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See detailImpact of Pre-Transplant Anti-T Cell Globulin (ATG) on Immune Recovery after Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation.
SERVAIS, Sophie ULiege; Menten-Dedoyart, Catherine; Beguin, Yves ULiege et al

in PloS one (2015), 10(6), 0130026

BACKGROUND: Pre-transplant infusion of rabbit anti-T cell globulin (ATG) is increasingly used as prevention of graft-versus-host disease (GVHD) after allogeneic peripheral blood stem cell transplantation ... [more ▼]

BACKGROUND: Pre-transplant infusion of rabbit anti-T cell globulin (ATG) is increasingly used as prevention of graft-versus-host disease (GVHD) after allogeneic peripheral blood stem cell transplantation (PBSCT). However, the precise impact of pre-transplant ATG on immune recovery after PBSCT is still poorly documented. METHODS: In the current study, we compared immune recovery after myeloablative PBSCT in 65 patients who either received (n = 37) or did not (n = 28) pre-transplant ATG-Fresenius (ATG-F). Detailed phenotypes of circulating T, B, natural killer (NK) and invariant NKT (iNKT) cells were analyzed by multicolor flow cytometry at serial time-points from day 40 to day 365 after transplantation. Thymic function was also assessed by sjTREC quantification. Serious infectious events were collected up to 2 years post-transplantation. RESULTS: Pre-transplant ATG-F had a prolonged (for at least up to 1-year) and selective negative impact on the T-cell pool, while it did not impair the recovery of B, NK nor iNKT cells. Among T cells, ATG-F selectively compromised the recovery of naive CD4+, central memory CD4+ and naive CD8+ cells, while it spared effector memory T and regulatory T cells. Levels of sjTRECs were similar in both cohorts at 1-year after PBSCT, suggesting that ATG-F unlikely impaired thymopoiesis at long-term after PBSCT. Finally, the incidence and rate of serious infections were similar in both groups, while ATG-F patients had a lower incidence of grade II-IV acute graft-versus-host disease. CONCLUSIONS: Pre-transplant ATG-F induces long-lasting modulation of the circulating T-cell pool after myeloablative PBSCT, that may participate in preventing graft-versus-host disease without deeply compromising anti-pathogen defenses. [less ▲]

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See detailImpact of pre-treatment processing on cereal by-products valorisation through enzymatic extraction of ferulic acid.
Barberousse, Hélène; Roiseux, Olivier; Deroanne, Claude et al

Poster (2008, June)

Detailed reference viewed: 34 (3 ULiège)
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See detailThe impact of preexisting semantic integration on associative memory in normal aging
Bastin, Christine ULiege

Conference (2016, July 19)

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See detailThe impact of preexisting semantic integration on associative memory in normal aging
Bastin, Christine ULiege

in Proceedings of the 6th International Conference on Memory (2016)

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See detailImpact of preoperative use of P2Y12 receptor inhibitors on clinical outcomes in cardiac and non-cardiac surgery: A systematic review and meta-analysis.
Siller-Matula, Jolanta M.; Petre, Alexandra; Delle-Karth, Georg et al

in European heart journal. Acute cardiovascular care (2015)

OBJECTIVE: To review systematically the evidence and perform a meta-analysis of benefits and risks associated with use of P2Y12 receptor inhibitors in coronary artery bypass graft-, non-cardiac- and ... [more ▼]

OBJECTIVE: To review systematically the evidence and perform a meta-analysis of benefits and risks associated with use of P2Y12 receptor inhibitors in coronary artery bypass graft-, non-cardiac- and device surgery. DATA SELECTION AND ANALYSIS: We performed a meta-analysis of published studies. Patients with preoperative use of clopidogrel, ticagrelor or prasugrel (late discontinuation: <5 days before surgery or no discontinuation) were compared with patients without preoperative use of the respective drug (early discontinuation: 5 days before surgery or no users of P2Y12 receptor inhibitors). Outcomes evaluated were re-operation for major bleeding, death, myocardial infarction, combined major adverse cardiac events (MACEs) and major haematoma. Using a random effect model, relative risks (RRs) and 95% confidence intervals (CI) were calculated for each outcome. RESULTS: Fifty-four studies met the selection criteria and included 50,048 patients. Preoperative use of clopidogrel on top of aspirin in patients undergoing coronary artery bypass graft was associated with a 2.5-fold increased risk of re-operation for bleeding (95% CI: 1.92-3.25; p<0.001) and a 1.47-fold increased risk of death (95% CI: 1.25-1.72; p<0.001), but did not diminish the risk for myocardial infarction (RR: 0.96; 95% CI: 0.75-1.25; p=0.18) or MACE (RR: 1.16; 95% CI: 0.90--1.50; p=0.30). In patients undergoing non-cardiac surgery, preoperative use of clopidogrel increased the RR of re-operation for major bleeding by 2.05-fold (95% CI: 1.13-3.73; p=0.002) but did not reduce the RR for MACE or death. Clopidogrel use during cardiac device implantation raised the RR for procedure-related haematoma by 3.0-fold (95% CI: 1.30--6.94; p=0.001). Whereas preoperative ticagrelor use did not increase the risk for mortality (RR: 1.03; 95% CI: 0.49-2.14), preoperative prasugrel use tended to increase the risk for death (RR: 5.06; 95% CI: 0.54-47.65). CONCLUSION: Preoperative exposure to clopidogrel on top of aspirin did not reduce the risk of MACE but was associated with increased risk of bleeding and mortality. [less ▲]

