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See detailMouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12
Gusareva, Elena ULg; Havelková, Helena; Blažková, Hana et al

in Immunogenetics (2009), 61(1), 15-25

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. It is often associated with development of allergic diseases such as asthma, rhinitis, and ... [more ▼]

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. It is often associated with development of allergic diseases such as asthma, rhinitis, and dermatitis. Production of IgE is influenced by genetic and environmental factors. In spite of progress in the study of heredity of atopy, the genetic mechanisms of IgE regulation have not yet been completely elucidated. The analysis of complex traits can benefit considerably from integration of human and mouse genetics. Previously, we mapped a mouse IgE-controlling locus Lmr9 on chromosome 4 to a segment of <9 Mb. In this study, we tested levels of total IgE and 25 specific IgEs against inhalant and food allergens in 67 Czech atopic families. In the position homologous to Lmr9 on chromosome 8q12 marked by D8S285, we demonstrated a novel human IgE-controlling locus exhibiting suggestive linkage to composite inhalant allergic sensitization (limit of detection, LOD=2.11, P=0.0009) and to nine specific IgEs, with maximum LOD (LOD=2.42, P=0.0004) to plantain. We also tested 16 markers at previously reported chromosomal regions of atopy. Linkage to plant allergens exceeding the LOD>2.0 was detected at 5q33 (D5S1507, LOD=2.11, P=0.0009) and 13q14 (D13S165, LOD=2.74, P=0.0002). The significant association with plant allergens (quantitative and discrete traits) was found at 7p14 (D7S2250, corrected P=0.026) and 12q13 (D12S1298, corrected P=0.043). Thus, the finding of linkage on chromosome 8q12 shows precision and predictive power of mouse models in the investigation of complex traits in humans. Our results also confirm the role of loci at 5q33, 7p14, 12q14, and 13q13 in control of IgE. [less ▲]

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See detailMouse vaccination with dendritic cells loaded with prion protein peptides overcomes tolerance and delays scrapie.
Bachy, Veronique; Ballerini, Clara; Gourdain, Pauline et al

in Journal of General Virology (The) (2010), 91(Pt 3), 809-20

Prion diseases are presumed to be caused by the accumulation in the brain of a pathological protein called prion protein (PrP) scrapie which results from the transconformation of cellular PrP, a ... [more ▼]

Prion diseases are presumed to be caused by the accumulation in the brain of a pathological protein called prion protein (PrP) scrapie which results from the transconformation of cellular PrP, a ubiquitous glycoprotein expressed in all mammals. Since all isoforms of PrP are perceived as self by the host immune system, a major problem in designing efficient immunoprophylaxis or immunotherapy is to overcome tolerance. The present study was aimed at investigating whether bone-marrow-derived dendritic cells (DCs) loaded with peptides previously shown to be immunogenic in PrP-deficient mice, can overcome tolerance in PrP-proficient wild-type mice and protect them against scrapie. Results show that, in such mice, peptide-loaded DCs elicit both lymphokine release by T cells and antibody secretion against native cellular PrP. Repeated recalls with peptide-loaded DCs reduces the attack rate of 139A scrapie inoculated intraperitoneally and retards disease duration by 40 days. Most interestingly, survival time in individual mice appears to be correlated with the level of circulating antibody against native cellular PrP. [less ▲]

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See detailMoustique tigre: un nouveau moustique tropical dangereux trouvé à Anvers
Louis, François; Boukraa, Slimane ULg; Francis, Frédéric ULg

Article for general public (2013)

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See detailMoustiques (Diptera : Culicidae) de la région du M’Zab-Ghardaïa, Algérie : biodiversité et importance médico-vétérinaire
Boukraa, Slimane ULg; Baba Aissa, Nadir; Abdelaziz, Brahim et al

Poster (2013, October 19)

De nombreuses espèces de moustiques sont susceptibles de jouer un rôle dans la transmission de divers agents pathogènes responsables des maladies infectieuses humaines et animales. D'autres, outre leur ... [more ▼]

