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See detailAssessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography.
Gosseries, Olivia ULg; Thibaut, Aurore ULg; Boly, Mélanie ULg et al

in Annales Françaises d'Anesthésie et de Réanimation (2014)

Thanks to advances in medical care, an increased number of patients recover from coma. However, some remain in vegetative/unresponsive wakefulness syndrome or in a minimally conscious state. Detection of ... [more ▼]

Thanks to advances in medical care, an increased number of patients recover from coma. However, some remain in vegetative/unresponsive wakefulness syndrome or in a minimally conscious state. Detection of awareness in severely brain-injured patients is challenging because it relies on behavioral assessments, which can be affected by motor, sensory and cognitive impairments of the patients. Other means of evaluation are needed to improve the accuracy of the diagnosis in this challenging population. We will here review the different altered states of consciousness occurring after severe brain damage, and explain the difficulties associated with behavioral assessment of consciousness. We will then describe a non-invasive technique, transcranial magnetic stimulation combined with high-density electroencephalography (TMS-EEG), which has allowed us to detect the presence or absence of consciousness in different physiological, pathological and pharmacological states. Some potential underlying mechanisms of the loss of consciousness will then be discussed. In conclusion, TMS-EEG is highly promising in identifying markers of consciousness at the individual level and might be of great value for clinicians in the assessment of consciousness. [less ▲]

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See detailAssessing deadwood using harmonized National Forest Inventory data
Rondeux, Jacques ULg; Bertini, Roberta; Bastrup-Birk, Annemarie et al

in Forest Science (2012), 58(3), 269-283

Deadwood plays an important role in forest ecological processes and is fundamental for the maintenance of biological diversity. Further, it is a forest carbon pool whose assessment must be reported for ... [more ▼]

Deadwood plays an important role in forest ecological processes and is fundamental for the maintenance of biological diversity. Further, it is a forest carbon pool whose assessment must be reported for international agreements dealing with protection and forest management sustainability. Despite wide agreement on deadwood monitoring by national forest inventories (NFIs), much work is still necessary to clarify definitions so that estimates can be directly compared or aggregated for international reporting. There is an urgent need for an international consensus on definitions and agreement on harmonization methods. The study addresses two main objectives : to analyze the feasibility of harmonization procedures for deadwood estimates and to evaluate the impact of the harmonization process based on different definitions on final deadwood estimates. Results are reported for an experimental harmonization test using NFI deadwood data from 9,208 sample plots measured in nine European countries and the United States. Harmonization methods were investigated for volume by spatial position (lying or standing), decay classes, and woody species accompanied by accuracy assessments. Estimates of mean plot volume based on harmonized definitions with minimum length/height of 1 m and minimum diameter thresholds of 10, 12, and 20 cm were on average 3, 8, and 30% smaller, respectively, than estimates based on national definitions. Volumedifferences were less when estimated for various deadwood categories. An accuracy assessment demonstrated that, on average, the harmonization procedures did not substantially alter deadwood observations (root mean square error 23.17%). [less ▲]

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See detailAssessing donor chimerism level among CD3 T, CD4 T, CD8 T, and NK cells predicts subsequent graft rejection, GVHD, and relapse after allogeneic HCT with nonmyeloablative conditioning
Baron, Frédéric ULg; Storb, R.; Gooley, T. et al

in Biology of Blood & Marrow Transplantation (2005), 11(2), 11

We previously showed that low levels of day-14 CD3 T and NK (CD56) cells donor chimerism predicted graft rejection, whereas high levels of day-28 CD3 T-cell donor chimerism predicted acute graft-versus ... [more ▼]

We previously showed that low levels of day-14 CD3 T and NK (CD56) cells donor chimerism predicted graft rejection, whereas high levels of day-28 CD3 T-cell donor chimerism predicted acute graft-versus-host disease (GVHD) after HCT with nonmyeloablative conditioning. Here we investigate whether assessing chimerism levels among CD4 T cells and CD8 T cells, and also the absolute number of lymphocyte subsets of donor and host origins, would lend greater precision to our initial observations. We analyzed data from 157 patients receiving HCT after conditioning with 2 Gy TBI +/− fludarabine as treatment for AML (n= 22), ALL (n= 4), CML (n= 13), CLL (n= 19), MDS (n= 26), MM (n= 24), NHL (n= 30), HD (n= 14), RCC (n= 4), and WASP deficiency (n= 1). Postgrafting immunosuppression included MMF and CSP. A total of 97 patients received grafts from HLA-identical siblings, and 60 patients received grafts from HLA-matched unrelated donors. Lymphocyte subsets were isolated from peripheral blood by flow cytometry on days 14, 28, and 42. The proportion of cells of donor origin (chimerism levels) were assessed by VNTR-PCR and quantified by phosphor imaging. Eighteen patients (11%) had graft rejection. Day-14 donor chimerism levels< 50% among CD3 T (P =.0007), CD4 T (P =.03), and NK cells (P =.003) but not CD8 T cells predicted graft rejection. High absolute numbers of CD3 T (P =.002) and NK cells (P= .002) of host origin on day 14 were each associated with increased risks of graft rejection when treated as continuous linear variables. Grades 2, 3, and 4 acute GVHD were seen in 40%, 9%, and 5% of patients, respectively. High donor chimerism levels on day 14 among CD3 T (P= .02), CD4 T (P =.03), and CD8 T cells (P =.02) but not NK cells were each associated with increased risks of grades 2–4 acute GVHD. High absolute numbers of CD4 T (P =.04) and CD8 T cells (P =.04) of donor origin on days 14–42 were each associated with increased risks of grade 2–4 acute GVHD when treated as continuous linear variables, whereas high donor CD3 T (P= .002), CD8 T (P= .006), and NK cell (P= .002) chimerism levels from days 14–42 were associated with decreased risks of relapse. No statistically significant correlations between absolute numbers of donor cells and risks of relapse were found. These data suggest that assessing CD3, CD4, CD8, and NK cell donor chimerism levels and determining absolute numbers of CD3 and NK cells of host and donor origins are useful for predicting HCT outcomes after nonmyeloablative conditioning. [less ▲]

