Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailNeoadjuvant chemotherapy in breast cancer induces miR-34a and miR-122 expression
FRERES, Pierre ULg; JOSSE, Claire ULg; Bovy, Nicolas ULg et al

in Journal of Cellular Physiology (2014)

Circulating microRNAs (miRNAs) have been extensively studied in cancer as biomarkers but little is known regarding the influence of anti-cancer drugs on their expression levels. In this article, we ... [more ▼]

Circulating microRNAs (miRNAs) have been extensively studied in cancer as biomarkers but little is known regarding the influence of anti-cancer drugs on their expression levels. In this article, we describe the modifications of circulating miRNAs profile after neoadjuvant chemotherapy (NAC) for breast cancer. The expression of 188 circulating miRNAs was assessed in the plasma of 25 patients before and after NAC by RT-qPCR. Two miRNAs, miR- 34a and miR-122, that were significantly increased after NAC, were measured in tumor tissue before and after chemotherapy in 7 patients with pathological partial response (pPR) to NAC. These 2 chemotherapy-induced miRNAs were further studied in the plasma of 22 patients with adjuvant chemotherapy (AC) as well as in 12 patients who did not receive any chemotherapy. Twenty-five plasma miRNAs were modified by NAC. Among these miRNAs, miR-34a and miR-122 were highly upregulated, notably in pPR patients with aggressive breast cancer. Furthermore, miR-34a level was elevated in the remaining tumor tissue after NAC treatment. Studying the kinetics of circulating miR-34a and miR-122 expression during NAC revealed that their levels were especially increased after anthracycline-based chemotherapy. Comparisons of the plasma miRNA profiles after NAC and AC suggested that chemotherapy-induced miRNAs originated from both tumoral and non-tumoral compartments. This study is the first to demonstrate that NAC specifically induces miRNA expression in plasma and tumor tissue, which might be involved in the anti-tumor effects of chemotherapy in breast cancer patients. [less ▲]

Detailed reference viewed: 11 (3 ULg)
Full Text
See detailNeoadjuvant chemotherapy in breast cancer patients induces expression of tumor suppressor miR-34a
FRERES, Pierre ULg

Poster (2014, May 19)

Circulating microRNAs (miRNAs) are extensively studied in cancer as biomarkers but little is known about the influence of anti-cancer drugs on their expression. In this presentation, we describe the ... [more ▼]

Circulating microRNAs (miRNAs) are extensively studied in cancer as biomarkers but little is known about the influence of anti-cancer drugs on their expression. In this presentation, we describe the modifications of circulating miRNAs profile under neoadjuvant chemotherapy (NAC) for breast cancer. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailNeoadjuvant Radiochemotherapy of Locally/Regionally Advanced Rectal Cancer is a standard treatment option
Farkas, Róbert; Al-Farhat, Yousuf; GULYBAN, Akos ULg et al

in Radiotherapy & Oncology (2006), 81(suppl1), 237

Peer Reviewed
See detailNeodymium: YAG laser hysteroscopy in large submucous fibroids.
Donnez, Jacques; Gillerot, Stéphane; Bourgonjon, Damien et al

in Fertility and Sterility (1990), 54(6), 999-1003

The preoperative use of a potent, subcutaneously injected gonadotropin-releasing hormone agonist (GnRH-a) was evaluated in a series of 60 women with large submucosal fibroids. Myomectomy by hysteroscopy ... [more ▼]

The preoperative use of a potent, subcutaneously injected gonadotropin-releasing hormone agonist (GnRH-a) was evaluated in a series of 60 women with large submucosal fibroids. Myomectomy by hysteroscopy and Nd:YAG laser was easily performed. In 12 cases, the largest portion of the myoma was not inside the uterine cavity and myomectomy was carried by a two-step hysteroscopy. In women who wished to become pregnant, a pregnancy rate of 66% was achieved. Advantages of preoperative use of a GnRH-a are (1) the significant decrease of the fibroid size, (2) a lower fluid absorption, and (3) the restoration of a normal hemoglobin concentration. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailNEOGENE TO QUATERNARY CLAY MINERAL FLUXES IN THE CENTRAL INDIAN BASIN
DEBRABANT, P.; Fagel, Nathalie ULg; CHAMLEY, H. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (1993), 103(3-4), 117-131