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See detailImpact of pro-oxidant agents on the morula-blastocyst transition in bovine embryos.
Feugang, Jean-Magloire; Donnay, Isabelle; Mermillod, Pascal et al

in Molecular Reproduction and Development (2005), 71(3), 339-46

Exposing day 5 bovine morulae to reactive oxygen species induces a delayed degeneration of some blastocysts on day 8 post-insemination (pi) but without affecting the blastocyst rates. The aim of this ... [more ▼]

Exposing day 5 bovine morulae to reactive oxygen species induces a delayed degeneration of some blastocysts on day 8 post-insemination (pi) but without affecting the blastocyst rates. The aim of this study was to characterize the resisting and the degenerating population of blastocysts. The kinetics of degeneration of the embryos exposed to the two pro-oxidant agents: 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) and buthionine sulfoximine (BSO) was evaluated using time-lapse cinematography. With both agents the first signs of degeneration appeared at day 7.5 pi but the duration of the degeneration process was shorter in presence of AAPH than BSO (4.2 vs. 12.5 hr, ANOVA, P < 0.05). The resisting blastocysts derived from morulae with a larger diameter (mean diameter: 161 vs. 154 microm, ANOVA, P < 0.05) and showed an earlier cavitation (135 vs. 142 hpi, P < 0.05) than the degenerating ones. The profile of protein neosynthesis at day 7 was not affected by the treatment. The proportion of male embryos was more important in the resisting than in the degenerating population (70 vs. 55%, chi2, P < 0.05) especially when the stress was induced by AAPH. The quality of the resisting embryos, measured by the total cell number and the rate of apoptosis, did not seem to be affected when compared to control embryos. In conclusion, resistance to oxidative stress seems related to the kinetics of development and/or the sex of the embryos. Resisting embryos apparently display a quality similar to untreated embryos. [less ▲]

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See detailImpact of prosthesis-patient mismatch on mitral regurgitation after aortic valve replacement
Unger, P.; Magne, Julien ULiege; Vanden Eynden, F. et al

in Heart (2010), 96(20), 1627-1632

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See detailImpact of prosthesis-patient mismatch on short-term mortality following mitral valve replacement.
Magne, Julien ULiege; Mathieu, P; Dumesnil, JG et al

Conference (2008)

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See detailImpact of Prosthesis-Patient Mismatch on Short-term Mortality Following Mitral Valve Replacement.
Magne, Julien ULiege; Mathieu, P; Dumesnil, JG et al

Conference (2008)

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See detailImpact of Prosthesis-Patient Mismatch on Short-term Mortality Following Mitral Valve Replacement.
Magne, Julien ULiege; Mathieu, P; Dumesnil, JG et al

Conference (2009)

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See detailImpact of prosthesis-patient mismatch on survival after mitral valve replacement
Magne, Julien ULiege; Dumesnil, J. G.; Tanné, D. et al

in Circulation (2007), 115(11), 1417-1425

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See detailImpact of Prosthesis-Patient Mismatch on Survival After Mitral Valve Replacement.
Magne, Julien ULiege; Mathieu, P; Dumesnil, JG et al

Conference (2006)

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See detailImpact of Prosthesis-Patient Mismatch on Survival following Mitral Valve Replacement.
Magne, Julien ULiege; Mathieu, P; Dumesnil, JG et al

Conference (2006)

