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Peer Reviewed
See detailInvolvement of 5-hydroxytryptamine in hyperdynamic pulmonary hemodynamics in endotoxemic calves
Desmecht, Daniel ULg; Linden, Annick ULg; Amory, Hélène ULg et al

in Pflügers Archiv : European Journal of Physiology (1995), 429

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See detailInvolvement of acyl coenzyme A oxidase isozymes in biotransformation of methyl ricinoleate into γ-decalactone by Yarrowia lipolytica
Waché, Y.; Laroche, C.; Bergmark, K. et al

in Applied and Environmental Microbiology (2000), 66(3), 1233-1236

We reported previously on the function of acyl coenzyme A (acyl-CoA) oxidase isozymes in the yeast Yarrowia lipolytica by investigating strains disrupted in one or several acyl-CoA oxidase-encoding genes ... [more ▼]

We reported previously on the function of acyl coenzyme A (acyl-CoA) oxidase isozymes in the yeast Yarrowia lipolytica by investigating strains disrupted in one or several acyl-CoA oxidase-encoding genes (POX1 through POX5) (H. Wang et al., J. Bacteriol. 181:5140-5148, 1999). Here, these mutants were studied for lactone production. Monodisrupted strains produced similar levels of lactone as the wild-type strain (50 mg/liter) except for Δpox3, which produced 220 mg of γ-decalactone per liter after 24 h. The Δpox2 Δpox3 double-disrupted strain, although slightly affected in growth, produced about 150 mg of lactone per liter, indicating that Aox2p was not essential for the biotransformation. The Δpox2 Δpox3 Δpox5 triple- disrupted strain produced and consumed lactone very slowly. On the contrary, the Δpox2 Δpox3 Δpox4 Δpox5 multidisrupted strain did not grow or biotransform methyl ricinoleate into γ-decalactone, demonstrating that Aox4p is essential for the biotransformation. [less ▲]

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See detailInvolvement of adamalysin proteases in modulations of tumor microenvironment and premetastatic niches
Donati, Kim ULg; Bekaert, Sandrine; Sepult, Christelle ULg et al

in European Respiratory Journal (2015, September), 46(59),

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See detailInvolvement of adamalysin proteases in modulations of tumor microenvironment and premetastatic niches.
Donati, Kim ULg; Bekaert, Sandrine; Sepult, Christelle ULg et al

Poster (2015, September)

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See detailInvolvement of autophagic pathway in the hypoxia-induced resistance to etoposide in HepG2
Cosse, Jean-Philippe ULg; Sermeus, Audrey; Flamant, Lionel et al

Poster (2009)

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See detailInvolvement of both prefrontal and inferior parietal cortex in dual-task performance
Collette, Fabienne ULg; Olivier, L.; Van der Linden, Martial ULg et al

in Cognitive Brain Research (2005), 24(2), 237-251

This PET study explored the neural substrate of both dual-task management and integration task using single tasks that are known not to evoke any prefrontal activation. The paradigm included two simple ... [more ▼]

This PET study explored the neural substrate of both dual-task management and integration task using single tasks that are known not to evoke any prefrontal activation. The paradigm included two simple (visual and auditory) discrimination tasks, a dual task and an integration task (requiring simultaneous visual and auditory discrimination), and baseline tasks (passive viewing and hearing). Data were analyzed using SPM99. As predicted, the comparison of each single task to the baseline task showed no activity in prefrontal areas. The comparison of the dual task to the single tasks demonstrated left-sided foci of activity in the frontal gyrus (BA 9/46, BA 10/47 and BA 6), inferior parietal gyrus (BA 40), and cerebellum. By reference to previous neuroimaging studies, BA 9/46 was associated with the coordinated manipulation of simultaneously presented information, BA 10/47 with selection processes, BA 6 with articulatory rehearsal, and BA 40 with attentional shifting. Globally similar regions were found for the integration task, except that the inferior parietal gyrus was not recruited. These results confirm the hypothesis that the left prefrontal cortex is implicated in dual-task performance. Moreover, the involvement of a parietal area in the dual task is in keeping with the hypothesis that a parieto-frontal network sustains executive functioning. [less ▲]

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Peer Reviewed
See detailInvolvement of different transduction pathways in NF-kappaB activation by several inducers
Legrand-Poels, Sylvie ULg; Zecchinon, Laurent; Piret, Bernard et al

in Free Radical Research (1997)

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See detailInvolvement of end-users in innovation processes: toward a user-driven approach of innovation. A qualitative analysis of 20 Livings Labs
Vanmeerbeek, Perrine; Vigneron, Lara ULg; Delvenne, Pierre ULg et al

Conference (2015)

Initially developed to bridge the gap between research and market, a Living Lab can be described as an open, innovative and collaborative process based on three core characteristics: user involvement in ... [more ▼]

