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See detailNEW CHALLENGES FOR 21ST CENTURY COMPETITION AUTHORITIES
Petit, Nicolas ULg

E-print/Working paper (2012)

This paper discusses challenges for competition authorities in the 21st century. Those challenges were identified on the basis of a statistical review of the articles published since January 2011 in five ... [more ▼]

This paper discusses challenges for competition authorities in the 21st century. Those challenges were identified on the basis of a statistical review of the articles published since January 2011 in five major antitrust law journals. The assumption underlying this literature review is that the topics that statistically attract the most the attention from contemporary antitrust scholars are those that will likely constitute the main challenges for 21st century competition authorities. [less ▲]

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See detailNew challenges for feature selection in data mining and knowledge discovery
Saeys, Yvan; Liu, Huan; Inza, Inaki et al

in Journal of Machine Learning Research (2008), 4

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See detailNew Chinese Migrants in Europe : The case of the Chinese community in Hungary
Florence, Eric ULg

in Nationalism & Ethnic Politics (2001), Vol. 7(Issue 1),

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See detailA New Cis Element Is Involved in the Her2 Gene Overexpression in Human Breast Cancer Cells
Grooteclaes, Madeleine; Vernimmen, Douglas; Plaza, S. et al

in Cancer Research (1999), 59(11), 2527-31

The HER2 proto-oncogene product is overexpressed in 30% of breast cancers, and this correlates with poor prognosis. Increased levels of HER2 mRNA in breast cancer cell lines result from increased gene ... [more ▼]

The HER2 proto-oncogene product is overexpressed in 30% of breast cancers, and this correlates with poor prognosis. Increased levels of HER2 mRNA in breast cancer cell lines result from increased gene transcription. We report the identification of a new 17-bp-long cis sequence located between positions -506 and -489 from the transcription start site. This sequence is recognized by a trans-activating factor that we tentatively named HER2 transcription factor (HTF). This factor, involved in the increased transcription of the HER2 gene in the BT-474 mammary tumor cells, has a molecular weight of about Mr 50,000. HTF can also bind, but with a lower affinity, to a related cis sequence present in the epidermal growth factor receptor promoter. Interestingly, the HTF binding activity is high in nuclear extracts from several mammary tumor cells overexpressing the HER2 gene. [less ▲]

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See detailNew Cold Plasma and DLC Surface Treatments for Medical Co-Cr-Mo and Ti-6Al-4V Prostheses
Matarazzo, Lucas; Gillet, Marie-Claire ULg; Forest, B et al

Poster (2006, September 27)

Recent studies indicate that the most important factor limiting the longevity of hip prostheses is the production of wear particles from the prosthetic components. We have studied the effect of two ... [more ▼]

Recent studies indicate that the most important factor limiting the longevity of hip prostheses is the production of wear particles from the prosthetic components. We have studied the effect of two surface treatment techniques on the Ti-6Al-4V alloy: ionic nitruration (cold plasma) and Diamond-like Coating (DLC). These two techniques create a layer of 7-8 μm in depth on the surface of the alloy, modifying its structure and hardening it considerably. Biocompatibility was analyzed using cellular culture to compare viability, proliferation (DNA quantification) and differentiation (ALP assay) of human osteoblast-like cells (MG 63) as well as cellular adhesion of human fibroblasts (WI 38) or osteoblasts, under SEM. [less ▲]

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See detailNew Colliding-Wind Massive Binaries
De Becker, Michaël ULg; Rauw, Grégor ULg

in Massive Stars in Interactive Binaries (2007)

We report on the recent discovery of two new massive binary systems: WR20a and CygOB2#8A. For both systems, we briefly present the orbital solutions and we discuss the strong phase-locked line profile ... [more ▼]

We report on the recent discovery of two new massive binary systems: WR20a and CygOB2#8A. For both systems, we briefly present the orbital solutions and we discuss the strong phase-locked line profile variability of the Halpha and HeII lambda 4686 lines for WR20a, and the HeII &; 4686 line in the case of CygOB2#8A. In both cases, we show that the profile variability reveals the signature of a wind interaction. The prospects for future high-energy observations are also discussed. [less ▲]

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See detailNew Combination Techniques in Dioxin Analysis
Focant, Jean-François ULg

in Lab Info (2008), 3

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See detailNew combinations in the Amblystegiaceae
Vanderpoorten, Alain ULg; Hedenäs, L.

in Journal of Bryology (2009), 31

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See detailA new combined bodian-luxol technique for staining unmyelinated axons in semithin, resin-embedded peripheral nerves: a comparison with electron microscopy.
Deprez, Manuel ULg; Ceuterick-de Groote, C.; Fumal, Arnaud ULg et al

in Acta Neuropathologica (1999), 98(4), 323-9

Quantitation of unmyelinated fibers (UF) in peripheral nerves has classically relied upon ultrastructural morphometry. Because this method is time-consuming, it is not typically performed in routine ... [more ▼]