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See detailImpact of Protective Compounds on the Viability, Physiological State and Lipid Degradation of FreezeDried Pseudomonas Fluorescens BTP1 during Storage
Mputu Kanyinda, Jean-Noël ULiege; Pierart, C.; Weekers, F. et al

in International Journal of Biotechnology and Biochemistry (2012), 8(4), 17-26

The drying of bacteria remains a major alternative in order to keep them long term. After centrifugation, the bacterial pellet of Pseudomonas fluorescensBTP1 was divided in two fractions one with ... [more ▼]

The drying of bacteria remains a major alternative in order to keep them long term. After centrifugation, the bacterial pellet of Pseudomonas fluorescensBTP1 was divided in two fractions one with protecting compounds (2% glycerol or 5% maltodextrine) and one without and freeze-dried. After freeze drying, powders were sealed in aluminium bag under vacuum and stored at 4 or 20°C. The parameters such as viability, the conductivity and the ratio of polyunsaturated fatty acids/saturated fatty acids were used to investigate the viability of freeze-dried powders during storage. For example cell concentration of powder with glycerol (PG) at CFU/g before storage is 4.109 and after 7 month 2.108 at 4°C and 3,5.107 at 20°C). The ratio of polyunsaturated fatty acids/saturated fatty acids decrease in function of time (e.g. at 4°C the ratios of C18:3 and C18:2 by C16:0 decreases respectively of 0,013 to 0,001 and 0,05 to 0,03 after 60 days of storage). In the present study, flow cytometric analysis was applied to evaluate the state in which the cells are at the end of storage time. We compared the survival results of bacteria obtained by plate count with the flow cytometric analysis results. [less ▲]

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See detailImpact of Public Market Information System (PMIS) on Farmers Food Marketing Decisions : Case of Benin
Kpènavoun Chogou, Sylvain; Lebailly, Philippe ULiege; Adégbidi et al

Conference (2009)

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See detailImpact of purification and fractionation process on the chemical structure and physical properties of locust bean gum
Gillet, Sébastien ULiege; Blecker, Christophe ULiege; Aguedo, Mario ULiege et al

in Carbohydrate Polymers (2014)

Crude locust bean gum (CLBG) was purified and fractionated into two parts : the first was obtained by solubilization in water at 25 °C (GM25) and the second consisted in a further extraction at 80 °C on ... [more ▼]

Crude locust bean gum (CLBG) was purified and fractionated into two parts : the first was obtained by solubilization in water at 25 °C (GM25) and the second consisted in a further extraction at 80 °C on the residual impoverished fraction (GM80). The complete structural characterization has shown that GM80 possessed relatively longer chain lengths than GM25, a slightly lower degree of galactose substitution and a somewhat sharper galactosyl distribution in substituted and unsubstituted regions. A physical behavior analysis was carried out on solubilization kinetics, viscosity, viscoelasticity and formation of associated gels with xanthan or carrageenan. The average structure of GM80 generated larger intra-chain, inter-chain and inter-molecular interactions, resulting in the appearance of a stronger network. Small structural differences therefore generated very different physical behaviors. This study thus allowed to establish, in a precise and complete manner, fractionation-purification-structure-function relationships of galactomannans extracted from carob. [less ▲]

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See detailImpact of Regiella insecticola infection on EBF production in Acyrthosiphon pisum Harris
Bauwens, Julien ULiege; Mazzucchelli, Gabriel ULiege; De Pauw, Edwin ULiege et al

Conference (2015, November 06)

Symbionts of aphids influence their host from many points of view. We investigate the potential influence of bacterial symbionts on the production and emission of the aphid alarm pheromone, E-β-franesene ... [more ▼]

Symbionts of aphids influence their host from many points of view. We investigate the potential influence of bacterial symbionts on the production and emission of the aphid alarm pheromone, E-β-franesene. Some trends could be observed in the total EβF production. Particularly, aphid strains infected by Buchnera only seemed to produce less alarm pheromone. By contrast, the presence of Regiella insecticola seemed to increase EβF production. Mevalonate pathway was investigated by RT-qPCR. This analysis showed a slightly lower transcription level o mIPPS in Regiella-infected strains. This enzyme is involved in the last step of EβF production. By contrast, two enzymes involved respectively in the linkage and release of farnesyl moeities on proteins c-terminal ends. Escape tests were conducted to assay if these results were traduced by differential behavior in front of a predator. Preliminary results showed significantly higher dropping behavior for Regiella-infected strains. [less ▲]

Detailed reference viewed: 72 (4 ULiège)