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See detailNew arguments supporting the intrinsic origin of BAL QSOs - Formation of the complex Ly-alpha+NV line profile
Hutsemekers, Damien ULg; Surdej, Jean ULg

in Bianchi, L.; Gilmozzi, R. (Eds.) Proceedings of the Second Torino Workshop "Mass Outflows from Stars and Galactic Nuclei" (1988)

A study is presented to further elucidate the question of whether or not all quasars are affected by the BAL phenomenon. The possibility that observed BAL profiles are formed in spherically symmetric ... [more ▼]

A study is presented to further elucidate the question of whether or not all quasars are affected by the BAL phenomenon. The possibility that observed BAL profiles are formed in spherically symmetric expanding atmospheres is investigated. [less ▲]

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See detailNew assessment of bovine tuberculosis risk factors in Belgium based on nationwide molecular epidemiology.
Humblet, M.-F.; Gilbert, M.; Govaerts, M. et al

in Journal of Clinical Microbiology (2010), 48(8), 2802-8

This assessment aimed to elaborate a statistical nationwide model for analyzing the space-time dynamics of bovine tuberculosis in search of potential risk factors that could be used to better target ... [more ▼]

This assessment aimed to elaborate a statistical nationwide model for analyzing the space-time dynamics of bovine tuberculosis in search of potential risk factors that could be used to better target surveillance measures. A database comprising Mycobacterium bovis molecular profiles from all isolates obtained from Belgian outbreaks during the 1995-to-2006 period (n = 415) allowed the identification of a predominant spoligotype (SB0162). Various databases compiling 49 parameters to be tested were queried using a multiple stepwise logistic regression to assess bovine tuberculosis risk factors. Two isolate datasets were analyzed: the first included all Mycobacterium bovis isolates, while the second included only data related to the SB0162 type strain. When all Mycobacterium bovis isolates were included in the model, several risk factors were identified: history of bovine tuberculosis in the herd (P < 0.001), proximity of an outbreak (P < 0.001), cattle density (P < 0.001), and annual amplitude of mean middle-infrared temperature (P < 0.001). The approach restricted to the predominant SB0162 type strain additionally highlighted the proportion of movements from an infected area during the current year as a main risk factor (P = 0.009). This study identified several risk factors for bovine tuberculosis in cattle, highlighted the usefulness of molecular typing in the study of bovine tuberculosis epidemiology, and suggests a difference of behavior for the predominant type strain. It also emphasizes the role of animals' movements in the transmission of the disease and supports the importance of controlling trade movements. [less ▲]

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See detailNew assessment of dependency in demented patients : impact on the quality of life in informal caregivers.
Andrieu, Sandrine; Rive, Benoït; Guilhaume, Chantal et al

in Psychiatry & Clinical Neurosciences (2007), 61(3), 234-242

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See detailNew asthma biomarkers: lessons from murine models of acute and chronic asthma.
Di Valentin, Emmanuel ULg; Crahay, Céline; Garbacki, Nancy ULg et al

in American Journal of Physiology - Lung Cellular and Molecular Physiology (2009), 296(2), 185-97

Many patients suffering from asthma are not fully controlled by currently available treatments, and some of them display an airway remodeling leading to exaggerated lung function decline. The aim of the ... [more ▼]

Many patients suffering from asthma are not fully controlled by currently available treatments, and some of them display an airway remodeling leading to exaggerated lung function decline. The aim of the present study was to unveil new mediators in asthma to better understand pathophysiology and propose or validate new potential therapeutic targets. A mouse model of asthma mimicking acute or chronic asthma disease was used to select genes undergoing a modulation in both acute and chronic conditions. Mice were exposed to ovalbumin or PBS for 1, 5, and 10 wk [short-, intermediate-, and long-term model (ST, IT, and LT)], and gene expression in the lung was studied using an Affymetrix 430 2.0 genome-wide microarray and further confirmed by RT-PCR and immunohistochemistry for selected targets. We report that 598, 1,406, and 117 genes were upregulated and 490, 153, 321 downregulated at ST, IT, and LT, respectively. Genes related to mucous secretion displayed a progressively amplified expression during the allergen exposure protocol, whereas genes corresponding to growth and differentiation factors, matrix metalloproteinases, and collagens were mainly upregulated at IT. By contrast, genes related to cell division were upregulated at ST and IT and were downregulated at LT. In this study, besides confirming that Arg1, Slc26a4, Ear11, and Mmp12 genes are highly modulated throughout the asthma pathology, we show for the first time that Agr2, Scin, and Cd209e genes are overexpressed throughout the allergen exposure and might therefore be considered as suitable new potential targets for the treatment of asthma. [less ▲]

