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See detailA multi-wavelength survey of AGN in the XMM-LSS field. I. Quasar selection via the KX technique
Nakos, Theodoros; Willis, J. P.; Andreon, S. et al

in Astronomy and Astrophysics (2009), 494

Aims. We present a sample of candidate quasars selected using the KX-technique. The data cover 0.68 deg[SUP]2[/SUP] of the X-ray Multi-Mirror (XMM) Large-Scale Structure (LSS) survey area where ... [more ▼]

Aims. We present a sample of candidate quasars selected using the KX-technique. The data cover 0.68 deg[SUP]2[/SUP] of the X-ray Multi-Mirror (XMM) Large-Scale Structure (LSS) survey area where overlapping multi-wavelength imaging data permits an investigation of the physical nature of selected sources. Methods: The KX method identifies quasars on the basis of their optical (R and z') to near-infrared (K_s) photometry and point-like morphology. We combine these data with optical (u^*,g', r',i',z') and mid-infrared (3.6-24 mum) wavebands to reconstruct the spectral energy distributions (SEDs) of candidate quasars. Results: Of 93 sources selected as candidate quasars by the KX method, 25 are classified as quasars by the subsequent SED analysis. Spectroscopic observations are available for 12/25 of these sources and confirm the quasar hypothesis in each case. Even more, 90% of the SED-classified quasars show X-ray emission, a property not shared by any of the false candidates in the KX-selected sample. Applying a photometric redshift analysis to the sources without spectroscopy indicates that the 25 sources classified as quasars occupy the interval 0.7 <= z <= 2.5. The remaining 68/93 sources are classified as stars and unresolved galaxies. [less ▲]

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See detailA multiaxial concrete model for applications in structural fire engineering
Gernay, Thomas ULg; Millard, Alain

in Fontana, M.; Frangi, A.; Knobloch, M. (Eds.) Proceedings of the 7th International Conference on Structures in Fire (2012, June 07)

Temperature-dependent material models are required in numerical softwares dedicated to the nonlinear analysis of structures in fire. Although structural concrete is widely used in civil engineering ... [more ▼]

Temperature-dependent material models are required in numerical softwares dedicated to the nonlinear analysis of structures in fire. Although structural concrete is widely used in civil engineering, proper modelling of its thermo-mechanical behaviour remains a challenging issue for engineers mainly because of the complexity of the phenomena that result from the microcracking process in this composite material and because of the lack of numerical robustness of the models. This paper presents a new multiaxial concrete model developed for the analysis of concrete structures in fire. The multiaxial model is based on a plastic-damage formulation and incorporates an explicit term for transient creep strain. After implementation in a finite element software for structural fire engineering calculations, numerical simulations have been performed to highlight the ability of the model to capture some of the main phenomena that develop in concrete (permanent strains, degradation of the elastic properties, unilateral effect) as well as the ability to be used for the fire analysis of large-scale structural elements. [less ▲]

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See detailA multiaxial constitutive model for concrete in the fire situation including transient creep and cooling down phases
Gernay, Thomas ULg

Doctoral thesis (2012)

Purpose - The present thesis aims to develop an efficient and reliable multiaxial concrete model for implementation in finite elements softwares dedicated to the analysis of structures in fire. The need ... [more ▼]

