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See detailNew Combination Techniques in Dioxin Analysis
Focant, Jean-François ULg

in Lab Info (2008), 3

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See detailNew combinations in the Amblystegiaceae
Vanderpoorten, Alain ULg; Hedenäs, L.

in Journal of Bryology (2009), 31

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See detailA new combined bodian-luxol technique for staining unmyelinated axons in semithin, resin-embedded peripheral nerves: a comparison with electron microscopy.
Deprez, Manuel ULg; Ceuterick-de Groote, C.; Fumal, Arnaud ULg et al

in Acta Neuropathologica (1999), 98(4), 323-9

Quantitation of unmyelinated fibers (UF) in peripheral nerves has classically relied upon ultrastructural morphometry. Because this method is time-consuming, it is not typically performed in routine ... [more ▼]

Quantitation of unmyelinated fibers (UF) in peripheral nerves has classically relied upon ultrastructural morphometry. Because this method is time-consuming, it is not typically performed in routine analysis of nerve biopsies. We applied the Bodian-Luxol technique to detect unmyelinated axons by light microscopy on semithin sections from resin-embedded nerve tissue. Estimates were compared to ultrastructural counts. The staining appeared highly specific for axons. Excellent correlation was found between optic densities and the population of UF larger than 0.5 microm. The smallest profiles detected by light microscopy had a diameter close to 0.6 microm. This new technique is not a substitute for ultrastructural quantitative morphometry of UF, as very small unmyelinated axons, especially regenerating ones, can not be reliably visualized. However, it provides a valuable light microscopic method for evaluating axonal loss among UF. [less ▲]

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See detailA new computational method for nonlinear normal modes of nonconservative systems
Renson, Ludovic ULg; Kerschen, Gaëtan ULg

in Proceedings of the Euromech Colloquium n. 541 - New Advances in the Nonlinear Dynamics and Control of Composites for Smart Engineering Design (2013, June)

The concept of nonlinear normal modes (NNMs) was introduced with the aim of providing a rigorous generalization of normal modes to nonlinear systems. Initially, NNMs were defined as periodic solutions of ... [more ▼]

The concept of nonlinear normal modes (NNMs) was introduced with the aim of providing a rigorous generalization of normal modes to nonlinear systems. Initially, NNMs were defined as periodic solutions of the underlying conservative system, and continuation algorithms were recently exploited to compute them. To extend the concept of NNMs to nonconservative systems, Shaw and Pierre defined an NNM as a two-dimensional invariant manifold in the system’s phase space. This contribution presents a novel algorithm for solving the set of partial differential equations governing the manifold geometry numerically. The resolution strategy takes advantage of the hyperbolic nature of the equations to progressively solve them in annular regions. Each region is defined by two different iso-energy curves and equations are discretized using a specific finite element technique. The proposed strategy also offers the opportunity to estimate the frequency-energy dependence of the mode without using time integration. The algorithm is applied to both conservative and nonconservative systems. [less ▲]

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See detailA new concept for bisphosphonate therapy: a rationale for the development of monthly oral dosing of ibandronate
Reginster, Jean-Yves ULg; Felsenberg, Dieter; Cooper, Cyrus et al

in Osteoporosis International (2006), 17(2), 159-166

Oral daily and weekly bisphosphonates represent the current mainstay of treatment for postmenopausal osteoporosis (PMO). However, the inconvenience of frequent dosing is known to negatively affect ... [more ▼]

