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See detailNew radioiodinated carboxylic and hydroxamic matrix metalloproteinase inhibitor tracers as potential tumor imaging agents
Oltenfreiter, R.; Staelens, L.; Lejeune, Annabelle ULg et al

in Nuclear Medicine & Biology (2004), 31(4), 459-468

Several studies have demonstrated a positive correlation between tumor progression and expression of extracellular proteinases such as matrix metalloproteinases (MMPs). MMP-2 and MMP-9 have become ... [more ▼]

Several studies have demonstrated a positive correlation between tumor progression and expression of extracellular proteinases such as matrix metalloproteinases (MMPs). MMP-2 and MMP-9 have become attractive targets for cancer research because of their increased expression in human malignant tumor tissues of various organs, providing a target for medical imaging techniques. Radioiodinated carboxylic and hydroxamic MMP inhibitors 2-(4'-[123]iodo-biphenyl-4-sulfonylainino)-3-(1H-indol-3-yl)-propionic acid (9) and 2-(4'-[I-123] iodo-biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide (11) were synthesized by electrophilic aromatic substitution of the tributylstannyl derivatives and resulted in radiochemical yields of 60% +/- 5% (n - 3) and 70% +/- 5% (n = 6), respectively. In vitro zymography and enzyme assays showed high inhibition capacities of the inhibitors on gelatinases. In vivo biodistribution showed no long-terin accumulation in organs and the possibility to accumulate in the tumor. These results warrant further studies of radioiodinated carboxylic and hydroxamic MNIP inhibitor tracers as potential SPECT tumor imaging agents. (C) 2004 Elsevier Inc. All rights reserved. [less ▲]

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See detailNew rationales for using TGFbeta inhibitors in radiotherapy.
Andarawewa, Kumari L.; Paupert, Jenny ULg; Pal, Anupama et al

in International journal of radiation biology (2007), 83(11-12), 803-11

PURPOSE: The first reports that ionizing radiation (IR) induces rapid and persistent activation of transforming growth factor beta1 (TGFbeta) were nearly two decades ago. Subsequent studies have shown ... [more ▼]

PURPOSE: The first reports that ionizing radiation (IR) induces rapid and persistent activation of transforming growth factor beta1 (TGFbeta) were nearly two decades ago. Subsequent studies have shown that TGFbeta is a major mediator of cellular and tissue responses to IR and have revealed novel facets of its complex biology. RESULTS: We and others have recently shown that inhibition of production or signaling of TGFbeta in epithelial cells modulates radiosensitivity and impedes activation of the DNA damage response program. The primary transducer of cellular response to DNA damage caused by ionizing radiation is the nuclear protein kinase ataxia telangiectasia mutated, whose activity is severely compromised when TGFbeta is inhibited. Thus, in conjunction, with its well-recognized contribution to normal tissue fibrosis, the role of TGFbeta in the genotoxic stress program provides a previously unsuspected avenue to modulate radiotherapy. CONCLUSIONS: We hypothesize that identification of the circumstances and tumors in which TGFbeta manipulation enhances tumor cell radiosensitivity, while protecting normal tissues, could significantly increase therapeutic index. [less ▲]

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See detailNew record of Encheliophis dubius (Carapidae) off Madagascar ?
Parmentier, Eric ULg; Bailly, Nicolas

in Cybium (2002), 26

When checking the identification of the Carapidae in the MNHN collection (Muséum National d’Histoire Naturelle, Paris) a specimen of Eurypleuron owasianum (Matsubara, 1953) (MNHN 1992-0914) caught off ... [more ▼]

When checking the identification of the Carapidae in the MNHN collection (Muséum National d’Histoire Naturelle, Paris) a specimen of Eurypleuron owasianum (Matsubara, 1953) (MNHN 1992-0914) caught off Madagascar (20°S, 42°30’E) was found to be incorrectly identified. The specimen is vey close to Carapus dubius (Putnam, 1874), which is known from the Eastern Pacific (Markle and Olney, 1990). [less ▲]

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See detailA new red colonial Pseudanabaena (Cyanoprokaryota, Oscillatoriales) from North American large lakes
Kling, H; Laughinghouse IV, Haywood ULg; Smarda, J et al

in Fottea (Praha) (2012), 12(2), 327-339

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See detailNew reflections on the sources, outcomes, defining features and motivations of grammaticalization
Breban, Tine; Vanderbiesen, Jeroen; Davidse, Kristin et al

in Breban, Tine; Brems, Lieselotte; Davidse, Kristin (Eds.) et al Grammaticalization and language change: new reflections (2012)

