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See detailAryl Hydrocarbon Receptor interacting Protein Gene Mutations in Bulgarian FIPA and Young Sporadic Pituitary Adenoma Patients
Yaneva, M.; Daly, Adrian ULg; Tichomirowa, M. A. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailAryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families.
Daly, Adrian ULg; Vanbellinghen, Jean-François ULg; Khoo, Sok Kean et al

in Journal of Clinical Endocrinology and Metabolism (2007), 92(5), 1891-1896

CONTEXT: An association between germline aryl hydrocarbon receptor-interacting protein (AIP) gene mutations and pituitary adenomas was recently shown. OBJECTIVE: The objective of the study was to assess ... [more ▼]

CONTEXT: An association between germline aryl hydrocarbon receptor-interacting protein (AIP) gene mutations and pituitary adenomas was recently shown. OBJECTIVE: The objective of the study was to assess the frequency of AIP gene mutations in a large cohort of patients with familial isolated pituitary adenoma (FIPA). DESIGN: This was a multicenter, international, collaborative study. SETTING: The study was conducted in 34 university endocrinology and genetics departments in nine countries. PATIENTS: Affected members from each FIPA family were studied. Relatives of patients with AIP mutations underwent AIP sequence analysis. MAIN OUTCOME MEASURES: Presence/absence and description of AIP gene mutations were the main outcome measures. INTERVENTION: There was no intervention. RESULTS: Seventy-three FIPA families were identified, with 156 patients with pituitary adenomas; the FIPA cohort was evenly divided between families with homogeneous and heterogeneous tumor expression. Eleven FIPA families had 10 germline AIP mutations. Nine mutations, R16H, G47_R54del, Q142X, E174frameshift, Q217X, Q239X, K241E, R271W, and Q285frameshift, have not been described previously. Tumors were significantly larger (P = 0.0005) and diagnosed at a younger age (P = 0.0006) in AIP mutation-positive vs. mutation-negative subjects. Somatotropinomas predominated among FIPA families with AIP mutations, but mixed GH/prolactin-secreting tumors, prolactinomas, and nonsecreting adenomas were also noted. Approximately 85% of the FIPA cohort and 50% of those with familial somatotropinomas were negative for AIP mutations. CONCLUSIONS: AIP mutations, of which nine new mutations have been described here, occur in approximately 15% of FIPA families. Although pituitary tumors occurring in association with AIP mutations are predominantly somatotropinomas, other tumor types are also seen. Further study of the impact of AIP mutations on protein expression and activity is necessary to elucidate their role in pituitary tumorigenesis in FIPA. [less ▲]

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See detailThe arylthiadiazine 1,1-dioxides in medicinal chemistry
De Tullio, Pascal ULg

Conference (2008, June 08)

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See detailLes arythmies ventriculaires.
Waleffe, A.; Pierard, Luc ULg

in Revue medicale de Liege (2004), 59(4), 190-5

Tachycardias arise from an arrhythmogenic substrate triggered by a random factor (generally an extrasystole) and modulated by the autonomic nervous system. The three components are interactive, but their ... [more ▼]

Tachycardias arise from an arrhythmogenic substrate triggered by a random factor (generally an extrasystole) and modulated by the autonomic nervous system. The three components are interactive, but their intensity and conjunction vary continuously. During the last decade, major achievements have been made to clarify definition and classification of data reported in the literature, helping our understanding of the mechanisms of ventricular arrhythmias. Nowadays, the pathophysiology of cardiac arrhythmias is well-known at the cellular and molecular ion channel activity. The progress of epidemiology and molecular genetics have allowed a better knowledge of the genotype-phenotype correlation in young patients presenting syncopes due to torsades de pointes or polymorphic ventricular tachychardia episodes which may degenerate into ventricular fibrillation and cause sudden death. The data of numerous large prospective randomised studies have led to more rational treatments with the progressive withdrawal of class I antiarrhythmics and their replacement by betablocking agents. The surgical approach of ventricular tachycardia has been overcome by the automatic implantable defibrillator and in some well-defined clinical situations, catheter ablation is used. [less ▲]

