Is there a relation between myocardial salvage and the release patterns of myoglobin and creatine kinase-MB in acute myocardial infarction submitted to thrombolysic?
; Pierard, Luc ; Chapelle, Jean-Paul et al
in Acta Cardiologica (1992)Detailed reference viewed: 12 (2 ULg)
is there a relation between myocardial salvage and the release patterns of myoglobin and creatine kinase-MB in acute myocardial infarction submitted to thrombolysis?
; Pierard, Luc ; Chapelle, Jean-Paul et al
Poster (1991, October)Detailed reference viewed: 6 (0 ULg)
Is there a relationship between perseverations and spatial short-term memory deficits in unilateral neglect?
Wansard, Murielle ; ; Gillet, Sophie et al
in Abstract Book Belgian Brain Congress (2012, October 27)
Introduction Spatial neglect is a multicomponent syndrome characterized by an inability to orient or to respond to stimuli arising in the hemispace contralateral to a brain lesion. According to many ... [more ▼]
Introduction Spatial neglect is a multicomponent syndrome characterized by an inability to orient or to respond to stimuli arising in the hemispace contralateral to a brain lesion. According to many authors, spatial neglect can be explained by an attentional deficit, and more specifically by a lateral attentional bias towards the right (magnetic attraction) and/or difficulties in disengaging attention from items to the right side. However, attentional theories are not sufficient to explain some behaviors such as revisiting and perseverations. Recently, it has been suggested that revisiting and perseveration behaviors in visual search tasks shown in parietal neglect could be related to impairments in visuo-spatial working memory (Husain et al., 2001; Malhotra et al., 2005; Malhotra, Mannan, Driver, & Husain, 2004). This hypothesis is supported by studies (1) in which a contrast is made between cancellation tasks with and without visual control, the absence of visual feedback increasing left neglect (omissions) and repeated cancellations (perseverations) towards the ipsilesional space, and (2) in which the Corsi test is administrated in a vertical way. However, Ronchi et al. (2009) did not confirm the link between impairments in spatial short-term memory and perseverations. Indeed, these authors found no correlation between perseverations in star cancellation and spatial memory performance in the Corsi test. Nevertheless, they did not use a condition without visual feedback, which is considered as involving more spatial short-term memory than a condition with visual feedback. This methodological choice could explain the lack of relationship between short-term memory and perseverations in the Ronchi et al.’s study. The purpose of our study was to test the hypothesis of a spatial short-term memory deficit being an explanatory factor of perseverations in unilateral neglect. Methods We assessed twenty right-damaged patients suffering from left neglect. Neglect signs were evaluated with the Batterie d’Evaluation de la Négligence (BEN) (Azouvi et al., 2002). Twenty healthy older participants matched for age and sociocultural level served as controls. In order to explore the relationship between perseverations and spatial short-term memory, two different tasks were administrated: a computerized version of the Corsi test and a cancellation task. All tests were computerized and presented on a touchscreen. The subject’s spatial span corresponded to the longest sequence in which at least three out of four sequences were correctly reproduced. The cancellation task consisted of 32 “O” presented in two conditions: with (visible) and without (invisible) visual feedback. Patients were instructed to cancel out all targets only once. The number of omissions and perseverations was calculated for each participant in both conditions. Results Control participants performed better than neglect patients in the Corsi test; eleven neglect patients showed a deficit in spatial short-term memory. In the cancellation tasks, Wilcoxon matched-pairs signed ranks tests highlighted that perseverations and omissions were greater in the invisible condition for each group. In this condition, neglect patients made more omissions and perseverations (all ps <.05) than control subjects, while in the visible condition there was only a significant difference for the omissions. However, spatial short-term memory did not explain perseverations in invisible condition (R² = .17, F(1,18) = 3.66, p = .07). Discussion These findings suggest that a spatial short-term memory deficit cannot be considered as an explanatory factor for the perseveration behavior in unilateral neglect. Moreover, perseverations and omissions were greater in the invisible condition than in the visible one; therefore, the hypothesis of the magnetic attraction is not confirmed either. In the neglect patients’ group, the visual feedback decreases, and even eliminates the neglect symptoms (omissions and perseverations) compared to the invisible condition. In other words, the presence of visual feedback can help patients to explore their visual environment. We propose that, in the invisible condition, difficulties to plan a visual search could exacerbate both omissions and perseverations, leading to recursive search towards the right side of the space and thus promote failure to explore left space. However, further investigations will be necessary to confirm this hypothesis. [less ▲]Detailed reference viewed: 104 (14 ULg)
Is there a role for "climatotherapy" in the sustainable development of mental health?
