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See detailMulticentre Evaluation of a Second Generation Point-of-Care Assay with an Extended Range for the Determination of N-Terminal Pro-Brain Natriuretic Peptide
Jorgensen, Bo; Bertsch, Thomas; Bröker, Hans-Joachim et al

in Clinical Laboratory (2012), 58

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See detailMulticentre evaluation of the Tosoh HbA1c G8 analyser
Chapelle, Jean-Paul ULg; Teixeira, Jelda ULg; Maisin, Diane et al

in Clinical Chemistry & Laboratory Medicine (2010), 48(3), 365-371

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See detailA multicentre, double-blind, placebo-controlled, dose-ranging study to investigate the efficacy and safety of oral doses dose of 311C90 in the acute treatment of migraine
Dahlöf, C.; Diener, H. C.; Goadsby, P. et al

in Clifford-Rose, F. (Ed.) New Advances in headache research (1994)

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See detailA multicentre, double-blind, randomized, placebo-controlled, parallel group study of multiple treatments of botulinum toxin type A (BoNTA) for the prophylaxis of episodic migraine headaches
Relja, M.; Poole, A. C.; Schoenen, Jean ULg et al

in Cephalalgia : An International Journal of Headache (2007), 27(6), 492-503

Our aim was to evaluate the safety and efficacy of botulinum toxin type A (BoNTA; BOTOX (R)) for prophylaxis of episodic migraine. In this double-blind, placebo-controlled study, patients were randomized ... [more ▼]

Our aim was to evaluate the safety and efficacy of botulinum toxin type A (BoNTA; BOTOX (R)) for prophylaxis of episodic migraine. In this double-blind, placebo-controlled study, patients were randomized to 225, 150 or 75 U of BoNTA or placebo after a 30-day placebo run-in for three 90-day treatment cycles. The primary efficacy end-point was the mean reduction from baseline in the frequency of migraine episodes at day 180 in the placebo non-responder stratum. All groups (N = 495) improved, with no significant differences. At day 180, the frequency of migraine episodes was reduced from baseline means of 4.3, 4.7, 4.7 and 4.4 by 1.6, 1.7, 1.5 and 1.4 for BoNTA 225 U, 150 U and 75 U and placebo, respectively. The primary end-point was not met. Treatment-related adverse events were transient and mild to moderate. BoNTA treatment was safe and well tolerated but did not result in significantly greater improvement than placebo in this study. Several factors may have confounded the results. [less ▲]

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See detailMulticentre, prospective, open study to evaluate the safety and efficacy of hylan G-F 20 in knee osteoarthritis subjects presenting with pain following arthroscopic meniscectomy.
Huskin, Jean-Pierre ULg; Vandekerckhove, B.; Delince, P. et al

in Knee Surgery, Sports Traumatology, Arthroscopy (2008), 16(8), 747-52

The aim of the study was to evaluate the safety and efficacy of viscosupplementation with hylan G-F 20 in patients with mild to moderate osteoarthritis (OA) presenting with persistent knee pain 4-12 weeks ... [more ▼]

The aim of the study was to evaluate the safety and efficacy of viscosupplementation with hylan G-F 20 in patients with mild to moderate osteoarthritis (OA) presenting with persistent knee pain 4-12 weeks after arthroscopic meniscectomy. A prospective, multi-centre, open study was carried out in patients with pain due to OA of the knee, not resolved by simple analgesics, 4-12 weeks after undergoing arthroscopic meniscectomy. To be eligible, patients had to score > or =50 mm and < or =90 mm on both walking pain and patient global assessment visual analogue scales (VAS; 0-100 mm) at baseline and be radiologically diagnosed pre-operatively with OA grade I or II on the Kellgren-Lawrence scale, with <50% joint space narrowing. Patients received three intra-articular, 2 ml injections of hylan G-F 20 in the target knee with an interval of 1 week between injections, and were followed for 52 weeks. The primary efficacy endpoint was the change from baseline in the walking pain VAS score at 26 weeks. Secondary outcome measures were the walking pain VAS scores at all other time points, the WOMAC Index at all time points, and patient and physician global assessment at all time points. The safety of the treatment was assessed using adverse event (AE) reports. A total of 62 patients (mean age 55.4 years, 52% male) were enrolled. The mean walking pain VAS score decreased by 36.8 mm from baseline at 26 weeks (P < 0.0001), and also showed statistically significant decreases (P < 0.0001) at all other time points. The change in WOMAC total and subscale scores from baseline were statistically significant (P < 0.0001) at all time points, as were the decreases in the physician and patient global assessment VAS scores. There were 18 target knee AEs (mostly pain and/or swelling and/or effusion) in 12 patients (19%) considered to be at least possibly related to treatment. The majority of these (78%) were mild or moderate in intensity. One patient (1.6%) experienced a serious adverse event (synovitis) in the target knee that was considered possibly related to study treatment. Hylan G-F 20 provides effective pain relief and improves stiffness and physical function in patients with mild to moderate OA presenting with persistent osteoarthritic pain 4-12 weeks after arthroscopic meniscectomy. Symptomatic efficacy was maximised at 12 weeks and maintained at 26 and 52 weeks. The type (pain and/or swelling and/or effusion) and the intensity (mostly mild/moderate) of AEs reported in this study are similar to those reported in other trials in different patient populations, but the incidence was higher (19%). The risk/benefit of hylan G-F 20 in this particular population of patients is favourable. [less ▲]

