKE, Philippe ULg et al

in 29ème Congrès de la Sofmer et 19ème Congrès européen de Médecine Physique et de Réadaptation (2014, May 26)

Objective: To determine the potential benefits, both physically and psychologically, of a multidisciplinary rehabilitation program among women treated for breast cancer. Materials and Methods: Thirty ... [more ▼]

Objective: To determine the potential benefits, both physically and psychologically, of a multidisciplinary rehabilitation program among women treated for breast cancer. Materials and Methods: Thirty patients were recruited, sixteen in the control group and fourteen in the treated group. This group has benefited from a rehabilitation of three months including a supervised training and various psycho-educational sessions. The assessments, performed before and after the programme, included anthropometric and body composition measurements, a functional assessment and various questionnaires. Results: After three months, the health state (quality of life), emotional state, physical, cognitive and social functions and the symptoms of insomnia and anxiety significantly improve in the treated group. This observation also applies to the flexibility, maximal aerobic power / body weight, time to exhaustion during the physical effort test and walking distance in six minutes. In the control group, these improvements do not appear. Discussion: This preliminary study demonstrates the feasibility and benefits of a multidisciplinary approach in women after their treatments for breast cancer. [less ▲]

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See detailMultidisciplinary study of the trophic diversity and functional role of amphipod crustaceans associated to Posidonia oceanica meadows
Michel, Loïc ULg; Lepoint, Gilles ULg; Gobert, Sylvie ULg et al

Poster (2009, November 27)

Posidonia oceanica is a seagrass endemic to the Mediterranean Sea, and is able to form large monospecific areas, called meadows. These meadows are critical features of the Mediterranean coastal zones, and ... [more ▼]

Posidonia oceanica is a seagrass endemic to the Mediterranean Sea, and is able to form large monospecific areas, called meadows. These meadows are critical features of the Mediterranean coastal zones, and are of great ecologic and economic importance. Posidonia oceanica meadows shelter high biomasses and biodiversities of amphipod crustaceans. In other temperate meadows, such as Atlantic Zostera marina meadows, the amphipods play an important part in the functioning of the ecosystem, notably in organic matter transfers from producers to higher level consumers. However, the situation in Posidonia oceanica meadows remains unclear, due to the lack of precise studies, and little is known about the trophic ecology of amphipods. In this context, our research is structured in three main tasks. We chose the Calvi Bay (NW Corsica, France) as a study site, and sampling is undertaken from the STARESO research station (University of Liège, Belgium). First, we study the exact composition of the amphipod community, as well as its temporal variation at diel and seasonal scale. This task is based on in situ collection of samples using three methods: the hand-towed net, litter collection and light traps. Completion of this task will allow us to have accurate and reliable data, taken on our study site, concerning the abundance and specific diversity of amphipods associated with P. oceanica meadows. The second task is a reconstruction of the diet of the studied animals. Indeed, amphipods from P. oceanica meadows are usually regarded as vegetal epiphytes grazers, or generalist detritivores, but few studies focus on the interspecific trophy diversity, or on the importance of alternative food sources. Our approach relies on in situ sampling of amphipods and potential food items. The techniques used combine traditional methods (gut content observation) and use of trophic markers, such as measurements of C and N stable isotope rations and fatty acid composition analysis. Finally, we use in vitro and in situ microcosms experiments to evaluate the impact of amphipod feeding activity on the ecosystem functioning, and more precisely on the dynamics of the epiphyte cover. By quantifying this interaction, our purpose is to put back the results obtained in the first two parts into a wider context, the functioning of the Posidonia oceanica meadow as an ecosystem. Thus, by combining in situ sampling and in vitro experimentation, and by combining traditional and innovating techniques, we hope, at the end of this research, to enhance the knowledge of the trophic diversity and the functional role of amphipod crustaceans associated with Mediterranean Posidonia meadows. [less ▲]

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See detailMultidisciplinary study of the Wealden deposits in the Mons Basin (Belgium): a progress report.
Yans, J; Spagna, P; Foucher, JC et al

in Aardkungigen Mededelingen (2002), 12

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See detailMultidisciplinary study of trophic diversity and functional role of amphipod crustaceans associated to Posidonia oceanica meadows
Michel, Loïc ULg

Doctoral thesis (2011)

Posidonia oceanica is the most abundant seagrass of the Mediterranean Sea. It can cover extensive areas with monospecific formations, called meadows. These meadows, whose extent is estimated to about 40 ... [more ▼]

