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See detailMyeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men
Zouaoui Boudjeltia, Karim; Delporte, Cédric; Van Antwerpen, Pierre et al

in Mediators of Inflammation (2013), 2013

The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation ... [more ▼]

The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macrophages, can modify LDL (Mox-LDL) at the surface of endothelial cells. In addition we observed that the activation of the endothelial cells by angiotensin II amplifies this process. We suggested that induction of the NADPH oxidase complex was a major step in the oxidative process. Based on these data, we asked whether there was an independent association, in 121 patients, between NADPH oxidase modulators, such as angiotensin II, adiponectin, and levels of circulating Mox-LDL. Our observations suggest that the combination of blood angiotensin II, MPO activity, and adiponectin explains, at least partially, serum Mox-LDL levels. [less ▲]

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See detailMyeloperoxydase concentration in bronchoalveolar lavage from healthy and heavy horses
Art, Tatiana ULg; Desmet, Christophe ULg; Lekeux, Pierre ULg et al

in Proceedings : 22nd Symposium of the Veterinary and Comparative Respiratory Society (2004)

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See detailMyocardial cardiotrophin-1 is differentially induced in congenital cardiac defects depending on hypoxemia.
Heying, Ruth; Qing, Ma; SCHUMACHER, Katharina ULg et al

in Future cardiology (2014), 10(1), 53-62

Aim: Cardiotrophin-1 (CT-1) is upregulated by hypoxemia and hemodynamic overload and is characterized by potent hypertrophic and protective properties on cardiac cells. This study aimed to investigate ... [more ▼]

Aim: Cardiotrophin-1 (CT-1) is upregulated by hypoxemia and hemodynamic overload and is characterized by potent hypertrophic and protective properties on cardiac cells. This study aimed to investigate whether CT-1 is differentially induced in the myocardium of infants with congenital cardiac defects depending on hypoxemia. Methods & results: Infants with Tetralogy of Fallot (n = 8) or with large nonrestrictive ventricular septal defect (n = 8) undergoing corrective surgery were investigated. Expression of CT-1 was assessed at mRNA and protein levels in the right atrial and ventricular myocardium. The activation of the STAT-3 and VEGF were measured. Degradation of cardiac troponin-I served as a marker of myocardial damage. CT-1 was detected in all patients with levels negatively correlating to the arterial oxygen saturation. Higher CT-1 expression in Tetralogy of Fallot patients was associated with activation of the JAK/STAT pathway and higher cardiac troponin-I degradation. Conclusion: CT-1 may mediate myocardial hypertrophy and dysfunction in infants with congenital cardiac defects, particularly in those with hypoxemia. [less ▲]

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See detailMyocardial contractile reserve during exercise predicts left ventricular reserve remodelling after cardiac resynchromization therapy
Lancellotti, Patrizio ULg; Senechal, Mario; Moonen, Marie ULg et al

in European Journal of Echocardiography (2009), 10(5), 663-8

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See detailMyocardial depression as a component of endotoxic shock in horses: preliminary results of an echocardiographic study
Borde, Laura ULg; Amory, Hélène ULg; Leroux, Aurélia ULg et al

Conference (2010, October 16)

Cardiovascular consequences of septic shock are well described in humans but these hemodynamic disturbances have not yet been studied in endotoxic horses. The endotoxins act directly and indirectly to ... [more ▼]

Cardiovascular consequences of septic shock are well described in humans but these hemodynamic disturbances have not yet been studied in endotoxic horses. The endotoxins act directly and indirectly to cause a myocardial depression associated with a systemic hypotension responsible for a fall of both the cardiac output and the systemic vascular resistance in end-stage endotoxic shock. The hypothesis was that myocardial depression was a component of endotoxic shock in horses. In this way, fifty horses admitted in clinic with signs of endotoxic shock and 17 healthy control horses were submitted to a doppler echocardiographic exam to assess the impact of endotoxic shock on equine cardiac function. A shock score from 1 to 4, based on clinical evaluation, non invasive systolic blood pressure, and blood tests was attributed to each endotoxic horse. Echocardiographic and Doppler parameters were compared between the 5 groups using a multivariable ANOVA analysis. Score 1, 2, 3 and 4 groups included 11, 17, 12 and 10 horses, respectively. Some markers of systolic function included the ejection time (ET), ET corrected for HR and mean velocity of circumferential fibre shortening corrected for HR, the aortic velocity time integral and deceleration time, and the stroke volume were significantly lower, whereas the HR and the peak velocity of the late diastolic filling of the mitral Doppler flow and its velocity time integral were significantly higher in endotoxemic horses than in controls. Thanks to an increase in HR, the cardiac output was not significantly different between groups. Even if the tachycardia, the fall in preload and a probable decrease in afterload doubtless influence the observed changes, the results of this study suggest that a myocardial depression with both an impaired systolic and diastolic left ventricular function could be a component of endotoxic shock in horses. [less ▲]