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See detailAssessing ecosystem changes in the North Western shelf of the Black Sea using 3D coupled models
Capet, Arthur ULg; Beckers, Jean-Marie ULg; Joassin, Pascal et al

Conference (2009, November 11)

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See detailAssessing Emigrant Participation in Home Country Elections: The Case of Mexico’s 2006 Presidential Election
Lafleur, Jean-Michel ULg; Calderon Chelius, Leticia

in International Migration (2011), 49(3), 99-124

How did Mexican migrants react to the opportunity to formally participate for the first time in home country politics during the 2006 Presidential Election? In this paper, we attempt to explain the low ... [more ▼]

How did Mexican migrants react to the opportunity to formally participate for the first time in home country politics during the 2006 Presidential Election? In this paper, we attempt to explain the low level of migrant voter registration in home country elections. Grounding ourselves on the existing literature on voter turnout, we verify two hypotheses that focus (1) on the role of Mexican authorities, and (2) on the interest of migrants and migrant associations in home country politics. Building on the case of Mexico, the paper concludes with proposing a series of variables upon which we suggest research could focus in order to assess migrant voter turnout in home country elections. [less ▲]

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See detailAssessing fitness in endurance horses
Fraipont, Audrey ULg; Van Erck, Emmanuelle; Ramery, Eve ULg et al

in Canadian Veterinary Journal = Revue Vétérinaire Canadienne (2012), 53

A field test and a standardized treadmill test were used to assess fitness in endurance horses. These tests discriminated horses of different race levels: horses participating in races of 120km and more ... [more ▼]

A field test and a standardized treadmill test were used to assess fitness in endurance horses. These tests discriminated horses of different race levels: horses participating in races of 120km and more showed higher values of VLA4 (velocity at which blood lactate reached 4 mmol/L) and V200 (velocities at which heart rates reached 200 beats per min) than horses of lower race levels. [less ▲]

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See detailAssessing gaps and needs for integrating building performance optimization tools in net zero energy buildings design
Attia, Shady ULg; Hamdy, Mohamed; O’Brien, William et al

in Energy and Buildings (2013), 60

This paper summarizes a study undertaken to reveal potential challenges and opportunities for integrating optimization tools in net zero energy buildings (NZEB) design. The paper reviews current trends in ... [more ▼]

This paper summarizes a study undertaken to reveal potential challenges and opportunities for integrating optimization tools in net zero energy buildings (NZEB) design. The paper reviews current trends in simulation-based building performance optimization (BPO) and outlines major criteria for optimization tools selection and evaluation. This is based on analyzing user's needs for tools capabilities and requirement specifications. The review is carried out by means of a literature review of 165 publications and interviews with 28 optimization experts. The findings are based on an inter-group comparison between experts. The aim is to assess the gaps and needs for integrating BPO tools in NZEB design. The findings indicate a breakthrough in using evolutionary algorithms in solving highly constrained envelope, HVAC and renewable optimization problems. Simple genetic algorithm solved many design and operation problems and allowed measuring the improvement in the optimality of a solution against a base case. Evolutionary algorithms are also easily adapted to enable them to solve a particular optimization problem more effectively. However, existing limitations including model uncertainty, computation time, difficulty of use and steep learning curve. Some future directions anticipated or needed for improvement of current tools are presented. [less ▲]

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See detailAssessing groundwater-surface water interaction and groundwater discharge in a contaminated site in an industrial, sub-urbanized area
Batlle-Aguilar, Jordi; Brouyère, Serge ULg

in Davis, G. B.; Johntson, C. D.; Trefry, M. G. (Eds.) Groundwater Quality 2007 Securing Groundwater Quality in Urban and Industrial Environments (2007)

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See detailAssessing heat stress effects on production traits of Holsteins in a temperate region
Hammami, Hedi ULg; Bormann, Jeanne; Gengler, Nicolas ULg

Conference (2012)

