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Peer Reviewed
See detailImpact of Percutaneous Oestradiol Gels in Postmenopausal Hormone Replacement Therapy on Clinical Symptoms and Endometrium
Foidart, Jean-Michel ULiege; Beliard, Aude ULiege; Hedon, B. et al

in British Journal of Obstetrics & Gynaecology (1997), 104(3), 305-10

OBJECTIVE: To compare the effects on endometrium, climacteric symptoms and the menstrual cycle, and the clinical and biological tolerance of two percutaneous oestradiol gels used as hormone replacement ... [more ▼]

OBJECTIVE: To compare the effects on endometrium, climacteric symptoms and the menstrual cycle, and the clinical and biological tolerance of two percutaneous oestradiol gels used as hormone replacement therapy. DESIGN: A large open randomised multicentre study. SETTING: France and Belgium. PARTICIPANTS: Two-hundred and fifty-four women with an intact uterus and who had experienced a natural menopause received either Oestrogel (n = 126) or Estreva, a new formulation of oestradiol gel (n = 128), (1.5 mg of oestradiol/day) for the 24 first days of each calendar month during six consecutive months. Nomegestrol acetate (Lutenyl), a norprogesterone derivative, was administered (5 mg/day) from day 11 to day 24 of each oestradiol cycle. MAIN OUTCOME MEASURES: Examination of endometrial biopsies taken before treatment and between days 18 and 24 of the last treatment cycle, climacteric symptoms assessed using a modified Kupperman index, control of menstrual cycle evaluated by diary cards, and clinical and biological tolerance. RESULTS: Both treatments lowered the frequency and intensity of hot flushes and the global Kupperman index. 96% of the cycles were followed by withdrawal bleeding. Breakthrough bleeding or spotting resulted in premature discontinuation of treatment in one volunteer. Mastodynia occurred in 20 women and contributed to the premature termination of treatment in three of them. Endometrial biopsies taken at the end of treatment showed identical histologies in both groups, with a secretory pattern in the majority of women, and absence of hyperplasia. CONCLUSIONS: This trial confirmed that, when the two oestradiol gels tested were administered cyclically with nomegestrol acetate to postmenopausal women, they were well tolerated, effective and suitable for the treatment of oestrogen deficiency syndrome. [less ▲]

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See detailImpact of performance anxiety on the accuracy of the singing voice among music students
Larrouy, Pauline ULiege; Clijsters, Céline; Morsomme, Dominique ULiege

Poster (2012, May 31)

Performance anxiety causes physical and cognitive symptoms. This emotional state can affect the vocal features thus the fundamental frequency which is the main parameter to evaluate the singing voice ... [more ▼]

Performance anxiety causes physical and cognitive symptoms. This emotional state can affect the vocal features thus the fundamental frequency which is the main parameter to evaluate the singing voice accuracy. The aim of this study is to observe the impact of performance anxiety on the singing voice accuracy. 31 music students from the Royal Conservatories of Belgium sang a melody three times. Twice in quiet situations and one time in a stress situation (the day of the examination). This performance was rated by a panel of teachers. The anxiety level was controlled by measuring the heart frequency. We analyzed errors concerning the interval accuracy and the respect of the tonal center. We observe that the heart frequency is significantly higher in the stress situation (F(2,28)=15,18 ; p<.001), especially for advanced students. The students have difficulty to maintain the tonal center (F(2,12)=7,17 ; p=.03), whereas the accuracy of the intervals is not altered (F(2,12)=1,1 ; p=.56). The rating of the jury correlates with interval accuracy (r=-.411; p=.03) and respect of the tonal center (r=-.452; p=.016), particularly at the beginning of the melody (r=-.516; p=.005). To conclude, performance anxiety leads to an increase of the heart frequency and alters the respect of the tonal center. This is particularly the case for advanced students for whom this situation is a real challenge. [less ▲]

Detailed reference viewed: 133 (21 ULiège)
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See detailImpact of Pharyngo laryngeal Reflux on voice quality by using the RFS and RSI on 96 subjects.
Morsomme, Dominique ULiege; Sugameli, Mélanie; Verduyckt, Ingrid

Conference (2010, June 05)

Pharyngo Laryngeal Reflux (PLR) influences the voice quality : hoarseness, vocal fatigue and hypertonia (Shaw et al, Hopkins et al). Our goal is to measure the influence of the PLR on the voice of 96 ... [more ▼]