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See detailNew regional initiatives in pigeonpea improvement
Kimani, PM; Mergeai, Guy ULg; Silim, SN et al

in Proceedings Regional Workshop on Status and Potential of Pigeonpea in Eastern and Southern Africa (2001)

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See detailNew relative K+-sparing high ceiling diuretics related to torasemide
Masereel, B.; Schynts, M.; Lorhmann, E. et al

Poster (1991, September)

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See detailNew relative K+-sparing high ceiling diuretics related to torasemide
Masereel, B.; Schynts, M.; Lohrmann, E. et al

Conference (1992)

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See detailNew relative K+-sparing high ceiling diuretics related to torasemide
Masereel, B.; Schynts, M.; Lohrmann, E. et al

in Journal de Pharmacie de Belgique (1992), 47

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See detailA new representative of the lichid genus Ohleum (Trilobita) from the Eifelian (Middle Devonian) of southern Belgium
Taghon, Peter; Bonino, Enrico; Mottequin, Bernard ULg

in Geologica Belgica (2012), 15(3), 120-125

Trilobites of the family Lichidae are relatively poorly diversified within the Eifelian mixed siliciclastic-carbonate succession of the southern margin of the Dinant Synclinorium (Belgium). Until now ... [more ▼]

Trilobites of the family Lichidae are relatively poorly diversified within the Eifelian mixed siliciclastic-carbonate succession of the southern margin of the Dinant Synclinorium (Belgium). Until now, they were only represented by species belonging to the genera Ceratarges and Eifliarges. The recent discovery of a well-preserved specimen within the Eifelian-aged Jemelle Formation in the Couvin area led us to propose the first detailed description of a representative of the genus Ohleum (Ohleum magreani sp. nov.) in the Ardennes. [less ▲]

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See detailNew Research for Periods of Ap Stars Observed at the ESO - III
Renson, Pierre ULg; Manfroid, Jean ULg

in Information Bulletin on Variable Stars (1979), 1658

Not Available

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See detailNew Results from the Excavations in the Northern Domestic Quarter (Field B)
Van der Stede, Véronique ULg

Scientific conference (2007, October 11)

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See detailNew Results in Exclusive Hard Reactions
Pire, Bernard; Semenov-Tyan-Shanskiy, Kirill ULg; Szymanowski, Lech et al

in PoS - Proceedings of Science (2011), EPS-HEP2011

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See detailNew results in the defensive chemistry of Crematogaster ants
Laurent, Pascal ULg; Hamdani, Anissa; Braekman, Jean-Claude et al

Poster (2002)

Ants of the genus Crematogaster are able to raise their abdomen forwards and over the thorax and head. In many Crematogaster species, the venom is emitted as a froth that accumulates on the spatulate ... [more ▼]

Ants of the genus Crematogaster are able to raise their abdomen forwards and over the thorax and head. In many Crematogaster species, the venom is emitted as a froth that accumulates on the spatulate portion and at the basis of the sting, and thus can be easily applied to the integument of enemies. In the three European species of Crematogaster ants, the Dufour gland contains complex mixtures of long chain derivatives bearing a (E,E)-cross-conjugated dienone linked to a primary acetate function. When the venom is emitted, these compounds are transformed into highly electrophilic and toxic 4-oxo-2,5-dienals by an esterase and an oxidase stored in the poison gland. On the other hand, the Dufour gland of one Crematogaster species from Papua-New Guinea produces long chain furan derivatives, whereas two Brazilian species produce furanocembrene diterpenes. To further investigate the defensive mechanisms in this genus and to assess whether the composition of the Dufour gland secretion could be used for taxonomic purposes, we have now studied two other Crematogaster species. The Dufour gland of C. nigriceps from Africa contains a mixture of l-alkyl-l,3,5-cyclohexanetriols. In C. montezumia, collected in Argentina, the defensive mechanism is based on the production of triacylglycerols bearing polyunsaturated fatty acids containing (Z,Z,Z)-conjugated trienes or (5E,8Z,10Z,12Z)-tetraenes, which are responsible for the strong sticking properties of the secretion. [less ▲]

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See detailNew results in the defensive chemistry of Crematogaster ants
Laurent, Pascal ULg; Hamdani, Anissa; Braekman, Jean-Claude et al

Poster (2002)

Ants of the genus Crematogaster are able to raise their abdomen forwards and over the thorax and head. In many Crematogaster species, the venom is emitted as a froth that accumulates on the spatulate ... [more ▼]

