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See detailThe antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells
Hajitou, Amin; Grignet, Christine ULg; Devy, L. et al

in FASEB Journal (2002), 16

Endostatin and angiostatin are known as tumor-derived angiogenesis inhibitors, but their mechanisms of action are not yet completely defined. We report here that endostatin and angiostatin, delivered by ... [more ▼]

Endostatin and angiostatin are known as tumor-derived angiogenesis inhibitors, but their mechanisms of action are not yet completely defined. We report here that endostatin and angiostatin, delivered by adenoviral vectors, reduced in vitro the neovessel formation in the mouse aortic ring assay by 85 and 40%, respectively. We also demonstrated in vivo that both endostatin and angiostatin inhibited local invasion and tumor vascularization of transplanted murine malignant keratinocytes, and reduced by 50 and 90% the development of highly vascularized murine mammary tumors. This inhibition of tumor growth was associated with a reduction of tumor vascularization. Expression analysis of vascular endothelial growth factor (VEGF) carried out in the mouse aortic ring model revealed a 3- to 10-fold down-regulation of VEGF mRNA expression in endostatin-treated rings. A similar down-regulation of VEGF expression at both mRNA and protein levels was also observed in the two in vivo cancer models after treatment with each angiogenesis inhibitor. This suggests that endostatin and angiostatin effects may be mediated, at least in part, by their ability to down-regulate VEGF expression within the tumor. This work provides evidence that endostatin and angiostatin act on tumor cells themselves. [less ▲]

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See detailAntitumoral Vaccination with Granulocyte-Macrophage Colony-Stimulating Factor or Interleukin-12-Expressing Dhd/K12 Colon Adenocarcinoma Cells
Lechanteur, Chantal ULg; Moutschen, Michel ULg; Princen, Frederic et al

in Cancer Gene Therapy (2000), 7(5), 676-82

Immunomodulating gene therapy for the treatment of malignant diseases is under extensive investigation. In this study, we induced an antitumoral immune response with murine interleukin-12 (mIL-12) and ... [more ▼]

Immunomodulating gene therapy for the treatment of malignant diseases is under extensive investigation. In this study, we induced an antitumoral immune response with murine interleukin-12 (mIL-12) and murine granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting tumor cells in a model of peritoneal carcinomatosis. Intraperitoneal injection of DHD/K12 tumoral cells engineered to produce IL-12 or GM-CSF did not generate any tumors, whereas untransduced DHD/K12 cells gave rise to peritoneal carcinomatosis. IL-12-expressing DHD/K12 cells also protected against tumors derived from coinjected parental cells. To test whether cytokine-producing cells could elicit a memory antitumoral immune response, animals received a challenge with parental DHD/K12 cells 35 days after the injection of proliferating or irradiated DHD/K12 engineered cells. Under our experimental conditions, irradiated tumor cells did not generate any antitumoral immunity. In contrast, tumor development was delayed and survival increased in the animals vaccinated with cytokine-secreting proliferating cells. A specific cytotoxic T-lymphocyte response against DHD/K12 parental cells was observed after vaccination with GM-CSF-expressing cells. Our results demonstrated that intraperitoneal vaccination with IL-12- or GM-CSF-expressing adenocarcinoma cells induced a systemic immune antitumoral response that may be useful as an adjuvant therapy after surgical resection of colorectal cancer. [less ▲]

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See detailAntiviral diabetes susceptibility gene
Geenen, Vincent ULg

in International Diabetes Monitor (2006), 18

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See detailAntiviral efficacy and resistance in patients on antiretroviral therapy in Kigali, Rwanda: the real-life situation in 2002.
Fischer, A; Karasi, Jean Claude ULg; Kibibi, D et al

in HIV Medicine (2006), 7(1), 64-6

Our study aimed to complete the published data on ARV therapy in Africa by describing the baseline situation in Rwanda before the launch of a large ARV programme (ESTHER). Prescription habits, frequency ... [more ▼]

Our study aimed to complete the published data on ARV therapy in Africa by describing the baseline situation in Rwanda before the launch of a large ARV programme (ESTHER). Prescription habits, frequency and reasons for treatment interruptions but also antiviral efficay, resistance to ARVs and genotypic variability of the viruses present in Rwanda were analysed. Among the 233 patients included in the study, it appeared that a vast majority (91%) were under triple therapy and that half of them had experienced at least one treatment interruption caused mainly by drug shortage or financial difficulties. Among 60 blood samples analysed, 26 were in virological failure with a viral load above 1000 RNA copies/ml and 11 presented major drug resistance mutations. Finally, virological failure could mainly be explained by the high frequency of treatment interruptions but also by the emergence of drug resistance mutations. Consequently the major objective for the ESTHER programme to improve the situation in Rwanda will be to reduce the drug shortage and facilitate the financial accessibility of the treatments. [less ▲]

