Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.; ; et al in Journal of Cell Biology (2003), 163(3), 625-35 Glypican (GPC)-3 inhibits cell proliferation and regulates cell survival during development. This action is demonstrated by GPC3 loss-of-function mutations in humans and mice. Here, we show that the GPC3 ... [more ▼] Glypican (GPC)-3 inhibits cell proliferation and regulates cell survival during development. This action is demonstrated by GPC3 loss-of-function mutations in humans and mice. Here, we show that the GPC3 core protein is processed by a furinlike convertase. This processing is essential for GPC3 modulating Wnt signaling and cell survival in vitro and for supporting embryonic cell movements in zebrafish. The processed GPC3 core protein is necessary and sufficient for the cell-specific induction of apoptosis, but in vitro effects on canonical and noncanonical Wnt signaling additionally require substitution of the core protein with heparan sulfate. Wnt 5A physically associates only with processed GPC3, and only a form of GPC3 that can be processed by a convertase is able to rescue epiboly and convergence/extension movements in GPC3 morphant embryos. Our data imply that the Simpson-Golabi-Behmel syndrome may in part result from a loss of GPC3 controls on Wnt signaling, and suggest that this function requires the cooperation of both the protein and the heparan sulfate moieties of the proteoglycan. [less ▲] Detailed reference viewed: 14 (0 ULg) Processing GPS measurements during periods of high ionospheric activityWarnant, René ; ; in Proceedings of EUREF 2002 Symposium (2003) Detailed reference viewed: 10 (0 ULg) Processing of Carbon Fibers Reinforced Mg Matrix Composites Via Pre-infiltration with AlMertens, Anne ; Montrieux, Henri-Michel ; et alin Journal of Materials Engineering and Performance (2012), 21(5), 701-706 Mg-C composites offer a suitable alternative to Al alloys while allowing for a significant weight reduction, but their production can be impaired by the poor wettability of C substrates by Mg. In the ... [more ▼] Mg-C composites offer a suitable alternative to Al alloys while allowing for a significant weight reduction, but their production can be impaired by the poor wettability of C substrates by Mg. In the present work, a new 'liquid' processing route has been investigated. By making use of the well-known effect of a pre-treatment of the C fibres with an aqueous solution of K2ZrF6 in favouring spontaneous wetting of C with Al, C yarns have been pre-impregnated with Al and the feasibility of further using them as reinforcements in Mg matrix composites has been assessed. More particularly, it has thus been shown that, under the thermal conditions involved in the process, C fibres did not suffer damage due to chemical reaction with Al, and also that special care should be taken in order to control the surface condition of the pre-infiltrated yarns. [less ▲] Detailed reference viewed: 15 (5 ULg) Processing of carbon fibers reinforced Mg matrix composites via pre-infiltration with AlMertens, Anne ; Lecomte-Beckers, Jacqueline ; Montrieux, Henri-Michel et alConference (2011, September) Mg matrix composites appear as suitable competitors to Al alloys for a wide number of applications, as they allow for a significant weight reduction while exhibiting potentially comparable mechanical ... [more ▼] Mg matrix composites appear as suitable competitors to Al alloys for a wide number of applications, as they allow for a significant weight reduction while exhibiting potentially comparable mechanical properties. And a large variety of processing routes have already been considered for their production, including 'liquid state' processes such as squeeze casting. These techniques necessitate a very careful control of the wetting behaviour and of the possible interfacial reactions between the reinforcements and the molten metal, along with the solidification process. And this is more particularly true in the case of Mg matrix composites with carbon fibers reinforcements, as Mg alloys are known to exhibit a poor wetting behaviour on carbon substrates. [less ▲] Detailed reference viewed: 15 (0 ULg) Processing of linguisitic and musical dimensions contained in songs : effects of an expertiseLarrouy, Pauline ; ; Poster (2010, August) Songs are universal in our lives and also offer an ecological material that links linguistic and musical information. It therefore provides a tool for observing the relationship between music and language ... [more ▼] Songs are universal in our lives and also offer an ecological material that links linguistic and musical information. It therefore provides a tool for observing the relationship between music and language. To examine the specificity of language and music information processing in songs, we studied the influence of expertise (i.e. musicians or speech therapists) on the use of transitional probabilities (TPs) in learning an artificial language (AL) either spoken or sung. This type of implicit statistical learning is especially important in language development (Saffran, Aslin, & Newport, 1996). We used the paradigm designed by Schön, Boyer, Moreno, Besson, Peretz and Kolinsky (2008). These authors have demonstrated the benefit of structural and motivational proprieties of music contained in the song in the learning process of AL in individuals with no expertise. Compared to a spoken AL, learning was enhanced for a singing AL, especially when the TPs of musical and linguistic materials were congruent. Our results did not replicate those of this