Purpose - The present thesis aims to develop an efficient and reliable multiaxial concrete model for implementation in finite elements softwares dedicated to the analysis of structures in fire. The need for proper concrete model remains a very challenging task in structural (fire) engineering because of the complexity of the concrete mechanical behavior characterization and the severe requirements for the material models raised by the development of performance-based design. Methodology - The thesis opted for a phenomenological approach for modeling the thermo-mechanical behavior of concrete. The specifications of the model are based on the study of published experimental data of concrete samples tests and on the specific needs related to the applications in structural fire engineering. With these specifications in mind, a state of the art review of concrete models is conducted in order to choose the general theoretical framework that best fits the criteria for the development of the new model. The thesis presents the theoretical development of the model and its numerical implementation in a finite elements software. Numerical simulations of experimental tests are then performed to verify that the model satisfy the specifications. Findings - The combination of elastoplasticity theory and damage theory allows to develop a phenomenological model suitable for concrete behavior modeling within the pragmatic and robust theoretical framework of continuum constitutive models based on smeared crack approach. The state of damage in concrete, assumed isotropic, is modeled by means of a fourth order damage tensor to capture the unilateral effect. When complex performance-based situations are considered, the effect of transient creep strain at high temperature must be taken into account by an explicit term in the strain decomposition. A generic transient creep model is therefore developed based on experimental data and the model is calibrated to yield the same results as the Eurocode implicit model in simple prescriptive situations. The concrete model comprises a limited number of parameters that can be identified by three simple tests; besides, a standard set of values to be used in predictive calculations is clearly defined for these parameters. Numerical simulations can deal with all stress states as the model is developed as fully three-dimensional. A large number of examples highlight the capabilities of the model that range from the modeling of sample tests to the modeling of large scale composite structures developing membrane action. Limitations – Due to the assumption that damage and plasticity are driven by the same internal variables in the model, a limitation appears for capturing the concrete post-peak behavior in highly confined stress states. This assumption allows for reducing the number of parameter but it restrains the domain of applicability of the model; it is suggested to adopt a different approach if the behavior in multiaxial compression at high confinement level has to be accurately captured. Another limitation of the model is related to the localization issue, which is only partly addressed in this work by means of the regularization of the crack energy. Further works should bring a more elaborated response while considering the case of reinforced concrete structures, in which numerous cracks develop. Finally, several simplifying assumptions have been adopted to restrain the scope of the research; for instance, the phenomenon of spalling has not been considered. Practical implications - The thesis includes implications for the development of advanced numerical tools for the simulation of concrete structures at ambient temperature and at high temperature. The use of such advanced tools in the design may lead to significant reduction in the building costs and to improved robustness of the structures. Value – The thesis contributes to fulfil an identified need to make available proper constitutive concrete model for implementation in finite elements softwares dedicated to the analysis of structures in fire. Special care is given to the numerical robustness of the model and to the clear definition of the material parameters as the model is intended to be used by structural (fire) engineers in real applications. [less ▲]

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See detailA multiaxial constitutive model for concrete in the fire situation
Gernay, Thomas ULg; Franssen, Jean-Marc ULg

in Proceedings of the 13th Fire and Materials Conference (2013, January 28)

Performance-based design in fire engineering leads to increasing demand for advanced temperature-dependent material models for the load bearing materials used in building structures. These models must be ... [more ▼]

Performance-based design in fire engineering leads to increasing demand for advanced temperature-dependent material models for the load bearing materials used in building structures. These models must be valid in natural fire situations including cooling down phase and must be sufficiently robust for complex numerical calculations such as, for example, the analysis of tensile membrane action in composite slabs. Although structural concrete is widely used in civil engineering, proper modelling of its thermo-mechanical behaviour remains a challenging issue for engineers mainly because of the complexity of the phenomena that result from the microcracking process in this material and because of the necessity to ensure the numerical robustness of the models. This paper presents a new multiaxial concrete model based on a plastic-damage formulation and developed to meet the specific requirements of structural fire engineers and researchers. The model, which incorporates an explicit term for transient creep strain and encompasses a limited number of material parameters, has been implemented in a finite element software dedicated to the nonlinear analysis of structures in fire. The paper presents a series of numerical simulations conducted to highlight the model ability to capture the main phenomena that develop in concrete under fire (permanent strains, degradation of the elastic properties, unilateral effect) as well as its ability to be used for the fire analysis of large-scale structural elements. As an example, the new concrete model is used in the numerical analysis of a full scale fire test on a composite steel-concrete slab and it is shown that the computed and measured results agree. [less ▲]

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See detailA multiaxial constitutive model for concrete in the fire situation: Theoretical formulation.
Gernay, Thomas ULg; Millard, Alain; Franssen, Jean-Marc ULg

in International Journal of Solids and Structures (2013), 50(22-23), 3659-3673

This paper aims to develop a multiaxial concrete model for implementation in finite element softwares dedicated to the analysis of structures in fire. The need for proper concrete model remains a ... [more ▼]