Desseilles, Martin ; ; et al
in The Behavioral and brain sciences (2013), 36(5), 487-8503-11
Climate, diet, lifestyle, and environmental settings have all been shown to modulate mood, play a role in mental disorders, and even pose a mental health risk. Can climatotherapy, in its adaptive approach ... [more ▼]
Climate, diet, lifestyle, and environmental settings have all been shown to modulate mood, play a role in mental disorders, and even pose a mental health risk. Can climatotherapy, in its adaptive approach aiming to restore balance among the economic, social, and ecological realms of human societies, situate itself as a therapeutic avenue for the promotion of sustainable mental health? [less ▲]Detailed reference viewed: 56 (2 ULg)
Is there a role for alpha-glucosidase inhibitors in the prevention of type 2 diabetes mellitus?
in Drugs (2003), 63(10), 933-51
Type 2 diabetes mellitus is a major health problem associated with excess morbidity and mortality. As the prevalence of this metabolic disorder is rapidly increasing and current treatment fails to ... [more ▼]
Type 2 diabetes mellitus is a major health problem associated with excess morbidity and mortality. As the prevalence of this metabolic disorder is rapidly increasing and current treatment fails to stabilise the disease in most patients, prevention should be considered as a key objective in the near future. People who develop type 2 diabetes pass through a phase of impaired glucose tolerance (IGT). Defects in the action and/or secretion of insulin are the two major abnormalities leading to development of glucose intolerance. Any intervention in the impaired glucose tolerance phase that reduces resistance to insulin or protects the beta-cells, or both, should prevent or delay progression to diabetes.Acarbose, miglitol and voglibose act by competitively inhibiting the alpha-glucosidases, a group of key intestinal enzymes involved in the digestion of carbohydrates. They decrease both postprandial hyperglycaemia and hyperinsulinaemia, and thereby may improve sensitivity to insulin and release the stress on beta-cells. These compounds do not induce hypoglycaemia and have a good safety profile, although gastrointestinal adverse effects may limit long-term compliance to therapy.The recent placebo-controlled prospective STOP-noninsulin-dependent diabetes mellitus (STOP-NIDDM) trial demonstrated that acarbose 100mg three times daily reduces the risk of developing type 2 diabetes in patients with IGT (relative risk reduction of 25% after a mean follow-up of 3.3 years). The 6-year Early Diabetes Intervention Trial (EDIT), comparing the effect of acarbose 50mg three times daily to that of metformin, showed a trend to a positive effect of acarbose compared with placebo, in a mid-term 3-year analysis, which should be confirmed in the final analysis.To our knowledge, no such prevention intervention trials have been or are currently being performed with miglitol or voglibose. In conclusion, because of its absence of toxicity and its particular mechanism of action on gastrointestinal tract and indirect consequences on both insulin action and beta-cell function, acarbose may be used to prevent type 2 diabetes. If the ongoing EDIT trial confirms the positive results of the recent STOP-NIDDM trial, acarbose could be used, either as an alternative or in addition to changes in lifestyle, to delay development of diabetes in patients with IGT. However, the best dosage of acarbose for this specific indication remains to be specified, especially when all three important parameters, efficacy, tolerance and cost, are taken into consideration. [less ▲]Detailed reference viewed: 78 (1 ULg)
Is there a role for intra-arterial therapy or isolated liver perfusion?
