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See detailMultiple domains of the glucocorticoid receptor involved in synergism with the CACCC box factor(s).
Muller, Marc ULg; Baniahmad, C.; Kaltschmidt, C. et al

in Molecular Endocrinology (Baltimore, Md.) (1991), 5(10), 1498-503

Steroid induction of responsive genes functions through the synergistic activity of steroid receptor-binding sequences with adjacent transcription factor-binding sites. To analyze the mechanism of synergy ... [more ▼]

Steroid induction of responsive genes functions through the synergistic activity of steroid receptor-binding sequences with adjacent transcription factor-binding sites. To analyze the mechanism of synergy we tested different human glucocorticoid receptor mutants for synergistic function with another transcription factor in comparison with intrinsic trans-activation obtained with a single receptor binding site (glucocorticoid response element). Multiple domains were found to be involved in synergistic activity of the glucocorticoid receptor with the CACCC box factor. Deletions within the N-terminal receptor half affected simultaneously intrinsic trans-activation and synergism. However, deletion of the hormone-binding domain mainly impaired synergism rather than intrinsic trans-activation, clearly showing that this domain synergizes by a mechanism independent of intrinsic activation. A chimeric protein where the DNA-binding domain of the glucocorticoid receptor was replaced by that of the yeast GAL4 protein also showed functional synergism. These data suggest that some of the receptor domains outside the DNA-binding domain synergize by their intrinsic trans-activating property, but the hormone-binding domain contributes to synergism by a different mechanism. [less ▲]

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See detailMultiple Endocrine Neoplasia 1 : From the clinic to the gene
Beckers, Albert ULg

Scientific conference (1998, January 30)

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See detailMultiple Endocrine Neoplasia, type 1
Beckers, Albert ULg

Scientific conference (2001, February 09)

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See detailMultiple exposure holographic interferometry with sillenite crystals applied to vibration measurement
Georges, Marc ULg; Thizy, Cédric ULg; Lemaire, Philippe ULg et al

in Nolte, D.; Salamo, G.; Siahmakoun, A. (Eds.) et al Photorefractive Effects, Materials, and Devices (2001, July)

A holographic camera is presented, which uses a sillenite crystal as dynamic recording medium. The camera operates in a pulse regime and is used to provide vibration analysis of an object. A 4 pulse real ... [more ▼]

A holographic camera is presented, which uses a sillenite crystal as dynamic recording medium. The camera operates in a pulse regime and is used to provide vibration analysis of an object. A 4 pulse real-time holographic technique was implemented to measure the amplitude and phase of the vibration. The implementation of this technique required bringing under control a Q-switched YAG laser. We present the experimental results for a metallic plate driven by a vibrating loud speaker. [less ▲]

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See detailMultiple feedback loops in circadian cycles: robustness and entrainment as selection criteria
Hafner, Marc; Sacré, Pierre ULg; Symul, Laura et al

in Proceedings of the Seventh International Workshop on Computational Systems Biology, WCSB 2010 (2010, June)

This paper discusses the contribution of an additional feedback loop to the entrainment and the robustness of a circadian system. To quantify robustness, we perform a global analysis of the system's ... [more ▼]

This paper discusses the contribution of an additional feedback loop to the entrainment and the robustness of a circadian system. To quantify robustness, we perform a global analysis of the system's parameter space. We quantify the parameter region where the circuit displays an experimentally observed behavior, under entrainment. This global measure is comleted with a classification based on the phase response curve (PRC). For two models of circadian rhythms, we found that the one with two loops is more robust than the one with a single loop: the two-loop model shows better resilience to parameter perturbations and it has also a larger region where the PRC matches experimental PRCs of circadian oscillators. [less ▲]

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See detailMultiple fMRI system-level baseline connectivity is disrupted in patients with consciousness alterations
Demertzi, Athina ULg; Gomez, Francisco; Crone, Julia-Sophia et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 52

Introduction: In healthy conditions, group-level fMRI resting state analyses identify ten resting state networks (RSNs) of cognitive relevance. Here, we aim to assess the tennetwork model in severely ... [more ▼]

