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See detailNew in situ generated ruthenium catalysts bearing N-heterocyclic carbene ligands for the ring-opening metathesis polymerization of cyclooctene
Delaude, Lionel ULg; Szypa, Magdalena; Demonceau, Albert ULg et al

in Advanced Synthesis & Catalysis (2002), 344(6-7), 749-756

New 1,3-diarylimidazol(in)ium chlorides bearing phenyl, 1-naphthyl, 4-biphenyl, 2-tolyl, 2,6-dimethylphenyl, and 3,5-dimethylphenyl substituents were synthesized. They were combined with [RuCl2 (p-cymene ... [more ▼]

New 1,3-diarylimidazol(in)ium chlorides bearing phenyl, 1-naphthyl, 4-biphenyl, 2-tolyl, 2,6-dimethylphenyl, and 3,5-dimethylphenyl substituents were synthesized. They were combined with [RuCl2 (p-cymene)](2) and potassium tert-butoxide or sodium hydride to generate the corresponding ruthenium-N-heterocyclic carbene complexes in situ. Catalyst precursors derived from imidazol(in)ium salts bearing the 2,4,6-trimethylphenyl (mesityl) and the 2,6-diisopropylphenyl groups were also prepared. The catalytic activity of all these species in the photoinduced ring-opening metathesis polymerization of cyclooctene was investigated. The C4-C5 double bond in the imidazole ring of the N-heterocyclic carbene ligands was not crucial to achieve high catalytic efficiencies. The presence or the absence of alkyl groups on the ortho positions of the phenyl rings had a more pronounced influence. Blocking all the ortho positions was a requisite for obtaining efficient catalysts. Failure to do so probably results in the ortho-metallation of the carbene ligand, thereby altering the coordination sphere of the ruthenium active centers. [less ▲]

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See detailA new in vitro model of Microsporum canis dermatophytosis in reconstituted feline skin
Tabart, J.; Baldo, Aline ULg; Vermout, S. et al

Conference (2006)

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See detailA new in-silico method for determination of helical transmembrane domains based on the PepLook scan: application to IL-2Rbeta and IL-2Rgammac receptor chains.
Charlois, Yan; Lins, Laurence ULg; Brasseur, Robert ULg

in BMC Structural Biology (2011), 11

BACKGROUND: Modeling of transmembrane domains (TMDs) requires correct prediction of interfacial residues for in-silico modeling and membrane insertion studies. This implies the defining of a target ... [more ▼]

BACKGROUND: Modeling of transmembrane domains (TMDs) requires correct prediction of interfacial residues for in-silico modeling and membrane insertion studies. This implies the defining of a target sequence long enough to contain interfacial residues. However, too long sequences induce artifactual polymorphism: within tested modeling methods, the longer the target sequence, the more variable the secondary structure, as though the procedure were stopped before the end of the calculation (which may in fact be unreachable). Moreover, delimitation of these TMDs can produce variable results with sequence based two-dimensional prediction methods, especially for sequences showing polymorphism. To solve this problem, we developed a new modeling procedure using the PepLook method. We scanned the sequences by modeling peptides from the target sequence with a window of 19 residues. RESULTS: Using sequences whose NMR-structures are already known (GpA, EphA1 and Erb2-HER2), we first determined that the hydrophobic to hydrophilic accessible surface area ratio (ASAr) was the best criterion for delimiting the TMD sequence. The length of the helical structure and the Impala method further supported the determination of the TMD limits. This method was applied to the IL-2Rbeta and IL-2Rgamma TMD sequences of Homo sapiens, Rattus norvegicus, Mus musculus and Bos taurus. CONCLUSIONS: We succeeded in reducing the variation in the TMD limits to only 2 residues and in gaining structural information. [less ▲]

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See detailNew indications for radiotherapy: primary liver cancer and secondary liver oligometastases
JANVARY, Zsolt Levente ULg; JANSEN, Nicolas ULg; MARTINIVE, Philippe ULg et al

in Belgian Journal of Medical Oncology [=BJMO] (2011), 5(1), 8-13

Surgery is considered to be the standard treatment for intrahepatic malignancies, primary <br />cancers and metastatic lesions. However, a great many patients are not eligible for surgical <br ... [more ▼]

Surgery is considered to be the standard treatment for intrahepatic malignancies, primary <br />cancers and metastatic lesions. However, a great many patients are not eligible for surgical <br />intervention. Modern stereotactic radiotherapy has the potential to be an effective alternative <br />treatment modality with low toxicity for patients with primary hepatocellular carcinoma <br />and liver oligometastases. In this paper we intend to review the current status and published <br />experiences in the field of liver irradiation. [less ▲]

