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See detailMatrix ‐ assisted laser desorption/ionization mass spectrometry and Raman spectroscopy: An interesting complementary approach for lipid detection in biological tissues
Jadoul, Laure ULg; Malherbe, Cédric ULg; calligaris, David et al

in European Journal of Lipid Science and Technology [=EJLST] (2014)

Recently, matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) has emerged as a powerful technique to study the distribution of lipids. However, quantification still remains a ... [more ▼]

Recently, matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) has emerged as a powerful technique to study the distribution of lipids. However, quantification still remains a challenge because the MALDI signal is strongly affected by ion suppression effects. On the contrary, Raman spectroscopy is recognized as a non‐destructive analysis method and spectral images can also be acquired. The combination of these two techniques was applied for lipids detection in tissue sections. In MALDI, two lipids families (glycerophosphocholine, PC; gycerophosphoethanolamine, PE), three MALDI matrices (1,5‐diaminonapthalene, 1,5‐DAN; 2,5‐dihydroxybenzoic acid, 2,5‐DHB; a‐4‐hydroxicinammic acid, CHCA), and various mixtures of lipids were investigated. The nature of the lipid, as well as the nature of the matrix and the composition of the sample influences the signal of a given lipid. In Raman, despite a strong overlap with the spectrum of the native tissue, an intensity profile constructed along the diameter of the section clearly shows that the signature of one given lipid (a glycerophosphocholine) can be detected on a doped biological sample. [less ▲]

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See detailA Matrix-Analytic approach to the N-player ruin problem
Swan, Yvik ULg; Bruss, F. Thomas

in Journal of Applied Probability (2006), 43

Consider N players, respectively owning x\, xi,..., x^ monetary units, who play a sequence of games, winning from and losing to each other integer amounts according to fixed rules. The sequence stops as ... [more ▼]

Consider N players, respectively owning x\, xi,..., x^ monetary units, who play a sequence of games, winning from and losing to each other integer amounts according to fixed rules. The sequence stops as soon as (at least) one player is ruined. We are interested in the ruin process of these N players, i.e. in the probability that a given player is ruined first, and also in the expected ruin time. This problem is called theN-player ruin problem. In this paper, the problem is set up as a multivariate absorbing Markov chain with an absorbing state corresponding to the ruin of each player. This is then discussed in the context of phase-type distributions where each phase is represented by a vector of size N and the distribution has as many absorbing points as there are ruin events. We use this modified phase-type distribution to obtain an explicit solution to the N-player problem. We define a partition of the set of transient states into different levels, and on itgive an extension of the folding algorithm (see Ye and Li (1994)). This provides an efficient computational procedure for calculating some of the key measures. [less ▲]

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See detailMatrix-assisted laser desorption/ionisation time-of-flight mass spectrometric (MALDI-TOF-MS) characterisation of pathogenic bacteria isolated from wastewater
Zaballos, Milagros; Ruelle, Virginie; Bonjean, Nicolas et al

Poster (2001)

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See detailMatrix-metalloproteinases in bronchopulmonary carcinomas.
Martinella-Catusse, C.; Nawrocki, B.; Gilles, Christine ULg et al

in Histology and Histopathology (1999), 14(3), 839-43

Matrix metalloproteinases (MMPs) represent a group of enzymes involved in the degradation of most of the components of the extracellular matrix and therefore participate in tumoural invasion. MMPs ... [more ▼]

Matrix metalloproteinases (MMPs) represent a group of enzymes involved in the degradation of most of the components of the extracellular matrix and therefore participate in tumoural invasion. MMPs, especially gelatinases A and B, MT1-MMP, the activator of gelatinase A, and stromelysin-3 were found overexpressed in many cancers including bronchopulmonary carcinomas. In vivo observations revealed that fibroblasts are the principal source of production of MMPs. Some of these enzymes such as MT1-MMP and stromelysin 3, displayed a focal stromal localisation near preinvasive and invasive tumour clusters. Furthermore, some tumour cell lines were shown to stimulate the expression of MT1-MMP by fibroblasts. All these in vivo and in vitro results suggest that certain tumour cells produce diffusible factors which could influence the MMP stromal expression. Among these factors, the TCSF (Tumor Collagenase Stimulatory Factor) which is known to upregulate some MMPs in vitro could be a good candidate for this stromal regulation, since it is produced by bronchial tumour cells in vivo. In this review, we address such a cooperation between tumour and stromal cells for the production of MMPs and emphasize their necessity for tumoural progression in bronchopulmonary carcinomas [less ▲]

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See detailMatter Matters
Farah, Jihad ULg

Article for general public (2014)

This article presents the book Radicals' City, then it investigates in what way Fregonese and Brand's analytical framework could serve as an innovative approach for analyzing middle-eastern cities and the ... [more ▼]

