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See detailThe mouse lymph organs
Heinen, Ernst ULg; Defresne, M. P.

in "Handbook of Vertebrate Immunology (1998)

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See detailMouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production
Guéders, Maud ULg; Paulissen, Geneviève ULg; Crahay, Céline et al

in Inflammation Research (2009), 58(12), 845-54

Objective Animal models of asthma mimic major features of human disease. Since the genetic background of experimental animals might affect hyperresponsiveness and inflammation, we studied its potential ... [more ▼]

Objective Animal models of asthma mimic major features of human disease. Since the genetic background of experimental animals might affect hyperresponsiveness and inflammation, we studied its potential influence and the mechanisms leading to differences in strains. Methods We applied a mouse model of allergic asthma to BALB/c and C57BL/6 mice. Results BALB/c mice displayed greater levels of airway reactivity to methacholine than C57BL/6 mice. Moreover, BALB/c mice exhibited higher numbers of mast cells in lung tissue when compared to C57BL/6. On the contrary, eosinophil and neutrophil counts in bronchoalveolar lavage fluid (BALF) as well as peribronchial eosinophilia were greater in C57BL/6. IL (Interleukin)-4, IL-5, IL-13, and CCL11 levels measured in whole-lung extracts were higher in BALB/c, while, in sharp contrast, CCL11 and CCL5 levels were higher in BALF of C57BL/6 mice. Conclusions We observed phenotypic differences between C57BL/6 and BALB/c mice in an asthma model with different distributions of pro-inflammatory cytokines and inflammatory cells. [less ▲]

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See detailMouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation
Maes, T.; Provoost, S.; Lanckacker, E. A. et al

in Respiratory Research (2010), 11(1), 7

Air pollutant exposure has been linked to a rise in wheezing illnesses. Clinical data highlight that exposure to mainstream tobacco smoke (MS) and environmental tobacco smoke (ETS) as well as exposure to ... [more ▼]

Air pollutant exposure has been linked to a rise in wheezing illnesses. Clinical data highlight that exposure to mainstream tobacco smoke (MS) and environmental tobacco smoke (ETS) as well as exposure to diesel exhaust particles (DEP) could promote allergic sensitization or aggravate symptoms of asthma, suggesting a role for these inhaled pollutants in the pathogenesis of asthma. Mouse models are a valuable tool to study the potential effects of these pollutants in the pathogenesis of asthma, with the opportunity to investigate their impact during processes leading to sensitization, acute inflammation and chronic disease. Mice allow us to perform mechanistic studies and to evaluate the importance of specific cell types in asthma pathogenesis. In this review, the major clinical effects of tobacco smoke and diesel exhaust exposure regarding to asthma development and progression are described. Clinical data are compared with findings from murine models of asthma and inhalable pollutant exposure. Moreover, the potential mechanisms by which both pollutants could aggravate asthma are discussed. [less ▲]

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See detailThe mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse
Schurmans, Stéphane ULg; Carrio, R.; Behrens, J. et al

in Genomics (1999), 62

SHIP2 is a new member of the inositol polyphosphate 5-phosphatase family showing homology to SHIP1. The structure of both enzymes is characterized by the presence of a 5' SH2 domain, a central catalytic ... [more ▼]

SHIP2 is a new member of the inositol polyphosphate 5-phosphatase family showing homology to SHIP1. The structure of both enzymes is characterized by the presence of a 5' SH2 domain, a central catalytic domain, and a 3' proline-rich region. Recent results suggest that SHIP2 and SHIP1 act downstream of various receptors by removing a phosphate from the 5' position of the phosphatidylinositol 3'-kinase phosphatidylinositol 3,4, 5-triphosphate product and of inositol 1,3,4,5-tetrakisphosphate. Human SHIP2 is highly expressed in adult heart, skeletal muscle, and placenta, whereas SHIP1 expression is limited to the hematopoietic system. We report here the molecular analysis of the mouse SHIP2 cDNA and the corresponding protein, the structure of the gene, and the identification of its promoter. SHIP2 mRNA expression was analyzed in embryonic and adult mouse tissues by reverse transcription-polymerase chain reaction and in situ hybridization. In embryonic day 15.5 mice, SHIP2 was strongly expressed in the liver, specific regions of the central nervous system, the thymus, the lung, and the cartilage perichondrium. In adult mice, SHIP2 mRNA was markedly present in the brain and the thymus and at different stages of spermatozoa maturation in the seminiferous tubules. The subtle differences in the protein structure of SHIP2 and SHIP1 as well as their different patterns of expression are discussed [less ▲]