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See detailA new automatic video multitracking system able to follow a large school
Delcourt, Johann ULg; Becco, Christophe ULg; Vandewalle, Nicolas ULg et al

in Noldus, L.P.P.J.; Grieco, F.; Loijens, L. W. S. (Eds.) et al Proceedings of Measuring Behavior 2005 (2005)

The study of shoaling behaviours is tackled by scientists by three approaches: the field, laboratory and computer modelling approach. The field studies are complicated and permit rarely an analysis of ... [more ▼]

The study of shoaling behaviours is tackled by scientists by three approaches: the field, laboratory and computer modelling approach. The field studies are complicated and permit rarely an analysis of individual positions. The third approach, consisting of development of mathematic models, is artificial. It requires a comparison with empiric results to validate and to determine the explications’ degree of each model. Thanks to the developments of digital imaging techniques, the laboratory studies on fish are able to measure the behavioural parameters with precision, impossible to realize with manual recording. Multitracking systems are rare and of recent development. These are insufficient to study the real size of shoals, often composed of hundreds of .shes. We have developed a new system of multitracking thanks to collaboration with the G.R.A.S.P. The G.R.A.S.P. has before realised other multitracking systems to follow some hundreds physical objects. Our video multitracking system is able to detect and to track more than a hundred unmarked fishes by gray scaling technique during some minutes. It permits an analysis as well at the group level as at the individual level. The multitraking program is able to attribute a number at each fish and to follow each one during the whole duration of the track. Our system permits the analysis of the movement of each individual, even if the trajectories of two fishes cross each other. It is possible thanks to the theoretical estimation of trajectory of each fish, compared with the real trajectory (analysis with feedback). The human eye is always necessary to detect the errors in identification but reediting is possible. However, if the fishes don’t move too rapidly, a rate of 25 images /s gives very good results, without too much visual expertise from the experimenter. If the fishes are too fast (i.e. escape response), it is better to use a high speed camera. [less ▲]

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See detailA new Barremian (Early Cretaceous) ichthyosaur from western Russia
Fischer, Valentin ULg; Masure, Edwige; Arkhangelsky, Maxim et al

in Journal of Vertebrate Paleontology (2011), 31(5), 1010-1025

A new ophthalmosaurid ichthyosaur, Sveltonectes insolitus gen. et sp. nov., is described from a sub-complete and three-dimensionally preserved specimen from the late Barremian of western Russia. This new ... [more ▼]

A new ophthalmosaurid ichthyosaur, Sveltonectes insolitus gen. et sp. nov., is described from a sub-complete and three-dimensionally preserved specimen from the late Barremian of western Russia. This new taxon is supported by 11 cranial, dental, and postcranial autapomorphies, and is also characterized by features previously considered as autapomorphic for some other Ophthalmosauridae, such as a processus narialis on the prefrontal and relatively long hindfins with pre- and postaxial accessory digits. We conducted a new phylogenetic analysis of Thunnosauria, which supports a ‘Stenopterygius-origin’ for Ophthalmosauridae. Sveltonectes is regarded as the sister taxon of Aegirosaurus, which shares a similar skull roof construction. Contrary to most other Cretaceous ichthyosaurs, Sveltonectes is characterized by delicate and sharply pointed teeth, confirming that the Ophthalmosauridae were ecologically highly diversified during the Early Cretaceous [less ▲]