This article presents the book Radicals' City, then it investigates in what way Fregonese and Brand's analytical framework could serve as an innovative approach for analyzing middle-eastern cities and the role their urban environments' materiality plays in their evolution. [less ▲]

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See detailThe Matter of the Detail
Delville, Michel ULg

in Phrasis: Studies in Language and Literature (2009), 50(1), 63-83

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See detailMatthew RAMSEY, Professional and Popular Medicine in France, 1770-1880
Havelange, Carl ULg

in Archives Internationales d'Histoire des Sciences (1988), 38(21),

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See detailMaturation de Form@sup : principes et instrument
Poumay, Marianne ULg

in Revue Internationale de Pédagogie Universitaire (2006), 3(2), 1-17

Without resuming its detailed description, the present article proposes a critical analysis of the options taken in Form@sup, a one-year postgraduate degree for higher education teachers who want to ... [more ▼]

Without resuming its detailed description, the present article proposes a critical analysis of the options taken in Form@sup, a one-year postgraduate degree for higher education teachers who want to question their professional practice through the development of their online course. The article justifies the theoretical backgrounds of this training program and underlines the difficulties encountered in carrying out each of its basic principles. It then presents the decisions made for 2005-2006, insisting on the influence of the Scholarship of Teaching and Learning movement. Through its concrete examples, it also aims at fostering reflection and exchange of practice amongst the instructional developers teams. [less ▲]

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See detailLa maturation de l’œuf, la fécondation, et les premières phases du développement embryonnaire des mammifères d’après des recherches faites chez le lapin
Van Beneden, Édouard ULg

in Bulletins de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique (1875), 40(7), 686-736

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See detailMaturation du raisonnement biomédical évalué par la discussion d’une vignette clinique multidisciplinaire : étude longitudinale et relation avec la capacité de délimitation des connaissances
Collard, Anne ULg; Bourguignon, Jean-Pierre ULg

Conference (2012, August)

Contexte: Dans un curriculum médical comprenant des séminaires PBL, un Test de Concordance de Script nous avait permis de démontrer la maturation de la capacité de raisonnement, corrélée positivement avec ... [more ▼]

Contexte: Dans un curriculum médical comprenant des séminaires PBL, un Test de Concordance de Script nous avait permis de démontrer la maturation de la capacité de raisonnement, corrélée positivement avec la capacité de délimiter le champ de ses connaissances. L’objectif de la présente étude est de tester ces observations dans le contexte certificatif d’évaluation orale du raisonnement, sur base d’une vignette clinique discutée avec un collège d’enseignants. Résumé des travaux: Les données longitudinales d’évaluation de 279 étudiants ont été utilisées de la 2ème à la 5ème année du curriculum. Elles comprenaient les scores à l’examen oral de raisonnement ainsi que les degrés de certitude aux tests de connaissances (QCM). La capacité de délimitation du champ des connaissances a été calculée sur base de la différence entre les degrés de certitudes aux réponses correctes et les degrés de certitude aux réponses incorrectes au QCM. Résumé des résultats: Les résultats montrent, chez 213 étudiants qui réussissent d’emblée, une augmentation significative des performances à l’examen oral de raisonnement et une augmentation de la capacité de délimitation du champ des connaissances au cours des 4 années. Chez 66 étudiants qui échouent en 2ème année, cette capacité est plus faible et augmente l’année suivante après réussite de la 2ème année. Une corrélation positive entre les 2 indices étudiés est observée. Conclusions: Cette étude confirme, dans un contexte certificatif longitudinal au cours du curriculum médical, la maturation du raisonnement et celle de la capacité de délimiter le champ de ses connaissances. [less ▲]

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See detailMaturation du raisonnement clinique et des connaissances factuelles au cours des études médicales et transfert a des situations inédites
Collard, Anne ULg; Gealaes, Sabine; Vanbelle, Sophie et al

Conference (2008, April)

Contexte et objectif: L'acquisition de connaissances et le développement du raisonnement clinique constituent des objectifs majeurs de la formation médicale. Depuis 2000, la Faculté de médecine de l ... [more ▼]