This paper aims to develop a multiaxial concrete model for implementation in finite element softwares dedicated to the analysis of structures in fire. The need for proper concrete model remains a challenging task in structural fire engineering because of the complexity of the concrete mechanical behavior characterization and the severe requirements for the material models raised by the development of performance-based design. A fully threedimensional model is developed based on the combination of elastoplasticity and damage theories. The state of damage in concrete, assumed isotropic, is modeled by means of a fourth order damage tensor to capture the unilateral effect. The concrete model comprises a limited number of parameters that can be identified by three simple tests at ambient temperature. At high temperatures, a generic transient creep model is included to take into account explicitly the effect of transient creep strain. The numerical implementation of the concrete model in a finite element software is presented and a series of numerical simulations are conducted for validation. The concrete behavior is accurately captured in a large range of temperature and stress states. A limitation appears when modeling the concrete post-peak behavior in highly confined stress states, due to the coupling assumption between damage and plasticity, but the considered levels of triaxial confinement are unusual stress states in structural concrete. [less ▲]

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See detailMultiaxial fatigue damage modeling of Ti6Al4V alloy
Marmi, Abdeljalil ULg; Habraken, Anne ULg; Duchene, Laurent ULg

in Proceedings of the ICMFF9 Conference (2010)

The aim of this study is to present a new multiaxial fatigue model based on phenomenological approach for the proportional loading. The model estimations are compared to the classical Lemaitre-Chaboche [1 ... [more ▼]

The aim of this study is to present a new multiaxial fatigue model based on phenomenological approach for the proportional loading. The model estimations are compared to the classical Lemaitre-Chaboche [1] fatigue model and experimental results. The comparison is done by simulation of SN curves of notched and un-notched forged TA6V samples. To take into account the effect of stress gradient near notch root, the applied loads such as stress amplitude and Von Mises stress are affected by the triaxialty function introduced by Lemaitre [2]. The models enhanced by triaxialty function give correct results for life estimation of notched samples. [less ▲]

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See detailMultiaxial fatigue damage modelling at Macro scale of Ti6AL4V alloy
Marmi, Abdeljalil ULg; Habraken, Anne ULg; Duchene, Laurent ULg

in International Journal of Fatigue (2009), 31

The Lemaitre and Chaboche fatigue model is investigated in order to predict the fatigue life of tensile samples with and without notches, defining different stress concentration fields. Elastoplastic FE ... [more ▼]

The Lemaitre and Chaboche fatigue model is investigated in order to predict the fatigue life of tensile samples with and without notches, defining different stress concentration fields. Elastoplastic FE simulations based on anisotropic yield locus description were carried out in order to obtain the stress and strain distributions near the notch root. The Lemaitre and Chaboche fatigue model was applied using the point method (local approach) and the gradient method (non-local approach). [less ▲]

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See detailMultibody Dynamics Analysis of Differentials in Vehicle Drivetrains
Virlez, Geoffrey ULg; Bruls, Olivier ULg; Poulet, Nicolas et al

in Proceedings of the First Joint International Conference on Multibody System Dynamics (2010, May 26)

Differentials are critical components whose behaviour influences the dynamics of vehicles. They often include complex phenomena whose modeling is not always easy. In this paper, a model has been developed ... [more ▼]

Differentials are critical components whose behaviour influences the dynamics of vehicles. They often include complex phenomena whose modeling is not always easy. In this paper, a model has been developed for a limited slip differential (type C Torsen) which is mainly composed of an epicyclic gear train. In order to take into account flexibility, the nonlinear finite element method based on the absolute nodal coordinates has been chosen. The differential is modeled as a multibody system with various gear pairs and contact conditions. The model has been validated qualitatively and future work will address the identification of the various parameters and comparisons with experimental data. [less ▲]

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See detailMultibody Dynamics Analysis of Differentials in Vehicle Drivetrains with SAMCEF MECANO
Virlez, Geoffrey ULg; Pretot, Philippe

Conference (2010, October 13)

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See detailMultibody Modelling of Mechanical Transmission Systems in Vehicle Dynamics
Virlez, Geoffrey ULg

Doctoral thesis (2014)

This thesis addresses the dynamic modelling of automotive driveline components by means of the nonlinear finite element method for flexible multibody systems. Starting from a detailed study of an ... [more ▼]

