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See detailImmunological principles relevant for immune-mediated inflammatory diseases and pregnancy
Geenen, Vincent ULiege

Scientific conference (2010, November 23)

Detailed reference viewed: 6 (0 ULiège)
Peer Reviewed
See detailImmunological reactivity of the Bovine Leukemia Virus glycoprotein gp51.
Portetelle, Daniel ULiege; Bruck, Claudine; Cleuter, Yvette et al

in Straub O.C. (Ed.) Current Topics in Veterinary Medicine and Animal Science (1982)

Detailed reference viewed: 6 (0 ULiège)
Peer Reviewed
See detailImmunological Status of Competitive Football Players During the Training Season
Bury, Thierry ULiege; Marechal, R.; Mahieu, P. et al

in International Journal of Sports Medicine (1998), 19(5), 364-8

We investigated possible immunological changes in 15 professional football players before, during and after the sports season. We studied the leucocyte count as well as different functions such as T ... [more ▼]

We investigated possible immunological changes in 15 professional football players before, during and after the sports season. We studied the leucocyte count as well as different functions such as T-lymphocyte proliferation, NK activity, chemotaxis and phagocytosis of neutrophils. Training and competitions did not produce any change in the total number of leucocytes but increased neutrophil counts and decreased T4 lymphocyte counts. We also observed a slight decrease of T-lymphocyte proliferation and a significant decrease of neutrophil functions. On the other hand, training and competitions did not induce significant changes in the number of NK cells nor in the total NK cytotoxic activity. The different change observed tended to normalize after the sports season. Our results suggest a predominant neutrophil function depression in football players during a training season which could partly explain the susceptibility of elite athletes to infections. [less ▲]

Detailed reference viewed: 15 (0 ULiège)
Peer Reviewed
See detailImmunological Techniques in Insect Biology (L.I. Gilbert & T.A. Miler, eds.)
Rentier, Bernard ULiege

in Biochemical Systematics & Ecology (1989), 17(6), 501-502

Detailed reference viewed: 33 (0 ULiège)
See detailImmunologie clinique
Heinen, Ernst ULiege

Book published by De Boeck (1993)

Detailed reference viewed: 19 (6 ULiège)
See detailImmunology in animal production.
Renaville, Bénédicte; Renaville, Robert ULiege

in Rosati, A.; Tewolde, A.; Mosconi, C. (Eds.) Advances in animal science (2007)

Detailed reference viewed: 48 (5 ULiège)
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See detailImmunology in the clinic review series. Focus on type 1 diabetes and virus: enterovirus, thymus and type 1 diabetes pathogenesis
Jaïdane, H.; Sane, F.; Hiar, R. et al

in Clinical & Experimental Immunology (2012), 168

Thymus dysfunction, especially immune suppression, is frequently associated with various virus infections.Whether viruses may disturb the thymus function and play a role in the pathogenesis of autoimmune ... [more ▼]

Thymus dysfunction, especially immune suppression, is frequently associated with various virus infections.Whether viruses may disturb the thymus function and play a role in the pathogenesis of autoimmune diseases is an open issue. Enteroviruses, especially Coxsackievirus B4 (CV-B4), have been largely suggested as potential inducers or aggravating factors of type 1 diabetes (T1D) pathogenesis in genetically predisposed individuals. Several pathogenic mechanisms of enterovirus-induced T1D have been suggested. One of these mechanisms is the impairment of central self-tolerance due to viral infections. Coxsackievirus-B4 is able to infect murine thymus in vitro and in vivo and to infect human thymus in vitro. Thymic epithelial cells and thymocytes are targets of infection with this virus, and several abnormalities, especially disturbance of maturation/differentiation processes, were observed.Altogether, these data suggest that CV-B infection of thymus may be involved in the pathogenesis of T1D. Further investigations are needed to explore this hypothesis. [less ▲]

Detailed reference viewed: 50 (5 ULiège)
Peer Reviewed
See detailImmunology of dermatophytosis
Mignon, Bernard ULiege; Vermout, S.; Tabart, J. et al

Conference (2004)