Ants of the genus Crematogaster are able to raise their abdomen forwards and over the thorax and head. In many Crematogaster species, the venom is emitted as a froth that accumulates on the spatulate portion and at the basis of the sting, and thus can be easily applied to the integument of enemies. In the three European species of Crematogaster ants, the Dufour gland contains complex mixtures of long chain derivatives bearing a (E,E)-cross-conjugated dienone linked to a primary acetate function. When the venom is emitted, these compounds are transformed into highly electrophilic and toxic 4-oxo-2,5-dienals by an esterase and an oxidase stored in the poison gland. On the other hand, the Dufour gland of one Crematogaster species from Papua-New Guinea produces long chain furan derivatives, whereas two Brazilian species produce furanocembrene diterpenes. To further investigate the defensive mechanisms in this genus and to assess whether the composition of the Dufour gland secretion could be used for taxonomic purposes, we have now studied two other Crematogaster species. The Dufour gland of C. nigriceps from Africa contains a mixture of l-alkyl-l,3,5-cyclohexanetriols. In C. montezumia, collected in Argentina, the defensive mechanism is based on the production of triacylglycerols bearing polyunsaturated fatty acids containing (Z,Z,Z)-conjugated trienes or (5E,8Z,10Z,12Z)-tetraenes, which are responsible for the strong sticking properties of the secretion. [less ▲]

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See detailNew results in the defensive chemistry of Crematogaster ants
Laurent, Pascal ULg; Hamdani, Anissa; Braekman, Jean-Claude et al

Poster (2002)

Ants of the genus Crematogaster are able to raise their abdomen forwards and over the thorax and head. In many Crematogaster species, the venom is emitted as a froth that accumulates on the spatulate ... [more ▼]

Ants of the genus Crematogaster are able to raise their abdomen forwards and over the thorax and head. In many Crematogaster species, the venom is emitted as a froth that accumulates on the spatulate portion and at the basis of the sting, and thus can be easily applied to the integument of enemies. In the three European species of Crematogaster ants, the Dufour gland contains complex mixtures of long chain derivatives bearing a (E,E)-cross-conjugated dienone linked to a primary acetate function. When the venom is emitted, these compounds are transformed into highly electrophilic and toxic 4-oxo-2,5-dienals by an esterase and an oxidase stored in the poison gland. On the other hand, the Dufour gland of one Crematogaster species from Papua-New Guinea produces long chain furan derivatives, whereas two Brazilian species produce furanocembrene diterpenes. To further investigate the defensive mechanisms in this genus and to assess whether the composition of the Dufour gland secretion could be used for taxonomic purposes, we have now studied two other Crematogaster species. The Dufour gland of C. nigriceps from Africa contains a mixture of l-alkyl-l,3,5-cyclohexanetriols. In C. montezumia, collected in Argentina, the defensive mechanism is based on the production of triacylglycerols bearing polyunsaturated fatty acids containing (Z,Z,Z)-conjugated trienes or (5E,8Z,10Z,12Z)-tetraenes, which are responsible for the strong sticking properties of the secretion. [less ▲]

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See detailNew results on forbidden transitions of [FE II], [FE III], [FE V], [FE VII], and [FE X] in stellar spectra
Swings, Polydore ULg; Struve, O.

in Publications of the American Astronomical Society (1946)

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See detailNew results on the UV Io footprint morphology and brightness
Bonfond, Bertrand ULg; Grodent, Denis ULg; Gérard, Jean-Claude ULg et al

Poster (2008, April 18)

The Io UV footprint is an auroral feature on Jupiter caused by the electromagnetic interaction between the satellite Io and the Jovian magnetosphere. The footprint morphology and the spots multiplicity ... [more ▼]

The Io UV footprint is an auroral feature on Jupiter caused by the electromagnetic interaction between the satellite Io and the Jovian magnetosphere. The footprint morphology and the spots multiplicity have been found to vary with the location of Io in the plasma torus. We show recent Hubble Space Telescope (HST) images that reveal a new feature in the footprint: a faint leading spot that appears upstream of the main spot in one hemisphere when Io is close to the opposite border of the torus. A possible interpretation relates the leading spots and one downward secondary spot to electron beams generated by downstream currents in the opposite hemisphere. We also present a 3D model of the Io footprint emissions in the 100 to 170 nm wavelength range. Comparisons between this model and the HST images enable us to study the actual size and shape of the different Io footprint features. It also allows to measure the footprint brightness on the new images with a better estimation of the geometric effects (e.g. limb brightening). The observations presented here provide critical constraints to the Io-plasma torus interaction modeling. [less ▲]

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See detailNew results on the variability of some WN stars
Gosset, Eric ULg; Vreux, Jean-Marie ULg; Manfroid, Jean ULg et al

in Davidson, K.; Moffat, A. F. J.; Lamers, H.J.G.L.M. (Eds.) Physics of Luminous Blue Variables (1989)

Not Available

Detailed reference viewed: 9 (1 ULg)