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See detailOARSI recommended performance-based tests to assess physical function in people with established hip and knee osteoarthritis
Dobson, F.; Hinman, R.S.; Roos, E.M. et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013),

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See detailThe OB binary HD 152219: a detached, double-lined, eclipsing system
Sana, H.; Gosset, Eric ULg; Rauw, Grégor ULg

in Monthly Notices of the Royal Astronomical Society (2006), 371(1), 67-80

We present the results of an optical spectroscopic campaign on the massive binary HD 152219 located near the core of the NGC 6231 cluster. Though the primary to secondary optical brightness ratio is ... [more ▼]

We present the results of an optical spectroscopic campaign on the massive binary HD 152219 located near the core of the NGC 6231 cluster. Though the primary to secondary optical brightness ratio is probably about 10, we clearly detect the secondary spectral signature and we derive the first reliable SB2 orbital solution for the system. The orbital period is close to 4.2403 d and the orbit is slightly eccentric (e = 0.08 +/- 0.01). The system is most probably formed by an O9.5 giant and a B1-2 V-III star. We derive minimal masses of 18.6 +/- 0.3 and 7.3 +/- 0.1 M-circle dot for the primary and secondary, respectively, and we constrain the stellar radius at values about 11 and 5 R-circle dot. INTEGRAL-Optical Monitoring Camera (OMC) data reveal that HD 152219 is the third O-type eclipsing binary known in NGC 6231. In the Hertzsprung-Russell (HR) diagram, the primary component lies on the blue edge of the beta Cep-type instability strip and its spectral lines display clear profile variations that are reminiscent of those expected from non-radial pulsations. Finally, we report the analysis of XMM-Newton observations of the system. The X-ray spectrum is relatively soft and is well reproduced by a two-temperature mekal model with kT(1) = 0.26 keV and kT(2) = 0.67 keV. The X-ray flux is most probably variable on a time-scale of days. The average X-ray luminosity during our campaign is log(L-X) approximate to 31.8 (erg s(-1)), but shows fluctuations of about 10 per cent around this value. [less ▲]

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See detailObama : l’avenir d’une illusion
Jamin, Jérôme ULg

Article for general public (2008)

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See detailObama, le passé d'une illusion
Jamin, Jérôme ULg

Article for general public (2009)

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See detailThe obese dog and its owner : a method to implement a weight loss program using a concept map
Diez, Marianne ULg; Picavet, Philippe; Istasse, Louis ULg et al

in Mussa, P. P.; Nery, J.; Sciavone, A. (Eds.) et al Congress Proceedings 13t h Congress of the ESVCN (2009)

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See detailL'obésité (féline) : de la prévention au défi du "thérapeutique"
Diez, Marianne ULg

in 15th FECAVA Eurocongress - Proceedings (2009)

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See detailObésité chez l'enfant
Battisti, Oreste ULg

Article for general public (2006)

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See detailObésité et carences préopératoires
DE FLINES, Jenny ULg; BRUWIER, Laurent; DE ROOVER, Arnaud ULg et al

in Nutrition Clinique et Metabolisme (2013), 27(2), 82-86

It is a common belief that nutritional deficiencies are rare in the Western world due to a wide variety of food supply. However, obese people usually consume dense-energy food but of poor nutritional ... [more ▼]

It is a common belief that nutritional deficiencies are rare in the Western world due to a wide variety of food supply. However, obese people usually consume dense-energy food but of poor nutritional value that lacks proteins, vitamins, minerals and fiber; consequently, a high prevalence of micronutrient deficiencies in obese subjects has been reported. Moreover, bariatric surgery has been proven the most effective treatment of morbid obesity, but micronutrient deficiency following bariatric surgery is a major concern, worsening pre-operative nutritional deficiencies. In this article, we reviewed the litterature and highlighted the prevalence of nutritional deficiencies in the morbidly obese population prior to bariatric surgery, clinical consequences of these deficiencies and practical recommendations for these subjects. [less ▲]

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See detailObesite et diabete de type 2.
Rorive, Marcelle ULg; Letiexhe, Michel ULg; Scheen, André ULg et al

in Revue Médicale de Liège (2005), 60(5-6), 374-82

Obesity is an epidemic disease associated with numerous cardiovascular risk factors as diabetes mellitus, dyslipidemia, hypertension. Insulin resistance seems to be an important promoter for the ... [more ▼]

Obesity is an epidemic disease associated with numerous cardiovascular risk factors as diabetes mellitus, dyslipidemia, hypertension. Insulin resistance seems to be an important promoter for the development of most of these abnormalities. Besides genetic background, obesity, especially abdominal adiposity, is by far the most important factor for the development of type 2 diabetes. The treatment of a diabetic obese subject begins with diet and regular physical activity, eventually with a psychological support. In case of failure of such lifestyle approach alone, addition of drug therapy should be considered. It may include pharmacological agents able to promote weight loss (orlistat, sibutramine, possibly rimonabant) and/or antihyperglycaemic compounds capable of reducing insulin resistance (metformin, glitazones, acarbose). In case of severe/morbid obesity complicated with type 2 diabetes not well controlled with medical means, bariatric surgery is the only treatment that can induce an important and sustained weight loss, associated with marked improvement of metabolic control and amelioration of overall prognosis. [less ▲]