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See detailNew indole aldehydic alkaloids of Strychnos variabilis
Tits, Monique ULg; Angenot, Luc ULg; Tavernier, Dirk

in Tetrahedron Letters (1980), 21

Two isomeric pairs of novel indoline aldehydic alkaloids have been isolated from the root barks of Strychnos variabillis. The isomerism finds its origin in the facile isomerisation of C16 and is set up ... [more ▼]

Two isomeric pairs of novel indoline aldehydic alkaloids have been isolated from the root barks of Strychnos variabillis. The isomerism finds its origin in the facile isomerisation of C16 and is set up rapidly at room temperature. So, they could be the biogenetic starting point of two series of alkaloids which have a different stereochemistry for C16: the "retuline" series and the epimer "isoretuline" series. [less ▲]

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See detailA new inhibition task for young children: The “Real Size Animal” task
Catale, Corinne ULg; Meulemans, Thierry ULg

in Books of Conference Abstract: The 9th European Conference on Psychological Assessment (2007)

In neuropsychology, inhibition deficits underlie a variety of cognitive and behavioural dysfunctions and are reported in numerous developmental and acquired disorders (such as Attention Deficit and ... [more ▼]

In neuropsychology, inhibition deficits underlie a variety of cognitive and behavioural dysfunctions and are reported in numerous developmental and acquired disorders (such as Attention Deficit and Hyperactivity Disorders–ADHD). Despite a large body of literature regarding inhibition functioning in adult’s neuropsychology, developmental studies on inhibition remained for a long time scarce. Furthermore, most inhibition tools were originally developed for adults and are of limited interest in children – particularly in pre-school children. In this study, we present a new computerized measure of inhibition suitable to young children. This task includes three conditions. The two first conditions assess speed processing and require children to decide quickly, by pressing a response-key, [1] the real size of animals (bird =small) and [2] the on screen size of black rectangles (big or small). The third condition measures inhibition and requires deciding the real size of animals displayed in congruent (big elephant) or incongruent size (big bird) on the screen. Sixty children without neurological disorders and twelve ADHD children aged from 4 to 10 took part in this study. Our aims were to examine the developmental curve of inhibition abilities and to determine the task’s sensitivity in ADHD children. Results show that this task is particularly suitable to preschooler children and provides a good measure of inhibition development (p<.01). Furthermore, this task appears sensitive to inhibition’s disturbances in ADHD children (p<.05). In conclusion, these preliminary results support the validity of this measure to assess inhibition control in young children and its clinical interest in ADHD children. [less ▲]

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See detailNew inhibitors of serine proteinases
Jiang, K. Y.; Schynts, M.; Fesquet, S. et al

Poster (1993, June)

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See detailNew initiator system for the "living" anionic polymerization of tert-alkyl acrylates
Fayt, Roger; Forte, C.; Jacobs, C. et al

in Macromolecules (1987), 20(6), 1442-1444

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See detailNew initiator system for the anionic polymerization of (meth)acrylates in toluene. IV. Random copolymerization of (meth)acrylates in toluene initiated by s-Buli ligated by lithium silanolates
Zune, Catherine; Zundel, Thomas; Dubois, Philippe ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1999), 37(14), 2525-2535

Copolymerization of binary mixtures of alkyl (meth)acrylates has been initiated in toluene by a mixed complex of lithium silanolate (s-BuMe2SiOLi) and s-BuLi (molar ratio > 21) formed in situ by reaction ... [more ▼]

Copolymerization of binary mixtures of alkyl (meth)acrylates has been initiated in toluene by a mixed complex of lithium silanolate (s-BuMe2SiOLi) and s-BuLi (molar ratio > 21) formed in situ by reaction of s-BuLi with hexamethylcyclotrisiloxane (D3). Fully acrylate and methacrylate copolymers, i.e., poly(methyl acrylate-co-n-butyl acrylate), poly(methyl methacrylate-co-ethyl methacrylate), poly(methyl methacrylate-co-n-butyl methacrylate), poly(methyl methacrylate-co-n-butyl methacrylate), poly(isobornyl methacrylate-co-n-butyl methacrylate), poly(isobornyl methacrylate-co-n-butyl methacrylate) of a rather narrow molecular weight distribution have been synthesized. However, copolymerization of alkyl acrylate and methyl methacrylate pairs has completely failed, leading to the selective formation of homopoly(acrylate). As result of the isotactic stereoregulation of the alkyl methacrylate polymerization by the s-BuLi/s-BuMe2SiOLi initiator, highly isotactic random and block copolymers of (alkyl) methacrylates have been prepared and their thermal behavior analyzed. The structure of isotactic poly(ethyl methacrylate-co-methyl methacrylate) copolymers has been analyzed in more detail by Nuclear Magnetic Resonance (NMR). [less ▲]