The late Cenozoic clay sedimentation in the Central Indian Basin was investigated by mineralogical analyses of five very long cores (33-49 m long), which were recovered between 1-degrees and 10-degrees-S ... [more ▼]

The late Cenozoic clay sedimentation in the Central Indian Basin was investigated by mineralogical analyses of five very long cores (33-49 m long), which were recovered between 1-degrees and 10-degrees-S along a transect at about 80-degrees-E and compared with data from adjacent ODP and piston cores. Progressive changes occur from North to South, and are especially marked by a decrease of illite and chlorite amounts balanced by increased contents of smectite and kaolinite. These changes arc attributed to a southwards reduction of Himalaya-derived detrital fluxes, and to a correlative augmentation both of smectite reworked from coastal Indian, Indonesian and volcanic submarine sources, and of kaolinite supplied from Australia and blocked by the equatorial divergence. The stratigraphic changes are more diversified than the geographic changes and develop discontinuously. High fluxes of illitic and chloritic materials during the middle-late Miocene reflect major activity of the Himalayan Main Central Thrust. A tectonic relaxation developed during the latest Miocene-early Pliocene, allowing alternating supply of illite-rich and smectite-rich sediments, which suggests periodical changes from distant to more local supply partly controlled by climate and by Indian intraplate deformations. The more abundant and constant amounts of smectite in late Pliocene-early Pleistocene sediments are chiefly attributed to erosion of Indian coastal zones favored by a worldwide sea-level drop. The middle to late Quaternary increase of the illite group resulted from the resumption of the tectonic activity in the Himalaya-Tibet range associated with a general climatic cooling. [less ▲]

Detailed reference viewed: 15 (1 ULg)
See detailLe néokantisme comme forme symbolique ? Merleau-Ponty et Panofsky
Cormann, Grégory ULg

Conference (2007, January 17)

Detailed reference viewed: 18 (0 ULg)
Full Text
Peer Reviewed
See detailNeoliberaal literatuuronderzoek. Thomas Vaessens over zijn methode, lecturen en stijl
Spinoy, Erik ULg

in Tijdschrift voor Nederlandse Taal- en Letterkunde (2002), 118(3),

This article is a reaction to Thomans Vaessens defence of his book Circus Dubio & Schroom.

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailNeología semántica y polisemia: el caso del truncamiento
Steffens, Marie ULg; Baiwir, Esther ULg

in Revista de Investigación Lingüística (2009), 12

Detailed reference viewed: 67 (9 ULg)
Full Text
Peer Reviewed
See detailThe neon content of nearby B-type stars and its implications for the solar model problem
Morel, Thierry ULg; Butler, K.

in Astronomy and Astrophysics (2008), 487

The recent downward revision of the solar photospheric abundances now leads to severe inconsistencies between the theoretical predictions for the internal structure of the Sun and the results of ... [more ▼]

The recent downward revision of the solar photospheric abundances now leads to severe inconsistencies between the theoretical predictions for the internal structure of the Sun and the results of helioseismology. There have been claims that the solar neon abundance may be underestimated and that an increase in this poorly-known quantity could alleviate (or even completely solve) this problem. Early-type stars in the solar neighbourhood are well-suited to testing this hypothesis because they are the only stellar objects whose absolute neon abundance can be derived from the direct analysis of photospheric lines. Here we present a fully homogeneous NLTE abundance study of the optical Ne I and Ne II lines in a sample of 18 nearby, early B-type stars, which suggests log É (Ne) = 7.97 ± 0.07 dex (on the scale in which log É [H] = 12) for the present-day neon abundance of the local interstellar medium (ISM). Chemical evolution models of the Galaxy only predict a very small enrichment of the nearby interstellar gas in neon over the past 4.6 Gyr, implying that our estimate should be representative of the Sun at birth. Although higher by about 35% than the new recommended solar abundance, such a value appears insufficient by itself to restore the past agreement between the solar models and the helioseismological constraints. Appendices A and B are only available in electronic form at http://www.aanda.org Table [see full text] is also available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/487/307 [less ▲]