Introduction: In healthy conditions, group-level fMRI resting state analyses identify ten resting state networks (RSNs) of cognitive relevance. Here, we aim to assess the tennetwork model in severely brain-injured patients suffering from disorders of consciousness and to identify those networks which will be most relevant to discriminate between patients and healthy subjects. Methods: 300 fMRI volumes were obtained in 27 healthy controls and 53 patients in minimally conscious state (MCS), vegetative state/unresponsive wakefulness syndrome (VS/ UWS) and coma. Independent component analysis (ICA) reduced data dimensionality. The ten networks were identified by means of a multiple template-matching procedure and were tested on neuronality properties (neuronal vs non-neuronal) in a data-driven way. Univariate analyses detected between-group differences in networks’ neuronal properties and estimated voxel-wise functional connectivity in the networks, which were significantly less identifiable in patients. A nearest-neighbor “clinical” classifier was used to determine the networks with high between-group discriminative accuracy. Results: Healthy controls were characterized by more neuronal components compared to patients in VS/UWS and in coma. Compared to healthy controls, fewer patients in MCS and VS/UWS showed components of neuronal origin for the left executive control network, default mode network (DMN), auditory, and right executive control network. The “clinical” classifier indicated the DMN and auditory network with the highest accuracy (85.3%) in discriminating patients from healthy subjects. [less ▲]

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See detailMultiple Frequency Analysis Methods for Blade Tip-Timing Data Analysis
Gallego-Garrido, Jon; Dimitriadis, Grigorios ULg

in Akay, A.; Arnas, O.; Cooper, J. E. (Eds.) et al Proceedings of 7th Biennial ASME Conference on Engineering Systems Design and Analysis (2004, July)

Blade Tip-Timing (BTT) is a method for the measurement of blade vibration in rotating bladed assemblies such as those found in turbomachinery. The system aims to replace strain gauge technology. However ... [more ▼]

Blade Tip-Timing (BTT) is a method for the measurement of blade vibration in rotating bladed assemblies such as those found in turbomachinery. The system aims to replace strain gauge technology. However all current BTT analysis methods fail to recover the correct frequencies when two blade modes are excited simultaneously by a synchronous vibration. In this paper, five new methods that can recover simultaneous frequencies from BTT data are presented. The methods are based on the auto-regressive approach. The approaches make use of data either from a single blade and single revolution or from multiple revolutions. Furthermore, some of the methods are designed to allow for the presence of measurement errors. The techniques are validated on three test cases in which simulated data was used. It is shown that most of the methods produce accurate estimates for the vibration frequency, even in the presence of significant noise levels, provided that a suitable amount of the response waveform is measured. The most consistent estimates are obtained from the methods that make use of data from multiple revolutions. [less ▲]

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See detailMultiple functional variants at the 3p21 locus contribute to ulcerative colitis: Results from a European consortium
Cleynen, I; Artieda, M; Verspaget, H et al

in Journal of Crohn’s and Colitis [=JCC] (2012)

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See detailMultiple material mesh generation for biomedical applications
D'Otreppe, Vinciane ULg; Boman, Romain ULg; Ponthot, Jean-Philippe ULg

in Proceedings of the 9th belgian day on biomedical engineering (2010, November 26)

The finite element method is commonly used in biomedical applications for the simulation of the behaviour of biological structures. However, extracting finite element meshes from medical images is still ... [more ▼]

The finite element method is commonly used in biomedical applications for the simulation of the behaviour of biological structures. However, extracting finite element meshes from medical images is still very challenging. We propose an innovative system to create accurate multiple domain tetrahedral meshes from medical images. Our approach is based on an enhanced Marching Tetrahedra algorithm that extracts the boundary surfaces delimiting the different material domains in an integrated manner. Moreover, a surface reconstruction method is employed to ensure that the resulting mesh is a smooth and accurate surface representation of the original sampled structure. Mesh smoothing and decimation algorithms are also revised to conform to the multiple material nature of the system as well as to adhere to the underlying volume data. [less ▲]

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See detailMultiple Material Mesh Generation For Biomedical Applications
D'Otreppe, Vinciane ULg; Boman, Romain ULg; Ponthot, Jean-Philippe ULg