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See detailArzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women.
Cummings, S. R.; McClung, M.; Reginster, Jean-Yves ULg et al

in Journal of Bone and Mineral Research (2011), 26(2), 397-404

BACKGROUND: Arzoxifene is a selective estrogen receptor modulator (SERM) more potent in preclinical testing than currently available agents. Its effects on clinical outcomes are not known. METHODS: In a ... [more ▼]

BACKGROUND: Arzoxifene is a selective estrogen receptor modulator (SERM) more potent in preclinical testing than currently available agents. Its effects on clinical outcomes are not known. METHODS: In a randomized blinded trial, women age 60 to 85 years with osteoporosis, defined as a femoral neck or lumbar spine bone mineral density T-score less than or equal to -2.5 or a vertebral fracture, and women with low bone mass, defined as a bone density T-score less than or equal to -1.0 and above -2.5, were assigned to arzoxifene 20 mg or placebo daily. The primary endpoints were new vertebral fracture in those with osteoporosis, and invasive breast cancer in the overall population. RESULTS: After 3 years, the cumulative incidence of vertebral fractures in patients with osteoporosis was 2.3% lower in the arzoxifene than in the placebo group, a 41% relative risk reduction (95% CI 0.45 to 0.77; P<0.001). In the overall population, the cumulative incidence of invasive breast cancer over 4 years was reduced by 1.3%, with a 56% relative reduction in risk (HR=0.44; 95% CI 0.26 to 0.76; P<0.001); there was no significant decrease in nonvertebral fracture risk. Arzoxifene increased the cumulative incidence of venous thromboembolic events by 0.7%, with a 2.3-fold relative increase (95% CI 1.5 to 3.7). CONCLUSION: Like other SERMs, arzoxifene decreased vertebral fractures and invasive breast cancer while the risk of venous thromboembolic events increased. (c) 2010 American Society for Bone and Mineral Research. [less ▲]

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See detailAs abordagens comportamentais e cognitivas na educaçao dos jovens com comportamento agressivo
Born, Michel ULg; Chevalier, V.

in Lepot-Froment, Christiane (Ed.) Educaçao Especializada (1999)

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See detailAs Above, so Below: Narrative Salience and Side Effects of National Innovation Systems
Claisse, Frédéric ULg; Delvenne, Pierre ULg

in Critical Policy Studies (2014), accepté à publication

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See detailAs if spoken: What do we really know about Late Egyptian as a vernacular language?
Winand, Jean ULg

Conference (2013, October 29)

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See detailAs relações imagem/legenda na astrofísica à luz da semiótica tensiva
Sturnack, Lionel ULg

Conference (2012, July 05)

PROPOREMOS NESTE TRABALHO EFETUAR A ANÁLISE TENSIVA DE TRÊS TIPOS DE TEXTOS QUE PERTENCEM AO DISCURSO CIENTÍFICO LATO SENSU DA ÁREA ASTROFÍSICA: O DISCURSO DA CIÊNCIA EM LABORATÓRIO, DA CIÊNCIA EM ARTIGOS ... [more ▼]