De nombreuses espèces de moustiques sont susceptibles de jouer un rôle dans la transmission de divers agents pathogènes responsables des maladies infectieuses humaines et animales. D'autres, outre leur rôle vecteur, sont un véritable fléau par les piqûres douloureuses qu’ils occasionnent et, constituent de ce fait un grand problème de nuisance. L'identification précise et la connaissance de la biodiversité fonctionnelle des vecteurs est un pas essentiel pour la compréhension du risque de (ré)-émergence et la dynamiques des maladies vectorielles. Le présent travail est une étude rétrospective des inventaires des Culicidae réalisés sur le terrain dans la région du M’Zab (Ghardaïa, Algérie) durant les années allant de 2008 à 2012. Les résultats de l’étude morphotaxonomique des Culicidae inventoriés ont montré la présence de dix espèces réparties en cinq genres (Culex, Culiseta, Ochlerotatus, Anopheles et Uranotaenia). Un aperçu sur le rôle vectoriel des espèces signalées dans la région et leur importance au niveau de la santé médicale et vétérinaire sont présentés à partir des données bibliographiques. Les espèces potentiellement vectrices d’arbovirus (Virus de Nile occidentale et Virus de la Vallée du Rift) et de protozoaires (Plasmodium spp) qui peuvent causer des problèmes épidémiologique au niveau de la région du M’Zab sont Cx. pipiens sl L., 1758, Cx. theileri Theobald, 1903, Ochlerotatus caspius Pallas, 1771, Anopheles sergentii Theobald, 1907, An. dthali Patton, 1905 et An. multicolor Cambouliu, 1902. [less ▲]

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See detailMoustiques de la région du M’Zab: sommes-nous en danger?
Boukraa, Slimane ULg

Conference given outside the academic context (2013)

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See detailLe mouvement des paysans sans terre au Brésil
Schoonbroodt, Bénédicte ULg

Conference (2006, May 08)

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See detailLe mouvement du désordre. Voyage au bout de la nuit par la Societas Raffaello Sanzio
Delhalle, Nancy ULg

Article for general public (1999)

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See detailLe mouvement étudiant devant M. Lacan
Cavazzini, Andrea ULg

Scientific conference (2010, March 20)

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See detailLe mouvement historiographique en Belgique
Kurth, Godefroid ULg

in Ned, Edouard (Ed.) L'Énergie belge, 1830-1905 : l'opinion d'une élite (1906)

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See detailLe mouvement intéllectuel et artistique en Espagne durant le premier tiers du 20e siècle
Ceballos Viro, Alvaro ULg

Conference given outside the academic context (2011)

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See detailLes Mouvements d’auteur du cinéma d’animation moderne belge
Tomasovic, Dick ULg

in Moins, Philippe (Ed.) Image par image, le cinéma d’animation en communauté Wallonie-Bruxelles (2001)

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See detailMouvements d'une histoire
Delhalle, Nancy ULg

in Vreux, Benoît (Ed.) Jouer le jeu. De l'autre côté du théâtre belge (2009)

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See detailMouvements de jeunes et socialisation politique; la dynamique de la J.É.C. à l'époque de Gérard Pelletier
Fournier, Bernard ULg

Book published by Laboratoire d'études politiques et administratives (1989)

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See detailLes mouvements Maï Maï de la République Démocratique du Congo. D'où viennent-ils et qui sont-ils?
Kabamba, Bob ULg

in International Documentation Network on the Great African Lakes Region (1999)

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See detailMouvements rythmés de la tête isolée de la Tortue terrestre
Fredericq, Léon ULg

in Archives Internationales de Physiologie (1926), XXVII

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See detailMovement behaviour of the small benthic Rhine sculpin Cottus rhenanus (Freyhof, Kottelat & Nolte, 2005) as revealed by radio-telemetry and pit-tagging
Ovidio, Michaël ULg; Detaille, Aurelie; Bontinck, Charlotte et al

in Hydrobiologia (2009), 636(1), 119-128

From February 2006 to June 2007, we followed the movement patterns of the Rhine sculpin (Cottus rhenanus) by combining short-term radio-telemetry (n = 10 radio-tagged sculpin with a miniature 0.5-g ... [more ▼]