Poster (2010, November 26)

The finite element (FE) method is commonly used in biomedical applications for the simulation of the behaviour of biological structures. A key component in FE simulation is the creation of a finite ... [more ▼]

The finite element (FE) method is commonly used in biomedical applications for the simulation of the behaviour of biological structures. A key component in FE simulation is the creation of a finite element mesh. In medical applications, the meshes should be directly generated from the medical scans. Moreover, biological structures are usually composed of several inner regions that need to be separately segmented, labelled and meshed to be able to apply different material properties in the finite element model. A procedure to create surface meshes from a multi-valued volume data sets is proposed. Following properties are guaranteed: (1) The generated mesh consists of a set of non manifold triangle meshes that separate each connected component in the labelled data set. These interface meshes join each other consistently along their boundaries, i.e., no T junctions nor gaps may appear. (2) The surface mesh is a geometrically accurate representation of the data represented in the medical scans. However, it is not be tainted by the typical aliasing and staircase artifacts that are due to the discrete nature of the voxels. [less ▲]

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See detailMultiple measures elucidate glucocorticoid responses to environmental variation in predation threat
Clinchy, Michael; Zanette, Liana; Charlier, Thierry ULg et al

in Oecologia (2011), 166

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See detailMultiple mechanisms control brain aromatase activity at the genomic and non-genomic level
Balthazart, Jacques ULg; Baillien, Michelle; Charlier, Thierry ULg et al

in Journal of Steroid Biochemistry & Molecular Biology (2003), 86

Evidence has recently accumulated indicating that aromatase activity in the preoptic area is modulated in parallel by both slow (hours to days) genomic and rapid (minutes to hours) non-genomic mechanisms ... [more ▼]

Evidence has recently accumulated indicating that aromatase activity in the preoptic area is modulated in parallel by both slow (hours to days) genomic and rapid (minutes to hours) non-genomic mechanisms. We review here these two types of control mechanisms and their potential contribution to various aspects of brain physiology in quail. High levels of aromatase mRNA, protein and activity (AA) are present in the preoptic area of this species where the transcription of aromatase is controlled mainly by steroids. Estrogens acting in synergy with androgens play a key role in this control and both androgen and estrogen receptors (ER; alpha and beta subtypes) are present in the preoptic area even if they are not necessarily co-localized in the same cells as aromatase. Steroids have more pronounced effects on aromatase transcription in males than in females and this sex difference could be caused, in part, by a sexually differentiated expression of the steroid receptor coactivator 1 in this area. The changes in aromatase concentration presumably control seasonal variations as well as sex differences in brain estrogen production. Aromatase activity in hypothalamic homogenates is also rapidly (within minutes) down-regulated by exposure to conditions that enhance protein phosphorylation such as the presence of high concentrations of calcium, magnesium and ATP. Similarly, pharmacological manipulations such as treatment with thapsigargin or stimulation of various neurotransmitter receptors (alpha-amino-3-hydroxy-methyl-4-isoxazole propionic acid (AMPA), kainate, and N-methyl-d-aspartate (NMDA)) leading to enhanced intracellular calcium concentrations depress within minutes the aromatase activity measured in quail preoptic explants. The effects of receptor stimulation are presumably direct: electrophysiological data confirm the presence of these receptors in the membrane of aromatase-expressing cells. Inhibitors of protein kinases interfere with these processes andWestern blotting experiments on brain aromatase purified by immunoprecipitation confirm that the phosphorylations regulating aromatase activity directly affect the enzyme rather than another regulatory protein. Accordingly, several phosphorylation consensus sites are present on the deduced amino acid sequence of the recently cloned quail aromatase. Fast changes in the local availability of estrogens in the brain can thus be caused by aromatase phosphorylation so that estrogen could rapidly regulate neuronal physiology and behavior. The rapid as well as slower processes of local estrogen production in the brain thus match well with the genomic and non-genomic actions of steroids in the brain. These two processes potentially provide sufficient temporal variation in the bio-availability of estrogens to support the entire range of established effects for this steroid. [less ▲]