Initially developed to bridge the gap between research and market, a Living Lab can be described as an open, innovative and collaborative process based on three core characteristics: user involvement in the innovation process, experimentation in real-life context and the gathering of stakeholders in public-private-people partnerships. The paper focuses on user involvement and provides an insight on how this principle is put in practice, through the qualitative analysis of interviews conducted with twenty Living Labs in Europe and Canada. Our results interestingly point out that practice of user-driven approach, unlike what is promoted in Living Lab theory, is rather limited. Indeed, many Living Labs do not involve users for the ideation phase at all, and those ones usually use a user-centered approach for the following steps. Besides, when observed, user-driven approach is often restricted to the ideation phase. We can though ask ourselves the question of what is, or should be, living in a Living Lab? Furthermore, our results suggest that a user-driven approach seems more suitable when a Living Lab aims to create social value than when its objective is to create economic value. [less ▲]

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See detailInvolvement of Executive Functions in Children’s Metamemory
Geurten, Marie ULg; Catale, Corinne ULg; Meulemans, Thierry ULg

in Applied Cognitive Psychology (2016), 30(1), 70-80

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were ... [more ▼]

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were assessed based on the performance of a group of 100 children (aged 4, 6, 9 and 11 years) on a battery of executive tasks. At the same time, the influence of variables such as intelligence, vocabulary and parental education level was also investigated. Results of mediation analyses reveal that the relation between children’s age and internal strategy knowledge was partially mediated by working memory skills but that executive functions did not mediate the impact of chronological age on children’s knowledge of external strategies or of memory functioning. Additionally, verbal fluency predicted internal and external strategy knowledge. Implications for general learning theories in childhood are discussed [less ▲]

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See detailInvolvement of fengycin-type lipopeptides in the multifaceted biocontrol potential of Bacillus subtilis
Ongena, MARC ULg; Jacques, Philippe ULg; Toure, Y. et al

in Applied Microbiology & Biotechnology (2005), 69(1), 29-38

In this work, the potential of Bacillus subtilis strain M4 at protecting plants against fungal diseases was demonstrated in different pathosystems. We provide evidence for the role of secreted ... [more ▼]

In this work, the potential of Bacillus subtilis strain M4 at protecting plants against fungal diseases was demonstrated in different pathosystems. We provide evidence for the role of secreted lipopeptides, and more particularly of fengycins, in the protective effect afforded by the strain against damping-off of bean seedlings caused by Pythium ultimum and against gray mold of apple in post-harvest disease. This role was demonstrated by the strong biocontrol activity of lipopeptide-enriched extracts and through the detection of inhibitory quantities of fengycins in infected tissues. Beside such a direct antagonism of the pathogen, we show that root pre-inoculation with M4 enabled the host plant to react more efficiently to subsequent pathogen infection on leaves. Fengycins could also be involved in this systemic resistance-eliciting effect of strain M4, as these molecules may induce the synthesis of plant phenolics involved in or derived from the defense-related phenylpropanoid metabolism. Much remains to be discovered about the mechanisms by which Bacillus spp suppress disease. Through this study on strain M4, we reinforce the interest in B. subtilis as a pathogen antagonist and plant defense-inducing agent. The secretion of cyclic fengycin-type lipopeptides may be tightly related to the expression of these two biocontrol traits. [less ▲]

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See detailInvolvement of glutathione as a mechanism of indirect protection against spontaneous ex vivo apoptosis associated with bovine leukemia virus.
Sanchez Alcaraz, Teresa; Kerkhofs, Pierre; Reichert, Michal et al

in Journal of virology (2004), 78(12),

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See detailInvolvement of hexokinase HXK1 in glucose catabolite repression of LIP2 encoding extracellular lipase in the yeast Yarrowia lipolytica
Fickers, Patrick ULg; Nicaud, J. M.; Destain, Jacqueline ULg et al

in Current Microbiology (2005), 50(3), 133-137

The yeast Yarrowia lipolytica produces an extracellular lipase encoded by the LIP2 gene. However, very little is known about the mechanisms controlling its expression, especially on glucose media. In this ... [more ▼]

The yeast Yarrowia lipolytica produces an extracellular lipase encoded by the LIP2 gene. However, very little is known about the mechanisms controlling its expression, especially on glucose media. In this work, the involvement of hexokinase Hxk1 in the glucose catabolite repression of LIP2 was investigated in a lipase overproducing mutant less sensitive to glucose repression. This mutant has a reduced capacity to phosphorylate hexose compared with the wild-type strain, but no differences could be observed between the HXK1 sequences in the two isolates. This suggested that the reduced phosphorylating activity of the mutant strain probably resulted from a modification in the level of HXK1 expression. However, overexpression of the HXK1 gene in this mutant led to a decrease of both LIP2 induction and extracellular lipase activity, suggesting that the hexokinase is involved in the glucose catabolite repression of LIP2 in Y lipolytica. [less ▲]