Conference (2014, October 10)
IS THERE A ROLE FOR INTRA-ARTERIAL THERAPY OR ISOLATED LIVER PERFUSION? Pr Olivier Detry, Dpt of Abdominal Surgery and Transplantation, CHU Liege, University of Liege, The liver is the most common ... [more ▼]
IS THERE A ROLE FOR INTRA-ARTERIAL THERAPY OR ISOLATED LIVER PERFUSION? Pr Olivier Detry, Dpt of Abdominal Surgery and Transplantation, CHU Liege, University of Liege, The liver is the most common visceral site of colorectal cancer (CRC) metastasis and recurrence. Approximately 25% of CRC patients present with synchronous hepatic metastases at time of initial diagnosis, and further 50% will develop metachronous metastases during the course of their illness. Unfortunately, only 25% of patients with hepatic CRC metastases are suitable for R0 resection at time of diagnosis or after chemotherapy. Intra‐arterial locoregional therapies are evolving tools in the management of CRC liver metastases. Although these therapies were initially used for salvage and palliation, they are becoming therapeutic options earlier in the course of disease in selected populations, to increase the rate of curative surgical resection, and to improve survival and quality of life. Furthermore, intra‐arterial therapies may serve as viable first‐line treatments for the large majority of patients who present with unresectable liver metastases, and as neoadjuvant chemotherapy prior to hepatectomy to minimize systemic effects. Hyperthermic isolated liver perfusion (HILP) has also been proposed by some groups as a mean to treat patients with unresectable liver metastases. Significant anti-tumoral effect has been demonstrated but HILP is a complicated procedure with a high morbidity. There remains a lack of robust, prospective randomized data for fair and balanced comparisons to be made between locoregional and modern systemic therapeutic modalities, as well as between locoregional therapies. Future RCTs addressing overall patient survival, tumor response and toxicity are required before any of these locoregional intra‐arterial treatments can be definitively recommended as the standard of care for hepatic colorectal liver mestastases. At the CHU of Liege, intra-arterial chemotherapy is now the usual way of administrating chemotherapy in patients with multiple CRC metastases limited to the liver after R0 liver resection. [less ▲]Detailed reference viewed: 38 (3 ULg)
Is there a role for orthopaedic ultrasonography in beef cattle? A single-centre retrospective study in Belgium.
Busoni, Valeria ; ;
in Veterinary Radiology and Ultrasound (2007)Detailed reference viewed: 13 (0 ULg)
Is there a specific pattern of lean/fat mass ratio in sarcopenic subjects?
Beaudart, Charlotte ; Reginster, Jean-Yves ; Croisier, Jean-Louis et al
in Osteoporosis International (2015), 26(S1), 145-146Detailed reference viewed: 33 (6 ULg)
Is there a specific pattern of lean/fat mass ratio in sarcopenic subjects?
Beaudart, Charlotte ; Reginster, Jean-Yves ; Croisier, Jean-Louis et al
in Journal of Frailty & Aging (2015), 4(S1), 61Detailed reference viewed: 31 (7 ULg)
Is There an Alignment of Quasars Near NGC 520?
Gosset, Eric ; Surdej, Jean ; Swings, Jean-Pierre
in Hewitt, Adelaide; Burbidge, Geoffrey; Fang, Li Zhi (Eds.) IAU Symposium, No. 124 "Observational Cosmology" (1987)
Three statistical tests applied to 65 UV excess objects in the field of NGC 520 lead to no detection of any significant alignment.Detailed reference viewed: 12 (0 ULg)
Is there an all-embracing construct of emotion reactivity? Adaptation and validation of the emotion reactivity scale among a French-speaking community sample
; ; et al
in Comprehensive Psychiatry (2014), 55(8), 1960-1967Detailed reference viewed: 22 (3 ULg)
Is there an alphabet of Moroccan cuisine? Notes on the materiality of cooking and eating.