Detailed reference viewed: 29 (6 ULiège)
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See detailThe Immunomodulating Peptide Thymosin Alpha 1 Has no Effect on Multiple Myeloma Evolution and on Immune Reconstitution
Binsfeld, Marilène ULiege; Otjacques, Eléonore ULiege; Hannon, Muriel ULiege et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 41

Detailed reference viewed: 48 (19 ULiège)
See detailImmunomodulation de la croissance: nouvelles perspectives
Portetelle, Daniel ULiege; Massart, Serge; Burny, Arsène et al

in 1° Carrefour des Productions Animales (1995)

Detailed reference viewed: 5 (1 ULiège)
See detailImmunomodulation of varicella-zoster virus antigens
Marc, Ph.; Sadzot-Delvaux, Catherine ULiege; Merville-Louis, M. P. et al

Poster (1989)

Detailed reference viewed: 13 (2 ULiège)
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See detailImmunomodulatory effects of probiotics in the intestinal tract.
Delcenserie, Véronique ULiege; Martel, D.; Lamoureux, M. et al

in Current Issues in Molecular Biology (2008), 10(1-2), 37-54

The intestinal microbiota is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human health. The interaction between probiotic and enterocytes is the ... [more ▼]

The intestinal microbiota is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human health. The interaction between probiotic and enterocytes is the initiating event in immunomodulation and merits particular attention. The effects of probiotic is strain dependent and for each new probiotic strain, profiles of cytokines secreted by lymphocytes, enterocytes or dendritic cells that come in contact with the strain should be systematically established. To evaluate the effects of probiotics on the immune system, models that mimic the mucosa, and thus the physiological reality, should be preferred whenever it is possible. Then, the in vitro observed effects should be backed up by properly conducted randomized double bind clinical studies. More detailed studies are needed to determine the precise action mode of probiotics on both mucosal and systemic immunity. [less ▲]

Detailed reference viewed: 46 (8 ULiège)
See detailImmunomodulatory effects of rapamycin in Graft versus Host Disease
Ehx, Grégory ULiege; Hannon, Muriel ULiege; Humblet-Baron, Stéphanie et al

Poster (2016, January 29)

Detailed reference viewed: 16 (2 ULiège)
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See detailImmunomodulatory effects of rapamycin in xenogeneic Graft versus Host Disease
Ehx, Grégory ULiege; Hannon, Muriel ULiege; DUBOIS, Sophie ULiege et al

in Biology of Blood and Marrow Transplantation (2017, March), 23(3), 365366

Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Several studies have suggested that rapamycin (RAPA), an mTOR ... [more ▼]

Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Several studies have suggested that rapamycin (RAPA), an mTOR inhibitor with immunosuppressive properties, may reduce GVHD severity and mortality, possibly by promoting regulatory T cells (Tregs). However, few data have been reported about the impact of this drug on overall T cell population. The present work aims at investigating the mechanisms by which RAPA impacts GVHD in a humanized mouse model of GVHD (NSG mice infused with human PBMCs). We observed that RAPA injections significantly reduced xenogeneic GVHD lethality and severity. RAPA dramatically reduced human cells chimerism in RAPA mice and increased CD4+/CD8+ T cells balance due to a lower proliferation of CD8+ T cells. In addition, the frequencies of naive CD4+ and CD8+ T cells were higher and the CD4+ T cells showed a reduced effector phenotype (CD45RO+CD27-). Further, the differentiation of helper T cells (Th1, Th2 and Th17) was significantly decreased in treated mice. Tregs were positively affected as RAPA up-regulated their expression of BCL-2 and KI67 as well as their STAT5 phosphorylation level, leading to higher Treg frequency in treated mice. Altogether these data suggest that RAPA ameliorates GVHD by lowering cytotoxic and effector CD4+ T cells frequency as well as promoting Tregs. [less ▲]

Detailed reference viewed: 30 (5 ULiège)
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See detailImmunomodulatory effects of Rapamycin in xenogeneic GVHD
Ehx, Grégory ULiege; HANNON, Muriel ULiege; DUBOIS, Sophie ULiege et al

Poster (2014, January 27)

Detailed reference viewed: 36 (17 ULiège)
See detailImmunomodulatory effects of Rapamycin in xenogeneic GVHD
Ehx, Grégory ULiege

Poster (2014, January 31)

Detailed reference viewed: 60 (14 ULiège)