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See detailThe involvement of hydrogen-producing and ATP-dependent NADPH-consuming pathways in setting the redox poise in the chloroplast of Chlamydomonas reinhardtii in anoxia.
Clowez, Sophie; Godaux, Damien ULg; Cardol, Pierre ULg et al

in The Journal of biological chemistry (2015), 290(13), 8666-76

Photosynthetic microalgae are exposed to changing environmental conditions. In particular, microbes found in ponds or soils often face hypoxia or even anoxia, and this severely impacts their physiology ... [more ▼]

Photosynthetic microalgae are exposed to changing environmental conditions. In particular, microbes found in ponds or soils often face hypoxia or even anoxia, and this severely impacts their physiology. Chlamydomonas reinhardtii is one among such photosynthetic microorganisms recognized for its unusual wealth of fermentative pathways and the extensive remodeling of its metabolism upon the switch to anaerobic conditions. As regards the photosynthetic electron transfer, this remodeling encompasses a strong limitation of the electron flow downstream of photosystem I. Here, we further characterize the origin of this limitation. We show that it stems from the strong reducing pressure that builds up upon the onset of anoxia, and this pressure can be relieved either by the light-induced synthesis of ATP, which promotes the consumption of reducing equivalents, or by the progressive activation of the hydrogenase pathway, which provides an electron transfer pathway alternative to the CO2 fixation cycle. [less ▲]

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See detailInvolvement of indole-3-acetic acid in the circadian growth of the first internode of Arabidopsis
Jouve, Laurent; Gaspar, Thomas ULg; Kevers, Claire ULg et al

in Planta (1999), 209(1), 136-142

The extension rate of the first inflorescence node of Arabidopsis was measured during light/dark or continuous light exposure and was found to exhibit oscillations which showed a circadian rhythmicity ... [more ▼]

The extension rate of the first inflorescence node of Arabidopsis was measured during light/dark or continuous light exposure and was found to exhibit oscillations which showed a circadian rhythmicity. Decapitation induced a strong inhibition of stem extension. Subsequent application of IAA restored growth and the associated extension-rate oscillations. In addition, IAA treatments, after decapitation, re-established the circadian rhythmicity visible in the intact plants during free run. This indicates that the upper zone of the inflorescence has a major influence on the extension rate of floral stems and implies a role for auxin. Application of N-(1-naphthyl)phthalamic acid, an IAA transport inhibitor, to an intact floral stem inhibited growth and the rhythmicity in the extension rate oscillations, indicating that IAA polar transport may play a role in the dynamics of stem elongation. Furthermore, IAA-aspartate application, after decapitation, did not restore growth and rhythmicity. Nevertheless, biochemical analysis of IAA and IAA-aspartate demonstrated circadian fluctuations of the endogenous levels of both compounds. These observations suggest that IAA metabolism is an essential factor in the regulation of the circadian growth rhythm of Arabidopsis floral stems. [less ▲]

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See detailInvolvement of Insulin-Like Growth Factors in Early T Cell Development: A Study Using Fetal Thymic Organ Cultures
Kecha, O.; Brilot, F.; Martens, Henri ULg et al

in Endocrinology (2000), 141(3), 1209-17

The expression of insulin-like growth factor (IGF) and IGF receptor genes was investigated by RT-PCR during ontogeny of the murine thymus. IGF-1, IGF-1R, M6P/IGF-2R genes are expressed in the thymus both ... [more ▼]

The expression of insulin-like growth factor (IGF) and IGF receptor genes was investigated by RT-PCR during ontogeny of the murine thymus. IGF-1, IGF-1R, M6P/IGF-2R genes are expressed in the thymus both in fetal and postnatal life, whereas IGF-2 messenger RNAs (mRNAs) decline after birth but are still detectable on the seventh week. By in situ hybridization, IGF-2 transcripts were located in the outer cortex and medulla of the postnatal thymus, and on the whole surface ofthe epithelial-like network in the fetal thymus. The effects of anti-IGFs and IGF-receptors neutralizing Abs on the generation of pre-T cell subpopulations were then investigated using fetal thymic organ cultures (FTOC). FTOC treatment with an anti-IGF-2 mAb, an anti-IGF-1R mAb, or an anti-M6P/IGF-2R polyclonal Ab induced a blockade of T cell differentiation at the CD4-CD8- stage, as shown by a significant increase in the percentage of CD4-CD8- cells and a decrease in the percentage of CD4+CD8+ cells. Moreover, anti-IGF-2 Ab treatment induced an increase in CD8+ cells suggesting that thymic IGF-2 might have a role in determining differentiation into the CD4 or CD8 lineage. Anti-IGF-1 Ab treatment decreased the proportion in CD4-CD8- cells and increased the frequency in CD4+CD8+. FTOC treatment with anti-(pro)insulin did not exert any significant effect on T cell development. These data indicate that the intrathymic IGF-mediated signaling plays an active role in the early steps of T cell differentiation during fetal development. [less ▲]

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