Conference (2016, July)
Short Abstract Stemming from the ethnographic material collected during an eighteen months fieldwork conducted among a group Moroccan of women in Milan to study their food practices, this paper focuses on ... [more ▼]
Short Abstract Stemming from the ethnographic material collected during an eighteen months fieldwork conducted among a group Moroccan of women in Milan to study their food practices, this paper focuses on the materiality of cooking and eating through adopting a micro-structural approach. Long Abstract Inspired by the work of Lévi-Strauss (1964) aimed at identifying the relationships of mutual intelligibility underlying some social and cultural facts such as the treatment of food, this paper will focus on the materiality of cooking and eating through adopting a micro-structural approach. The ethnographic data collected during an eighteen months fieldwork conducted among a group of Moroccan women in Milan to study their cooking and eating habits will be analysed by paying particular attention to the practices and elements that made the "alphabet" of Moroccan cuisine. This means that, if we considered dishes as complex sentences which can be deciphered by people that share a same language, we could try to identify the littlest components that made them happen. Which norms regulated the combination of ingredients? Which ways of cooking described this food culture? Which gestures and embodied knowledge seemed essential to give an intelligible cultural connotation to the cooking and eating of food? Which variations were admitted? The analysis of the actors' discourses and practices will show how Lévi-Strauss approach and model to the study of foodways can meet a material culture approach and still be relevant nowadays. [less ▲]Detailed reference viewed: 24 (0 ULg)
Is there an interest to determine the gait’s profile of MCI subjects to predict the risk of Alzheimer disease?
Gillain, Sophie ; Lekeu, Françoise ; Wojtasik, Vinciane et al
in Journal of Nutrition, Health & Aging (The) (2009, June), 13(Supp 1),Detailed reference viewed: 60 (5 ULg)
Is there any interest in combining treatments in osteoporosis?
Rabenda, Véronique ; ; et al
in Current Rheumatology Reviews (2005), 1Detailed reference viewed: 7 (2 ULg)
Is There Any Place for Salmon Calcitonin in Prevention of Postmenopausal Bone Loss?
Reginster, Jean-Yves ; Deroisy, Rita ; et al
in Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology (1988), 2(3), 195-204Detailed reference viewed: 9 (2 ULg)
Is there any rationale for prescribing hormone replacement therapy (HRT) to prevent or to treat osteoarthritis?
Kvasz, Angela ; Bruyère, Olivier ; Neuprez, Audrey et al
in Osteoporosis International (2002, November), 13(Suppl.3), 59Detailed reference viewed: 28 (1 ULg)
is there any rationale for prescribing hormone replacement therapy (HTR) to prevent or to treat osteoarthritis?
Reginster, Jean-Yves ; Kvasz, Angela ; Bruyère, Olivier et al
in Osteoarthritis and Cartilage (2003), 11(2), 87-91
Background: During the last two decades of the 20th century, hormone replacement therapy (HRT) has been considered as the sole pharmacological approach for counterbalancing or mitigating the effects of ... [more ▼]
Background: During the last two decades of the 20th century, hormone replacement therapy (HRT) has been considered as the sole pharmacological approach for counterbalancing or mitigating the effects of estrogens deprivation in post-menopausal women. Subsequently, HRT has been widely recommended for the management of chronic diseases occurring, in women during the second half of their life. The overall risk/benefit ratio of estrogens has been recently reassessed in the light of long-term prospective studies failing to demonstrate the expected benefit of HRT on cardiovascular diseases incidence. Osteoarthritis (OA) is one of the chronic conditions for which HRT has been suggested to provide beneficial outcomes. Results: The presence of estrogen receptors in human cartilage is no longer debated. However, cellular or animal models of OA do not provide an unequivocal pathway for the influence of gonadal steroids on cartilage. Similarly, studies attempting to correlate serum or urinary levels of sex steroids to the onset or progression of OA gave conflicting results. No randomized, prospective, controlled trial was designed to specifically assess the impact of hormone replacement therapy on symptomatic or structural progression of OA. Large-scale observational studies or trials designed to assess other potential benefits of estrogens suggest that HRT use does not provide symptomatic relief in OA but may interfere with its long-term structural progression, particularly in the lower limbs. Conclusion: Based on the recent results of the Women Health Initiative suggesting that HRT health risks may outweigh benefits, one can hardly recommend, with the current level of evidence, HRT as a first-line treatment against progression of OA. (C) 2003 OsteoArthritis Research Society International. Published by Elsevier Science Ltd. All rights reserved. [less ▲]Detailed reference viewed: 33 (5 ULg)
Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?