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See detailThe new inotropic phosphodiesterase inhibitors. The use of positive inotropic drugs in intensive care medicine
EL ALLAF, D; D'Orio, Vincenzo ULg; CARLIER, J

in Archives Internationales de Physiologie et de Biochimie (1984), 92

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See detailNew insight in the Lymnaeids intermediate host of Fasciola hepatica in Belgium
Caron, Yannick ULg

Conference (2011)

The present work was carried out in the frame of a Belgian Science Policy project (PONDSCAPE -“Towards a sustainable management of pond diversity at the landscape level”). During the summer 2008, 7103 ... [more ▼]

The present work was carried out in the frame of a Belgian Science Policy project (PONDSCAPE -“Towards a sustainable management of pond diversity at the landscape level”). During the summer 2008, 7103 lymnaeids snails were collected from 125 ponds distributed in 5 clusters of 25 ponds each. Each cluster was located in a different geological region of Belgium. These snails belonged to the following species or genus: 2474 Galba truncatula (the main intermediate host of Fasciola hepatica in Belgium) and 4629 Radix sp. Moreover, several biological (presence of trampling and dungs, snail size …) and non biological factors (pH, depth, fences …) were also registered from the different biotopes. DNA was extracted based on Chelex® technique. Then the snail DNAs were screened through a multiplex PCR that amplifies the lymnaeid internal transcribed spacer 2 sequence (500-600 bp) (acting as an internal control) and a 124 bp Fasciola sp. sequence. Lymnaeid snails were found in 93 biotopes (66%). Thirty Galba truncatula (1.31%) and 7 Radix sp. (0.16%) were found positive for Fasciola sp. A classification and regression tree (CART) analysis was performed in an attempt to better understand the relative importance and relationships among the different recorded factors. For example, the geographic localization is one of the best explanatory variables for the abundance of the different snail species and the presence/absence of faecal material is the best explanatory variable for the presence of specific F. hepatica DNA material in the different screened snails. [less ▲]

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See detailA new insight in the structure, composition and functioning of central African moist forests
Fayolle, Adeline ULg; Picard, Nicolas; Doucet, Jean-Louis ULg et al

in Forest Ecology & Management (2014), (329), 195-205

The greater part of the semi-deciduous moist forests of the Congo basin has been given to logging companies for exploitation. In the next decades, very few of these forests will remain intact. In this ... [more ▼]

The greater part of the semi-deciduous moist forests of the Congo basin has been given to logging companies for exploitation. In the next decades, very few of these forests will remain intact. In this paper, we aimed to identify large-scale variations in the structure, composition and functioning of African moist forests that could serve as a baseline for both management and conservation purposes. Commercial forest inventory data were assembled for 49,711 0.5-ha plots, covering an area of more than six million hectares, crossing the borders of Cameroon, Central African Republic and Republic of Congo. Floristic composition was analyzed for a subset of 176 genera reliably identified in the field. Three key functional traits of tropical trees: regeneration guild, leaf phenology, and wood specific gravity, were collected at the species level from various sources, and assigned at the genus level. We first investigated the main variations in forest structure and composition, and identified seven forest types based on these variations. Differences in the percentage of pioneer and deciduous stems, and mean wood specific gravity were tested between forest types. Most of the study area was composed of a mosaic of the structural variations of the forests characterized by the occurrence of Celtis (Ulmaceae) species, which are mostly composed of frequent and abundant genera that formed the common floristic pool of the region. Secondary Musanga (Moraceae) forest is located in repeatedly disturbed areas, along roads and around main cities; mixed Manilkara (Sapotaceae) forest covers a huge area in the southern Central African Republic and in the northern Republic of Congo; and monodominant Gilbertiodendron (Fabaceae) forest is sparsely distributed along rivers. The contrasted structure, composition, and functioning of the forest types imply pronounced differences in population and ecosystem processes, and call for adapted management and conservation strategies. [less ▲]

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See detailNew insight into the concept of ferroelectric correlation volume
Geneste, Gregory; Bousquet, Eric ULg; Ghosez, Philippe ULg

in Journal Of Computational And Theoretical Nanoscience (2008), 5(4), 517-520

Using an effective Hamiltonian derived from first-principles calculations, we discuss the concept of "ferroelectric correlation volume" and show that it cannot be uniquely defined: it is not the size but ... [more ▼]

Using an effective Hamiltonian derived from first-principles calculations, we discuss the concept of "ferroelectric correlation volume" and show that it cannot be uniquely defined: it is not the size but the anisotropic shape of the polar region that is crucial for stabilizing a ferroelectric distortion into a ferroelectric materials. To provide basic understanding of this result, the stability of a polar region is analyzed in term of intra-chain and inter-chain interactions. [less ▲]