Posidonia oceanica is the most abundant seagrass of the Mediterranean Sea. It can cover extensive areas with monospecific formations, called meadows. These meadows, whose extent is estimated to about 40,000 km2, are critical features of the Mediterranean coastal zones. Moreover, they shelter important biomass and biodiversity of vagile invertebrates. Among these invertebrates, amphipod crustaceans are, alongside gastropod mollusks and polychaete annelids, one of the dominant groups. Amphipods are key-features of other temperate seagrass systems. As they are generally primary consumers, they are important in the transfers of organic matter from producers to higher rank consumers. In addition, their grazing activity on the epiphytes that grow on the seagrasses influence the dynamics of the epiphytic cover, and therefore the functioning of the whole meadow as an ecosystem. However, the situation in Mediterranean Posidonia oceanica meadows is still unclear. In particular, several lacks of information limit the comprehension of actual trophic ecology of amphipods, and of the impact of their feeding activity on the meadow functioning. In this context, the main goal of this work was to enhance the knowledge of the trophic diversity and the functional role of amphipods associated to Posidonia oceanica meadows. To achieve this, we structured our research in three main tasks. For each of these tasks, we chose Calvi Bay (NW Corsica, France) as study site, and all sampling and experimentation was undertaken from the STARESO research station (University of Liège). The first task (chapter 3) was the study of the precise composition of the amphipod community structure at our study site, and its temporal variation at day/night and seasonal scale. Our results show that the fauna of Posidonia oceanica meadows of Calvi Bay is abundant and diverse. The density and the structure of the community were different in each season (November, March and June), probably in relation with meadow parameters such as foliar surface, epiphytic biomass and abundance of litter in the meadow. Moreover, day/night variations were very important. Most amphipods performed vertical migrations that could be a mechanism to avoid predation and/or competition for food and habitat. The comparison of three sampling techniques (hand-towed net, litter collection and light traps) yielded deeply different results, suggesting that each of them only collects a subset of a complex assemblage. Combination of several sampling methods is therefore advised to have a holistic and accurate view of the community. These faunistic data also allowed highlighting the most abundant and/or representative species of the studied community. These include Apherusa chiereghinii, Aora spinicornis, Dexamine spiniventris, Amphithoe helleri, Caprella acanthifera, Gammarella fucicola and Gammarus aequicauda. These species were therefore chosen as target species for the second task. The second task (chapter 4) was the assessment of the extent of interspecific trophic diversity among the studied community. This phenomenon could indeed be important to limit food competition. We tried to perform a full reconstruction of the diet of the dominant species of the community and to evaluate the contribution of each of the potential food items offered by the meadow (animal and vegetal epiphytes from the leaves, rhizomes and litter fragments, SPOM, BPOM, living and dead P. oceanica material). To have an accurate view of the dietary habits of the dominant species, we used a triple strategy based on the joint use of traditional methods (gut content examination) and trophic markers (stable isotopes of C & N, fatty acids). The combination of these three methods proved to be successful, as each method had specific strengths and weaknesses. Overall, results indicate that all dominant species relied on macroalgal epiphytes for a large part of their diet. Our insights were unfortunately limited by the poor discrimination between potential food items, due to high inter-source similarity. Considerable interspecific differences could nonetheless be highlighted, notably concerning preferences of epiphytes from leaves or litter fragments vs. epiphytes from rhizomes. In addition, most species had a mixed diet, and relied on several food items. None of the examined species seemed to graze on their seagrass host, but Gammarus aequicauda partly relied on seagrass leaf detritus. Contribution of microepiphytes (e.g. diatoms) to the diet of amphipods was apparently anecdotical. Our data also suggested the existence of a certain extent of intraspecific trophic diversity that should be taken into account for future work. In the third and final task (chapter 5), we aimed to put the data obtained in the first two parts of this study in the wider context of the functioning of the Posidonia oceanica meadow as an ecosystem. We used in vitro and in situ microcosms experiments to characterize the interaction between epiphytes and amphipods from a triple point of view (resource depletion, resource assimilation by the consumer and secondary production), and to understand how amphipod grazing could influence the dynamics of the epiphytic cover of the leaves of P. oceanica. Amphipod grazing had no effect on the total epiphytic biomass, or on the encrusting epiphytes’ biomass. However, all three taxa (A. chiereghinii, D. spiniventris and Gammarus spp.) consumed significant amounts (45 to 90 % of total biomass) of erected epiphytes, both vegetal and animal. This selective top-down control might influence the structure and biomass-specific productivity rates of the epiphytic cover. In addition, amphipod grazing caused an increase in N availability and residence time. Through epiphyte removal and N enrichment, amphipods could boost seagrass production. Overall, amphipods of Posidonia oceanica meadows could be seen as ecosystem engineers. Assimilation of the consumed epiphytes was clear for all taxa. However, the utilization of this biomass for secondary production was hard to measure, due to low survival rates of animals. In fine, by combining in situ sampling and microcosm experimentation, and trough the joint use of traditional and innovative techniques, we showed that feeding activity of amphipods influence their biotope through several effects, and that they could be pivotal items of Posidonia oceanica meadows. In doing so, we improved, to some extent, the understanding of these critically important, yet endangered ecosystems. [less ▲]