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See detailMulticentric evaluation of a turbidimetric myoglobin immunoassay
Lammers, M.; Chapelle, Jean-Paul ULg; Delanghe, J. et al

Poster (1992, August)

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See detailA multicentric evaluation of IDMS-traceable creatinine enzymatic assays
Pieroni, Laurence; DELANAYE, Pierre ULg; Boutten, Anne et al

in Clinica Chimica Acta (2011), 412

Chronic kidney disease definition is based on glomerular filtration rate (GFR) estimations which are derived from creatinine-based equations. The accuracy of GFR estimation is thus largely dependent of ... [more ▼]

Chronic kidney disease definition is based on glomerular filtration rate (GFR) estimations which are derived from creatinine-based equations. The accuracy of GFR estimation is thus largely dependent of those of serum creatinine assays. International recommendations highlight the need for traceable creatinine assays. The French Society of Clinical Biochemistry conducted a study for measuring accuracy of creatinine enzymatic methods. This evaluation involved 25 clinical laboratories. Creatinine was measured in serum pools ranging from 35.9±0.9 μmol/L to 174.5±3.1 μmol/L (IDMS determination) using 12 creatinine enzymatic methods. For all creatinine values greater than 74.4±1.4 μmol/L, the bias and imprecision did not exceed 5% and 5.9%, respectively. For the lowest value (35.9±0.9 μmol/L), the bias ranged from −1.8 to 9.9% (with one exception). At this level, the imprecision ranged from 1.9 to 7.8%. The true performances of the assays (couples of bias and relative standard deviation), were evaluated using Monte-Carlo simulations. Most of the assays fall within the maximum Total Error of 12% at all concentrations. This study demonstrates substantial improvements in the calibration, traceability and precision of the enzymatic methods, reaching the NKDEP recommendations. Moreover, most of these assays allowed accurate creatinine measurements for creatinine levels lower than 40 μmol/L. [less ▲]

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See detailMulticentric evaluation of turbimetric myoglobin immunoassay
Lammers, M.; Chapelle, Jean-Paul ULg; Delanghe, J. et al

in Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum (1992), 52(221), 109

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See detailMulticité. Le jeu du développement urbain
Beckers, Jacqueline ULg; Demeuse, Yves; Merenne-Schoumaker, Bernadette ULg et al

in G.E.O. (1997), 41(Numéro spécial),

Une équipe municipale doit définir le devenir de sa cité et gérer une série de projets (écoles, multiplex, logements sociaux, parcs industriels) avec comme consigne la minimisation des coûts pour la ... [more ▼]

Une équipe municipale doit définir le devenir de sa cité et gérer une série de projets (écoles, multiplex, logements sociaux, parcs industriels) avec comme consigne la minimisation des coûts pour la maximisation des retombées pour la collectivité ; elle fait appel à des bureaux d’études qui doivent monter ces projets. Le jeu se joue sur un territoire (plateau de jeu) avec ses quartiers d’habitat, son centre, ses réseaux de communication et aussi 350 îlots colorés selon l’affectation du sol et leur statut (public et privé). Le jeu – qui se déroule aussi sur deux fois 50 minutes dans sa version courte (un projet) – permet d’abord à l’équipe municipale de définir ses critères de choix et aux bureaux d’étude de monter leur projet, il met ensuite les protagonistes en contact puis en débat avant le choix final. Outre le plateau figurant le territoire, le jeu comprend encore des fiches relatives aux équipements, des consignes particulières pour les membres du bureau d’études et de l’équipe municipale (dont une fiche budget et une fiche argumentaire). À l’issue du jeu, il est possible non seulement de mettre en évidence les facteurs de localisation des équipements mais également le jeu des acteurs et les contraintes d’une politique de développement communal. [less ▲]

