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See detailoncologie gastro-intestinale
Frei, A.; Coucke, Philippe ULg; Felley, C. et al

in Revue Médicale Suisse (1999), 760

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See detailThe oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.
Franzoso, G.; Bours, Vincent ULg; Azarenko, V. et al

in EMBO Journal (1993), 12(10), 3893-901

Previously we have proposed a role for Bcl-3 in facilitating transactivation through kappa B sites by counteracting the inhibitory effects of bound, non-transactivating homodimers of the p50 subunit of NF ... [more ▼]

Previously we have proposed a role for Bcl-3 in facilitating transactivation through kappa B sites by counteracting the inhibitory effects of bound, non-transactivating homodimers of the p50 subunit of NF-kappa B. Such homodimers are abundant for example in nuclei of unstimulated primary T cells. Here we extend the model and provide new evidence which fulfills a number of predictions. (i) Bcl-3 preferentially targets p50 homodimers over NF-kappa B heterodimers since the homodimers are completely dissociated from kappa B sites at concentrations of Bcl-3 which do not affect NF-kappa B. (ii) Select kappa B sites associate very strongly and stably with p50 homodimers, completely preventing binding by NF-kappa B. Such kappa B sites are likely candidates for regulation by p50 homodimers and Bcl-3. (iii) Bcl-3 and p50 can be co-localized in the nucleus, a requirement for active removal of homodimers from their binding sites in vivo. (iv) The ankyrin repeat domain of Bcl-3 is sufficient for the reversal of p50 homodimer-mediated inhibition, correlating with the ability of this domain alone to inhibit p50 binding to kappa B sites in vitro. Our data support the model that induction of nuclear Bcl-3 may be required during cellular stimulation to actively remove stably bound p50 homodimers from certain kappa B sites in order to allow transactivating NF-kappa B complexes to engage. This exact mechanism is demonstrated with in vitro experiments. [less ▲]

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See detailThe oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers.
Bours, Vincent ULg; Franzoso, G.; Azarenko, V. et al

in Cell (1993), 72(5), 729-39

Bcl-3 is an I kappa B-related protein with ankyrin repeat motifs. Its gene is located at a site of recurrent translocations in a subset of B cell chronic lymphocytic leukemias. Bcl-3 associates tightly ... [more ▼]

Bcl-3 is an I kappa B-related protein with ankyrin repeat motifs. Its gene is located at a site of recurrent translocations in a subset of B cell chronic lymphocytic leukemias. Bcl-3 associates tightly with p50B (NFKB2, p52) homodimers in cells, and together these proteins form a ternary complex with DNA at kappa B sites. Such an association functionally leads to a novel and potent form of transactivation through the kappa B motif: the tethering of Bcl-3 to DNA via the p50B homodimers allows Bcl-3 to transactivate directly, while p50B homodimers alone cannot. Transactivation mediated by Bcl-3 requires two cooperating domains located amino- and carboxy-terminal to the ankyrin domain. Bcl-3 is localized to the nucleus, and a Bcl-3-p50B complex is detected in certain lymphoid cells. Our data reveal a novel role for Bcl-3, distinct from that of the inhibitor I kappa B. The results have implications for tumorigenesis. [less ▲]

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See detailOncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase
Lefebvre, Laurent; Vanderplasschen, Alain ULg; Ciminale, Vincenzo et al

in Journal of Virology (2002), 76(3), 1400-1414

G4 and p13(II) are accessory proteins encoded by the X region of bovine leukemia virus and human T-cell leukemia virus type 1 (HTLV-1), respectively. Disruption of the G4 and p13(II) open reading frames ... [more ▼]