Pharyngo Laryngeal Reflux (PLR) influences the voice quality : hoarseness, vocal fatigue and hypertonia (Shaw et al, Hopkins et al). Our goal is to measure the influence of the PLR on the voice of 96 subjects by using the Belafsky’s reflux symptom index (RSI) and reflux finding score (RFS). 46 dysphonic patients (26M/24F) constitute the experimental group (EG) and 50 subjects (13 M/33F) without vocal or gastric complaint the control group (CG). All are evaluated by subjective measures (RSI), D-type scale (DS-16, Denollet et al) and objective measures (Video Laryngo Stroboscopy, RFS). The EG shows a RSI score significantly higher on test than on the retest (p=0.002). The specificity of the RSI calculated on the CG amounts to 98 % (chi ²: p < 0,05, Cramer: 0,678). The EG scores are significantly higher than those of the CG (p=0,000) although the CG obtains scores significantly higher as for the eating risk habits (p=0,001). In the EG, we note a correlation between the coffee consumption, the item 9 (pyrosis) (rho: 0,32; p < 0,05 ) and the global RSI score (rho: 0,35; p < 0,05). In the CG, alcohol consumption influences significantly the item 9 (rho: 0,47). The correlations between RSI and RFS are not significant (p < 0.05). The ENT evaluation is severe and probably influences the result. We observe no influence of the gender and of the D-type scale on the RSI scores (p <0.05). The RSI scale is an interesting tool for the detection of RPL. [less ▲]

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See detailImpact of phenotypic heterogeneity and metabolic specialisation on metabolic engineering strategies: case of study of E.coli as a representative microbial cell factory
Brognaux, Alison ULiege; Delepierre, Anissa ULiege; Pecheux, Hélène ULiege et al

Conference (2015, July 21)

The goal of this research is to directly highlight the simultaneous occurrence of several phenotypes with distinct metabolic function among clonal population of E. coli., often used for recombinant ... [more ▼]

The goal of this research is to directly highlight the simultaneous occurrence of several phenotypes with distinct metabolic function among clonal population of E. coli., often used for recombinant protein and pDNA production in bioprocesses. This phenotypic heterogeneity, first due to the noise, is reinforced by environmental heterogeneities occurring at large scale during fed-batch processes. This phenotypic heterogeneity has been tracked according to GFP reporter strains (biosensors) that circulate in the bioreactor and encounter environmental heterogeneities. First, we have highlighted the simultaneous occurrence of several phenotypes with distinct metabolic functions. Indeed, a diversity of glucose uptake strategies has recently been noticed with the PtsG and MglABC transporters. Moreover, when E.coli encounters zones of glucose excess, acetate is produced through the overflow metabolism. Only the sub-population with high acs expression (acetate transporter) could consume this acetate. GFP reporter strains have thus been constructed for PtsG, MgIABC and acs genes. In addition of the stable GFP, two destabilized GFP variants for each gene have been used to obtain more instantaneous responses. The response of these biosensors have been followed by on-line flow cytometry. In the end, this experimental strategy for direct phenotyping at the single cell level will also be used to investigate the impact of metabolic engineering strategies on phenotypic heterogeneity, robustness and fitness of microbial population in industrial conditions. [less ▲]

Detailed reference viewed: 119 (14 ULiège)
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See detailImpact of phonological awareness on reading and writing in Down’s syndrome
Frenkel, Stéphanie ULiege; Vicari, Stefano

Conference (2010, June)

Detailed reference viewed: 20 (3 ULiège)
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See detailImpact of physical properties of inulin on stability during moisture sorption.
Ronkart, Sébastien; Paquot, Michel ULiege; Fougnies, C. et al

Poster (2008, July)

Detailed reference viewed: 44 (5 ULiège)
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See detailImpact of place of residence on relationship between quality of life and cognitive decline in dementia
Missotten, Pierre ULiege; Thomas, Philippe; Squelard, Gilles ULiege et al

in Alzheimer Disease and Associated Disorders (2009), 23(4), 395-400

The aim of this descriptive study was to estimate and compare the association between cognitive decline and quality of life (QOL) for 2 groups of dementia patients differing by place of residence: home or ... [more ▼]

The aim of this descriptive study was to estimate and compare the association between cognitive decline and quality of life (QOL) for 2 groups of dementia patients differing by place of residence: home or institution. Each subject was placed within a specific subgroup according to their Mini-Mental State Examination (MMSE) score and was evaluated by a QOL proxy-assessment [Alzheimer Disease Related Quality of Life (ADRQL)] and a dependency assessment (Katz Activities of Daily Living classification). For the ‘‘at home’’ and ‘‘institution’’ groups, global and subscale ADRQL scores showed significant differences between the 5 MMSE subgroups. Place of residence and MMSE subgroups significantly affected global and subscale ADRQL scores. The MMSE 4 to 8, 9 to 13, and 14 to 18 subgroups had ADRQL global scores significantly better in the institution group than the at home group. In contrast, the MMSE 19 to 23 and 0 to 3 subgroups had similar ADRQL global scores in both places of residence. In conclusion, there is no direct relationship between cognitive decline and QOL, and QOL does not seem to be better at home compared with the institution. [less ▲]