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See detailMultidrug resistance gene-1 polymorphisms and resistance to cyclosporine a in patients with steroid resistant ulcerative colitis
Daniel, F.; Loriot, M. A.; Seksik, P. et al

in Inflammatory Bowel Diseases (2007), 13(1), 19-23

Background: Cyclosporine A (CsA) is inconstantly effective in inducing remission in acute attacks of ulcerative colitis (UC) not responding to steroids. This study aimed to establish whether multidrug ... [more ▼]

Background: Cyclosporine A (CsA) is inconstantly effective in inducing remission in acute attacks of ulcerative colitis (UC) not responding to steroids. This study aimed to establish whether multidrug resistance gene (MDR)1 polymorphisms would be associated with CsA failure. Patients and Methods: The distribution of the different genotypes of single nucleotide polymorphisms (SNP) G2677T/A and C3435T of MDR1 exons 21 and 26, respectively, was studied in 154 patients (mean age, 44 yr) who had received CsA to treat severe attacks of steroid resistant UC in 11 centers in France and Belgium. Patients were classified as CsA failure (n = 50) when they needed colectomy within 30 days after CsA initiation. The SNPs were detected by use of a 5' nuclease allelic discrimination assay. Results: There was a significant association between the G2677T/A polymorphism distribution (exon 21) and the risk for CsA failure (P = 0.0001). The TT genotype of exon 21 was significantly associated with the risk compared with the two other genotypes (odds ratio, 3.77; 95% confidence interval, 1.42-9.97, P = 0.007). There was no significant association between the genotype C3435T distribution (exon 26) and the risk of CsA failure (P = 0.23). Conclusion: The TT genotype of exon 21 MDR1 polymorphisms is associated with a higher risk of CsA failure in patients with steroid resistant UC. Further studies should be performed to establish whether other treatments could be more efficient to avoid surgery in this subset of patients. [less ▲]

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See detailMultidsiciplinary Management of Migraine: Pharmacological, Manual And Other Therapies.
Fernández-de-las-Peñas, C; Chaitow, L; Schoenen, Jean ULg

Book published by Jones & Bartlett Learning (2012)

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See detailMultifaceted dermal ultrastructural clues for Ehlers-Danlos syndrome with arterial rupture and type I collagen R-to-C substitution.
Hermanns-Lê, Trinh ULg; Pierard, Gérald ULg

in American Journal of Dermatopathology (2007), 29(5), 449-51

Type I collagen arginine-to-cysteine (R-to-C) substitutions were found in three middle-aged adults suffering from spontaneous dissection of medium-size arteries. This disorder enters the heterogeneous ... [more ▼]

Type I collagen arginine-to-cysteine (R-to-C) substitutions were found in three middle-aged adults suffering from spontaneous dissection of medium-size arteries. This disorder enters the heterogeneous spectrum of the Ehlers-Danlos syndrome (EDS). Despite similar genetic mutation and arterial alterations, two distinct clinical presentations were identified showing signs of either the EDS classic type or premature osteopenia alone. Ultrastructural changes were found in the dermal collagen fibrils, elastic fibers, and proteoglycan components. The cross-section of most collagen fibrils was rounded, but with diverse diameters. Flower-like outlines of collagen fibrils were rarely disclosed. Large hyaluronic acid globules pushed apart the collagen bundles in the case with EDS classic-type presentation. Elastic fibers contained unusual annular microcalcifications. In conclusion, ultrastructural changes were found in diverse connective-tissue components despite the fact that the mutations were found to be specific for the collagen molecules. In addition, two distinct clinical presentations were found and were correlated with peculiar ultrastructural alterations. [less ▲]