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailNeonatal ABO incompatibility stays a potentially severe haemolytic disease of the newborn and implies adequate care
Senterre, Thibault ULg; Minon, Jean-Marc

in Archives Françaises de Pédiatrie (2011), 18(3), 279-282

Detailed reference viewed: 22 (0 ULg)
Peer Reviewed
See detailNeonatal and Preweanling Rats Are Able to Express Short-Term Behavioral Sensitization to Cocaine
Tirelli, Ezio ULg; Ferrara, Marie-Antoinette ULg

in European Journal of Pharmacology (1997), 328(2-3), 103-14

The present study assessed the ability of suckling rats to express short-term behavioral sensitization to cocaine prior to weaning. Rat pups, aged either 3, 5, 10, 12, 17 or 19 days at the beginning of ... [more ▼]

The present study assessed the ability of suckling rats to express short-term behavioral sensitization to cocaine prior to weaning. Rat pups, aged either 3, 5, 10, 12, 17 or 19 days at the beginning of the experiment, were placed in a chamber after daily injection with cocaine (7.5 or 15 mg/kg. i.p.) for either 2 or 4 consecutive days, and were tested for behavioral responsiveness to cocaine in the same chamber 24 h later (at either 7, 14 or 21 days of age). Such a short post-treatment interval was adopted, along with a consistent pairing of the testing context with the drug effect and a sensitive technique of behavioral measurement (video recording), in order to maximize the possibility of detecting any cocaine sensitization. Locomotion was sensitized at all ages, after both regimens in 14-day-old pups, but solely after 2 injections in 21- and 4 injections in 7-day-old pups. Sensitization was also expressed via behaviors specific to each age. Four cocaine injections augmented cocaine-induced uncoordinated movements of head, paws and body (horizontal activity) in 7-day-old pups, and mouth movements in 14-day-old pups. In 21-day-old pups, sensitization was dose- and regimen-dependently expressed via adult-like stereotyped head movements. In neonatal 7-day-old pups, cocaine sensitization was also visible as reductions in immobility (both injection regimens). Contrary to previous studies, these results indicate that, given the use of an appropriate methodology, short-term sensitization to the motoric effects of cocaine can be expressed by suckling rats prior to weaning, even after relatively short regimens of daily injections. [less ▲]

Detailed reference viewed: 11 (0 ULg)
Full Text
See detailNeonatal cirrhosis without iron overload: congenital alloimmune hepatitis
HARVENGT, Julie ULg; de HALLEUX, Virginie ULg; GUIDI, Ornella et al

Conference (2011, March 19)

Background. Fetal liver disease is a rare antenatal disorder for which etiology is frequently unknown. Recently, congenital alloimmune hepatitis emerged as a major cause of antenatal liver disease. Its ... [more ▼]