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See detailObésité et hypertension artérielle: de la physiopathologie au traitement
Geronooz, Isabelle; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2000), 55(10), 921-928

Obesity constitutes a problem of major concern in our industrialized countries. Overweight is frequently associated with hypertension (50% of hypertensive subjects are obese and the prevalence of ... [more ▼]

Obesity constitutes a problem of major concern in our industrialized countries. Overweight is frequently associated with hypertension (50% of hypertensive subjects are obese and the prevalence of hypertension in obese patients is twice that of the normal population). Both pathologies are major cardiovascular risk factors. This review aims at a better understanding of the relationship between hypertension and overweight and at giving to the clinicians simple and consistent guidelines to treat these two medical entities. [less ▲]

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See detailL'obesite feminine: souci esthetique ou probleme medical?
Luyckx, Françoise ULg; Scheen, André ULg; Lefebvre, Pierre ULg

in Revue Médicale de Liège (1999), 54(4), 262-7

Women more and more frequently refer to medical doctors for treating weight excess. Even if the primum movens is usually a pure esthetic concern, medical aspects should not be neglected. Indeed, if ... [more ▼]

Women more and more frequently refer to medical doctors for treating weight excess. Even if the primum movens is usually a pure esthetic concern, medical aspects should not be neglected. Indeed, if obesity with gynoid adipose tissue distribution is less deleterious than android obesity from a metabolic point of view, severe obesity is frequently associated with cardiovascular risk factors which may hinder the prognosis of these female patients. Other complications are common in obese women, such as oestrogen-related cancers, osteoarticular problems and psychological disturbances. Various therapeutic approaches are available which permit an encouraging weight loss and a rapid improvement of risk factors. Unfortunately, long-term results are often disappointing, essentially because of the difficulty to follow on the long term a strict diet regimen and practice physical exercise and because of the usual unrealistic expectations of the obese women who consult medical doctors. [less ▲]

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See detailObesite, insulinoresistance et diabete de type 2: facteurs de risque du cancer du sein.
SCHEEN, André ULg; Beck, Emmanuel ULg; DE FLINES, Jenny ULg et al

in Revue Médicale de Liège (2011), 66(5-6), 238-44

Obesity and type 2 diabetes are two risk factors of breast cancer, especially after menopause. Underlying mechanisms are multiple and include hyperinsulinism due to insulin resistance (insulin, as insulin ... [more ▼]

Obesity and type 2 diabetes are two risk factors of breast cancer, especially after menopause. Underlying mechanisms are multiple and include hyperinsulinism due to insulin resistance (insulin, as insulin-like-growth factor -IGF-, is a growth factor), hyperleptinaemia associated with hypoadiponectinaemia, and high levels of estrogens resulting from aromatization of androgens in adipose tissue. In presence of type 2 diabetes associated with obesity, hyperglycaemia might provide energy substrate promoting tumour growth. These data have therapeutic implications with expected favourable effects of weight loss, resulting in a reduction of fat mass and insulin resistance, and the promising results recently reported with metformin contrasting with the negative effects of exogenous administration of high doses of insulin. [less ▲]

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See detailObesite: aspects therapeutiques
Scheen, André ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2001), 156(10-12), 471-9480-2

Obesity is now recognized as a chronic disease. Its treatment implies a prolonged negative energy balance, by reducing caloric intake and/or increasing energy expenditure. In practice, three therapeutic ... [more ▼]

Obesity is now recognized as a chronic disease. Its treatment implies a prolonged negative energy balance, by reducing caloric intake and/or increasing energy expenditure. In practice, three therapeutic approaches can be considered: 1) life-style modifications, combining well-balanced hypocaloric diet and regular physical exercise, the key-issue in obesity management; 2) in case of failure and as adjunct treatment, anti-obesity drugs, especially orlistat, an intestinal lipase inhibitor, and sibutramine, a central appetite regulator; and 3) in patients with extreme refractory obesity, surgical procedures consisting of gastric restriction (gastroplasty) or intestinal bypass. Anti-obesity treatments must be evaluated in the long run, in terms of efficacy/safety ratio, upon criteria of weight loss, reduction in associated risk factors, improvement of quality of life and, if possible, reduction of morbidity and mortality. [less ▲]

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See detailObesite: aspects therapeutiques.
Scheen, André ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2001), 156(10-12), 471-9480-2

Obesity is now recognized as a chronic disease. Its treatment implies a prolonged negative energy balance, by reducing caloric intake and/or increasing energy expenditure. In practice, three therapeutic ... [more ▼]