Oral daily and weekly bisphosphonates represent the current mainstay of treatment for postmenopausal osteoporosis (PMO). However, the inconvenience of frequent dosing is known to negatively affect adherence to therapy in the long term. This has prompted the development of convenient oral bisphosphonate regimens that feature simple, less frequent dosing schedules. Such regimens require high potency agents, which can be given at low effective doses and that also have good tolerability. Ibandronate is a potent, nitrogen-containing bisphosphonate with proven efficacy when given intermittently to estrogen-depleted beagle dogs, rats and cynomolgus monkeys. Clinically, a pivotal prospective study has established that oral ibandronate has significant vertebral fracture efficacy in PMO, whether given daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months; extended between-dose interval > 2 months). Both oral regimens were well tolerated, which is noteworthy as patients with a history of gastrointestinal (GI) disturbance were not specifically excluded. As a result of these findings, a large, multinational, randomized, double-blind study (Monthly Oral iBandronate In LadiEs: MOBILE) is currently exploring the non-inferiority of once-monthly oral ibandronate (100 or 150 mg) to the oral daily ibandronate (2.5 mg) regimen with proven anti-fracture efficacy, in terms of lumbar spine bone mineral density (BMD) change. As with the trials investigating the weekly administration of other bisphosphonates, vertebral fracture efficacy will be inferred if the study demonstrates the non-inferiority of once-monthly ibandronate to the proven oral daily regimen in terms of spinal BMD change. The availability of this once-monthly ibandronate regimen is expected to offer benefits in terms of convenience (by having to follow dosing recommendations once a month vs. once daily or weekly) and potentially tolerability (by reducing the potential for upper GI irritation that can result from frequent, repeated exposure). Greater convenience and tolerability may enhance the therapy adherence and, hence, improve long-term therapeutic outcomes in PMO. [less ▲]

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See detailThe new concept-temporary stents, an experimental study.
Kavteladze, Z. A.; Dundua, D. P.; Dondelinger, R. F. et al

in International Journal of Interventional Cardioangiology (2003), 1

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See detailNew concepts for the design of joints
Jaspart, Jean-Pierre ULg; Weynand, K.

in Proceedings of the 10th DASt-Forschungs-kolloquium Stahlbau (1997)

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See detailNew concepts in type 2 immunity: Damage-associated signals and Protective IgE
Marichal, Thomas ULg

Scientific conference (2013, November)

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See detailNew Constraints on Companions and Dust within a Few AU of Vega
Mennesson, B.; Serabyn, E.; Hanot, Charles ULg et al

in Astrophysical Journal (2011), 736

We report on high contrast near-infrared (~2.2 μm) observations of Vega obtained with the Palomar Fiber Nuller, a dual sub-aperture rotating coronagraph installed at the Palomar Hale telescope. The data ... [more ▼]

We report on high contrast near-infrared (~2.2 μm) observations of Vega obtained with the Palomar Fiber Nuller, a dual sub-aperture rotating coronagraph installed at the Palomar Hale telescope. The data show consistent astrophysical null depth measurements at the ~= 10[SUP]–3[/SUP] level or below for three different baseline orientations spanning 60 deg in azimuth, with individual 1σ uncertainties <=7 × 10[SUP]–4[/SUP]. These high cancellation and accuracy levels translate into a dynamic range greater than 1000:1 inside the diffraction limit of the 5 m telescope beam. Such high contrast performance is unprecedented in the near-infrared and provides improved constraints on Vega's immediate (sime20 to 250 mas, or sime0.15 to 2 AU) environment. In particular, our measurements rule out any potential companion in the [0.25-1 AU] region contributing more than 1% of the overall near-infrared stellar flux, with limits as low as 0.2% near 0.6 AU. These are the best upper limits established so far by direct detection for a companion to Vega in this inner region. We also conclude that any dust population contributing a significant (>=1%) near-infrared thermal excess can arise only within 0.2 AU of the star, and that it must consist of much smaller grains than in the solar zodiacal cloud. Dust emission from farther than sime2 AU is also not ruled out by our observations, but would have to originate in strong scattering, pointing again to very small grains. Based on observations obtained at the Hale Telescope, Palomar Observatory as part of a continuing collaboration between the California Institute of Technology, NASA/JPL, and Cornell University. [less ▲]

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See detailNew constraints on the delivery of cometary water and nitrogen to Earth from the 15N/14N isotopic ratio
Hutsemekers, Damien ULg; Manfroid, Jean ULg; Jehin, Emmanuel ULg et al

in Icarus: International Journal of Solar System Studies (2009), 204

New independent constraints on the amount of water delivered to Earth by comets are derived using the [SUP]15[/SUP]N/[SUP]14[/SUP]N isotopic ratio, measured to be roughly twice as high in cometary CN and ... [more ▼]