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See detailMulticlass classification of FDG PET scans for the distinction between Parkinson's disease and atypical parkinsonian syndromes
Garraux, Gaëtan ULg; Phillips, Christophe ULg; Schrouff, Jessica ULg et al

in NeuroImage: Clinical (2013), 2

Most available pattern recognition methods in neuroimaging address binary classification problems. Here, we used relevance vector machine (RVM) in combination with booststrap resampling (‘bagging’) for ... [more ▼]

Most available pattern recognition methods in neuroimaging address binary classification problems. Here, we used relevance vector machine (RVM) in combination with booststrap resampling (‘bagging’) for non-hierarchical multiclass classification. The method was tested on 120 cerebral 18fluorodeoxyglucose (FDG) positron emission tomography (PET) scans performed in patients who exhibited parkinsonian clinical features for 3.5 years on average but that were outside the prevailing perception for Parkinson's disease (PD). A radiological diagnosis of PD was suggested for 30 patients at the time of PET imaging. However, at follow-up several years after PET imaging, 42 of them finally received a clinical diagnosis of PD. The remaining 78 APS patients were diagnosed with multiple system atrophy (MSA, N = 31), progressive supranuclear palsy (PSP, N = 26) and corticobasal syndrome (CBS, N = 21), respectively. With respect to this standard of truth, classification sensitivity, specificity, positive and negative predictive values for PD were 93% 83% 75% and 96%, respectively using binary RVM (PD vs. APS) and 90%, 87%, 79% and 94%, respectively, using multiclass RVM (PD vs. MSA vs. PSP vs. CBS). Multiclass RVM achieved 45%, 55% and 62% classification accuracy for, MSA, PSP and CBS, respectively. Finally, a majority confidence ratio was computed for each scan on the basis of class pairs that were the most frequently assigned by RVM. Altogether, the results suggest that automatic multiclass RVM classification of FDG PET scans achieves adequate performance for the early differentiation between PD and APS on the basis of cerebral FDG uptake patterns when the clinical diagnosis is felt uncertain. This approach cannot be recommended yet as an aid for distinction between the three APS classes under consideration. [less ▲]

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See detailMulticollinearity
Van Steen, Kristel ULg; Molenberghs, G.

in Chow (Ed.) Encyclopedia of Biopharmaceutical Statistics (2010)

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See detailMulticollinearity
Van Steen, Kristel ULg; Molenberghs, G.

in Chow, Shein-Chung (Ed.) Encyclopedia of Biopharmaceutical Statistics (2004)

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See detailMulticollinearity in prognostic factor analyses using the EORTC QLQ-C30: identification and impact on model selection
Van Steen, Kristel ULg; Curran, D.; Kramer, J. et al

in Statistics in Medicine (2002), 21(24), 3865-3884

Clinical and quality of life (QL) variables from an EORTC clinical trial of first line chemotherapy in advanced breast cancer were used in a prognostic factor analysis of survival and response to ... [more ▼]

Clinical and quality of life (QL) variables from an EORTC clinical trial of first line chemotherapy in advanced breast cancer were used in a prognostic factor analysis of survival and response to chemotherapy. For response, different final multivariate models were obtained from forward and backward selection methods, suggesting a disconcerting instability. Quality of life was measured using the EORTC QLQ-C30 questionnaire completed by patients. Subscales on the questionnaire are known to be highly correlated, and therefore it was hypothesized that multicollinearity contributed to model instability. A correlation matrix indicated that global QL was highly correlated with 7 out of 11 variables. In a first attempt to explore multicollinearity, we used global QL as dependent variable in a regression model with other QL subscales as predictors. Afterwards, standard diagnostic tests for multicollinearity were performed. An exploratory principal components analysis and factor analysis of the QL subscales identified at most three important components and indicated that inclusion of global QL made minimal difference to the loadings on each component. suggesting that it is redundant in the model, In a second approach, we advocate a bootstrap technique to assess the stability of the models. Based on these analyses and since global QL exacerbates problems of multicollinearity, we therefore recommend that global QL be excluded from prognostic factor analyses using the QLQ-C30. The prognostic factor analysis was rerun without global QL in the model, and selected the same significant prognostic factors as before. Copyright (C) 2002 John Wiley Sons, Ltd. [less ▲]

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See detailThe Multicoloured Asian Ladybird, invasive or not in agroecosystems ?
Vandereycken, Axel ULg; Durieux, Delphine ULg; Fassotte, Bérénice ULg et al

Poster (2013, September 10)