This thesis addresses the dynamic modelling of automotive driveline components by means of the nonlinear finite element method for flexible multibody systems. Starting from a detailed study of an industrial application, the TORSEN differential, several contributions are proposed in the field of contact modelling. The contact between rigid bodies in several geometric configurations is investigated and the influence of the squeeze film of lubricating oil is studied. A contact formulation between flexible bodies modelled as superelements is also developed and applied to the modelling of 3D flexible gear pairs. [less ▲]

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See detailMULTICENTER BELGIAN SURVEY ON DONOR MORBIDITY AND MORTALITY IN ADULT-TO-ADULT LIVING DONOR LIVER TRANSPLANTATION
Troisi, Roberto I; Vogelaers, Dirk; Lerut, Jan et al

in Transplant International (2011, September), 24(2), 13-13

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See detailA multicenter collaborative study to measure the prevalence of pituitary disease : methodology and preliminary findings
Tikhomirova, M.; Daly, Adrian ULg; Petrossians, Patrick ULg et al

in 15th Meeting of the Belgian Endocrine Society : Bruxelles, 26 novembre 2005 (2005, November)

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See detailA multicenter collaborative study to measure the prevalence of pituitary disease : methodology and preliminary findings
Daly, Adrian ULg; Petrossians, Patrick ULg; Murat, A. et al

in 9th International Pituitary Congress - Abstract book (2005)

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See detailMulticenter evaluation of analytical performance of the Liaison((R)) troponin I assay
Pagani, F.; Stefini, F.; Chapelle, Jean-Paul ULg et al

in Clinical Biochemistry (2004), 37(9), 750-757

Objectives: This study evaluated the analytical characteristics of the Liaison(R) immunoassay for cardiac troponin I (cTnI). Design and methods: The protocol consisted of eight sections: evaluation of ... [more ▼]

Objectives: This study evaluated the analytical characteristics of the Liaison(R) immunoassay for cardiac troponin I (cTnI). Design and methods: The protocol consisted of eight sections: evaluation of antibody specificity, linearity, detection limit and imprecision, method comparison, evaluation of endogenous interferents, anticoagulant interference, sample stability, and reference values. Results: The assay equally measured free and complexed cTnI. The minimum detectable cTnI concentration was 0.021 mug/l. The cTnI concentration corresponding to a total CVof 10% was 0.056 mug/l. Linearity of response was demonstrated along the entire dynamic range of the assay. Assay interferences were minimal. cTnI concentrations in serum and heparinized plasma were significantly different. Values in EDTA plasma were on average approximately 5% higher than in matched serum, but this difference was not significant. The 99th percentile cTnI value in healthy subjects was 0.036 mug/l. Conclusions: Being sensitive, specific, and precise, the Liaison(R) cTnI assay meets current requirements to aid in the diagnosis of myocardial necrosis. (C) 2004 The Canadian Society of Clinical Chemists. All rights reserved. [less ▲]

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See detailMulticenter implementation of geriatric assessment in Belgian patients with cancer: A survey on treating physicians' general experiences and expectations.
Kenis, Cindy; Heeren, Pieter; Bron, Dominique et al

in Journal of geriatric oncology (in press)

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A ... [more ▼]

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A survey was carried out in 9 Belgian hospitals, which participated in a national GA implementation project focusing on older patients with cancer. A newly developed questionnaire was completed by their treating physicians. Data collection comprised of reviewing hospital data, general respondent data, and treating physicians' general experiences and expectations regarding GA. Descriptive statistics were calculated. RESULTS: Eighty-two physicians from 9 hospitals participated. The GA team composition can vary substantially, with a nurse as core member. Ideally, all older patients with cancer in whom a treatment decision is necessary, should benefit from the GA. Nearly all GA domains are reported as very important. Availability of GA results can be improved. Treating physicians want geriatricians to coordinate geriatric recommendations related to the identified GA problems, and expect from trained healthcare workers (THCWs) to collect GA data, to report GA results, and to follow-up the implementation of geriatric recommendations. CONCLUSION: This study identifies relevant information for improving the implementation of GA in older patients with cancer in Belgium and reveals priorities for a THCW from the treating physician's point of view. To increase the effectiveness of GA, further efforts are needed to improve the implementation of geriatric recommendations. [less ▲]