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See detailMouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12
Gusareva, Elena ULg; Havelková, Helena; Blažková, Hana et al

in Immunogenetics (2009), 61(1), 15-25

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. It is often associated with development of allergic diseases such as asthma, rhinitis, and ... [more ▼]

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. It is often associated with development of allergic diseases such as asthma, rhinitis, and dermatitis. Production of IgE is influenced by genetic and environmental factors. In spite of progress in the study of heredity of atopy, the genetic mechanisms of IgE regulation have not yet been completely elucidated. The analysis of complex traits can benefit considerably from integration of human and mouse genetics. Previously, we mapped a mouse IgE-controlling locus Lmr9 on chromosome 4 to a segment of <9 Mb. In this study, we tested levels of total IgE and 25 specific IgEs against inhalant and food allergens in 67 Czech atopic families. In the position homologous to Lmr9 on chromosome 8q12 marked by D8S285, we demonstrated a novel human IgE-controlling locus exhibiting suggestive linkage to composite inhalant allergic sensitization (limit of detection, LOD=2.11, P=0.0009) and to nine specific IgEs, with maximum LOD (LOD=2.42, P=0.0004) to plantain. We also tested 16 markers at previously reported chromosomal regions of atopy. Linkage to plant allergens exceeding the LOD>2.0 was detected at 5q33 (D5S1507, LOD=2.11, P=0.0009) and 13q14 (D13S165, LOD=2.74, P=0.0002). The significant association with plant allergens (quantitative and discrete traits) was found at 7p14 (D7S2250, corrected P=0.026) and 12q13 (D12S1298, corrected P=0.043). Thus, the finding of linkage on chromosome 8q12 shows precision and predictive power of mouse models in the investigation of complex traits in humans. Our results also confirm the role of loci at 5q33, 7p14, 12q14, and 13q13 in control of IgE. [less ▲]

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See detailMouse vaccination with dendritic cells loaded with prion protein peptides overcomes tolerance and delays scrapie.
Bachy, Veronique; Ballerini, Clara; Gourdain, Pauline et al

in Journal of General Virology (The) (2010), 91(Pt 3), 809-20

Prion diseases are presumed to be caused by the accumulation in the brain of a pathological protein called prion protein (PrP) scrapie which results from the transconformation of cellular PrP, a ... [more ▼]

Prion diseases are presumed to be caused by the accumulation in the brain of a pathological protein called prion protein (PrP) scrapie which results from the transconformation of cellular PrP, a ubiquitous glycoprotein expressed in all mammals. Since all isoforms of PrP are perceived as self by the host immune system, a major problem in designing efficient immunoprophylaxis or immunotherapy is to overcome tolerance. The present study was aimed at investigating whether bone-marrow-derived dendritic cells (DCs) loaded with peptides previously shown to be immunogenic in PrP-deficient mice, can overcome tolerance in PrP-proficient wild-type mice and protect them against scrapie. Results show that, in such mice, peptide-loaded DCs elicit both lymphokine release by T cells and antibody secretion against native cellular PrP. Repeated recalls with peptide-loaded DCs reduces the attack rate of 139A scrapie inoculated intraperitoneally and retards disease duration by 40 days. Most interestingly, survival time in individual mice appears to be correlated with the level of circulating antibody against native cellular PrP. [less ▲]

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See detailMoustique tigre: un nouveau moustique tropical dangereux trouvé à Anvers
Louis, François; Boukraa, Slimane ULg; Francis, Frédéric ULg

Article for general public (2013)

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See detailMoustiques (Diptera : Culicidae) de la région du M’Zab-Ghardaïa, Algérie : biodiversité et importance médico-vétérinaire
Boukraa, Slimane ULg; Baba Aissa, Nadir; Abdelaziz, Brahim et al