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See detailMyocardial dynamic contrast-enhanced MR: vascular diseases and beyond
NCHIMI LONGANG, Alain ULg; DJEKIC, Julien; RASKINET, Bruno et al

in JBR-BTR : Journal Belge de Radiologie - Belgisch Tijdschrift voor Radiologie (2014), 97

Contrast-enhanced cardiac magnetic resonance enables the evaluation of both myocardial perfusion and its composition. This paper reviews and discusses the conditions that cause abnormal findings on ... [more ▼]

Contrast-enhanced cardiac magnetic resonance enables the evaluation of both myocardial perfusion and its composition. This paper reviews and discusses the conditions that cause abnormal findings on contrast-enhanced myocardial magnetic resonance. Their knowledge helps in most cases to avoid inappropriate referrals to invasive imaging in patients suspected of myocardial vascular disease, undergoing contrast-enhanced cardiac magnetic resonance. [less ▲]

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See detailMyocardial expression of cytokines influence postoperative outcome after cardiac surgery for congenital cardiac defects
Sprute, Johanna; Heying, Ruth; Buding, Brigitte et al

Conference (2014, January)

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See detailMyocardial infarct size quantification in mice by SPECT using a novel algorithm independent of a normal perfusion database
Roelants, Véronique; DELGAUDINE, Marie ULg; Walrand, Stephan et al

in European Journal of Nuclear Medicine and Molecular Imaging Research (2012), 2

Background: There is a growing interest in developing non-invasive imaging techniques permitting infarct size (IS) measurements in mice. The aim of this study was to validate the high-resolution rodent ... [more ▼]

Background: There is a growing interest in developing non-invasive imaging techniques permitting infarct size (IS) measurements in mice. The aim of this study was to validate the high-resolution rodent Linoview single photon emission computed tomography (SPECT) system for non-invasive measurements of IS in mice by using a novel algorithm independent of a normal database, in comparison with histology. Methods: Eleven mice underwent a left coronary artery ligature. Seven days later, animals were imaged on the SPECT 2h30 after injection of 173 ± 27 MBq of Tc-99m-sestamibi. Mice were subsequently killed, and their hearts were excised for IS determination with triphenyltetrazolium chloride (TTC) staining. SPECT images were reconstructed using the expectation maximization maximum likelihood algorithm, and the IS was calculated using a novel algorithm applied on the 20-segment polar map provided by the commercially available QPS software (Cedars-Sinai Medical Center, CA, USA). This original method is attractive by the fact that it does not require the implementation of a normal perfusion database. Results: Reconstructed images allowed a clear delineation of the left ventricles borders in all mice. No significant difference was found between mean IS determined by SPECT and by TTC staining [37.9 ± 17.5% vs 35.6 ± 17.2%, respectively (P = 0.10)]. Linear regression analysis showed an excellent correlation between IS measured on the SPECT images and IS obtained with TTC staining (y = 0.95x + 0.03 (r = 0.97; P < 0.0001)), without bias, as demonstrated by the Bland-Altman plot. Conclusion: Our results demonstrate the accuracy of the method for the measurement of myocardial IS in mice with the Linoview SPECT system. [less ▲]

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See detailMyocardial Viability. Stress Echocardiography Vs Nuclear Medicine
Pierard, Luc ULg; Lancellotti, Patrizio ULg; Benoit, T.

in European Heart Journal (1997), 18(Suppl D), 117-23

Myocardial dyssynergy does not necessarily indicate myocardial necrosis in patients with coronary artery disease. The differentiation between viable and non-viable tissue is of great clinical importance ... [more ▼]

Myocardial dyssynergy does not necessarily indicate myocardial necrosis in patients with coronary artery disease. The differentiation between viable and non-viable tissue is of great clinical importance in order to make the most appropriate clinical decision in the individual patient. Several techniques are used to assess myocardial viability. Nuclear medicine gives reliable information on regional perfusion, metabolism and cell membrane integrity, while echocardiography provides real time visualization of myocardial thickening in basal conditions and continuously during pharmacological interventions. The presence or absence of contractile reserve in akinetic regions can be evaluated by pharmacological stress echocardiography. This article presents the semiology of myocardial viability as characterized by these different methods and reviews their relative value in different clinical settings. [less ▲]