Background. Fetal liver disease is a rare antenatal disorder for which etiology is frequently unknown. Recently, congenital alloimmune hepatitis emerged as a major cause of antenatal liver disease. Its typical presentation can be as a severe neonatal liver failure with hepatic and extrahepatic iron overload, a clinical state called neonatal hemochromatosis. Methods. A pregnant woman was investigated for heterogeneous fetal hepatomegaly. Pregnancy was also complicated by fetal alloimmune thrombocytopenia. The newborn presented at birth with liver cirrhosis and mild liver dysfunction. Follow-up until 36 months showed progressive normalization of all liver parameters. All metabolic and infectious analyses were negative. Liver biopsy showed severe hepatitis with post-necrotic fibrosis and regenerative nodules. There was no iron overload. To search for immune injury, paraffine sections of the liver biopsy were stained with an antibody against the membrane attack complex (MAC, anti human c5b-9, Peter Whitington’s Lab, Children’s Memorial Hospital, Chicago, IL), the terminal complement cascade neoantigen occurring specifically in complement activation by the IgG-mediated classical pathway, and which is responsible for cell death. Results. Strong immunostaining against MAC-antigen was found in the liver of the patient, with 90% of target hepatocytes whereas in a control group of patients with other neonatal liver diseases, it was 10.8±12.5%. Because IgG in neonates originate only from the mother, it signs the alloimmune nature of the disease. Conclusion. For a long time, pathophysiology of neonatal hemochromatosis remained unsolved. Recently, it was elucidated as congenital alloimmune hepatitis. With this case, we expend the recognized clinical spectrum by showing that congenital alloimmune hepatitis can present as milder cases, without iron overload. It should be considered as a cause of unexplained neonatal liver disease, even in the absence of siderosis. Such diagnosis is of great importance regarding the necessity of immunotherapy in further pregnancies in order to avoid recurrence of alloimmune injury [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailNeonatal Group B Streptococcal Disease: From Pathogenesis to Preventive strategies
MELIN, Pierrette ULg

in Clinical Microbiology & Infection (2011)

Streptococcus agalactiae, or group B streptococcus (GBS), remains the leading cause of neonatal sepsis and meningitis, early onset and late onset diseases (EOD, LOD). Where consensus guidelines to detect ... [more ▼]

Streptococcus agalactiae, or group B streptococcus (GBS), remains the leading cause of neonatal sepsis and meningitis, early onset and late onset diseases (EOD, LOD). Where consensus guidelines to detect and treat intrapartum women with GBS colonization have been widely adopted, incidence of neonatal EOD has dramatically declined. In response to both successful impacts on the incidence of GBS-EOD and analyses of missed opportunities, the first American guidelines for prevention issued in the 90s have since been adapted in several stages to improve their efficacy. In some countries in Europe, nationwide guidelines, whether screening-based or risk-based, for the prevention of neonatal GBS diseases have also been issued and adopted, with the expected impact on incidence of GBS-EOD. In spite of universal screening, in spite of the great progress that has been made, GBS-EOD continues to occur and the GBS burden remains a significant public health issue. Continuous efforts to improve screening for GBS status continue to be important and may be able to take advantage of new rapid diagnostic technologies. The current screening-based strategy for prevention is highly effective but imperfect. Given the challenges, limitations and potential complications of maternal intrapartum prophylaxis, a new approach is still needed. Maternal immunization against GBS is an attractive alternative for the prevention of not only neonatal diseases but also stillbirths and maternal diseases. Vaccines against GBS may likely become the most effective and sustainable long-term preventive strategy. [less ▲]

Detailed reference viewed: 61 (20 ULg)
Full Text
See detailNeonatal Group B Streptococcal Infections: Overview and Prevention Strategies
MELIN, Pierrette ULg

Conference (2013, October 13)

Emerging abruptly in the 1970s as an important life-threatening pathogen in neonates causing severe invasive bacterial infections, Streptococcus agalactiae or group B streptococcus (GBS) has become a ... [more ▼]

