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See detailThe new 2011 ACCF/AHA Guidelines on Coronary Artery Bypass Grafting Surgery: are they different from the 2010 ESC/EACTS Guidelines on Myocardial Revascularisation?
Kolh, Philippe ULg; Sousa Uva, Miguel; Wijns, William

in EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2012), 8(1), 33-4

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See detailNew 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as putative KATP channel openers: design, synthesis and pharmacological evaluation
Somers, F.; De Tullio, Pascal ULg; Boverie, S. et al

in Fundamental & Clinical Pharmacology (1999), 13

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See detailNew 3-deoxyanthocyanidins from leaves of Arrabidaea chica
Devia, B.; Llabres, Gabriel ULg; Wouters, J. et al

in Phytochemical Analysis [=PCA] (2002), 13(2, Mar-Apr), 114-120

Two new 3-deoxyanthocyanidins, 6,7,3',4'-tetrahydroxy-5-methoxyflavylium and 6,7,4'-trihydroxy-5-methoxyflavylium, and the pigment carajurin, which has been previously identified, were isolated from dried ... [more ▼]

Two new 3-deoxyanthocyanidins, 6,7,3',4'-tetrahydroxy-5-methoxyflavylium and 6,7,4'-trihydroxy-5-methoxyflavylium, and the pigment carajurin, which has been previously identified, were isolated from dried leaves of Arrabidaea chica, a creeper native to the American tropics. The structures of the components were elucidated by H-1- and C-13-NMR spectroscopy and HPLC-MS, including X-ray crystallographic analysis for carajurin. Copyright (C) 2002 John Wiley Sons, Ltd. [less ▲]

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See detailA new 48, XXYY/47, XYY syndrome associated with multiple skeletal abnormalities, congenital heart disease and mental retardation.
Mutesa, Leon; JAMAR, Mauricette ULg; PIERQUIN, Geneviève ULg et al

in Indian journal of human genetics (2012), 18(3), 352-5

While the XYY and XXYY syndromes have been several time described in patients, the combination of both syndromes in an individual is a rare event and may result in a severe phenotype. In the present ... [more ▼]

While the XYY and XXYY syndromes have been several time described in patients, the combination of both syndromes in an individual is a rare event and may result in a severe phenotype. In the present observation, a boy with congenital scoliosis due to segmented thoracic hemivertebra associated with radioulnar synostosis and congenital heart disease is described. Chromosome G-banding and FISH analysis demonstrated a de novo mosaic karyotype 48, XXYY/47, XYY in this patient. To the best of our knowledge, this is the first report of a combination of XYY and XXYY syndromes. [less ▲]

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See detailNew 5-Aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting.
Mathieu, Véronique; Van Den Brege, E; Ceusters, Justine ULg et al

in Journal of Medicinal Chemistry (2013), 56(17), 6626-6637

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See detailA new acute respiratory distress syndrome in newborn calves : clinical, laboratory and post-mortem findings
Dardenne, A; Danlois, F; Rollin, Frédéric ULg et al

in In Proceedings of the 15th Comparative Respiratory Society Meeting (1997)

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See detailNew acylnitroso compounds for the asymetric oxyamination of dienes
Gouverneur, Véronique; Mc Carthy, S. J.; Mineur, C. et al

in Tetrahedron (1998), 54(35), 10537-10554

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See detailNew Advances for In Situ Protein Identification by MALDI In-Source Decay FTMS Imaging
Calligaris, David; Longuespée, Rémi ULg; Zimmerman, Tyler et al

Poster (2012, November)

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See detailNew Advances for In Situ Protein Identification by MALDI In-Source Decay FTMS Imaging
Calligaris, David ULg; Zimmerman, Tyler ULg; Debois, Delphine ULg et al

Poster (2012, April 18)

MALDI imaging mass spectrometry has proven to be effective for the discovery and the monitoring of disease-related proteins. With this technique a molecular analysis could be performed directly from ... [more ▼]

MALDI imaging mass spectrometry has proven to be effective for the discovery and the monitoring of disease-related proteins. With this technique a molecular analysis could be performed directly from tissue sections in the region of the diseased area. The use of in-source decay (ISD), allowing fast and reliable sequences assignments of proteins termini, has proven to be a crucial tool for proteins identification in solution and tissue slices. However, it is necessary to develop additional tools that allow unambiguous assignment of proteins sequences in complex tissue slices. The development of bioinformatic tools and the use of ultra-high mass resolution and high mass accuracy of Fourier transform ion-cyclotron (FTICR) mass spectrometry are ideal for this purpose. In this study, we show that FTICR mass spectrometry combined with data filtering with a software that subtracts matrix peaks aid protein identification. All measurements were carried out on a SolariX FTMS (9.4 Tesla) equipped with a Dual Source with a smartbeamTMII laser (Bruker Daltonics). Mouse brain tissue slices of 14 µm thickness were rinsed to obtain optimal sensitivity and high-quality ions. Before matrix application, a spot of myelin was deposited near mouse brain. 1,5-Diaminionaphtalene was sprayed using an ImagePrep (Bruker Daltonics). Results were interpreted using BioToolsTM 3.2 in combination with MascotTM (Matrix Science) for ISD spectra and FlexImagingTM 3.0 for MALDI-ISD imaging experiments. Matrix peaks were subtracted using an in-house written Java code that sequentially scans all peak lists from acquired spectra against the DAN mass list. Then, another Java code allows to create 2D ion images at selected m/z ratios. The studies were carried out by MALDI-ISD imaging to create interest on FTICR mass spectrometer for proteins identification in the field of biomarkers characterization. It is demonstrated that protein ISD leads to the same pattern of fragmentation observed during MALDI-TOF analyzes. Fragmentation generates cn- and zn-series ions of myelin in presence of DAN. The internal calibration of all the data provides a mass accuracy neighboring 2.5 ppm over the m/z range of interest (300-2500 Da) and a mass resolution of 70000 at m/z 400 Da. It allows the assignment of ISD fragments of proteins in the low mass range (m/z between 300 and 900) that is unambiguously validated by the “ISD signal” recorded from the spots of pure protein solution (myelin) near tissue slice. Moreover, the use of our software “cleans” MS imaging data by reducing/eliminating MALDI matrix peaks that are isobaric to an analyte peak. Novel aspect This study evidences the main input of FTICR mass spectrometer for pathologies diagnosis based on biomarkers localization and identification by MALDI-ISD imaging. [less ▲]