G4 and p13(II) are accessory proteins encoded by the X region of bovine leukemia virus and human T-cell leukemia virus type 1 (HTLV-1), respectively. Disruption of the G4 and p13(II) open reading frames interferes with viral spread in animal model systems, indicating that the corresponding proteins play a key role in viral replication. In addition, G4 is oncogenic in primary cell cultures and is absolutely required for efficient onset of leukemogenesis in sheep. To gain insight into the function of these proteins, we utilized the yeast two-hybrid system to identify protein partners of G4. Results revealed that G4 interacts with farnesyl pyrophosphate synthetase (FPPS), a protein involved in the mevalonate/squalene pathway and in synthesis of FPP, a substrate required for prenylation of Ras. The specificity of the interaction was verified by glutathione S-transferase (GST) pull-down assays and by coimmunoprecipitation experiments. Furthermore, confocal microscopy showed that the subcellular localization of G4 was profoundly affected by FPPS. The G4 protein itself was not prenylated, at least in rabbit reticulocyte lysate-based assays. The domain of G4 required for binding to FPPS was restricted to an amphipathic alpha-helix rich in arginine residues. Subtle mutation of this alpha-helix abrogated G4 oncogenic potential in vitro, providing a biological relevance for FPPS-G4 complex formation in cells. Finally, HTLV-1 p13(II) was also found to specifically interact with FPPS (in yeast as well as in GST pull-down assays) and to colocalize with G4 in mitochondria, suggesting a functional analogy between these oncoviral accessory proteins. Identification of FPPS as a molecular partner for p13(II) and G4 accessory proteins opens retrovirus-induced leukemia. [less ▲]

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See detailL’onde de contraction systolique des oreillettes du cœur de chien
Fredericq, Léon ULg

in Archives Internationales de Physiologie (1913), XIII

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See detailL’onde F dans tous ses états
WANG, François-Charles ULg; Massart, Nicolas ULg; Kaux, Jean-François ULg et al

in Revue Neurologique (2011), 167

F-waves result from the discharge of the motoneurons following their antidromic activa- tion. The F-wave appears, as an indirect (the F-wave latency decreases when the stimulation site moves away from the ... [more ▼]

F-waves result from the discharge of the motoneurons following their antidromic activa- tion. The F-wave appears, as an indirect (the F-wave latency decreases when the stimulation site moves away from the muscular detection) and late response (occurring after the M response). In practice, the most useful parameter is the F-wave minimal latency, provided that at least seven distinct F-waves are evoked. When the analysis is relative either to the controlateral side, or to a former examination, this parameter is one of most sensitive in electroneuromyography. F-wave evocation implies conduction along the entire peripheral nervous system, and particularly its proximal part, which is not investigated by nervous trunks conduction velocity studies. Thus, F wave study is the most useful in plexopathies and polyradiculonevritis. In the early phase of Guillain-Barre ́ syndrome, their absence may be the unique sign indicative of proximal conduction blocks. [less ▲]

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See detailOndelettes et télédétection
Charles, Catherine ULg; Rasson, Jean-Paul

in Revue des Nouvelles Technologies de l'Information [=RNTI] (2003), 1

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See detailOndelettes et télédétection.
Charles, Catherine ULg

in Actes des XXXVèmes Journées de Statistiques (2003)

Detailed reference viewed: 13 (4 ULg)
See detailOnderzoek betreffende de secundaire agglomeratiepolen en de hiërarchische structurering ervan - Geval Luik
Donnay, Jean-Paul ULg; Sporck, José A.; Tock, Thierry

in STERO (1980), (13), 6-15

Detailed reference viewed: 4 (0 ULg)
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See detailOnderzoek en praktijk in de Franstalige neerlandistiek
Spinoy, Erik ULg; Janssens, Guy ULg; Sereni, Sabrina

in n/f (2004), 4

This volume collects the revised papers of the december 2003 Conference (Liège) of the Association des neerlandistes de Belgique francophone.

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See detailOnderzoek Verplaatsingsgedrag Vlaanderen 4.1 (2008-2009): Verkeerskundige interpretatie van de belangrijkste gegevens
Miermans, Willy; Janssens, Davy; Cools, Mario ULg et al

Report (2010)

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See detailOnderzoek Verplaatsingsgedrag Vlaanderen 4.2 (2009-2010): Analyserapport
Janssens, Davy; Cools, Mario ULg; Miermans, Willy et al

Report (2011)

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See detailOnderzoek Verplaatsingsgedrag Vlaanderen 4.2 (2009-2010): Tabellenrapport
Cools, Mario ULg; Declercq, Katrien; Janssens, Davy et al

Report (2011)

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See detailOndes de choc et pathologies abarticulaires
Kaux, Jean-François ULg

Conference (2011, April 06)

Detailed reference viewed: 51 (5 ULg)
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See detailOndes de choc et tendinopathies : expérience clinique du CHU de Liège
Kaux, Jean-François ULg

Conference (2014, March 11)

Detailed reference viewed: 32 (3 ULg)
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See detailOndes de choc et traitement des lésions tendinomusculaires en 2011
Kaux, Jean-François ULg

Conference (2011, October 24)

Detailed reference viewed: 80 (13 ULg)