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See detailAntiwindup regulation of saturated linear systems
Forni, Fulvio ULg; Zaccarian, Luca; Sepulchre, Rodolphe ULg

in 51st IEEE Conference on Decision and Control (2012, December)

We consider the output regulation problem for linear systems subject to actuators saturation. A state-feedback unconstrained regulator is transformed into an error-feedback bounded regulator by ... [more ▼]

We consider the output regulation problem for linear systems subject to actuators saturation. A state-feedback unconstrained regulator is transformed into an error-feedback bounded regulator by introducing an observer which is then decomposed into the sum of "unconstrained" and "antiwindup" dynamics. The unconstrained dynamics are regulated towards a predefined reference trajectory, by a control signal u which may violate the saturation bounds during transients. The antiwindup dynamics transiently store the mismatch between unconstrained and constrained dynamics. The antiwindup design also applies to a predefined error-feedback dynamic regulator for the unconstrained system, as in standard antiwindup setting. As a particular case of distinct interest, the design provides a new global asymptotic stabilizer for saturated null-controllable systems. [less ▲]

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See detailAntoine Garapon, Peut-on réparer l’histoire ? Colonisation, esclavage, Shoah, Paris, Odile Jacob, 2008, 287 p.
Grandjean, Geoffrey ULg

in Cahiers de Sciences Politiques de l'ULg (2009)

This article gives a summary of a book on restorative justice.

Detailed reference viewed: 88 (5 ULg)
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See detailAntoine Wiertz : un peintre belge contemporain
De Laveleye, Émile ULg

in Revue des Deux Mondes (Paris, France : 1948) (1866), Tome 66(Période 2), 829-848

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See detailAntoine, Jacques
Habrand, Tanguy ULg

in Nouvelle biographie nationale (2016)

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See detailAntoinette de Jésus
Henneau, Marie-Elisabeth ULg

in Fella, Audrey (Ed.) Les femmes mystiques. Histoire et dictionnaire (2013)

Detailed reference viewed: 24 (4 ULg)
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See detailAnton de Kom, historiographe. La construction d’un passé national pour les esclaves du Surinam
Andringa, Kim ULg

in Amnis : Revue de Civilisation Contemporaine Europes/Amériques (2014), 13

Detailed reference viewed: 24 (0 ULg)
See detailAntonin de Bemels. Le danseur, le pantin et la métamorphose
Tomasovic, Dick ULg

in Aubenas, Jacqueline (Ed.) Filmer la danse (2007)

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See detailAntoninos de Cos, les lophoura et les soins vétérinaires
Marganne, Marie-Hélène ULg

in Doyen-Higuet, Anne-Marie; Van den Abeele, Baudouin (Eds.) Chevaux, chiens, faucons. L’art vétérinaire antique et médiéval à travers les sources écrites, archéologiques et iconographiques (Louvain-La-Neuve, 24-26 mars 2011) (2015)

Poursuivant les recherches ébauchées à propos d'Antoninos de Cos, dont le nom apparaît, à propos de soins vétérinaires, dans un papyrus grec daté du début du IIIe siècle de notre ère réédité récemment par ... [more ▼]

Poursuivant les recherches ébauchées à propos d'Antoninos de Cos, dont le nom apparaît, à propos de soins vétérinaires, dans un papyrus grec daté du début du IIIe siècle de notre ère réédité récemment par nos soins (Matière médicale ou doxographie ? Révision de PSI inv. 3011 [MP3 2388], dans V. Boudon-Millot – A. Garzya – J. Jouanna & A. Roselli (éd.), Histoire de la tradition et édition des médecins grecs. Actes du VIe Colloque international, Paris, 12-14 avril 2008, Napoli, 2010, pp. 43-59 [Collectanea, 27]), on s'attache à rassembler les fragments qui pourraient être attribués à cet auteur, qu'ils relèvent de la médecine humaine ou vétérinaire, à retracer tant leur contexte chronologique que les étapes de leur transmission, à analyser leur contenu et à définir enfin leur apport à la connaissance de l'art vétérinaire antique et de son expression écrite. [less ▲]

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See detailAntonio Lobo Antunes
Delville, Michel ULg

in Culture, le magazine culturel de l'Université de Liège (2010)

Detailed reference viewed: 259 (5 ULg)
See detailAntonio Machado (á ne pas confondre avec Antonio Machado)
Ceballos Viro, Alvaro ULg

Article for general public (2012)

Detailed reference viewed: 67 (9 ULg)
See detailAntonio Muñoz Molina, Fenêtres de Manhattan
Dechêne, Antoine ULg

Article for general public (2012)

Detailed reference viewed: 79 (1 ULg)