Quantitation of unmyelinated fibers (UF) in peripheral nerves has classically relied upon ultrastructural morphometry. Because this method is time-consuming, it is not typically performed in routine analysis of nerve biopsies. We applied the Bodian-Luxol technique to detect unmyelinated axons by light microscopy on semithin sections from resin-embedded nerve tissue. Estimates were compared to ultrastructural counts. The staining appeared highly specific for axons. Excellent correlation was found between optic densities and the population of UF larger than 0.5 microm. The smallest profiles detected by light microscopy had a diameter close to 0.6 microm. This new technique is not a substitute for ultrastructural quantitative morphometry of UF, as very small unmyelinated axons, especially regenerating ones, can not be reliably visualized. However, it provides a valuable light microscopic method for evaluating axonal loss among UF. [less ▲]

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See detailA new computational method for nonlinear normal modes of nonconservative systems
Renson, Ludovic ULg; Kerschen, Gaëtan ULg

in Proceedings of the Euromech Colloquium n. 541 - New Advances in the Nonlinear Dynamics and Control of Composites for Smart Engineering Design (2013, June)

The concept of nonlinear normal modes (NNMs) was introduced with the aim of providing a rigorous generalization of normal modes to nonlinear systems. Initially, NNMs were defined as periodic solutions of ... [more ▼]

The concept of nonlinear normal modes (NNMs) was introduced with the aim of providing a rigorous generalization of normal modes to nonlinear systems. Initially, NNMs were defined as periodic solutions of the underlying conservative system, and continuation algorithms were recently exploited to compute them. To extend the concept of NNMs to nonconservative systems, Shaw and Pierre defined an NNM as a two-dimensional invariant manifold in the system’s phase space. This contribution presents a novel algorithm for solving the set of partial differential equations governing the manifold geometry numerically. The resolution strategy takes advantage of the hyperbolic nature of the equations to progressively solve them in annular regions. Each region is defined by two different iso-energy curves and equations are discretized using a specific finite element technique. The proposed strategy also offers the opportunity to estimate the frequency-energy dependence of the mode without using time integration. The algorithm is applied to both conservative and nonconservative systems. [less ▲]

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See detailA new concept for bisphosphonate therapy: a rationale for the development of monthly oral dosing of ibandronate
Reginster, Jean-Yves ULg; Felsenberg, Dieter; Cooper, Cyrus et al

in Osteoporosis International (2006), 17(2), 159-166

Oral daily and weekly bisphosphonates represent the current mainstay of treatment for postmenopausal osteoporosis (PMO). However, the inconvenience of frequent dosing is known to negatively affect ... [more ▼]

Oral daily and weekly bisphosphonates represent the current mainstay of treatment for postmenopausal osteoporosis (PMO). However, the inconvenience of frequent dosing is known to negatively affect adherence to therapy in the long term. This has prompted the development of convenient oral bisphosphonate regimens that feature simple, less frequent dosing schedules. Such regimens require high potency agents, which can be given at low effective doses and that also have good tolerability. Ibandronate is a potent, nitrogen-containing bisphosphonate with proven efficacy when given intermittently to estrogen-depleted beagle dogs, rats and cynomolgus monkeys. Clinically, a pivotal prospective study has established that oral ibandronate has significant vertebral fracture efficacy in PMO, whether given daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months; extended between-dose interval > 2 months). Both oral regimens were well tolerated, which is noteworthy as patients with a history of gastrointestinal (GI) disturbance were not specifically excluded. As a result of these findings, a large, multinational, randomized, double-blind study (Monthly Oral iBandronate In LadiEs: MOBILE) is currently exploring the non-inferiority of once-monthly oral ibandronate (100 or 150 mg) to the oral daily ibandronate (2.5 mg) regimen with proven anti-fracture efficacy, in terms of lumbar spine bone mineral density (BMD) change. As with the trials investigating the weekly administration of other bisphosphonates, vertebral fracture efficacy will be inferred if the study demonstrates the non-inferiority of once-monthly ibandronate to the proven oral daily regimen in terms of spinal BMD change. The availability of this once-monthly ibandronate regimen is expected to offer benefits in terms of convenience (by having to follow dosing recommendations once a month vs. once daily or weekly) and potentially tolerability (by reducing the potential for upper GI irritation that can result from frequent, repeated exposure). Greater convenience and tolerability may enhance the therapy adherence and, hence, improve long-term therapeutic outcomes in PMO. [less ▲]