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See detailNew insights for an old topic: seagrasses as bioindicators of coastal trace element pollution
Richir, Jonathan ULg; Lejeune, Pierre; Gobert, Sylvie ULg

in ARGYRO ZENETOS, ZENETOS (Ed.) Mediterranean Marine Science (2014, March)

The marine magnoliophyte Posidonia oceanica (L.) Delile has been widely used since the mid-70th to biomonitor the coastal pollution of the Mediterranean in Cr, Ni, Cu, Zn, Cd, Pb and/or Fe. In contrast ... [more ▼]

The marine magnoliophyte Posidonia oceanica (L.) Delile has been widely used since the mid-70th to biomonitor the coastal pollution of the Mediterranean in Cr, Ni, Cu, Zn, Cd, Pb and/or Fe. In contrast, other trace elements (TEs) like As, V, Ag, Be, Al, Mn, Co, Se, Mo, Sn, Sb and Bi, many of them categorized as TEs of environmental emerging concern, have been subject to nearly no ecotoxicological survey with that species. It has been shown that the French Mediterranean littoral was submitted to local, diffuse and/or chronic contaminations both by TEs broadly or little biomonitored with P. oceanica; high TE levels could further be linked to specific anthropic activities such as agriculture (Mo), mining (Cr, Sb, Zn), industries (As), storage and refinement of oil products (V, Pb) or presence of major ports and urban centres (Sn, Bi, Ag). It seems therefore necessary to expand the short list of the seven metals commonly monitored to other TEs, what is today easily achievable as current analytical methods allow the simultaneous determination of all a series of TEs within the same sample. Furthermore, only a multielement analysis in appropriate bioindicator species allow to correctly intercompare the pollution status of numerous sampling sites. To do this, we have calculated proper environmental indices, the trace element pollution index TEPI and the trace element spatial variation index TESVI. The TEPI is an index of the global contamination of a site, giving the same weight to each TE after mean normalization of their environmental concentrations. The TESVI estimates the global spatial variability of environmental concentrations of each TE levels, taking into account both punctual contaminations in impacted sites and the overall coastal spatial heterogeneity between all monitored sites.These two indices were successfully applied both at large (French Mediterranean littoral) and small (a Bay) spatial scales. Furthermore, they can be used in the framework of an intercomparative study compiling data from any previous monitoring surveys. We also highlighted that the ecophysiology and surrounding levels of TEs influenced in an equivalent manner the bioaccumulation process of TEs in P. oceanica. Consequently, this natural cyclic evolution of TE concentrations should be systematically quantified in regional reference sites. Finally, the rapid and proportionnal accumulation of TEs in P. oceanica traps huge amounts of contaminants and can stock them for longer periods of time in their bellow grounds tissues. P. oceanica meadows therefore play an efficient role of natural filter of TE coastal pollutions. [less ▲]

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See detailNew insights from metallic tracers on the feeding ecology of common dolphins in European waters
Lahaye, V.; Bustamante, Paco; Dabin, W. et al

Conference (2005)

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See detailNew insights in auditory organ development: the inner pillar cell goes it own way
Thelen, Nicolas; Malgrange, B; Thiry, Marc ULg

Poster (2008)

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See detailNew insights in mammalian auditory organ development
Thelen, Nicolas ULg; Malgrange, Brigitte ULg; Thiry, Marc

Conference (2008, October 30)

Although the structure of the auditory organ in mature mammals, the organ of Corti, is clearly established, its development is far from being elucidated. Using cytochemical and immunohistochemical methods ... [more ▼]

Although the structure of the auditory organ in mature mammals, the organ of Corti, is clearly established, its development is far from being elucidated. Using cytochemical and immunohistochemical methods at the light and electron microscope levels, we examined its spatiotemporal development in rats from embryonic day 16 (E16) to E19. At E16, whatever the region of the cochlear studied (base, middle, apex), the organ of Corti was not present. We demonstrate that the organ of Corti develops from a non-proliferative cell zone that is located in the junctional region between the greater epithelial ridge and the lesser epithelial ridge of the cochlear duct and that is characterized by the presence of numerous microvilli. Using the periodic acid-thiocarbohydrazide-silver proteinate method, we revealed that the first cells to develop in this zone are the inner pillar cells, a particular type of nonsensory supporting cells. They arise in the base of the cochlear duct at the boundary between the two ridges at E16. The cell differentiation in this prosensory region continues according to a base-to-apex gradient, the inner hair cells appearing in the greater epithelial ridge at E17 and the outer hair cells in the lesser epithelial ridge at E18. At E19, all the different cell types of the organ of Corti are well in place. We also showed that the development of the inner pillar cells within the prosensory region does not involve Notch1 signaling. These results highlight the central role that the inner pillar cells could play in the development of the organ of Corti. [less ▲]

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