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See detailNew Basic Membrane-Destabilizing Peptides For Plasmid-Based Gene Delivery In Vitro And In Vivo
Rittner, K.; Benavente, A.; Bompard-Sorlet, A. et al

in Molecular Therapy (2002), 5(2), 104-14

We have designed new basic amphiphilic peptides, ppTG1 and ppTG20 (20 amino acids), and evaluated their efficiencies in vitro and in vivo as single-component gene transfer vectors. ppTG1 and ppTG20 bind ... [more ▼]

We have designed new basic amphiphilic peptides, ppTG1 and ppTG20 (20 amino acids), and evaluated their efficiencies in vitro and in vivo as single-component gene transfer vectors. ppTG1 and ppTG20 bind to nucleic acids and destabilize liposomes consisting of 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) and cholesterol (3:1 mol/mol) at pH 5 and pH 7. Complexes of plasmid DNA and ppTG1 gave rise to efficient transfection in a variety of human and murine cell lines at low charge ratios ([+/-] between 1 and 2). In cell culture experiments, such vectors were superior to the membrane-destabilizing peptide KALA. In comparison with cationic lipid-, dendrimer-, and polymer-based transfection agents like Superfect, polyethylenimine (PEI), and Lipofectin, ppTG1 vectors showed good transfection efficiencies, especially at low DNA doses. Moreover, we demonstrated for the first time successful gene transfer in living animals with a single-component peptide vector. In the mouse, intravenous injection of a luciferase expression plasmid complexed with ppTG1 or ppTG20 led to significant gene expression in the lung 24 hours after injection. Structure-function studies with ppTG1, ppTG20, and sequence variants suggest that the high gene transfer activity of these peptides is correlated with their propensity to exist in alpha-helical conformation, which seems to be strongly influenced by the nature of the hydrophobic amino acids. [less ▲]

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See detailA new benzotriazole-mediated stereoflexible gateway to hetero-2,5-diketopiperazines
Monbaliu, Jean-Christophe ULg; Hansen, Finn; Beagle, Lucas et al

in Chemistry : A European Journal (2011), 18

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See detailNew Biological Investigations on 3-Bromophenyl 6-Acetoxymethyl-2-oxo-2H-1-Benzopyran-3-Carboxylate as Anti-angiogenic Agent
Hemmer, M.; Kempen, Isabelle; De Tullio, Pascal ULg et al

in Drug Development Research (2010), 71

The development of blood vessels inside tumors is required to provide the nutrients and oxygen needed for tumor growth and to allow the spread of cancer cells at a distance to form metastasis ... [more ▼]

The development of blood vessels inside tumors is required to provide the nutrients and oxygen needed for tumor growth and to allow the spread of cancer cells at a distance to form metastasis. Angiogenesis is also implicated in ocular diseases like age-related macular degeneration. The present work describes the potential anti-angiogenic properties of a coumarinic derivative, 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate (IK9), previously described as a potent inhibitor of HT 1080 fibrosarcoma cell invasion in vitro and tumor growth in vivo. In vivo, ex vivo, and in vitro models were used to delineate the anti-angiogenic properties of IK9. The anti-angiogenic effect of IK9 was demonstrated in vivo in a choroidal neovascularization mice model and additionally ex vivo in a rat aortic ring assay where it was more active than the known matrix metalloproteinase inhibitor Ro 28-2653. IK9 did not affect apoptosis, proliferation, or endothelial cell invasiveness in vitro. These findings suggest a complex mechanism of action of the compound via direct or indirect effects on endothelial cell properties. This study identifies IK9 as a new potent inhibitor of angiogenesis and suggests its potential use as a therapeutic agent. [less ▲]