Obesity is now recognized as a chronic disease. Its treatment implies a prolonged negative energy balance, by reducing caloric intake and/or increasing energy expenditure. In practice, three therapeutic approaches can be considered: 1) life-style modifications, combining well-balanced hypocaloric diet and regular physical exercise, the key-issue in obesity management; 2) in case of failure and as adjunct treatment, anti-obesity drugs, especially orlistat, an intestinal lipase inhibitor, and sibutramine, a central appetite regulator; and 3) in patients with extreme refractory obesity, surgical procedures consisting of gastric restriction (gastroplasty) or intestinal bypass. Anti-obesity treatments must be evaluated in the long run, in terms of efficacy/safety ratio, upon criteria of weight loss, reduction in associated risk factors, improvement of quality of life and, if possible, reduction of morbidity and mortality. [less ▲]

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See detailObésité: aube hésitée, et quoi pour moi demain
Battisti, Oreste ULg

Conference (2006, June)

cette journée aborde le cocnept familial, l'aspect communautaire, l'épidémiologie, l'aspect nutritionnel, l'aspect somatique et l'aspect psychologique de l'obésité de l'enfant dans le cadre familial.

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See detailL'obésité: un modèle d'interactions complexes entre génétique et environnement
PAQUOT, Nicolas ULg; DE FLINES, Jenny ULg; RORIVE, Marcelle ULg

in Revue Médicale de Liège (2012), 67(5-6), 332-336

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See detailObesity
Nguyen, Patrick; Diez, Marianne ULg

in Ettinger, Stephen J; Feldman, Edwards C (Eds.) Textbook of Veterinary Internal Medicine 7th edition (2010)

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See detailObesity : epidemiology, pathophysiology and management of the obese dog
Diez, Marianne ULg; Nguyen, Patrick

in Pibot, Pascale; Biourge, Vincent; Elliott, Denise (Eds.) Encyclopedia of Canine Clinical Nutrition (2006)

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See detailObesity and liver disease.
Scheen, André ULg; Luyckx, Françoise ULg

in Best practice & research. Clinical endocrinology & metabolism (2002), 16(4), 703-16

Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance. It is frequently associated with obesity, especially visceral fat, and is intimately related to fatty liver and ... [more ▼]

Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance. It is frequently associated with obesity, especially visceral fat, and is intimately related to fatty liver and markers of the insulin resistance syndrome. Both the prevalence and the severity of liver steatosis are related to body mass index, waist circumference, hyperinsulinaemia, hypertriglyceridaemia and impaired glucose tolerance or type 2 diabetes. The identification of obese patients who may progress from steatosis to NASH and from NASH to fibrosis/cirrhosis is an important clinical challenge. Substantial weight loss is accompanied by a marked attenuation of insulin resistance and related metabolic syndrome and, concomitantly, by a remarkable regression of liver steatosis in most patients, although increased inflammation may be detected in some subjects. Thus, NASH may be considered as another disease of affluence, as is the insulin resistance syndrome, and perhaps being part of it, especially in obese patients. [less ▲]

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See detailObesity and nutrition in children. The Belgian Luxembourg Child Study IV.
Guillaume, Michèle ULg; Lapidus, L.; Lambert, A.

in European Journal of Clinical Nutrition (1998), 52(5), 323-8

OBJECTIVE: To analyse the association between nutritional and familial factors and obesity in boys and girls. DESIGN: Randomized, cross-sectional population study. SETTING: Province de Luxembourg, Belgium ... [more ▼]

OBJECTIVE: To analyse the association between nutritional and familial factors and obesity in boys and girls. DESIGN: Randomized, cross-sectional population study. SETTING: Province de Luxembourg, Belgium. Subjects: One thousand and twenty-eight boys and girls in age strata 6-8, 8-10 and 10-12 y, comprising 70.3% of primary cohort. METHODS: Examinations included anthropometric measurements and questionnaires covering familial, socioeconomic and psychosocial factors. A three day dietary record was obtained in 955 children. This was analysed in relation to the anthropometric data. RESULTS: In comparison with similar studies from other regions and recommended allowances, the intakes of total energy, fat, particularly saturated fat and cholesterol, were high, while consumption of carbohydrate and fiber was low, as well as the polyunsaturated/saturated ratio of fat. Total energy intake showed no or weakly significant correlations with anthropometric factors. However, total fat (P=0.045) and saturated fat (P=0.0005) intake showed consistent positive correlations with body mass index (BMI, kg/m2) and skinfold thickness, with corresponding negative relationships to carbohydrate intake (P=0.034) in boys. Such relationships were also found when calculated as energy density. These associations were not statistically significant in girls. The high fat, low carbohydrate pattern of the nutritional status seemed to be more pronounced in families where the father had a low level of education (lipids, boys, P=0.0007), and where both parents were obese (saturated fat, boys, P=0.023), suggesting involvement of socioeconomic and familial factors. CONCLUSION: The lack of correlation between factors indicating obesity and total energy intake suggests that the positive energy balance causing obesity is due mainly to a low energy output. However, since energy intake measurements are imprecise, overeating can not be excluded, particularly since elevated consumption of food with high contents of fat, found in these children seems to be poorly regulated. [less ▲]

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