Emerging abruptly in the 1970s as an important life-threatening pathogen in neonates causing severe invasive bacterial infections, Streptococcus agalactiae or group B streptococcus (GBS) has become a notable global problem. Today it remains the leading cause of neonatal sepsis and meningitis, early onset and late onset diseases (EOD, LOD). From the 1990s to the present, where guidelines for prevention of perinatal GBS disease have been widely implemented, the incidence of EOD has dramatically decreased to <0.5 cases per 1,000 live births but has not been eradicated. Selective intravenous antimicrobial prophylaxis with β-lactams administered during labor and delivery to women who are colonized by GBS appears to be the most practical and effective mode of prevention of GBS EOD at this time. There are different prevention strategies at this time, screening-based or risk-based, but none are 100% effective in the eradication of neonatal GBS EOD and there are no preventive strategies for LOD. In spite of the great progress that has been made, GBS EOD continues to occur and the GBS burden remains a significant public health issue. Extended efforts to improve screening for GBS status continue to be important and may be able to take advantage of new rapid diagnostic technologies. Given challenges, limitations and potential complications of maternal intrapartum prophylaxis, a new approach is still needed. Maternal immunization against GBS is an attractive alternative for the prevention of not only EOD and LOD but also stillbirths and maternal diseases. Development of a group B streptococcal vaccine is the most promising approach for the prevention of severe GBS neonatal disease through transplacental delivery of antibodies directly from immunized mothers. It may likely become the most effective and sustainable long-term preventive strategy. [less ▲]

Detailed reference viewed: 33 (0 ULg)
Full Text
Peer Reviewed
See detailNeonatal health in calves - Comprehensive solutions for complex enteric disorders
Makoschey, B.; Klee, W.; Martella, V. et al

in Berliner und Munchener Tierarztliche Wochenschrift (2009), 122

Detailed reference viewed: 22 (3 ULg)
Full Text
Peer Reviewed
See detailNeonatal inhibition of brain estrogen synthesis alters adult neural Fos responses to mating and pheromonal stimulation in the male rat.
Bakker, Julie ULg; Baum, M. J.; Slob, A. K.

in Neuroscience (1996), 74(1), 251-60

Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and ... [more ▼]

Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and partner preference in adulthood. The medial preoptic area receives chemosensory inputs via a sexually dimorphic vomeronasal projection circuit, which responds to reproductively relevant pheromonal cues. The medial preoptic area also receives genital somatosensory inputs via the midbrain central tegmental field and the medial amygdala. We used Fos immunoreactivity as a marker of neuronal activation to determine whether there is a correspondence between the behavioral profiles of neonatally ATD-treated male rats and their neuronal responses in the medial preoptic area and other brain regions to somatosensory and chemosensory stimuli. Achieving eight intromissions with an estrous female led to a greater neuronal Fos immunoreactivity in the medial preoptic area of neonatally ATD-treated male rats compared with neonatally cholesterol-treated male rats. Exposure for 1.5 h to chemosensory cues derived from soiled bedding of estrous females induced Fos immunoreactivity throughout the vomeronasal pathway (i.e. medial amygdala, bed nucleus of the stria terminalis and medial preoptic area) in both ATD and cholesterol males (Experiment 2a). By contrast, exposure for 1.5 h to chemosensory cues derived from soiled bedding of sexually active males revealed clear differences between ATD and cholesterol males in neuronal Fos immunoreactive (Experiment 2b). At peripheral portions of the vomeronasal pathway (i.e. the accessory olfactory bulb and the medial amygdala), there were no differences in the number of Fos immunoreactivity neurons between ATD and cholesterol males. However, neurons in the more central portions of the vomeronasal pathway (i.e. the bed nucleus of the stria terminalis and the medial preoptic area) showed increased Fos immunoreactivity after exposure to odors from sexually active males in ATD males as opposed to cholesterol males. Females, like ATD males, showed neuronal Fos immunoreactivity at each level of the vomeronasal pathway after being exposed to odors from sexually active males. These results suggest that the responsiveness of neurons in the central portion of the vomeronasal projection circuit to odors from sexually active males, but not estrous females, is sexually differentiated in male rats due to the neonatal action of estrogens. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Peer Reviewed
See detailNeonatal intracranial hemorrhage and phenobarbital
Battisti, Oreste ULg; Bertrand, J. M.; Langhendries, J. P.

in Pediatrics (1987), 79

Detailed reference viewed: 12 (4 ULg)
Full Text
Peer Reviewed
See detailNEONATAL INVASIVE GROUP B STREPTOCOCCAL (GBS) INFECTIONS IN EUROPE
MELIN, Pierrette ULg; Berner, Reinhard; Afshar, Baharak et al