Heat stress impaired productive, reproductive and animal behaviour. Examination of milk production loss due to heat stress was mainly evaluated in USA and few tropical countries using the temperature ... [more ▼]

Heat stress impaired productive, reproductive and animal behaviour. Examination of milk production loss due to heat stress was mainly evaluated in USA and few tropical countries using the temperature humidity index (THI1) developed in the 1950’s. The main objective of this study was to evaluate the effects of six new environmental stress indices on production traits in a temperate region. These indices include solar radiation and wind speed in addition to the temperature and humidity only defining THI1. For that purpose, 530820 milk, fat, protein, and somatic cell count first-lactation test-day records (TD) collected between 2000 and 2011 in Luxembourg were used. TD records were merged with meteorological data from 14 public weather stations. Each TD was assigned to the average daily thermal index of the 3 days before. Firstly, broken-line regression models were applied to identify the threshold of heat stress (THR) for each of the thermal indices. The decline of daily production of the different traits above THR point was assessed by mixed linear models including regression on unit of each of the thermal index. Estimates of THR were specific to each thermal index and trait. Significant decrease of milk, fat and protein yields above THR was observed for all studied thermal predictors. Whereas, an increase of the somatic cell score was observed above the specific THR point. THR estimates for THI1 and THI6 were of 68 and 80 and 62 and 78 for milk and protein yields respectively. Respective rate of decline per unit were of 0.243 and 0.188 kg and 0.0045 and 0.0051 kg respectively. Results from this phenotypic analysis show that evaluating heat tolerance based on bio-meteorological indicators is promising and phenotypic and genetic implications should be investigated. [less ▲]

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See detailAssessing heat stress effects on production traits of Holsteins in a temperate region
Hammami, Hedi ULg; Bormann, Jeanne; Gengler, Nicolas ULg

in Book of abstracts of the 63rd Annual Meeting of the European Association for Animal Production (2012)

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See detailAssessing IT Innovations in US State Governments: a research framework
Markus, M. Lynne; Bui, Quang Neo; Jacobson, Dax D. et al

Poster (2011, August)

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See detailAssessing local Ca2+ concentrations in calcium phosphate scaffolds by computational modelling
Manhas, Varun ULg; Guyot, Yann ULg; Chai, Yoke Chin et al

Poster (2013, October 24)

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See detailAssessing overall heating efficiency of office buildings
Parys, Wout; Bertagnolio, Stéphane ULg; Saelens, Dirk et al

in Lemort, Vincent; Andre, Philippe; Bertagnolio, Stéphane (Eds.) 8th Conference on System Simulation in Buildings (2010, December 13)

The current methodology applied to estimate system efficiencies oversimplifies the complex interaction between the building, the occupants and the system. By detailed modelling of the building and the ... [more ▼]

The current methodology applied to estimate system efficiencies oversimplifies the complex interaction between the building, the occupants and the system. By detailed modelling of the building and the system, it is possible to define system efficiencies at the building level as a function of the system type and the building characteristics. In this study, the performance of a simple heating system in a middle-sized office building is simulated. The monthly average total efficiency, defined at the building level, proves to be very well correlated with the monthly ratio of heat gains over heat losses of the building. At ratios over 0.6, the efficiency falls sharply. This is mainly due to declining control efficiency. This secondary effect can annul partly the targeted increase in energy efficiency of well insulated and airtight buildings. [less ▲]

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See detailAssessing Quality of Origin-Destination Matrices Derived from Activity and Travel Surveys: Results from a Monte Carlo Experiment
Cools, Mario ULg; Moons, Elke; Wets, Geert

in Proceedings of the 89th Annual Meeting of the Transportation Research Board (DVD-ROM) (2010)

To support policy makers combating travel-related externalities, quality data is required for the design and management of transportation systems and policies. To this end, large amounts of money have ... [more ▼]

To support policy makers combating travel-related externalities, quality data is required for the design and management of transportation systems and policies. To this end, large amounts of money have been spent on collecting household and person-based data. The main objective of this paper is to assess the quality of origin-destination matrices derived from household activity/travel surveys. To this purpose, a Monte Carlo experiment is set up to estimate the precision of OD-matrices given different sampling rates. The Belgian 2001 census data, containing work/school-related travel information for all 10,296,350 residents, are used for the experiment. For different sampling rates, 2000 random stratified samples are drawn. For each sample, three origin-destination-matrices are composed: one at municipality level, one at district level, and one at provincial level. The correspondence between the samples and the population is assessed by using the Mean Absolute Percentage Error (MAPE) and a censored version of the MAPE (MCAPE). The results show that no accurate OD-matrices can be directly derived from these surveys. Only when half of the population is queried, an acceptable OD-matrix is obtained at provincial level. Therefore, it is recommended to use additional information to better grasp the behavioral realism underlying destination choices and to collect information about particular origin-destination pairs by means of vehicle intercept surveys. In addition, the results suggest using the MCAPE next to traditional criteria to examine dissimilarities between different OD matrices. An important avenue for further research is the investigation of the effect of sampling proportions on travel demand model outcomes. [less ▲]

Detailed reference viewed: 16 (0 ULg)