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See detailLa myocardiopathie hypertrophique obstructive: options therapeutiques chirurgicales.
Radermecker, Marc ULg; SakalihasanN, Natzi ULg; Partoune, B. et al

in Revue Médicale de Liège (1993), 48(12), 659-65

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See detailMyocellular Enzyme Leakage, Polymorphonuclear Neutrophil Activation and Delayed Onset Muscle Soreness Induced by Isokinetic Eccentric Exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Deby-Dupont, G. et al

in Archives of Physiology & Biochemistry (1996), 104(3), 322-9

To address the question of whether delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of the arachidonic acid derived product ... [more ▼]

To address the question of whether delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of the arachidonic acid derived product prostaglandin E2 (PGE2). 10 healthy male subjects were submitted to eccentric and concentric isokinetic exercises on a Kin Trex device at 60 degrees/s angular velocity. Exercise consisted of 8 stages of 5 maximal contractions of the knee extensor and flexor muscle groups of both legs separated by 1 min rest phases. There was an interval of at least 30 days between eccentric and concentric testing, and the order of the two exercise sessions was randomly assigned. The subjective presence and intensity of DOMS was evaluated using a visual analogue scale, immediately, following 24 h and 48 h after each test. Five blood samples were drawn from an antecubital vein: at rest before exercise, immediately after, after 30 min recovery, 24 h and 48 h after the tests. The magnitude of the acute inflammatory response to exercise was assessed by measuring plasma levels of polymorphonuclear elastase ([EL]), myeloperoxidase ([MPO]) and PGE2 ([PGE2]). Using two way analysis of variance, it appeared that only eccentric exercise significantly increased [EL] and DOMS, especially of the hamstring muscles. Furthermore, a significant decrease in eccentric peak torque of this muscle group only was observed on day 2 after eccentric work (- 21%; P < 0.002). Serum activity of creatine kinase and serum concentration of myoglobin increased significantly 24 and 48 h after both exercise tests. However, these variables reached significantly higher values following eccentric contractions 48 h after exercise. Mean [PGE2] in the two exercise modes remained unchanged over time and were practically equal at each time point. On the basis of these findings, we conclude that the magnitude of polymorphonuclear (PMN) activation, muscle damage, and DOMS are greater after eccentric than after concentric muscle contractions. However, the hypothesized interplay between muscle damage, increased PGE2 production, DOMS sensations, and reduced isokinetic muscle performance was not substantiated by the present results. [less ▲]

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See detailMyoclonin1/EFHC1 in cell division, neuroblast migration, synapse/dendrite formation in juvenile myoclonic epilepsy
Grisar, Thierry ULg; Lakaye, Bernard ULg; de Nijs, Laurence ULg et al

in Noebels, JL; Avoli, M; Rogawski, MA (Eds.) et al Jasper's Basic Mechanisms of the Epilepsies, 4th edition (2012)

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See detailMyoferlin is a key regulator of EGFR activity in breast cancer.
Turtoi, Andrei ULg; Blomme, Arnaud ULg; Bellahcene, Akeila ULg et al

in Cancer Research (2013)

Myoferlin is a member of the ferlin family of proteins that participate in plasma membrane fusion, repair and endocytosis. While some reports have implicated myoferlin in cancer, the extent of its ... [more ▼]

Myoferlin is a member of the ferlin family of proteins that participate in plasma membrane fusion, repair and endocytosis. While some reports have implicated myoferlin in cancer, the extent of its expression in and contributions to cancer are not well established. In this study, we show that myoferlin is overexpressed in human breast cancers and that it is has a critical role in controlling degradation of the EGFR after its activation and internalization in breast cancer cells. Myoferlin depletion blocked EGF-induced cell migration and epithelial-to-mesenchymal transition. Both effects were induced as a result of impaired degradation of phosphorylated EGFR via dysfunctional plasma membrane caveolae and alteration of caveolin homooligomerization. In parallel, myoferlin depletion reduced tumor development in a chicken chorioallantoic membrane xenograft model of human breast cancer. Considering the therapeutic significance of EGFR targeting, our findings identify myoferlin as an novel candidate function to target for future drug development. [less ▲]

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See detailMyofibrillar composition of some red- and white-blooded Antarctic teleosts
Feller, Georges ULg; Boinet, P.

in Molecular Physiology (1984), 5

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See detailMyofibroblastic inflammatory urinary bladder tumors in dogs: report of 8 cases
Bohme, Béatrice; Ngendahayo, P.; Hamaide, Annick ULg et al

Poster (2008, July)

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