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See detailThe multifaceted struggle for power in the bioeconomy
Delvenne, Pierre ULg; Hendrickx, Kim ULg

in Technology in Society (2013), 35(2),

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See detailMultifactorial Relationship Between 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography Signaling and Biomechanical Properties in Unruptured Aortic Aneurysms
NCHIMI LONGANG, Alain ULg; CHERAMY-BIEN, Jean-Paul ULg; Gasser, T. Christian et al

in Circulation. Cardiovascular imaging (2014), 7

BACKGROUND: -The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations (FES) and 18F-fluoro-deoxyglucose (18F-FDG ... [more ▼]

BACKGROUND: -The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations (FES) and 18F-fluoro-deoxyglucose (18F-FDG) positron emission tomography (PET). METHODS AND RESULTS: -The study included 53 patients (45 males) with aortic aneurysms, 47 infrarenal (AAA) and 6 thoracic (TAA), who had at least one 18F-FDG PET/computed tomography. Over a 30-month period, more clinical events occurred in patients with increased 18F-FDG uptake on their last examination than in those without (5/18 (28%) vs. 2/35 (6%); P=0.03). Wall stress and stress/strength index computed by FES and 18F-FDG uptake were evaluating a total of 68 examinations. 25 (38%) examinations demonstrated at least one aneurysm wall area of increased 18F-FDG uptake. The mean number of these areas per examination was 1.6 (18/11) in TAAs vs. 0.25 (14/57) in AAAs, while the mean number of increased uptake areas co-localizing with highest wall stress and stress/strength index areas was 0.55 (6/11) and 0.02 (1/57), respectively. Quantitatively, 18F-FDG PET uptake correlated positively with both wall stress and stress/strength index (P<0.05). 18F-FDG uptake was particularly high in subjects with personal history of angina pectoris and familial aneurysm. CONCLUSIONS: -Increased 18F-FDG PET uptake in aortic aneurysms is strongly related to aneurysm location, wall stress as derived by FES and patient's risk factors such as acquired and inherited susceptibilities. [less ▲]

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See detailMultifocal choroid plexus papilloma: a case report.
Scholsem, Martin; Scholtes, Félix ULg; Robe, Pierre ULg et al

in Clinical neuropathology (2012), 31(6), 430-4

BACKGROUND: Multiple choroid plexus papillomas (CPPs) are rare. Usually, they correspond to villous hypertrophy or metastasis occurring during cerebrospinal dissemination. Multiple CPPs have rarely been ... [more ▼]

BACKGROUND: Multiple choroid plexus papillomas (CPPs) are rare. Usually, they correspond to villous hypertrophy or metastasis occurring during cerebrospinal dissemination. Multiple CPPs have rarely been reported as synchronous tumors. CASE REPORT: Three synchronous CPPs were resected in a 59-year-old female 6 years after their first imaging description. Pathology showed mucus-producing CPP in all 3, 1 of the 3 presenting some signs of atypia. No p53 or hSNF5/INI1 mutation, or signs of polyoma viruses infection were found. CONCLUSION: Although no clear cause for the multifocality was found, the simultaneous presence of the three tumors and their benign histology suggest that they were synchronous and not metastatic. The issue of differentiating synchronous CPPs from metastatic CPP is discussed. [less ▲]

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See detailMultifocal motor and sensory neuropathy following whiplash injury
DIVE, Dominique ULg; NOEZ, Stéphanie ULg; ISERENTANT, Cynthia ULg et al

in Journal of Neurology (2001)

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See detailMultifocal serous cystadenoma of the pancreas synchronous with ampullary adenocarcinoma
Quatresooz, Pascale ULg; Honore, Pierre ULg; Vivario, M. et al

in Annales de Pathologie (2002), 22(4), 317-320

Pancreatic cysts are common, but cystic tumors are uncommon. We report a rare case of serous cystadenoma of the pancreas synchronous with ampullary adenocarcinoma which supports a common etiopathogeny of ... [more ▼]

Pancreatic cysts are common, but cystic tumors are uncommon. We report a rare case of serous cystadenoma of the pancreas synchronous with ampullary adenocarcinoma which supports a common etiopathogeny of these tumors. We discuss the differential diagnosis with mucinous cystadenoma which is potentially malignant and recall the microscopic and radiologic features. [less ▲]

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See detailA multifractal analysis of air temperature signals based on the wavelet leaders method
Deliège, Adrien ULg; Nicolay, Samuel ULg

Conference (2014, August 20)

We present the wavelet leaders method (introduced by S. Jaffard) as a tool to study the Hölder regularity of signals, which is closely related to some functional spaces. We use the associated multifractal ... [more ▼]