Poster (2011, September)

Objectives: To describe clinical characteristics and capsular type of GBS isolates responsible of invasive infections in infants from Belgium, Bulgaria, Czech-Republic, Denmark, Germany, Italy, Spain and ... [more ▼]

Objectives: To describe clinical characteristics and capsular type of GBS isolates responsible of invasive infections in infants from Belgium, Bulgaria, Czech-Republic, Denmark, Germany, Italy, Spain and United Kingdom, representing one of the main objectives of the DEVANI (DEsign of a Vaccine Against Neonatal Infections) project. Methods: Surveillance of invasive GBS infections in infants was performed from mid-2008 through December 2010. For each case, a standardized case report form was filled. Samples from cases were processed using local procedures. GBS isolates were characterised in national central labs using standardised type-specific (Ia, Ib-IX) latex agglutination and molecular typing methods. Results: Data on 188 infants with invasive infection were analysed: 144 (60.6%) early onset diseases (EOD) and 74 (39.4%) late onset diseases (LOD). In EOD, mean/median ages at onset were 14/0 hours and the male:female ratio was 1.25. The predominant manifestation at onset was respiratory distress (42% cases); 83% cases were associated with sepsis/bacteremia, 15% with pneumonia and 6% with meningitis. Late-prenatal screening cultures were obtained from 51% of cases’ mothers and only half of these were positive for GBS. Non-elective C-section, intrapartum fever and rupture of membrane (>18h) were more frequent in EO-cases’ mothers versus healthy babies’ GBS-positive mothers. The major serotypes were III (43%), V (21%) and Ia (18%). In LOD, mean/median ages at onset were 42/34 days and the male:female ratio was 0.9. The predominant characteristic at onset was fever (62% cases); 70% cases were associated with sepsis and 30% with meningitis. Very rare manifestations were osteomyelitis and cellulitis. Serotype III was highly predominant (80.6%) followed mainly by Ia (12.5%). Death rates were 4.7/1.5% in EOD/LOD. Conclusions: Clinical presentations were associated with age at onset of infection. Serotype III predominated in neonatal infections. Prenatal screening was not universal neither sensitive. Study funded through the European Commission Seventh Framework. [less ▲]

Detailed reference viewed: 40 (4 ULg)
Full Text
Peer Reviewed
See detailNeonatal liver cirrhosis without iron overload caused by gestational alloimmune liver disease.
DEBRAY, François-Guillaume ULg; de Halleux, Virginie; Guidi, Ornella et al

in Pediatrics (2012), 129(4), 1076-9

Gestational alloimmune liver disease has emerged as the major cause of antenatal liver injury and failure. It usually manifests as neonatal liver failure with hepatic and extrahepatic iron overload, a ... [more ▼]

Gestational alloimmune liver disease has emerged as the major cause of antenatal liver injury and failure. It usually manifests as neonatal liver failure with hepatic and extrahepatic iron overload, a clinical presentation called neonatal hemochromatosis. We report on a newborn in whom fetal hepatomegaly was detected during pregnancy and who presented at birth with liver cirrhosis and mild liver dysfunction. Liver biopsy showed the absence of iron overload but strong immunostaining of hepatocytes for the C5b-9 complex, the terminal complement cascade neoantigen occurring specifically during complement activation by the immunoglobulin G-mediated classic pathway, which established the alloimmune nature of the hepatocyte injury. The infant survived with no specific therapy, and follow-up until 36 months showed progressive normalization of all liver parameters. This case report expands the recognized clinical spectrum of congenital alloimmune liver disease to include neonatal liver disease and cirrhosis, even in the absence of siderosis. Such a diagnosis is of utmost importance regarding the necessity for immunotherapy in further pregnancies to avoid recurrence of alloimmune injury. [less ▲]

Detailed reference viewed: 57 (1 ULg)