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See detailThe new concept-temporary stents, an experimental study.
Kavteladze, Z. A.; Dundua, D. P.; Dondelinger, R. F. et al

in International Journal of Interventional Cardioangiology (2003), 1

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See detailNew concepts for the design of joints
Jaspart, Jean-Pierre ULg; Weynand, K.

in Proceedings of the 10th DASt-Forschungs-kolloquium Stahlbau (1997)

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See detailNew concepts in type 2 immunity: Damage-associated signals and Protective IgE
Marichal, Thomas ULg

Scientific conference (2013, November)

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See detailNew Constraints on Companions and Dust within a Few AU of Vega
Mennesson, B.; Serabyn, E.; Hanot, Charles ULg et al

in Astrophysical Journal (2011), 736

We report on high contrast near-infrared (~2.2 μm) observations of Vega obtained with the Palomar Fiber Nuller, a dual sub-aperture rotating coronagraph installed at the Palomar Hale telescope. The data ... [more ▼]

We report on high contrast near-infrared (~2.2 μm) observations of Vega obtained with the Palomar Fiber Nuller, a dual sub-aperture rotating coronagraph installed at the Palomar Hale telescope. The data show consistent astrophysical null depth measurements at the ~= 10[SUP]–3[/SUP] level or below for three different baseline orientations spanning 60 deg in azimuth, with individual 1σ uncertainties <=7 × 10[SUP]–4[/SUP]. These high cancellation and accuracy levels translate into a dynamic range greater than 1000:1 inside the diffraction limit of the 5 m telescope beam. Such high contrast performance is unprecedented in the near-infrared and provides improved constraints on Vega's immediate (sime20 to 250 mas, or sime0.15 to 2 AU) environment. In particular, our measurements rule out any potential companion in the [0.25-1 AU] region contributing more than 1% of the overall near-infrared stellar flux, with limits as low as 0.2% near 0.6 AU. These are the best upper limits established so far by direct detection for a companion to Vega in this inner region. We also conclude that any dust population contributing a significant (>=1%) near-infrared thermal excess can arise only within 0.2 AU of the star, and that it must consist of much smaller grains than in the solar zodiacal cloud. Dust emission from farther than sime2 AU is also not ruled out by our observations, but would have to originate in strong scattering, pointing again to very small grains. Based on observations obtained at the Hale Telescope, Palomar Observatory as part of a continuing collaboration between the California Institute of Technology, NASA/JPL, and Cornell University. [less ▲]

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See detailNew constraints on the delivery of cometary water and nitrogen to Earth from the 15N/14N isotopic ratio
Hutsemekers, Damien ULg; Manfroid, Jean ULg; Jehin, Emmanuel ULg et al

in Icarus: International Journal of Solar System Studies (2009), 204

New independent constraints on the amount of water delivered to Earth by comets are derived using the [SUP]15[/SUP]N/[SUP]14[/SUP]N isotopic ratio, measured to be roughly twice as high in cometary CN and ... [more ▼]

New independent constraints on the amount of water delivered to Earth by comets are derived using the [SUP]15[/SUP]N/[SUP]14[/SUP]N isotopic ratio, measured to be roughly twice as high in cometary CN and HCN as in the present Earth. Under reasonable assumptions, we find that no more than a few percent of Earthâ s water can be attributed to comets, in agreement with the constraints derived from D/H. Our results also suggest that a significant part of Earthâ s atmospheric nitrogen might come from comets. Since the [SUP]15[/SUP]N/[SUP]14[/SUP]N isotopic ratio is not different in Oort-cloud and Kuiper-belt comets, our estimates apply to the contribution of both types of objects. [less ▲]

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See detailNew constraints on the Karliova Triple Junction between Arabia, Eurasia and Anatolia.
Hubert, Aurelia ULg; Van Der Woerd, Jerome; King, G. et al

in Geophysical Research Abstracts (2007, April), 9

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See detailNew constraints on the slip rate of the North Anatolian Fault, Turkey
Hubert, Aurelia ULg; Armijo, R; Meyer, B et al

in Terra nova (European Union of Geosciences abstracts) (1997, March), 9

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See detailNew constraints on very light pseudoscalars
Payez, Alexandre ULg; Cudell, Jean-René ULg; Hutsemekers, Damien ULg

in Zioutas, K. (Ed.) 7th Patras Workshop on Axions, WIMPs and WISPs (2012, January 01)

Nearly massless axion-like particles are of interest for astrophysical observations, and some constraints on their parameter space do exist in the literature. Here, we propose to put new constraints on ... [more ▼]

Nearly massless axion-like particles are of interest for astrophysical observations, and some constraints on their parameter space do exist in the literature. Here, we propose to put new constraints on these particles using polarisation and, in particular, the polarisation differences observed between different quasar classes. [less ▲]

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