Contexte et objectif: L'acquisition de connaissances et le développement du raisonnement clinique constituent des objectifs majeurs de la formation médicale. Depuis 2000, la Faculté de médecine de l'Université de Liège a introduit des séminaires d'Apprentissage Par Problèmes tout au long de son curriculum de formation (7 ans). L'objectif de cette recherche est d'évaluer la maturation du raisonnement clinique et la capacité de transfert à de nouvelles situations par comparaison à l'évolution des connaissances factuelles, dans un curriculum privilégiant la contextualisation des apprentissages (à partir de vignette cliniques). Méthodologie: Un test de connaissances factuelles (Vrai/Faux) et un test de raisonnement clinique (Test de Concordance de Scripts) ont été administrés à 104 étudiants (de la 3ième à la 6ième année) et à un panel de référents. Le Test de Concordance de Scripts (TCS) a été adapté en créant 2 séries de questions : une série portant sur des situations similaires à celles de l'apprentissage et une série portant sur des situations inédites. Le domaine de recherche choisi était l'endocrinologie. Résultats et Conclusion: La maturation au cours du curriculum est associée à un accroissement des performances au TCS et à une diminution des performances au test de connaissances factuelles. Une corrélation positive entre les performances aux deux tests est observée uniquement pour les étudiants plus jeunes (3ème et 4ème années). La différence entre les performances au TCS en contexte d'apprentissage versus en contexte inédit ne change pas en fonction du niveau d'étude, ce qui suggère une capacité de transfert présente dès le début de la formation APP. Contrairement à nos attentes, le score aux questions TCS portant sur des situations inédites était supérieur à celui obtenu pour des situations similaires à celles de l'apprentissage. Ces résultats suggèrent qu'un contexte nouveau et/ou plus plausible pourraient activer davantage le raisonnement. [less ▲]

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See detailMaturation et fécondation in vitro chez les bovins: naissance d'un veau
Ectors, Fabien ULg; Van Der Zwalmen, P.; Touati, Kamal ULg et al

in Annales de Médecine Vétérinaire (1989), 133

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See detailMaturation of intestinal digestive and immune systems by food polyamines
Peulen, Olivier ULg; Deloyer, Patricia; Dandrifosse, Guy ULg

in Zabielski, R.; Gregory, P. C.; Weström, B. (Eds.) Biology of the Intestine in Growing Animals (2005)

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See detailMaturation of knowledge transfer and clinical reasoning throughout the medical curriculum
Collard, Anne ULg; Gelaes, Sabine; Defraigne, Jean-Olivier ULg et al

Poster (2008, August)

Since 2000, the Faculty of Medicine at the University of Liege has introduced Problem-Based Learning (PBL) in the curriculum of medical studies (7 years). This contextualized learning raises the issue oc ... [more ▼]

Since 2000, the Faculty of Medicine at the University of Liege has introduced Problem-Based Learning (PBL) in the curriculum of medical studies (7 years). This contextualized learning raises the issue oc capacity of knowledge transfer and generalization, and maturation of clinical reasoning, troughout the curriculum. Two tests were administered to 108 students (year three to six) and to reference panel. The selected topic was endocrinology. We adapted the script concordance test (i.e., the SCT, see http://cme.umontreal.ca/tcs/) with 60 questions asking for evaluation of the impact of a new information, in a context (short clinical scenario) that was written similar versus different of the original learning context. A True/False test was used to assess factual knowledge. Progress throughout the curriculum was associated with increase in clinical reasoning performance together with a decrease in factual knowledge scores. Early capacity of knowledge transfer was observed, with no difference between the 4 years studied. Overall, the SCT score obtained out of the original context were unexpectedly higher than in such a context. We hypothesize that a new information may result in greater activation of reasoning in a new and realistic context than in a known and possibly factitious context. [less ▲]

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See detailMaturation of the Escherichia coli divisome occurs in two steps
Aarsman, Mirjam E. G.; Piette, André ULg; Fraipont, Claudine ULg et al

in Molecular Microbiology (2005), 55(6), 1631-1645

Cell division proteins FtsZ ( FtsA, ZipA, ZapA), FtsE/X, FtsK, FtsQ, FtsL/B, FtsW, PBP3, FtsN and AmiC localize at mid cell in Escherichia coli in an interdependent order as listed. To investigate whether ... [more ▼]

Cell division proteins FtsZ ( FtsA, ZipA, ZapA), FtsE/X, FtsK, FtsQ, FtsL/B, FtsW, PBP3, FtsN and AmiC localize at mid cell in Escherichia coli in an interdependent order as listed. To investigate whether this reflects a time dependent maturation of the divisome, the average cell age at which FtsZ, FtsQ, FtsW, PBP3 and FtsN arrive at their destination was determined by immuno- and GFP- fluorescence microscopy of steady state grown cells at a variety of growth rates. Consistently, a time delay of 14 - 21 min, depending on the growth rate, between Z-ring formation and the mid cell recruitment of proteins down stream of FtsK was found. We suggest a two-step model for bacterial division in which the Z-ring is involved in the switch from cylindrical to polar peptidoglycan synthesis, whereas the much later localizing cell division proteins are responsible for the modification of the envelope shape into that of two new poles. [less ▲]

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See detailMaturation of the small intestine is induced by spermine but not by other similar amines
Peulen, Olivier ULg; Grandfils, Christian ULg; Dandrifosse, Guy ULg

in Pflügers Archiv : European Journal of Physiology (2000, September 19), 440

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See detailMaturation of toxins in the venom duct of conustextile
Dobson, Rowan ULg; Collodoro, Mike; Gilles, Nicolas et al

Poster (2009, June)

Detailed reference viewed: 11 (1 ULg)