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See detailA multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis.
Pierard, Claudine ULg; Goffin, Véronique ULg; Decroix, Jacques et al

in Skin Pharmacology & Applied Skin Physiology (2002), 15(6), 434-41

Ketoconazole (KET) and zinc pyrithione (ZPT) are compounds active against the Malassezia spp. yeasts, which are believed to play a major role in dandruff and seborrheic dermatitis. We compared the ... [more ▼]

Ketoconazole (KET) and zinc pyrithione (ZPT) are compounds active against the Malassezia spp. yeasts, which are believed to play a major role in dandruff and seborrheic dermatitis. We compared the efficacy and safety of KET 2% and ZPT 1% in shampoo formulations for the alleviation of severe dandruff and seborrheic dermatitis. This open randomized, parallel-group trial began with a 2-week run-in phase during which subjects applied a neutral non-antidandruff shampoo. It was followed by a 4-week randomized treatment phase and a subsequent 4-week follow-up phase without treatment. Shampooing during the treatment period was carried out twice weekly for the KET group and at least twice weekly for the ZPT group in accordance with the label instructions. A total of 343 subjects were recruited to enter the trial. Of the 331 eligible volunteers, 171 were randomized to KET 2% and 160 to ZPT 1%. Clinical assessments were performed. Beneficial effects were evidenced for both medicated shampoos, but the effect was significantly better for KET 2%, which achieved a 73% improvement in the total dandruff severity score compared with 67% for ZPT 1% at week 4 (p < 0.02). The recurrence rate of the disease was also significantly lower following KET 2% treatment than following ZPT 1% treatment. As a consequence, the overall clearing of the skin condition at the end of treatment and follow-up phase was in favor of the KET 2% formulation (p = 0.004). Side effects were minimal. It is concluded that after a 4-week treatment, KET 2% shampoo was significantly superior to ZPT 1% shampoo in the treatment of subjects with severe dandruff or seborrheic dermatitis of the scalp. It is our assumption that this difference is noticeable for the patient and as a consequence relevant. Both formulations were well tolerated. [less ▲]

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See detailMulticenter randomized-control led clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after ileo-caecal resection
Van Gossum, André; Dewit, Olivier; Louis, Edouard ULg et al

in Inflammatory Bowel Diseases (2007), 13(2), 135-142

Background: Seventy percent of Crohn's disease (CD) patients exhibit anastomotic recurrence within I year after ileo-caecal surgery, Recent clinical trials suggest the beneficial use of probiotics in the ... [more ▼]

Background: Seventy percent of Crohn's disease (CD) patients exhibit anastomotic recurrence within I year after ileo-caecal surgery, Recent clinical trials suggest the beneficial use of probiotics in the control of intestinal inflammation in pouchitis and ulcerative colitis. This study is a multicenter clinical trial evaluating the efficacy of an oral administration of the probiotic LA1 on early postoperative endoscopic recurrence of CD. Methods: Seventy patients with CD were enrolled prior to elective ileo-caecal resection and randomly assigned after surgery to daily treatment with either Lactobacillus johnsonii, LA1, Nestle (10(10) colony-forming units, CFU) (group A, n = 34) or placebo (group B, n = 36) for 12 weeks. The primary objective was to assess the effect of LA1 on the endoscopic recurrence rate at 12 weeks. Stratification was performed according to smoking status at randomization. Results: Seven and 14 patients were excluded in the LA1 and placebo groups, respectively. In intention-to-treat analysis, the mean endoscopic score was not significantly different between the two treatment groups at 3 months (LA1 versus placebo: 1.50 +/- 1.32 versus 1.22 +/- 1.37, treatment effect: P = 0.48, smoke effect: P = 0.72). The percentage of patients with severe recurrence (i3 + i4) was 21% and 15% in the LA1 and placebo groups, respectively (P = 0.33). Using a per-protocol (PP) analysis, the mean endoscopic score was not significantly different between the two treatment groups (LA1 versus placebo groups: 1.44 +/- 1.31 versus 1.05 +/- 1.21, P = 0.32). The percentage of patients with severe recurrence (i3 + i4) was 19% and 9% in the LA1 and placebo groups, respectively (P = 0.054). Clinical relapse rate (CDAI [CD activity index] > 150, with an increase of CDAI > 70 points or greater from baseline) in the LAI and placebo groups was 15% (4/27) and 13.5% (3/22), respectively (PP analysis: chi-square test, P = 0.91 and log-rank test: P = 0.79). Conclusion: Oral administration of the probiotic LA1 in patients with CID failed to prevent early endoscopic recurrence at 12 weeks after ileo-caecal resection. [less ▲]