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See detailMultiple Migrations, Displacements and Land Transfers at Ta Kream in Northwest Cambodia
Pilgrim, John; Ngin, Chanrith; Diepart, Jean-Christophe ULg

in Hecht, Susanna; Kandel, Susan; Morales, Abelardo (Eds.) Migration, Rural Livelihoods and Natural Resource Management (2012)

The Cambodian case examines migration, land tenure and land management, in a context of conflict and the use of force in land transfers since the time of the Khmer Rouge regime to the present, by studying ... [more ▼]

The Cambodian case examines migration, land tenure and land management, in a context of conflict and the use of force in land transfers since the time of the Khmer Rouge regime to the present, by studying five agro-ecological zones close to the Kamping Pouy irrigation system in Battambang Province. The study combines analysis of demographic and socioeconomic characteristics of household use of land and labor with a historical and ethnographic review of conflict and institutional factors in successive land administrations. Continuing in-migration is reflected in population increases in Battambang and other provinces of Northwest Cambodia in conditions of limited land availability and landlordism, and conflict over expropriation of land by armed groups and business interests. Land transfers to a growing wealthy class of businessmen and government officials have contributed to the creation of a subclass of very poor, landless households whose livelihoods depend on agricultural wage labor, locally and in Thailand, and access to the commons. Access to land for a substantial proportion of the community depends on either tenancy, sharecropping or wage labor on the land of wealthier farmers. Three problematic processes that run counter to the Cambodian Constitution and Land Law are systemic: 1) the usurpation of land rights by locally operating armed groups; 2) legitimation of such land acquisition by military-business-government officials by corrupt officeholders and local government officials; and 3) the capture of rents or profits by agencies responsible for safeguarding natural resources. [less ▲]

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See detailMultiple mode analysis of the self-excited vibrations of rotary drilling systems
Germay, Christophe; Denoël, Vincent ULg; Detournay, Emmanuel

in Journal of Sound & Vibration (2009), 325(1-2), 362-381

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See detailMultiple muscarinic receptor subtypes mediating pulmonary oedema in the rabbit.
Delaunois, Annie ULg; Gustin, Pascal ULg; Ansay, Michel ULg

in Pulmonary Pharmacology (1994), 7(3), 185-93

The effects of various muscarinic antagonists on acetylcholine (ACh)-induced pulmonary oedema were studied in isolated perfused rabbit lungs. ACh induced a dose-dependent increase in the capillary ... [more ▼]

The effects of various muscarinic antagonists on acetylcholine (ACh)-induced pulmonary oedema were studied in isolated perfused rabbit lungs. ACh induced a dose-dependent increase in the capillary filtration coefficient (Kf,c). This effect has been previously related to the activation of the capsaicin-sensitive nerve fibres and the release of substance P. Atropine, pirenzepine (M1-selective antagonist) and 4-DAMP (M3-selective antagonist) altered this response, producing a dose-dependent shift to the right of the ACh concentration-Kf,c response curve. By contrast, the M2-selective antagonist AFDX-116 shifted the ACh concentration-response curve to the left. Atropine, pirenzepine and 4-DAMP also significantly reduced the capsaicin-induced increase in the Kf,c, while AFDX-116 enhanced it. We conclude that multiple muscarinic receptor subtypes are present in the rabbit lung, located on the C-fibres, and are involved in the ACh-induced pulmonary oedema. M1 and M3 receptors seem to stimulate the release of neuropeptides from C-fibres, whereas M2 receptors have an inhibitory effect on these fibers. [less ▲]

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See detailMultiple myeloma cells instruct myeloid-derived suppressor cells to release pro-angiogenic cytokines
Binsfeld, Marilène ULg; Heusschen, Roy ULg; Lamour, Virginie et al

in Belgian Journal of Hematology (2014)

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See detailMultiple Myeloma, an update on diagnosis and treatment.
Caers, Jo ULg; Vande Broek, Isabelle; De Raeve, Hendrik et al

in European Journal of Haematology (2008), 81(5), 329-343

Detailed reference viewed: 11 (3 ULg)