PROPOREMOS NESTE TRABALHO EFETUAR A ANÁLISE TENSIVA DE TRÊS TIPOS DE TEXTOS QUE PERTENCEM AO DISCURSO CIENTÍFICO LATO SENSU DA ÁREA ASTROFÍSICA: O DISCURSO DA CIÊNCIA EM LABORATÓRIO, DA CIÊNCIA EM ARTIGOS ESPECIALIZADOS E DA CIÊNCIA EM ARTIGOS DE VULGARIZAÇÃO. OS TRÊS DISCURSOS PERTENCEM À MESMA VONTADE DE CONSEGUIR DESCREVER AS IMAGENS, SEGUNDO VÁRIAS MODALIDADES. POR ISSO SE PODEM CHAMAR DISCURSOS DE LEGENDA. ISSO SIGNIFICA QUE PARTICIPAM DO MESMO MOVIMENTO QUE TENTA DEFINIR A COMPOSIÇÃO E O SENTIDO DAS IMAGENS. O PROCESSO É MAIS AMPLO NO CASO DO DISCURSO DE LABORATÓRIO, JÁ QUE CORRESPONDE À PRIMEIRA TENTATIVA DE INTERPRETAÇÃO DAS IMAGENS, ENQUANTO OS DEMAIS, SENDO ESCRITOS EM ARTIGOS, ESTÃO NUM ESTÁGIO POSTERIOR, NO QUAL AS FORMAS ESTÃO ESTABILIZADAS. O PROPÓSITO É DE ANALISAR OS TRÊS DISCURSOS COM AS FERRAMENTAS PROPOSTAS PELA SEMIÓTICA TENSIVA, TAL COMO FOI DESENVOLVIDA POR CLAUDE ZILBERBERG E JACQUES FONTANILLE. O OBJETIVO CORRESPONDE A ESTABELECER OS CRITÉRIOS TENSIVOS SOBRE OS QUAIS PODERÍAMOS EFETUAR UMA DIFERENCIAÇÃO GENÉRICA ENTRE OS DISCURSOS ANALISADOS, DIFERENCIAÇÃO ESTABELECIDA SOBRE UMA BASE TENSIVA. UM OUTRO OBJETIVO, QUE SERIA MAIS LATERAL, SERÁ TAMBÉM RECONHECER ALGUMAS PERGUNTAS ESPECÍFICAS QUE PROPÕE O OBJETO À SEMIÓTICA TENSIVA. PRETENDEMOS ENTÃO DESEMBOCAR EM UMA SISTEMATIZAÇÃO DAS DIFERENÇAS ENTRE ESTES DISCURSOS, QUE ESTARIA ALÉM DAS CONSIDERAÇÕES ARGUMENTATIVAS OU FIGURATIVAS, E SUSTENTARIA POR CONSEGUINTE OS MAIS RECENTES DESENVOLVIMENTOS DA SEMIÓTICA, APLICADA À IMAGEM CIENTÍFICA. UMA CARACTERIZAÇÃO TENSIVA DESSES TEXTOS AJUDARIA A COMPREENSÃO DO CAMPO DISCURSIVO ASTROFÍSICO QUE IRIA ALÉM DA DISTINÇÃO A PRIORI, BASEADA NO LUGAR DE ENUNCIAÇÃO E NO TIPO DE RECEPÇÃO. UMA ANÁLISE MAIS PROFUNDA DAS ESTRUTURAS TENSIVAS DE CADA UM LEVARIA EM CONSIDERAÇÃO OS TIPOS DE APRESENTAÇÃO E DE DINAMISMO DOS CONTEÚDOS PRÓPRIOS PARA CADA TIPO, OFERECENDO UMA BASE ESTÁVEL DE DIFERENCIAÇÃO. POR ISSO, USAREMOS CINCO CONCEITOS FUNDAMENTAIS DA SEMIÓTICA TENSIVA: OS MODOS DE PRESENÇA, OS MODOS DE EFICIÊNCIA, OS MODOS DE EXISTÊNCIA, OS MODOS DE JUNÇÃO E A FIDÚCIA. O ÂMBITO SEMIÓTICO NO QUAL SE COLOCA A NOSSA PESQUISA, JÁ BASTANTE DESENVOLVIDO, É O DA SEMIÓTICA DA IMAGEM CIENTÍFICA. APOIANDO-NOS EM DONDERO, BORDRON E LATOUR, ESCLARECEREMOS O LUGAR DO NOSSO TRABALHO ENTRE AS QUESTÕES RELATIVAS AO CAMPO DE ESTUDO SEMIÓTICO DAS IMAGENS E DOS DISCURSOS CIENTÍFICOS. O ÂMBITO PARTICULAR NO QUAL NOS SITUAMOS NA SEMIÓTICA DAS IMAGENS CIENTÍFICAS É O DAS CHAMADAS “PRÁTICAS DE INSTANCIAÇÃO” EM QUE SE RECONHECEM TRÊS ETAPAS QUE ESTRUTURAM AS PESQUISAS CIENTÍFICAS EM GERAL: INTERROGAÇÃO, ESTABILIZAÇÃO E INSTITUCIONALIZAÇÃO (DONDERO, 2010). AS ANÁLISES QUE FAREMOS PRETENDEM DESCREVER E DISTINGUIR OS PROCESSOS DO DINAMISMO DOS CONTEÚDOS IMPLICADOS NESTES TRÊS NÍVEIS DO FLUXO DA PESQUISA. SOB OS PREÂMBULOS DA ANÁLISE TENSIVA, PRETENDEMOS EXPLICITAR EM PRIMEIRO LUGAR ALGUMAS TENDÊNCIAS DOS DISCURSOS NO NÍVEL MACROSCÓPICO DA PESQUISA E ALGUMAS ORIENTAÇÕES PARTICULARES DOS DISCURSOS ISOLADOS NO NÍVEL MICROSCÓPICO. POR FIM, CONSEGUIREMOS ORGANIZAR O CAMPO DISCURSIVO ANALISADO EM FUNÇÃO DE DOIS ELEMENTOS. POR UM LADO, SEGUINDO LOUIS HÉBERT (2009), DISTINGUIREMOS ENTRE CARÁTER ANALÍTICO OU SINTÉTICO DA COMPOSIÇÃO DO VALOR DOS OBJETOS. POR OUTRO LADO, EFETUAREMOS A DIFERENCIAÇÃO ENTRE DOIS CAMPOS, O SABER E O CRER, NOS QUAIS DE DESENVOLVEM A IMPLICAÇÃO E A CONCESSÃO, AS OPERAÇÕES LÓGICAS RECONHECIDAS PELA SEMIÓTICA TENSIVA. FINALMENTE SERÃO IDENTIFICADAS OS MOVIMENTOS TENSIVOS PRÓPRIOS PARA CADA DISCURSO. [less ▲]

