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See detailNeonatal Group B Streptococcal Disease: From Pathogenesis to Preventive strategies
MELIN, Pierrette ULg

in Clinical Microbiology & Infection (2011)

Streptococcus agalactiae, or group B streptococcus (GBS), remains the leading cause of neonatal sepsis and meningitis, early onset and late onset diseases (EOD, LOD). Where consensus guidelines to detect ... [more ▼]

Streptococcus agalactiae, or group B streptococcus (GBS), remains the leading cause of neonatal sepsis and meningitis, early onset and late onset diseases (EOD, LOD). Where consensus guidelines to detect and treat intrapartum women with GBS colonization have been widely adopted, incidence of neonatal EOD has dramatically declined. In response to both successful impacts on the incidence of GBS-EOD and analyses of missed opportunities, the first American guidelines for prevention issued in the 90s have since been adapted in several stages to improve their efficacy. In some countries in Europe, nationwide guidelines, whether screening-based or risk-based, for the prevention of neonatal GBS diseases have also been issued and adopted, with the expected impact on incidence of GBS-EOD. In spite of universal screening, in spite of the great progress that has been made, GBS-EOD continues to occur and the GBS burden remains a significant public health issue. Continuous efforts to improve screening for GBS status continue to be important and may be able to take advantage of new rapid diagnostic technologies. The current screening-based strategy for prevention is highly effective but imperfect. Given the challenges, limitations and potential complications of maternal intrapartum prophylaxis, a new approach is still needed. Maternal immunization against GBS is an attractive alternative for the prevention of not only neonatal diseases but also stillbirths and maternal diseases. Vaccines against GBS may likely become the most effective and sustainable long-term preventive strategy. [less ▲]

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See detailNeonatal Group B Streptococcal Infections: Overview and Prevention Strategies
MELIN, Pierrette ULg

Conference (2013, October 13)

Emerging abruptly in the 1970s as an important life-threatening pathogen in neonates causing severe invasive bacterial infections, Streptococcus agalactiae or group B streptococcus (GBS) has become a ... [more ▼]

Emerging abruptly in the 1970s as an important life-threatening pathogen in neonates causing severe invasive bacterial infections, Streptococcus agalactiae or group B streptococcus (GBS) has become a notable global problem. Today it remains the leading cause of neonatal sepsis and meningitis, early onset and late onset diseases (EOD, LOD). From the 1990s to the present, where guidelines for prevention of perinatal GBS disease have been widely implemented, the incidence of EOD has dramatically decreased to <0.5 cases per 1,000 live births but has not been eradicated. Selective intravenous antimicrobial prophylaxis with β-lactams administered during labor and delivery to women who are colonized by GBS appears to be the most practical and effective mode of prevention of GBS EOD at this time. There are different prevention strategies at this time, screening-based or risk-based, but none are 100% effective in the eradication of neonatal GBS EOD and there are no preventive strategies for LOD. In spite of the great progress that has been made, GBS EOD continues to occur and the GBS burden remains a significant public health issue. Extended efforts to improve screening for GBS status continue to be important and may be able to take advantage of new rapid diagnostic technologies. Given challenges, limitations and potential complications of maternal intrapartum prophylaxis, a new approach is still needed. Maternal immunization against GBS is an attractive alternative for the prevention of not only EOD and LOD but also stillbirths and maternal diseases. Development of a group B streptococcal vaccine is the most promising approach for the prevention of severe GBS neonatal disease through transplacental delivery of antibodies directly from immunized mothers. It may likely become the most effective and sustainable long-term preventive strategy. [less ▲]

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See detailNeonatal health in calves - Comprehensive solutions for complex enteric disorders
Makoschey, B.; Klee, W.; Martella, V. et al

in Berliner und Munchener Tierarztliche Wochenschrift (2009), 122

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See detailNeonatal inhibition of brain estrogen synthesis alters adult neural Fos responses to mating and pheromonal stimulation in the male rat.
Bakker, Julie ULg; Baum, M. J.; Slob, A. K.

in Neuroscience (1996), 74(1), 251-60

Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and ... [more ▼]

Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and partner preference in adulthood. The medial preoptic area receives chemosensory inputs via a sexually dimorphic vomeronasal projection circuit, which responds to reproductively relevant pheromonal cues. The medial preoptic area also receives genital somatosensory inputs via the midbrain central tegmental field and the medial amygdala. We used Fos immunoreactivity as a marker of neuronal activation to determine whether there is a correspondence between the behavioral profiles of neonatally ATD-treated male rats and their neuronal responses in the medial preoptic area and other brain regions to somatosensory and chemosensory stimuli. Achieving eight intromissions with an estrous female led to a greater neuronal Fos immunoreactivity in the medial preoptic area of neonatally ATD-treated male rats compared with neonatally cholesterol-treated male rats. Exposure for 1.5 h to chemosensory cues derived from soiled bedding of estrous females induced Fos immunoreactivity throughout the vomeronasal pathway (i.e. medial amygdala, bed nucleus of the stria terminalis and medial preoptic area) in both ATD and cholesterol males (Experiment 2a). By contrast, exposure for 1.5 h to chemosensory cues derived from soiled bedding of sexually active males revealed clear differences between ATD and cholesterol males in neuronal Fos immunoreactive (Experiment 2b). At peripheral portions of the vomeronasal pathway (i.e. the accessory olfactory bulb and the medial amygdala), there were no differences in the number of Fos immunoreactivity neurons between ATD and cholesterol males. However, neurons in the more central portions of the vomeronasal pathway (i.e. the bed nucleus of the stria terminalis and the medial preoptic area) showed increased Fos immunoreactivity after exposure to odors from sexually active males in ATD males as opposed to cholesterol males. Females, like ATD males, showed neuronal Fos immunoreactivity at each level of the vomeronasal pathway after being exposed to odors from sexually active males. These results suggest that the responsiveness of neurons in the central portion of the vomeronasal projection circuit to odors from sexually active males, but not estrous females, is sexually differentiated in male rats due to the neonatal action of estrogens. [less ▲]

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See detailNeonatal intracranial hemorrhage and phenobarbital
Battisti, Oreste ULg; Bertrand, J. M.; Langhendries, J. P.

in Pediatrics (1987), 79

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See detailNEONATAL INVASIVE GROUP B STREPTOCOCCAL (GBS) INFECTIONS IN EUROPE
MELIN, Pierrette ULg; Berner, Reinhard; Afshar, Baharak et al

Poster (2011, September)

Objectives: To describe clinical characteristics and capsular type of GBS isolates responsible of invasive infections in infants from Belgium, Bulgaria, Czech-Republic, Denmark, Germany, Italy, Spain and ... [more ▼]

Objectives: To describe clinical characteristics and capsular type of GBS isolates responsible of invasive infections in infants from Belgium, Bulgaria, Czech-Republic, Denmark, Germany, Italy, Spain and United Kingdom, representing one of the main objectives of the DEVANI (DEsign of a Vaccine Against Neonatal Infections) project. Methods: Surveillance of invasive GBS infections in infants was performed from mid-2008 through December 2010. For each case, a standardized case report form was filled. Samples from cases were processed using local procedures. GBS isolates were characterised in national central labs using standardised type-specific (Ia, Ib-IX) latex agglutination and molecular typing methods. Results: Data on 188 infants with invasive infection were analysed: 144 (60.6%) early onset diseases (EOD) and 74 (39.4%) late onset diseases (LOD). In EOD, mean/median ages at onset were 14/0 hours and the male:female ratio was 1.25. The predominant manifestation at onset was respiratory distress (42% cases); 83% cases were associated with sepsis/bacteremia, 15% with pneumonia and 6% with meningitis. Late-prenatal screening cultures were obtained from 51% of cases’ mothers and only half of these were positive for GBS. Non-elective C-section, intrapartum fever and rupture of membrane (>18h) were more frequent in EO-cases’ mothers versus healthy babies’ GBS-positive mothers. The major serotypes were III (43%), V (21%) and Ia (18%). In LOD, mean/median ages at onset were 42/34 days and the male:female ratio was 0.9. The predominant characteristic at onset was fever (62% cases); 70% cases were associated with sepsis and 30% with meningitis. Very rare manifestations were osteomyelitis and cellulitis. Serotype III was highly predominant (80.6%) followed mainly by Ia (12.5%). Death rates were 4.7/1.5% in EOD/LOD. Conclusions: Clinical presentations were associated with age at onset of infection. Serotype III predominated in neonatal infections. Prenatal screening was not universal neither sensitive. Study funded through the European Commission Seventh Framework. [less ▲]

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See detailNeonatal liver cirrhosis without iron overload caused by gestational alloimmune liver disease.
DEBRAY, François-Guillaume ULg; de Halleux, Virginie; Guidi, Ornella et al

in Pediatrics (2012), 129(4), 1076-9

Gestational alloimmune liver disease has emerged as the major cause of antenatal liver injury and failure. It usually manifests as neonatal liver failure with hepatic and extrahepatic iron overload, a ... [more ▼]

Gestational alloimmune liver disease has emerged as the major cause of antenatal liver injury and failure. It usually manifests as neonatal liver failure with hepatic and extrahepatic iron overload, a clinical presentation called neonatal hemochromatosis. We report on a newborn in whom fetal hepatomegaly was detected during pregnancy and who presented at birth with liver cirrhosis and mild liver dysfunction. Liver biopsy showed the absence of iron overload but strong immunostaining of hepatocytes for the C5b-9 complex, the terminal complement cascade neoantigen occurring specifically during complement activation by the immunoglobulin G-mediated classic pathway, which established the alloimmune nature of the hepatocyte injury. The infant survived with no specific therapy, and follow-up until 36 months showed progressive normalization of all liver parameters. This case report expands the recognized clinical spectrum of congenital alloimmune liver disease to include neonatal liver disease and cirrhosis, even in the absence of siderosis. Such a diagnosis is of utmost importance regarding the necessity for immunotherapy in further pregnancies to avoid recurrence of alloimmune injury. [less ▲]