study in participants having no music expertise. However, an interaction occurred between the type of AL and expertise of the participants. Indeed, only music experts seemed to benefit from the congruence between the TPs of musical and linguistic materials in extracting TP-based linguistic units. On the opposite, experts in language seemed to be favoured by the incongruence between the TPs of linguistic and musical information. These results are discussed in relation to the notions of the specificity of processing of lyrics and tunes in songs. [less ▲] Detailed reference viewed: 56 (16 ULg) Processing of Ti alloys by additive manufacturing: a comparison of the microstructures obtained by laser cladding, selective laser melting and electron beam meltingReginster, Sylvie ; Mertens, Anne ; Paydas, Hakan et alin Materials Science Forum (2013) Additive manufacturing processes such as laser cladding (LC) or selective laser melting (SLM) appear very promising in view of an economic near-net-shape production – and also, in the case of LC, the ... [more ▼] Additive manufacturing processes such as laser cladding (LC) or selective laser melting (SLM) appear very promising in view of an economic near-net-shape production – and also, in the case of LC, the restoration - of complex and (almost) fully dense parts from Ti alloys. Both techniques involve the melting of a metallic powder with a laser. In the SLM process, the metallic powder is deposited layer by layer in a powder bed and then molten locally according to the desired shape, whereas in LC, the metallic powder is directly projected onto a substrate through a nozzle coaxial with the laser beam. The present research aims at comparing Ti-6Al-4V samples processed by these two techniques with reference samples produced by electron beam melting (EBM), another well established additive manufacturing process (patented by Arcam AB Company) in which a powder bed is molten locally by means of an electron beam. In all three processes, the melt pool undergoes an ultrafast cooling and solidifies very rapidly once the beam has left the area, thus giving rise to strongly out-of-equilibrium microstructures. Yet, each one of these processes also has its own specificities e.g. in terms of scanning strategy and of working atmosphere (low vacuum vs. protective Ar flow). In the present work, the microstructures obtained by these three processes have been compared in details, with a particular attention for characteristics such as porosity, grain size, and the various phases present. Since epitaxial growth of the newly deposited layer on the material previously solidified has been shown [1, 2] to exert a strong influence on the microstructure and on the resulting mechanical properties, great care has been taken to study the microstructural anisotropy associated with each one of the three processes. [less ▲] Detailed reference viewed: 89 (15 ULg) Processing of X-ray tomographic images: a procedure adapted for the analysis of phase distribution in MellapakPlus 752.Y and Katapak-SP packings; Aferka, Saïd ; et alin Flow Measurement & Instrumentation (2011), 22 We developed a simple practical methodology to face common problems encountered in the analysis of tomographic images to get quantitative information on phase distributions in gas liquid contacting ... [more ▼] We developed a simple practical methodology to face common problems encountered in the analysis of tomographic images to get quantitative information on phase distributions in gas liquid contacting columns packed with complex metallic packings. In particular, the procedure (thresholding and normalisation) was developed and validated on images of geometrically well known Mellapak Plus 752 Y packings. The methodology was extended to images of Katapak-SP modular packings which are made of an alternation of Mellapak Plus 752 Y sheets and catalytic baskets. Global liquid hold-up, obtained by averaging tomographic results over the column height, were found in agreement with bed scale data measured on the same Mellapak Plus 752 Y and Katapak-SP (11 and 12) packings at a given liquid load. Moreover, gas-liquid interfacial area were calculated and reported to the installed geometric area. [less ▲] Detailed reference viewed: 24 (4 ULg) Processing samples of benthic marine diatoms from Mediterranean oligotrophic areasVermeulen, Simon ; Lepoint, Gilles ; Gobert, Sylvie ![]() in Journal of Applied Phycology (2012), 24 The processing of benthic diatoms is tedious and involves several potentially damaging steps for cells. Although the preservation of siliceous frustules is of paramount importance in the implementation of ... [more ▼] The processing of benthic diatoms is tedious and involves several potentially damaging steps for cells. Although the preservation of siliceous frustules is of paramount importance in the implementation of biotic indices, only few studies quantified treatment-induced cell losses. We assumed that commonly used treatments may lead to mechanical (centrifugation, sedimentation, boiling, sonication and mounting in Naphrax) and chemical (cold H2O2 digestion) damages on diatoms. We analysed the potential adverse effects of these treatments and the cleaning efficiency of H2O2 and incineration in order to find out the most suitable technique to process lightly silicified Mediterranean populations. Results showed that successive resuspensions of material after each concentration treatment (sedimentation and centrifugation) and low speed centrifugation did not alter the physical integrity of frustules. In contrast, boiling and sonication exhibited adverse effects especially on the preservation of large frustules and Naphrax mounting proved to be the most damaging step whatever the size of diatoms. For cleaning treatments, incineration provided the most satisfactory results and acted on a non-selective way as opposed to hydrogen peroxide which led to either a large number of non-cleaned frustules or dissolved valves. Our recommendations for processing samples of lightly silicified Mediterranean benthic diatoms include the use of low speed centrifugations, dehydration at room temperature, incineration and dry mounting. [less ▲] Detailed reference viewed: 50 (13 ULg) Processing spatial and pitch attributes of sounds in the absence of visual experience : an fMRI study; Vandewalle, Gilles ; et alin NeuroImage (2010), 51(Suppl. 