From February 2006 to June 2007, we followed the movement patterns of the Rhine sculpin (Cottus rhenanus) by combining short-term radio-telemetry (n = 10 radio-tagged sculpin with a miniature 0.5-g transmitter) and long-term individual (PIT-tag) mark-recapture (n = 452 PIT-tagged sculpin during six removal electric fishing operations) studies in a small tributary of the River Meuse, Belgium. During a 25- to 27-day period, the radio-tracked sculpin displayed various mobility patterns, showing frequent movement from one day to another and longitudinal home ranges from 7 to 46 m, with cumulative distances up to 149 m. During the mark-recapture study, most (99%) recaptured PIT-tagged individuals moved from their original 5-m long site, subsequently using longitudinal home ranges between 5 and 435 m (mean, 50 m; median, 20 m). The most common movement behaviour was alternation between upstream and downstream movements (62%), followed by directional upstream (26%) and directional downstream (11%) movement. Using the latest available techniques, this study builds on the current knowledge on the Cottus genus and closes gaps in the comprehension of sculpin movement and home range at a scale that had not been investigated to date. [less ▲]

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See detailMovement patterns and spawning activity of individual nase Chondrostoma nasus (L.) in flow-regulated and weir-fragmented rivers
Ovidio, Michaël ULg; Philippart, Jean-Claude ULg

in Journal of Applied Ichthyology (2008), 24(3), 256-262

Eighteen adult nase Chondrostoma nasus (L.) (37.6-48.2 cm FL) from three highly fragmented Belgian rivers were tagged with surgically implanted radio transmitters and manually tracked from the banks of ... [more ▼]

Eighteen adult nase Chondrostoma nasus (L.) (37.6-48.2 cm FL) from three highly fragmented Belgian rivers were tagged with surgically implanted radio transmitters and manually tracked from the banks of the rivers for 3-34 weeks. Their movements were mainly recorded during the circum reproduction period in 2001, 2002 and 2006 in river stretches delimited by physical barriers and/or minimum flow conditions. To reach the spawning grounds, nase displayed different patterns of movements that were mainly influenced by the configuration of the study site, the date of observation and the associated environmental conditions. Nase never cleared any physical obstacle but were able to spawn in minimum flow conditions or just downstream from physical obstacles. Nase were present on spawning grounds in late March in the warmest spring (2001) and from mid-April to early May in the coldest spring (2006). After spawning, a major proportion of C. nasus migrated a substantial distance downstream, whereas others remained near their capture site and showed frequent movements, sometimes corresponding to group displacements from one river to another. [less ▲]

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See detailMovement patterns, spatial distribution and depth preference by individual whitefish, Coregonus lavaretus in a small artificial lake
Ovidio, Michaël ULg; Neus, Yvan ULg; Rimbaud, Gilles ULg et al

in Folia Zoologica (2006), 55(4), 375-385

Using manual acoustic tracking our study quantified (1) the spatial distribution (2) the movement patterns and (3) the depth preference of adult whitefish, Coregonus lavaretus in it small artificial lake ... [more ▼]

Using manual acoustic tracking our study quantified (1) the spatial distribution (2) the movement patterns and (3) the depth preference of adult whitefish, Coregonus lavaretus in it small artificial lake of eastern Belgium were the species was introduced in 1978 for recreational fishing. From June to October 2004, n=6 C. lavaretus (LF 285-519 mm) were tracked (pingers and depth sensor transmitters) from a small boat over periods ranging from 98 to 108 days in Robertville Lake (elevation: 490 m; area: 63 ha max. depth: 47 in). Whitefish were consistently mobile but showed quite variable lake use patterns. Two individuals traveled the entire length and breadth of the lake, whereas others remained in movement in the deep zone in the middle part of the lake or near the retaining darn wall. Whitefish occupied positions in the water column ranging front 2.6 to 27.0 m (mean 12.7 +/- 5.6 m) that varied depending on individuals. This first study on individual whitefish behaviour provides a better understanding of the behavioural ecology of the species in small artificial lake. [less ▲]

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