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See detailMulticenter Study of 19 Aortopulmonary Window parathyroid Tumors : The callenge of Embryologic origin
Arnault, Vincent; Beaulieu, Anthony; Lifante, Jean-Christophe et al

in World Journal of Surgery (2010), 34

Background Ectopic abnormal parathyroid glands are relatively common in the superior mediastinum but are rarely situated in the aortopulmonary window (APW). The embryological origin of these abnormal ... [more ▼]

Background Ectopic abnormal parathyroid glands are relatively common in the superior mediastinum but are rarely situated in the aortopulmonary window (APW). The embryological origin of these abnormal parathyroid glands is controversial. The purpose of this investigation was to investigate the embryological origin and the surgical management of abnormal parathyroid glands situated in the APW. Methods The databases of patients operated on for primary, secondary, and tertiary hyperparathyroidism at eight European medical centers with a special interest in endocrine surgery were reviewed to identify those with APW adenomas. Demographic features, localization procedures, and perioperative and pathology findings were documented. The embryological origin was determined based on the number and position of identified parathyroid glands. Results Nineteen (0.24%) APW parathyroid tumors were identified in 7,869 patients who underwent an operation for hyperparathyroidism (HPT) and 181 patients (2.3%) with mediastinal abnormal parathyroid glands. Ten patients had primary, eight had secondary, and one had tertiary HPT. Sixteen patients had undergone previous unsuccessful cervical exploration. In three patients, an APW adenoma was suspected by preoperative localization studies and was cured at the initial operation. Sixteen patients had persistent HPTof whom 15 were reoperated, resulting in 6 failures. Evaluation of 17 patients who had bilateral neck exploration allowed us to determine the most probable origin of the APW parathyroid tumors: 12 were supernumerary, 4 appeared to originate from a superior, and 1 from an inferior gland. Conclusions Abnormal parathyroid glands situated in the APW are rare and usually identified after an unsuccessful cervical exploration. Preoperative imaging of the mediastinum and neck are essential. The origin of these ectopically situated tumors is probably, as suggested by our data, from a supernumerary fifth parathyroid gland or from abnormal migration of a superior parathyroid gland during the embryologic development. [less ▲]

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See detailA multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation
Wlodarczyk, Zbigniew; Vanrenterghem, Yves; Krämer, Bernhard k et al

in BMC Nephrology (2012), 13

Background: This multicenter phase II study in renal transplantation compared 3 concentration-controlled ranges of FK778 (manitimus) with mycophenolate mofetil (MMF) both given in combination with ... [more ▼]

Background: This multicenter phase II study in renal transplantation compared 3 concentration-controlled ranges of FK778 (manitimus) with mycophenolate mofetil (MMF) both given in combination with tacrolimus and corticosteroids. Methods: 364 patients were randomized to 12-month treatment: high-level FK778 group (H, N = 87) received 4x600mg/day (4 days) followed by 120 mg/day; mid-level FK778 group (M, N = 92) received 3x600mg/day (3 days) followed by 110 mg/day, low-level FK778 group (L, N = 92) received 2x600mg/day (2 days) followed by 100 mg/day, and control group received MMF 1 g/day (MMF, N = 93). After week 6, FK778 doses were adjusted to trough ranges of 75–125 μg/mL (H), 50–100 μg/mL (M) and 25–75 μg/mL (L). Tacrolimus and steroids were administered at the same dose in each of the 4 groups. Results: Biopsy proven acute rejection (BPAR) at 24 weeks, the primary study endpoint, was comparable in the L (22.8%) and MMF (17.2%) groups but higher in the H (34.5%) and M (29.3%) groups. BPAR at 12 months was comparable in the L (23.9%) and MMF (19.4%) groups but higher in the H (34.5%) and M (31.5%) groups. Graft and patient survival were lowest in the H group and renal function was poorest in the H and M groups. Premature study withdrawal was highest in the H group. Conclusions: Efficacy was similar between the low-level FK778 and MMF groups. Increased FK778 exposure was poorly tolerated and did not improve efficacy. [less ▲]

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