We present the wavelet leaders method (introduced by S. Jaffard) as a tool to study the Hölder regularity of signals, which is closely related to some functional spaces. We use the associated multifractal formalism to show that surface air temperature signals are monofractal, i.e. these are regularly irregular. Then we use this result to establish a climate classification of weather stations in Europe which matches the Köppen-Geiger climate classification. This result could give rise to new criteria to determine the effectiveness of current climatic models. [less ▲]

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See detailMultifractal analysis of air temperature signals using the wavelet leaders method
Deliège, Adrien ULg; Nicolay, Samuel ULg

Conference (2014, May 22)

We use the discrete "wavelet transform microscope" to show that the surface air temperature signals of weather stations selected in Europe are monofractal. This study reveals that the information obtained ... [more ▼]

We use the discrete "wavelet transform microscope" to show that the surface air temperature signals of weather stations selected in Europe are monofractal. This study reveals that the information obtained in this way are richer than previous works studying long range correlations in meteorological stations. The approach presented here allows to bind the Hölder exponents with the climate variability. We also establish that such a link does not exist with methods previously carried out, such as the detrended fluctuation analysis. [less ▲]

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See detailMultifractal properties of pore-size distribution in apple tissue using X-ray imaging
Mendoza, Fernando; Verboven, Pieter; Ho, Quang Tri et al

in JOURNAL OF FOOD ENGINEERING (2010), 99(2), 206-215

The pore-size distribution (PSD) has an important influence on the complex gas transport phenomena (02 and CO(2)) that occur in apple tissue during storage under controlled atmosphere conditions. It ... [more ▼]

The pore-size distribution (PSD) has an important influence on the complex gas transport phenomena (02 and CO(2)) that occur in apple tissue during storage under controlled atmosphere conditions. It defines the apple tissue microstructure that is correlated to many other apple properties. In this article multifractal analysis (MFA) has been used to study the multiscale structure of the PSD using generalized dimensions in three varieties of apples (Jonagold, Greenstar, and Kanzi) based on X-ray imaging technology (8.5 mu m resolution). Tomographic images of apple samples were taken at two positions within the parenchyma tissue: close to the peel and near to the core. The images showed suitable scaling properties. The generalized dimensions were determined with an R(2) greater than 0.98 in the range of moment orders between -1 and +10. The variation of D(q) with respect to q and the shape of the multifractal generalized spectrum revealed that the PSD structure of apple tissue has properties close to multifractal self-similarity measures. Comparisons among cultivars showed that, in spite of the complexity and variability of the pore space of these apple samples, the extracted generalized dimensions from PSD were significantly different (p < 0.05). The generalized dimensions D(0), D(1), D(2), and the quantity D(0)-D(2) could be used to discriminate tissue samples from different positions or cultivars. Also, high correlations were found between these parameters and the porosity (R(2) >= 0.935). These results demonstrate that MFA is an appropriate tool for characterizing the internal pore-size distribution of apple tissue and thus may be used as a quantitative measure to understand how tissue microstructure affects important physical properties of apple. (C) 2010 Elsevier Ltd. All rights reserved. [less ▲]

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See detailMultifractal wave functions of simple quantum maps
Martin, John ULg; Garcia-Mata, Ignacio; Giraud, Olivier et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2010), 82

We study numerically multifractal properties of two models of one-dimensional quantum maps: a map with pseudointegrable dynamics and intermediate spectral statistics and a map with an Anderson-like ... [more ▼]

We study numerically multifractal properties of two models of one-dimensional quantum maps: a map with pseudointegrable dynamics and intermediate spectral statistics and a map with an Anderson-like transition recently implemented with cold atoms. Using extensive numerical simulations, we compute the multifractal exponents of quantum wave functions and study their properties, with the help of two different numerical methods used for classical multifractal systems (box-counting and wavelet methods). We compare the results of the two methods over a wide range of values. We show that the wave functions of the Anderson map display a multifractal behavior similar to eigenfunctions of the three-dimensional Anderson transition but of a weaker type. Wave functions of the intermediate map share some common properties with eigenfunctions at the Anderson transition (two sets of multifractal exponents, with similar asymptotic behavior), but other properties are markedly different (large linear regime for multifractal exponents even for strong multifractality, different distributions of moments of wave functions, and absence of symmetry of the exponents). Our results thus indicate that the intermediate map presents original properties, different from certain characteristics of the Anderson transition derived from the nonlinear sigma model. We also discuss the importance of finite-size effects. [less ▲]

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