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See detailNew biomarkers of Crohn's disease: serum biomarkers and development of diagnostic tools
Meuwis, Marie-Alice ULg; Fillet, Marianne ULg; Chapelle, Jean-Paul ULg et al

in Expert Review of Molecular Diagnostics (2008), 8

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See detailNew bisphosphonates for the treatment of osteoporosis : concerns and hopes
Reginster, Jean-Yves ULg

in Revue du Rhumatisme (English ed.) (1996), 63(7-8), 461-464

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See detailNew bounds on trilinear R-parity violation from lepton flavor violating observables
Dreiner, H. K.; Nickel, K.; Staub, F. et al

in Physical Review. D, Particles, Fields, Gravitation, and Cosmology (2012), 86

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See detailNew capabilities of the INCL4.6 model implemented into high-energy transport codes
Leray, S.; Boudard, A.; Braunn, B. et al

in Proceedings of Shielding Aspects of Accelerators, Targets and Irradiation Facilities 2011 (2013)

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See detailA new case of consensual decision: collective movement in earthworms
Zirbes, Lara ULg; Deneubourg, Jean-Louis; Brostaux, Yves ULg et al

in Ethology (2010), 115

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See detailA new case of gravitational lensing
Surdej, Jean ULg; Magain, Pierre ULg; Swings, J.-P. et al

in Nature (1987), 329

The authors have begun a systematic search from ESO for gravitational lens systems in a selected sample of highly luminous quasars; M[SUB]V[/SUB] < -29.0. They give a brief description of their first ... [more ▼]

The authors have begun a systematic search from ESO for gravitational lens systems in a selected sample of highly luminous quasars; M[SUB]V[/SUB] < -29.0. They give a brief description of their first identified gravitational lens system UM673 = Q0142-100 = PHL3703. It consists of two images, A (m[SUB]R[/SUB] = 16.9) and B (m[SUB]R[/SUB] = 19.1), separated by 2.2 arc s at a redshift z[SUB]q[/SUB] = 2.719. The lensing galaxy (m[SUB]R[/SUB] â 19, Z[SUB]L[/SUB] â 0.49) has also been found. It lies very near the line connecting the two QSO images, â ¡0.8 arc s from the fainter one. A value M[SUB]0[/SUB] â 2.4×10[SUP]11[/SUP]M_sun; for the mass of the lensing galaxy and Deltat â 7 weeks for most likely travel-time difference between the two light paths to the QSO are found (assuming H[SUB]0[/SUB] = 75 km s[SUP]-1[/SUP]Mpc[SUP]-1[/SUP], q[SUB]0[/SUB] = 0). [less ▲]

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See detailNew catalysis for fast bulk ring-opening polymerization of lactide monomers
Degée, Philippe; Dubois, Philippe ULg; Jérôme, Robert ULg et al

in Macromolecular Symposia (1999), 144

The ring-opening polymerization of lactides has been studied in bulk using either 2-ethylhexanoic acid tin(II) salt, Sn(Oct)2, or aluminum triisopropoxide, Al(OiPr)3, as the initiator over a wide range of ... [more ▼]

The ring-opening polymerization of lactides has been studied in bulk using either 2-ethylhexanoic acid tin(II) salt, Sn(Oct)2, or aluminum triisopropoxide, Al(OiPr)3, as the initiator over a wide range of temperature and monomer-to-initiator molar ratio, A high increase in the bulk polymerization rate has been observed when the initiator was added with an equimolar amount of a Lewis base, such as triphenylphosphine and 4-picoline (C6H7N) added to Sn(Oct)2 and Al(OiPr)3, respectively Melt stable polylactides of high molecular weight and reasonably narrow molecular weight distribution have been accordingly prepared. The use of the Sn(Oct)2. equimolar combination has allowed for reaching an acceptable balance between propagation and depolymerization rates, so that the polymerization is fast enough to be performed through a continuous single-stage process in a twin-screw extruder A global activation mechanism is proposed and discussed by comparison with both investigated initiation systems. [less ▲]

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See detailA new CCD camera for the Echelec spectrograph.
Gilliotte, A.; Magain, Pierre ULg

in The Messenger (1987), 50

Not Available

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