Henrotin, Yves ; ;
in Arthritis Research & Therapy (2012), 14(1), 201
ABSTRACT: Glucosamine in its acetylated form is a natural constituent of some glycosaminoglycans (for example, hyaluronic acid and keratan sulfate) in the proteoglycans found in articular cartilage ... [more ▼]
ABSTRACT: Glucosamine in its acetylated form is a natural constituent of some glycosaminoglycans (for example, hyaluronic acid and keratan sulfate) in the proteoglycans found in articular cartilage, intervertebral disc and synovial fluid. Glucosamine can be extracted and stabilized by chemical modification and used as a drug or a nutraceutical. It has been approved for the treatment of osteoarthritis (OA) in Europe to promote cartilage and joint health and is sold over the counter as a dietary supplement in the United States. Various formulations of glucosamine have been tested, including glucosamine sulfate and glucosamine hydrochloride. In vitro and in vivo studies have uncovered glucosamine's mechanisms of action on articular tissues (cartilage, synovial membrane and subchondral bone) and justified its efficacy by demonstrating structure-modifying and anti-inflammatory effects at high concentrations. However, results from clinical trials have raised many concerns. Pharmacokinetic studies have shown that glucosamine is easily absorbed, but the current treatment doses (for example, 1,500 mg/day) barely reach the required therapeutic concentration in plasma and tissue. The symptomatic effect size of glucosamine varies greatly depending on the formulation used and the quality of clinical trials. Importantly, the effect size reduces when evidence is accumulated chronologically and evidence for the structure-modifying effects of glucosamine are sparse. Hence, glucosamine was at first recommended by EULAR and OARSI for the management of knee pain and structure improvement in OA patients, but not in the most recent NICE guidelines. Consequently, the published recommendations for the management of OA require revision. Glucosamine is generally safe and although there are concerns about potential allergic and salt-related side effects of some formulations, no major adverse events have been reported so far. This paper examines all the in vitro and in vivo evidence for the mechanism of action of glucosamine as well as reviews the results of clinical trials. The pharmacokinetics, side effects and differences observed with different formulations of glucosamine and combination therapies are also considered. Finally, the importance of study design and criteria of evaluation are highlighted as new compounds represent new interesting options for the management of OA. [less ▲]Detailed reference viewed: 45 (9 ULg)
Is there anybody in there? Detecting awareness in disorders of consciousness.
; Vanhaudenhuyse, Audrey ; et al
in Expert Review of Neurotherapeutics (2008), 8(11), 1719-30
The bedside detection of awareness in disorders of consciousness (DOC) caused by acquired brain injury is not an easy task. For this reason, differential diagnosis using neuroimaging and ... [more ▼]
The bedside detection of awareness in disorders of consciousness (DOC) caused by acquired brain injury is not an easy task. For this reason, differential diagnosis using neuroimaging and electrophysiological tools in search for objective markers of consciousness is being employed. However, such tools cannot be considered as diagnostic per se, but as assistants to the clinical evaluation, which, at present, remains the gold standard. Regarding therapeutic management in DOC, no evidence-based recommendations can be made in favor of a specific treatment. The present review summarizes clinical and paraclinical studies that have been conducted with neuroimaging and electrophysiological techniques in search of residual awareness in DOC. We discuss the medical, scientific and ethical implications that derive from these studies and we argue that, in the future, the role of neuroimaging and electrophysiology will be important not only for the diagnosis and prognosis of DOC but also in establishing communication with these challenging patients. [less ▲]Detailed reference viewed: 28 (0 ULg)