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See detailAs/zteken. Gedichtendagessay
Spinoy, Erik ULg

Book published by Poëziecentrum / De Bezige Bij Antwerpen (2012)

This essay discusses the changing nature of (Flemish) poetry at the beginning of the 21ste century: the genre appears to become increasingly obsolete and unpopular; on the other hand, it continues to show ... [more ▼]

This essay discusses the changing nature of (Flemish) poetry at the beginning of the 21ste century: the genre appears to become increasingly obsolete and unpopular; on the other hand, it continues to show an unexpected vitality. This may be explained by the fact that both poetry and the inescapable frailty of human identifications are two faces of the same coin. [less ▲]

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See detailL'asbestose pleuro-parenchymateuse. Interet de l'analyse du liquide de lavage broncho-alveolaire.
CORHAY, Jean-Louis ULg; Hotermans, G; Biquet, J F et al

in Revue Médicale de Liège (1989), 44(6), 218-28

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See detailLes ASBL belges: Principes et Constitution
Gol, Déborah ULg

in Benoit, Nathalie; Caprasse, Olivier; Thirion, Nicolas (Eds.) A.S.B.L., Fondations et Associations internationales (2004)

La loi du 27 juin 1921 relative aux associations sans but lucratif a été modifiée par une loi du 2 mai 2002 relative aux associations sans but lucratif, aux fondations et aux associations internationales ... [more ▼]

La loi du 27 juin 1921 relative aux associations sans but lucratif a été modifiée par une loi du 2 mai 2002 relative aux associations sans but lucratif, aux fondations et aux associations internationales sans but lucratif. Cette partie de l'ouvrage rappelle les principes qui gouvernent la notion d'association sans but lucratif (définition, absence de but de lucre et comparaison de l'ASBL avec d'autres groupements tels que la société à finalité sociale ou l'association de fait) ainsi que les règles relatives à la constitution des ASBL telles que modifiées par la loi de 2002 (acte constitutif, acquisition de la personnalité juridique, engagements pris au nom d'une ASBL en formation et formalités de publicité). [less ▲]

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See detailASBL et activités commerciales : le fil d'Ariane
Pasteger, David ULg

in Gol, Déborah; T'kint, Philippe (Eds.) Les personnes morales sans but lucratif : questions choisies (2012)

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See detailASBL, Fondations et Associations internationales
Thirion, Nicolas ULg; Caprasse, Olivier ULg

Book published by La Charte (2004)

Ouvrage collectif visant à présenter dans son ensemble le régime juridiques des ASBL, des fondations et des associations internationale après la réforme de 2002

Detailed reference viewed: 77 (9 ULg)