The Multicoloured Asian Ladybird, Harmonia axyridis Pallas (Coleoptera: Coccinellidae) is known to thrive principally in shrubby and arboreal habitats. Its occurrence in agroecosystems remains poorly ... [more ▼]

The Multicoloured Asian Ladybird, Harmonia axyridis Pallas (Coleoptera: Coccinellidae) is known to thrive principally in shrubby and arboreal habitats. Its occurrence in agroecosystems remains poorly documented. This study focuses on the occurrence of this exotic species and its seasonal abundance in various field crops. The abundance of adults and larvae of H. axyridis was evaluated over a four-year period, from 2009 to 2012, in four important agronomical crops (wheat, corn, broad bean and potato) in Belgium. A total of 28 aphid predator species were observed including 14 coccinellid species, 13 hoverfly species and one lacewing species. H. axyridis is present and reproduces in all of the four crops studied, with the largest numbers recorded in corn and broad bean crops. In corn, H. axyridis numbers were found to increase over the four inventoried year, reaching 86% of the aphid predators in 2012, while it represented only 15% in 2009. H. axyridis was not always recorded where aphids were abundant, e.g. aphids were abundant on wheat where no H. axyridis were recorded. H. axyridis starts reproducing after the peak in aphid population, suggesting that H. axyridis is able to complete its development by feeding on alternative prey such as larvae and pupae of the same and other species of ladybird and other aphidophagous species. H. axyridis is often considered to be bivoltine but it only completes one generation per year in field crops. The second generation generally develops late in the season in other habitats. Harmonia axyridis is an invasive and an intraguild predator present in high quantities in some specific crops. In these crops, H. axyridis could negatively impact on population of native species due to IGP observed in several other studies. [less ▲]

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See detailMulticompartment micelles from blends of terpolymers
Gohy, Jean-François; Lefèvre, Nathalie ULg; D'haese, Cécile et al

in Polymer Chemistry (2011), 2(2), 328-332

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See detailA multicomponent exploration of verbal short-term storage deficits in normal aging and Alzheimer’s disease
Peters, Frédéric; Majerus, Steve ULg; Olivier, Laurence et al

in Journal of Clinical & Experimental Neuropsychology (2007), 29(4), 405-417

Although many studies have shown diminished performance in verbal short-term memory tasks in normal aging and Alzheimer's disease (AD), the cognitive processes responsible for this verbal short-term ... [more ▼]

Although many studies have shown diminished performance in verbal short-term memory tasks in normal aging and Alzheimer's disease (AD), the cognitive processes responsible for this verbal short-term storage (STS) impairment are still unclear for both populations. We explored verbal STS functioning in patients with AD, elderly participants, and young participants, by investigating a series of processes that could underlie STS impairments in normal elderly and AD populations. The processes we investigated were (a) the influence of lexical and sublexical language knowledge on short-term storage performance, (b) functioning of the phonological loop component via word length and phonological similarity effects, and (c) executive control processes (coordination and integration). For the AD and elderly groups, the influence of language knowledge on verbal STS performance and the functioning of the phonological loop were preserved. In contrast, the AD group showed deficits for coordination and integration processes. Our results suggest that the verbal STS deficit observed in AD patients is related to impaired executive control processes. On the other hand, language-related processes underlying passive storage capacity seem to be preserved. [less ▲]

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See detailMulticomponent reactive modelling of ammonium contamination at a former coal carbonisation plant
Haerens, B.; Dassargues, Alain ULg; Prommer, H. et al

in Aardkundige Mededelingen (2002), 12

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See detailMulticonfiguration Dirac-Fock wavelengths and transition rates in the X-ray spectra of highly charged Ga-like ions from Yb39+ to U61+
Quinet, Pascal ULg; Biémont, Emile ULg; Palmeri, P. et al

in Atomic Data and Nuclear Data Tables (2007), 93(1), 167-182

A multiconfiguration Dirac-Fock (MCDF) technique has been used for computing the wavelengths and transition probabilities for lines in the X-ray spectra of the gallium-like ions from Yb XL to U LXII ... [more ▼]

A multiconfiguration Dirac-Fock (MCDF) technique has been used for computing the wavelengths and transition probabilities for lines in the X-ray spectra of the gallium-like ions from Yb XL to U LXII. Results are presented for the 4s(2)4p-4s(2)4d and 4s(2)4p-4s4p(2) allowed transitions (E1) as well as for the forbidden transitions (M1 and E2) within the ground configuration 4s(2)4p. A comparison of the calculated wavelengths with the few experimental results available is also presented. (c) 2006 Elsevier Inc. All rights reserved. [less ▲]

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