New independent constraints on the amount of water delivered to Earth by comets are derived using the [SUP]15[/SUP]N/[SUP]14[/SUP]N isotopic ratio, measured to be roughly twice as high in cometary CN and HCN as in the present Earth. Under reasonable assumptions, we find that no more than a few percent of Earthâ s water can be attributed to comets, in agreement with the constraints derived from D/H. Our results also suggest that a significant part of Earthâ s atmospheric nitrogen might come from comets. Since the [SUP]15[/SUP]N/[SUP]14[/SUP]N isotopic ratio is not different in Oort-cloud and Kuiper-belt comets, our estimates apply to the contribution of both types of objects. [less ▲]

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See detailNew constraints on the Karliova Triple Junction between Arabia, Eurasia and Anatolia.
Hubert, Aurelia ULg; Van Der Woerd, Jerome; King, G. et al

in Geophysical Research Abstracts (2007, April), 9

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See detailNew constraints on the slip rate of the North Anatolian Fault, Turkey
Hubert, Aurelia ULg; Armijo, R; Meyer, B et al

in Terra nova (European Union of Geosciences abstracts) (1997, March), 9

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See detailNew constraints on very light pseudoscalars
Payez, Alexandre ULg; Cudell, Jean-René ULg; Hutsemekers, Damien ULg

in Zioutas, K. (Ed.) 7th Patras Workshop on Axions, WIMPs and WISPs (2012, January 01)

Nearly massless axion-like particles are of interest for astrophysical observations, and some constraints on their parameter space do exist in the literature. Here, we propose to put new constraints on ... [more ▼]

Nearly massless axion-like particles are of interest for astrophysical observations, and some constraints on their parameter space do exist in the literature. Here, we propose to put new constraints on these particles using polarisation and, in particular, the polarisation differences observed between different quasar classes. [less ▲]

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See detailNew construction or renovation in Belgium: Setting the net and nearly zero energy building target in perspective
Attia, Shady ULg

in PassiveHouse 2012 Conference Proceedings (2012, October 05)

The recast of the European Performance of Buildings Directive (EPBD) requires all new buildings to be “nearly zero energy’ buildings (nZEB) by 2020, including existing buildings undergoing major ... [more ▼]

The recast of the European Performance of Buildings Directive (EPBD) requires all new buildings to be “nearly zero energy’ buildings (nZEB) by 2020, including existing buildings undergoing major renovations. The revised Energy Performance in Buildings Directive calls governments to meet the nearly zero energy targets by 2020. Governments must adopt and publish regulations and procedures for the other requirements mainly the cost optimal calculation by July 2012. Many elements of the EPBD recast pertain to new buildings. Unfortunately, the recast does not set targets for improving existing buildings and non-legislative measures are required to address how to achieve a greater share of renovation. Therefore, this paper aims to identify the share of the newly constructed buildings by 2020 in Belgium. The objective is to put the nearly zero energy targets in a wider perspective in relation to the existing building stock. The paper investigates some future scenarios for the national buildings stock growth rate, coupled with demographic growth by 2050. The study’s results indicate that newly constructed building will be less than 7% by 2020 and less than 15% by 2050 in Belgium. Thus by not addressing the potential for energy renovations in the building sector the EPBD is avoiding the larger problem. [less ▲]

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See detailNew contributions to heavy-quarkonium production
Lansberg, Jean-Philippe ULg; Cudell, Jean-René ULg; Kalinovsky, Y. L.

in Physics Letters B (2006), 633(2-3), 301-308

We reconsider quarkonium production in a field-theoretical setting and we show that the lowest-order mechanism for heavy-quarkonium production receives in general contributions from two different cuts ... [more ▼]

We reconsider quarkonium production in a field-theoretical setting and we show that the lowest-order mechanism for heavy-quarkonium production receives in general contributions from two different cuts. The first one corresponds to the usual colour-singlet mechanism. The second one has not been considered so far. We treat it in a gauge-invariant manner, and introduce new 4-point vertices, suggestive of the colour-octet mechanism. These new objects enable us to go beyond the static approximation. We show that the contribution of the new cut can be as large as the usual colour-singlet mechanism at high P-T for J/psi. In the psi' case, theoretical uncertainties are shown to be large and agreement with data is possible. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailNew contributions to the analysis of conditioned temporal regulations in animals
Lejeune, Helga ULg; Blondin, Christiane ULg; Mantanus, H. et al

in Experimental Brain Research (1975), 23

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See detailA new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms
Sacre, Pierre-Yves ULg; Lebrun, Pierre ULg; Chavez, Pierre-François ULg et al

in Analytica Chimica Acta (2014), 818

During galenic formulation development, homogeneity of distribution is a critical parameter to check since it may influence activity and safety of the drug. Raman hyperspectral imaging is a technique of ... [more ▼]