Poster (2013, October 19)

De nombreuses espèces de moustiques sont susceptibles de jouer un rôle dans la transmission de divers agents pathogènes responsables des maladies infectieuses humaines et animales. D'autres, outre leur ... [more ▼]

De nombreuses espèces de moustiques sont susceptibles de jouer un rôle dans la transmission de divers agents pathogènes responsables des maladies infectieuses humaines et animales. D'autres, outre leur rôle vecteur, sont un véritable fléau par les piqûres douloureuses qu’ils occasionnent et, constituent de ce fait un grand problème de nuisance. L'identification précise et la connaissance de la biodiversité fonctionnelle des vecteurs est un pas essentiel pour la compréhension du risque de (ré)-émergence et la dynamiques des maladies vectorielles. Le présent travail est une étude rétrospective des inventaires des Culicidae réalisés sur le terrain dans la région du M’Zab (Ghardaïa, Algérie) durant les années allant de 2008 à 2012. Les résultats de l’étude morphotaxonomique des Culicidae inventoriés ont montré la présence de dix espèces réparties en cinq genres (Culex, Culiseta, Ochlerotatus, Anopheles et Uranotaenia). Un aperçu sur le rôle vectoriel des espèces signalées dans la région et leur importance au niveau de la santé médicale et vétérinaire sont présentés à partir des données bibliographiques. Les espèces potentiellement vectrices d’arbovirus (Virus de Nile occidentale et Virus de la Vallée du Rift) et de protozoaires (Plasmodium spp) qui peuvent causer des problèmes épidémiologique au niveau de la région du M’Zab sont Cx. pipiens sl L., 1758, Cx. theileri Theobald, 1903, Ochlerotatus caspius Pallas, 1771, Anopheles sergentii Theobald, 1907, An. dthali Patton, 1905 et An. multicolor Cambouliu, 1902. [less ▲]

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See detailMoustiques de la région du M’Zab: sommes-nous en danger?
Boukraa, Slimane ULg

Conference given outside the academic context (2013)

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See detailLe mouvement des paysans sans terre au Brésil
Schoonbroodt, Bénédicte ULg

Conference (2006, May 08)

Detailed reference viewed: 17 (8 ULg)
See detailLe mouvement du désordre. Voyage au bout de la nuit par la Societas Raffaello Sanzio
Delhalle, Nancy ULg

Article for general public (1999)

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See detailLe mouvement étudiant devant M. Lacan
Cavazzini, Andrea ULg

Scientific conference (2010, March 20)

Detailed reference viewed: 9 (0 ULg)
See detailLe mouvement historiographique en Belgique
Kurth, Godefroid ULg

in Ned, Edouard (Ed.) L'Énergie belge, 1830-1905 : l'opinion d'une élite (1906)

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See detailLe mouvement intéllectuel et artistique en Espagne durant le premier tiers du 20e siècle
Ceballos Viro, Alvaro ULg

Conference given outside the academic context (2011)

Detailed reference viewed: 1 (0 ULg)
See detailLes Mouvements d’auteur du cinéma d’animation moderne belge
Tomasovic, Dick ULg

in Moins, Philippe (Ed.) Image par image, le cinéma d’animation en communauté Wallonie-Bruxelles (2001)

Detailed reference viewed: 42 (15 ULg)
See detailMouvements d'une histoire
Delhalle, Nancy ULg

in Vreux, Benoît (Ed.) Jouer le jeu. De l'autre côté du théâtre belge (2009)

Detailed reference viewed: 33 (17 ULg)
See detailMouvements de jeunes et socialisation politique; la dynamique de la J.É.C. à l'époque de Gérard Pelletier
Fournier, Bernard ULg

Book published by Laboratoire d'études politiques et administratives (1989)

Detailed reference viewed: 50 (12 ULg)
See detailLes mouvements Maï Maï de la République Démocratique du Congo. D'où viennent-ils et qui sont-ils?
Kabamba, Bob ULg

in International Documentation Network on the Great African Lakes Region (1999)

Detailed reference viewed: 14 (3 ULg)