1), Detailed reference viewed: 8 (0 ULg) La procession dansante d'EchternachKurth, Godefroid ![]() in Revue Générale : Religion, Politique, Histoire (1876), XXIV Detailed reference viewed: 7 (0 ULg) La procession-spectacle comme recomposition de l’espaceDelfosse, Annick ![]() Conference (2008, April 10) Detailed reference viewed: 18 (11 ULg) Les processions de l’Europe baroque : définition, typologie et enjeuxDelfosse, Annick ![]() Scientific conference (2009, March 27) Detailed reference viewed: 22 (6 ULg) Processions-spectacles et catholicisme baroque : les cérémonies belges pour la canonisation d'Ignace de Loyola et François-XavierDelfosse, Annick ![]() Scientific conference (2008, April 11) Detailed reference viewed: 10 (3 ULg) Processos a políticas (locais) de integração : estado do conhecimento e ilações; Martiniello, Marco ![]() in Marques, Margarida (Ed.) Estado-Nação e Migrações Internacionais (2010) Detailed reference viewed: 39 (0 ULg) Processos a políticas (locais) de integração : estado do conhecimento e ilações; Martiniello, Marco ![]() in Marques, M. (Ed.) Estado-Nação e Migrações Internacionais (2010) Detailed reference viewed: 12 (1 ULg) Processus attentionnels et maladie d'AlzheimerCollette, Fabienne ; Van der Linden, Martial ![]() in Couillet, J.; Leclerq, M.; Moroni, C. (Eds.) et al La neuropsychologie de l'attention (2002) La maladie d'Alzheimer se caractérise par l'accumulation progressive de déficits affectant différents domaines cognitifs.(...)Il est maintenant largement reconnu que la maladie d'Alzheimer n'affecte pas ... [more ▼] La maladie d'Alzheimer se caractérise par l'accumulation progressive de déficits affectant différents domaines cognitifs.(...)Il est maintenant largement reconnu que la maladie d'Alzheimer n'affecte pas tous les processus cognitifs de façon équivalente.(...)Les modèles cognitifs de l'attention suggèrent que l'attention n'est pas un système homogène et que différents types de processus attentionnels peuvent être distingués.(...)Le but de ce chapitre est de présenter les travaux les plus représentatifs ayant exploré ces différents types de processus dans la maladie d'Alzheimer. [less ▲] Detailed reference viewed: 69 (7 ULg) Processus attentionnels et vieillissement normalAdam, Stéphane ; Van der Linden, Martial ; Collette, Fabienne ![]() in Couillet, Josettte; Leclerq, Michel; Moroni, Christine (Eds.) et al Neuropsychologie de l'attention (2002) De très nombreuses études ont mis en évidence une diminution de performance des sujets âgés dans une grande variété de tâches cognitives, à la fois en condition de laboratoire et dans la vie réelle ... [more ▼] De très nombreuses études ont mis en évidence une diminution de performance des sujets âgés dans une grande variété de tâches cognitives, à la fois en condition de laboratoire et dans la vie réelle. Cependant, ce déclin lié à l'âge n'est pas observé dans toutes les situations et les personnes âgées peuvent même présenter dans certaines tâches des performances supérieures à celles des sujets jeunes. [less ▲] Detailed reference viewed: 105 (8 ULg) Les processus climatologiques intervenant dans le bilan hydrologique de petits bassins versants boisésAlexandre, Jean ; Petit, François ![]() in Les Ecosystèmes Forestiers en Wallonie (1983) Detailed reference viewed: 8 (2 ULg) Les processus contrôlant l'évolution du tracé d'une rivière ardennaise. Zeitschrift für GeomorphologiePetit, François ![]() in Zeitschrift für Geomorphologie (1984) Detailed reference viewed: 20 (6 ULg) Processus d'aménagement et des gestion des espaces publicsPartoune, Christine ; Schmitz, Serge ; Dalimier, Isabelle et alin Tableau de bord "Participation et espaces publics" - Pour un développement et une gestion concertée des espaces publics (2010) La recherche-action TOPOZYM a produit un tableau de bord qui est un outil au service des personnes qui sont des vecteurs de changement de comportement des acteurs de l’espace (animateurs territoriaux ... [more ▼] La recherche-action TOPOZYM a produit un tableau de bord qui est un outil au service des personnes qui sont des vecteurs de changement de comportement des acteurs de l’espace (animateurs territoriaux, médias, secteur éducatif, agents de développement local,...) dans une perspective d’une meilleure intégration des principes du développement durable. Dans le tableau de bord, pour simplifier, ce type d’intervenant a été désigné par le terme d’animateur territorial. Ce tableau de bord a pour objectif de les aider à concevoir et/ou à évaluer des démarches participatives efficientes et cohérentes dans le cadre de la gouvernance territoriale des lieux et des espaces publics. [less ▲] Detailed reference viewed: 15 (2 ULg) |
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