Detailed reference viewed: 90 (5 ULiège)
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See detailImpact of pollen resources drift on common bumble bees in NW Europe
Roger, Nathalie; Moerman, Romain; Carvalheiro, Luisa et al

Conference (2016)

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See detailImpact of pollen resources drift on common bumblebees in NW Europe
Roger, N.; Moerman, R.; Carvalheiro, L. G. et al

in Global Change Biology (2017), 23(1), 68-76

Several bee species are experiencing significant population declines. As bees exclusively rely on pollen for development and survival, such declines could be partly related to changes in their host plant ... [more ▼]

Several bee species are experiencing significant population declines. As bees exclusively rely on pollen for development and survival, such declines could be partly related to changes in their host plant abundance and quality. Here, we investigate whether generalist bumblebee species, with stable population trends over the past years, adapted their diets in response to changes in the distribution and chemical quality of their pollen resources. We selected five common species of bumblebee in NW Europe for which we had a precise description of their pollen diet through two time periods (‘prior to 1950’ and ‘2004–2005’). For each species, we assessed whether the shift in their pollen diet was related with the changes in the suitable area of their pollen resources. Concurrently, we evaluated whether the chemical composition of pollen resources changed over time and experimentally tested the impact of new major pollen species on the development of B. terrestris microcolonies. Only one species (i.e. B. lapidarius) significantly included more pollen from resources whose suitable area expanded. This opportunist pattern could partly explain the expansion of B. lapidarius in Europe. Regarding the temporal variation in the chemical composition of the pollen diet, total and essential amino acid contents did not differ significantly between the two time periods while we found significant differences among plant species. This result is driven by the great diversity of resources used by bumblebee species in both periods. Our bioassay revealed that the shift to new major pollen resources allowed microcolonies to develop, bringing new evidence on the opportunist feature of bumblebee in their diets. Overall, this study shows that the response to pollen resource drift varies among closely related pollinators, and a species-rich plant community ensures generalist species to select a nutrient-rich pollen diet. © 2016 John Wiley & Sons Ltd [less ▲]

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See detailImpact of polyunsaturated fatty acid degradation on survival and acidification activity of freeze-dried Weissella paramesenteroides LC11 during storage
Yao, Amenan Anastasie ULiege; Coulibaly, Ibourahema ULiege; Lognay, Georges ULiege et al

in Applied Microbiology & Biotechnology (2008), 79(6), 1045-1052

Abstract The impact of polyunsaturated fatty acid (PUFA) degradation on the survival and acidification activity of freeze-dried Weissella paramesenteroides LC11 was investigated over 90-days storage at 4 ... [more ▼]

Abstract The impact of polyunsaturated fatty acid (PUFA) degradation on the survival and acidification activity of freeze-dried Weissella paramesenteroides LC11 was investigated over 90-days storage at 4 °C or 20 °C in vacuumsealed aluminium foil or glass tubes with two water activities (aw=0.11 or 0.23). Colony counts, acidification activity (% lactic acid/g), linoleic/palmitic (18:2/16:0) or linolenic/palmitic (18:3/16:0) ratio by gas chromatography and 18:2 or 18:3 oxylipins by reversed phase-high performance liquid chromatography were determined. The viable cells, acidification activity and 18:2/16:0 or 18:3/ 16:0 ratio decreased as the storage time increased. The survival, acidification activity and 18:2/16:0 or 18:3/16:0 ratio were greatest for the freeze-dried strain held in vacuum-sealed aluminium foil at 4 °C. The 18:2/16:0 or 18:3/16:0 ratio decrease was correlated with the accumulation of 18:2 or 18:3 oxylipins during storage in glass tubes. Hydroperoxy PUFAs, hydroxy PUFAs, divinyl ether PUFAs and oxo PUFAs were the main oxylipins identified. A large decrease in the 18:2/16:0 or 18:3/16:0 ratio and a rapid accumulation of oxylipins during storage might be enough to cause high cell death and loss of metabolic activity. These results provide further experimental support for the hypothesis that lipid oxidation and survival or activity of freeze-dried bacteria might be related. [less ▲]