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See detailNew advances in asteroseismology of pulsating hot subdwarf stars
Charpinet, S.; Van Grootel, Valérie ULg; Randall, S. K. et al

in Highlights of Astronomy (2010, November 01), 15

Hot subdwarf stars (of the sdB and sdO type) host three known classes of nonradial pulsators. Two of them feature short period (P ~ 60 - 600 s) accoustic mode oscillations, while the third group is ... [more ▼]

Hot subdwarf stars (of the sdB and sdO type) host three known classes of nonradial pulsators. Two of them feature short period (P ~ 60 - 600 s) accoustic mode oscillations, while the third group is characterized by slow g-mode deformations with periods of ~ 1 - 2h. These pulsations offer favorable grounds to infer some of the internal properties of these objects through asteroseismology. This has been exploited for the rapid p-mode sdB pulsators and the present contribution reviews some of the recent advances in this field. The long period g-mode pulsators, whose vibrations probe much deeper inside the star, are also of high interest. With the advent of space observations using CoRoT and KEPLER, the asteroseismology of these slower oscillators will also become a possibility, and likely contribute to significant breakthroughs in our understanding of these hot and compact stars. [less ▲]

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See detailNew advances in method validation and measurement uncertainty aimed at improving the quality of chemical data
Feinberg, M.; Boulanger, Bruno ULg; Dewé, Walthère ULg et al

in Analytical and Bioanalytical Chemistry (2004), 380(3), 502-514

The implementation of quality systems in analytical laboratories has now, in general, been achieved. While this requirement significantly modified the way that the laboratories were run, it has also ... [more ▼]

The implementation of quality systems in analytical laboratories has now, in general, been achieved. While this requirement significantly modified the way that the laboratories were run, it has also improved the quality of the results. The key idea is to use analytical procedures which produce results that fulfil the users' needs and actually help when making decisions. This paper presents the implications of quality systems on the conception and development of an analytical procedure. It introduces the concept of the life-cycle of a method as a model that can be used to organize the selection, development, validation and routine application of a method. It underlines the importance of method validation, and presents a recent approach based on the accuracy profile to illustrate how validation must be fully integrated into the basic design of the method. Thanks to the beta-expectation tolerance interval introduced by Mee (Technometrics (1984) 26(3):251-253), it is possible to unambiguously demonstrate the fitness for purpose of a new method. Remembering that it is also a requirement for accredited laboratories to express the measurement uncertainty, the authors show that uncertainty can be easily related to the trueness and precision of the data collected when building the method accuracy profile. [less ▲]

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See detailNew Advances in the Understanding of the In-Source Decay Fragmentation of Peptides in MALDI-TOF-MS.
Demeure, Kevin ULg; Gabelica, Valérie ULg; De Pauw, Edwin ULg

in Journal of the American Society for Mass Spectrometry (2010), 21(11), 1906-17

In-source decay (ISD) is a rapid fragmentation occurring in the matrix-assisted laser desorption/ionization (MALDI) source before the ion extraction. Despite the increasing interest for peptides de novo ... [more ▼]

In-source decay (ISD) is a rapid fragmentation occurring in the matrix-assisted laser desorption/ionization (MALDI) source before the ion extraction. Despite the increasing interest for peptides de novo sequencing by ISD, the influence of the matrix and of the peptide itself is not yet fully understood. Here we compare matrices with high ISD efficiencies to gain deeper insight in the ISD fragmentation process(es). The major ISD fragments are the c- and z-ions, but other types of fragments are also observed, and their origin is studied here. Two main pathways lead to fragmentation in the source: a radical-induced pathway that leads to c-, z-, w-, and d-ions, and a thermally activated pathway that leads to y-, b-, and a-ions. A detailed analysis of the ISD spectra of selected peptides revealed that (1) the extents of the two in-source pathways are differently favored depending on the matrix used, that (2) the presence of a positive/negative charge on the radical-induced fragments is necessary for their observation in positive/negative mode, respectively, and that (3), for a same peptide, the patterns of the different types of fragments differ according to the matrix used. [less ▲]

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See detailNew alginate-chitosan hydrogel beads with anti-inflammatory and anabolic effects on human chondrocytes
Oprenyeszk, Frédéric ULg; Sanchez, Christelle ULg; Dubuc, Jean-Emile et al

in Arthritis and Rheumatism (2011), 63(10), 697

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See detailNew alginate-chitosan hydrogel beads with anti-inflammatory and anabolic effects on human chondrocytes
Oprenyeszk, Frédéric ULg; Mathy, Marianne ULg; Sanchez, Christelle ULg et al

in Osteoarthritis and Cartilage (2011), 19(Suppl 1), 222

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See detailNew algorithm concept for a model of mixed lubrication in cold rolling
STEPHANY, A.; Ponthot, Jean-Philippe ULg; COLLETTE, C. et al

in Proceedings of METEC 2003, European Rolling Conference (2003)

Detailed reference viewed: 17 (1 ULg)