During galenic formulation development, homogeneity of distribution is a critical parameter to check since it may influence activity and safety of the drug. Raman hyperspectral imaging is a technique of choice for assessing the distributional homogeneity of compounds of interest. Indeed, the combination of both spectroscopic and spatial information provides a detailed knowledge of chemical composition and component distribution. Actually, most authors assess homogeneity using parameters of the histogram of intensities (e.g. mean, skewness and kurtosis). However, this approach does not take into account spatial information and loses the main advantage of imaging. To overcome this limitation, we propose a new criterion: Distributional Homogeneity Index (DHI). DHI has been tested on simulated maps and formulation development samples. The distribution maps of the samples were obtained without validated calibration model since different formulations were under investigation. The results obtained showed a linear relationship between content uniformity values and DHI values of distribution maps. Therefore, DHI methodology appears to be a suitable tool for the analysis of homogeneity of distribution maps even without calibration during formulation development. [less ▲]

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See detailA new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms
Sacre, Pierre-Yves ULg; Lebrun, Pierre ULg; Chavez, Pierre-François ULg et al

Conference (2013, September)

During galenic formulation development, homogeneity of distribution is a critical parameter to check since it may influence activity and safety of the drug. Several techniques exist to assess this ... [more ▼]

During galenic formulation development, homogeneity of distribution is a critical parameter to check since it may influence activity and safety of the drug. Several techniques exist to assess this homogeneity, the most used and recognized being HPLC. However, these techniques are destructive, time consuming and uses a lot of organic solvents. Vibrational spectroscopies are promising green chemistry techniques that may replace HPLC for several analysis tasks thanks of their rapid, non-destructive and non-pollutant characteristics. Raman hyperspectral imaging is a technique of choice for assessing the distributional homogeneity of compounds of interest. Indeed, the combination of both spectroscopic and spatial information provides a detailed knowledge of chemical composition and component distribution. When dealing with hyperspectral imaging, multivariate data analysis is necessary to extract the concentration map of the compound of interest that will be used to assess sample homogeneity. Actually, most authors assess homogeneity using parameters of the histogram of intensities (e.g. mean, skewness and kurtosis). However, this approach does not take into account spatial information and loses the main advantage of imaging. Recently, Rosas et al. proposed a homogeneity index based on the Poole index. However, it necessitates cutting the maps in non-overlapping macropixels and is therefore quickly limited with small maps. To overcome this limitation, we propose a new criterion that combines Continuous Level Moving Blocks and homogeneity curves with a randomization step to assess the distributional homogeneity. This distributional homogeneity index (DHI) enables analysis of hyperspectral maps without apriori knowledge. It has been applied on five pharmaceutical formulations with different blending conditions. The uniformity content values of the API (present at a concentration of 7% w/w) measured by HPLC ranged from RSD: 0.46% to 11.04%. Ten tablets per formulation have been mapped over a region of interest of 4 mm². After extracting pure spectra by MCR-ALS, the concentration maps of the API were computed using classical least squares analysis. DHI have been computed with a hundred simulations for the randomization step for each concentration map. Afterwards, a mean DHI and standard deviation values were computed per formulation. A linear relationship has been observed between the RSD values and the mean DHI. These results enabled us to select the formulation with the best homogeneity. Further experiments are in progress to check whether hyperspectral imaging combined with DHI could be used in routine to assess blending homogeneity of well-known formulations. [less ▲]

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See detailNew cycles found in air temperature data and proxy series
Nicolay, Samuel ULg; Mabille, Georges ULg; Fettweis, Xavier ULg et al

Conference (2008, October 01)

We apply the wavelet transform tool to detect unsuspected cycles in several climatic time series

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