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See detailImpact of poor adherence to bisphosphonates therapy on hip fracture risk in osteoporotic women
Rabenda, Véronique ULiege; Fabri, Véronique; Mertens, Raf et al

in Arthritis and Rheumatism (2007, September), 56(number 9 (suppl.)), 271

Detailed reference viewed: 12 (4 ULiège)
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See detailImpact of poplar trees on the soil water dynamics of a maize field in West-Flanders
Coussement, Tom; Janssens, Pieter; Elsen, Annemie et al

Conference (2017, February 15)

Detailed reference viewed: 20 (1 ULiège)
Peer Reviewed
See detailImpact of population history on Viola calaminaria conservation, an endemic species of calamine sites
Bizoux, Jean-Philippe ULiege; Mahy, Grégory ULiege

Conference (2011, June)

The zinc violet, Viola calaminaria is a threatened species, endemic to calamine sites in Belgium and West Germany. Since the end of 19th century, the V. calaminaria habitat network have exhibited a huge ... [more ▼]

The zinc violet, Viola calaminaria is a threatened species, endemic to calamine sites in Belgium and West Germany. Since the end of 19th century, the V. calaminaria habitat network have exhibited a huge dynamics, with creation of new habitats resulting from industrial pollution and destruction of habitats by urbanisation and site remediation. In the present study, we analysed the effect of population history (recent/ancient population) on genetic diversity, fitness and reproductive success in order to discuss conservation strategies for the species. Recently founded populations exhibited similar level of genetic diversity (Hs) as ancient populations but showed a lower genetic differentiation among population (Fst). No indication of strong founder effects in recently established populations was detected. Plant fitness (seed set and germination percentage) was higher in recent populations while other reproductive traits (vegetative density, flower density, fructification percentage) did not differ according to population history. Results suggest that the creation of habitats through human activities can provide new opportunities for conservation of this species. In increasingly disturbed environments, this indicates that, at least for some species, conservation strategies should not focus solely on traditional and natural habitats but also consider the potential benefits offered by modified landscapes. [less ▲]

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See detailImpact of postural education on child’s sitting position in classroom and on back pain
Fettweis, Tatiana ULiege; Nattier, Elodie; Vanderthommen, Marc ULiege

Poster (2016, November)

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See detailImpact of Pre-Transplant Anti-T Cell Globulin (ATG) on Immune Recovery after Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation.
SERVAIS, Sophie ULiege; Menten-Dedoyart, Catherine; Beguin, Yves ULiege et al

in PloS one (2015), 10(6), 0130026

BACKGROUND: Pre-transplant infusion of rabbit anti-T cell globulin (ATG) is increasingly used as prevention of graft-versus-host disease (GVHD) after allogeneic peripheral blood stem cell transplantation ... [more ▼]

BACKGROUND: Pre-transplant infusion of rabbit anti-T cell globulin (ATG) is increasingly used as prevention of graft-versus-host disease (GVHD) after allogeneic peripheral blood stem cell transplantation (PBSCT). However, the precise impact of pre-transplant ATG on immune recovery after PBSCT is still poorly documented. METHODS: In the current study, we compared immune recovery after myeloablative PBSCT in 65 patients who either received (n = 37) or did not (n = 28) pre-transplant ATG-Fresenius (ATG-F). Detailed phenotypes of circulating T, B, natural killer (NK) and invariant NKT (iNKT) cells were analyzed by multicolor flow cytometry at serial time-points from day 40 to day 365 after transplantation. Thymic function was also assessed by sjTREC quantification. Serious infectious events were collected up to 2 years post-transplantation. RESULTS: Pre-transplant ATG-F had a prolonged (for at least up to 1-year) and selective negative impact on the T-cell pool, while it did not impair the recovery of B, NK nor iNKT cells. Among T cells, ATG-F selectively compromised the recovery of naive CD4+, central memory CD4+ and naive CD8+ cells, while it spared effector memory T and regulatory T cells. Levels of sjTRECs were similar in both cohorts at 1-year after PBSCT, suggesting that ATG-F unlikely impaired thymopoiesis at long-term after PBSCT. Finally, the incidence and rate of serious infections were similar in both groups, while ATG-F patients had a lower incidence of grade II-IV acute graft-versus-host disease. CONCLUSIONS: Pre-transplant ATG-F induces long-lasting modulation of the circulating T-cell pool after myeloablative PBSCT, that may participate in preventing graft-versus-host disease without deeply compromising anti-pathogen defenses. [less ▲]

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See detailImpact of pre-treatment processing on cereal by-products valorisation through enzymatic extraction of ferulic acid.
Barberousse, Hélène; Roiseux, Olivier; Deroanne, Claude et al

Poster (2008, June)

Detailed reference viewed: 34 (3 ULiège)