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See detailNeonatal on-line respiratory mechanics: Stability and effect of ventilatory mode
Rigo, Vincent ULg; Rigo, Jacques ULg

in Edition Spéciale SBP, Vol 1 (2008, February)

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See detailNeonatal Osteopenia and Bone Mineralization
Rigo, Jacques ULg

in eNeonatal review (2008), 6(4),

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See detailNeonatal progeroid variant of Marfan syndrome with congenital lipodystrophy results from mutations at the 3' end of FBN1 gene.
Jacquinet, Adeline ULg; Verloes, Alain; Callewaert, Bert et al

in European journal of medical genetics (2014), 57(5), 230-4

We report a 16-year-old girl with neonatal progeroid features and congenital lipodystrophy who was considered at birth as a possible variant of Wiedemann-Rautenstrauch syndrome. The emergence of ... [more ▼]

We report a 16-year-old girl with neonatal progeroid features and congenital lipodystrophy who was considered at birth as a possible variant of Wiedemann-Rautenstrauch syndrome. The emergence of additional clinical signs (marfanoid habitus, severe myopia and dilatation of the aortic bulb) lead to consider the diagnosis of the progeroid variant of Marfan syndrome. A de novo donor splice-site mutation (c.8226+1G>A) was identified in FBN1. We show that this mutation leads to exon 64 skipping and to the production of a stable mRNA that should allow synthesis of a truncated profibrillin-1, in which the C-terminal furin cleavage site is altered. FBN1 mutations associated with a similar phenotype have only been reported in four other patients. We confirm the correlation between marfanoid phenotype with congenital lipodystrophy and neonatal progeroid features (marfanoid-progeroid-lipodystrophy syndrome) and frameshift mutations at the 3' end of FBN1. This syndrome should be considered in differential diagnosis of neonatal progeroid syndromes. [less ▲]

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See detailNeonatal rat organ of Corti forms supernumerary hair cells in response to growth factor treatment
Lefèbvre, P; Malgrange, B; Thiry, Marc ULg et al

Conference (1999)

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See detailNeonatal rat organ of Corti forms supernumerary hair cells in response to growth factor treatment
Malgrange, B; Lefebvre, P; Rigo, J-M et al

Poster (1999)

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See detailNeonatal rat organ of Corti forms supernumerary hair cells in response to growth factor treatment
Lefebvre, P; Malgrange, B; Thiry, Marc ULg et al

Conference (1999)

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See detailNeonatal screening for sickle cell disease in Central Africa: a study of 1825 newborns with a new enzyme-linked immunosorbent assay test
Mutesa, Léon; Boemer, François ULg; Ngendahayo, Louis et al

in Journal of Medical Screening (2007), 14(3), 113-116

Objectives To evaluate the feasibility of systematic neonatal screening for sickle cell disease in the region of Great Lakes in Central Africa using a new approach with limited costs. Methods Between July ... [more ▼]

Objectives To evaluate the feasibility of systematic neonatal screening for sickle cell disease in the region of Great Lakes in Central Africa using a new approach with limited costs. Methods Between July 2004 and July 2006, 1825 newborn dried blood samples were collected onto filter papers in four maternity units from Burundi, Rwanda and the East of the Democratic Republic of Congo. We tested for the presence of haemoglobin C and S in the eluted blood by an enzyme-linked immunosorbent assay (ELISA) test using a monoclonal antibody. All ELISA-positive samples (multiple of the median (MoM) >= 1.5) were confirmed by a simple molecular test. The statistica software version 7.1 was used to create graphics and to fix the MoM cut-off, and the chi(2) of Pearson was used to compare the genotype incidences between countries. Results Of the 1825 samples screened, 97 (5.32%) were positive. Of these, 60 (3.28%) samples were heterozygous for Hb S, and four (0.22%) for Hb C; two (0.11%) newborns were Hb SS homozygotes. Conclusions The lower cost and the high specificity of ELISA test are appropriate for developing countries, and such systematic screening for sickle cell anaemia is therefore feasible. [less ▲]

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See detailNeonatal screening of hemoglobinopathies on dried blood
BOEMER, François ULg

Conference (2007)

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See detailNeonatal seizures or convulsions
Battisti, Oreste ULg; DUBRU, Jean-Marie ULg

Learning material (2013)

diaporama et video des convulsions néonatales

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See detailNeonatal thyroid-stimulating hormone concentrations in Belgium: a useful indicator for detecting mild iodine deficiency?
Vandevijvere, S; Coucke, W; Vanderpas, J et al

in PLoS ONE (2012)

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See detailNéonatalogie équine
Amory, Hélène ULg

Learning material (2011)

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See detailNeonates show transient and incomplete anti-inflammatory response to cardiac surgery
Wiecker, Carola; Buding, Brigitte; Vazquez-Jimenez, Jaime et al

Conference (2013, January)

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