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See detailMultiple Material Mesh Generation For Biomedical Applications
D'Otreppe, Vinciane ULg; Boman, Romain ULg; Ponthot, Jean-Philippe ULg

Poster (2010, November 26)

The finite element (FE) method is commonly used in biomedical applications for the simulation of the behaviour of biological structures. A key component in FE simulation is the creation of a finite ... [more ▼]

The finite element (FE) method is commonly used in biomedical applications for the simulation of the behaviour of biological structures. A key component in FE simulation is the creation of a finite element mesh. In medical applications, the meshes should be directly generated from the medical scans. Moreover, biological structures are usually composed of several inner regions that need to be separately segmented, labelled and meshed to be able to apply different material properties in the finite element model. A procedure to create surface meshes from a multi-valued volume data sets is proposed. Following properties are guaranteed: (1) The generated mesh consists of a set of non manifold triangle meshes that separate each connected component in the labelled data set. These interface meshes join each other consistently along their boundaries, i.e., no T junctions nor gaps may appear. (2) The surface mesh is a geometrically accurate representation of the data represented in the medical scans. However, it is not be tainted by the typical aliasing and staircase artifacts that are due to the discrete nature of the voxels. [less ▲]

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See detailMultiple measures elucidate glucocorticoid responses to environmental variation in predation threat
Clinchy, Michael; Zanette, Liana; Charlier, Thierry ULg et al

in Oecologia (2011), 166

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See detailMultiple mechanisms control brain aromatase activity at the genomic and non-genomic level
Balthazart, Jacques ULg; Baillien, Michelle; Charlier, Thierry ULg et al

in Journal of Steroid Biochemistry & Molecular Biology (2003), 86

Evidence has recently accumulated indicating that aromatase activity in the preoptic area is modulated in parallel by both slow (hours to days) genomic and rapid (minutes to hours) non-genomic mechanisms ... [more ▼]

Evidence has recently accumulated indicating that aromatase activity in the preoptic area is modulated in parallel by both slow (hours to days) genomic and rapid (minutes to hours) non-genomic mechanisms. We review here these two types of control mechanisms and their potential contribution to various aspects of brain physiology in quail. High levels of aromatase mRNA, protein and activity (AA) are present in the preoptic area of this species where the transcription of aromatase is controlled mainly by steroids. Estrogens acting in synergy with androgens play a key role in this control and both androgen and estrogen receptors (ER; alpha and beta subtypes) are present in the preoptic area even if they are not necessarily co-localized in the same cells as aromatase. Steroids have more pronounced effects on aromatase transcription in males than in females and this sex difference could be caused, in part, by a sexually differentiated expression of the steroid receptor coactivator 1 in this area. The changes in aromatase concentration presumably control seasonal variations as well as sex differences in brain estrogen production. Aromatase activity in hypothalamic homogenates is also rapidly (within minutes) down-regulated by exposure to conditions that enhance protein phosphorylation such as the presence of high concentrations of calcium, magnesium and ATP. Similarly, pharmacological manipulations such as treatment with thapsigargin or stimulation of various neurotransmitter receptors (alpha-amino-3-hydroxy-methyl-4-isoxazole propionic acid (AMPA), kainate, and N-methyl-d-aspartate (NMDA)) leading to enhanced intracellular calcium concentrations depress within minutes the aromatase activity measured in quail preoptic explants. The effects of receptor stimulation are presumably direct: electrophysiological data confirm the presence of these receptors in the membrane of aromatase-expressing cells. Inhibitors of protein kinases interfere with these processes andWestern blotting experiments on brain aromatase purified by immunoprecipitation confirm that the phosphorylations regulating aromatase activity directly affect the enzyme rather than another regulatory protein. Accordingly, several phosphorylation consensus sites are present on the deduced amino acid sequence of the recently cloned quail aromatase. Fast changes in the local availability of estrogens in the brain can thus be caused by aromatase phosphorylation so that estrogen could rapidly regulate neuronal physiology and behavior. The rapid as well as slower processes of local estrogen production in the brain thus match well with the genomic and non-genomic actions of steroids in the brain. These two processes potentially provide sufficient temporal variation in the bio-availability of estrogens to support the entire range of established effects for this steroid. [less ▲]

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See detailMultiple Migrations, Displacements and Land Transfers at Ta Kream in Northwest Cambodia
Pilgrim, John; Ngin, Chanrith; Diepart, Jean-Christophe ULg

in Hecht, Susanna; Kandel, Susan; Morales, Abelardo (Eds.) Migration, Rural Livelihoods and Natural Resource Management (2012)

The Cambodian case examines migration, land tenure and land management, in a context of conflict and the use of force in land transfers since the time of the Khmer Rouge regime to the present, by studying ... [more ▼]

The Cambodian case examines migration, land tenure and land management, in a context of conflict and the use of force in land transfers since the time of the Khmer Rouge regime to the present, by studying five agro-ecological zones close to the Kamping Pouy irrigation system in Battambang Province. The study combines analysis of demographic and socioeconomic characteristics of household use of land and labor with a historical and ethnographic review of conflict and institutional factors in successive land administrations. Continuing in-migration is reflected in population increases in Battambang and other provinces of Northwest Cambodia in conditions of limited land availability and landlordism, and conflict over expropriation of land by armed groups and business interests. Land transfers to a growing wealthy class of businessmen and government officials have contributed to the creation of a subclass of very poor, landless households whose livelihoods depend on agricultural wage labor, locally and in Thailand, and access to the commons. Access to land for a substantial proportion of the community depends on either tenancy, sharecropping or wage labor on the land of wealthier farmers. Three problematic processes that run counter to the Cambodian Constitution and Land Law are systemic: 1) the usurpation of land rights by locally operating armed groups; 2) legitimation of such land acquisition by military-business-government officials by corrupt officeholders and local government officials; and 3) the capture of rents or profits by agencies responsible for safeguarding natural resources. [less ▲]

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See detailMultiple mode analysis of the self-excited vibrations of rotary drilling systems
Germay, Christophe; Denoël, Vincent ULg; Detournay, Emmanuel

in Journal of Sound & Vibration (2009), 325(1-2), 362-381

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See detailMultiple muscarinic receptor subtypes mediating pulmonary oedema in the rabbit.
Delaunois, Annie ULg; Gustin, Pascal ULg; Ansay, Michel ULg

in Pulmonary Pharmacology (1994), 7(3), 185-93

The effects of various muscarinic antagonists on acetylcholine (ACh)-induced pulmonary oedema were studied in isolated perfused rabbit lungs. ACh induced a dose-dependent increase in the capillary ... [more ▼]

The effects of various muscarinic antagonists on acetylcholine (ACh)-induced pulmonary oedema were studied in isolated perfused rabbit lungs. ACh induced a dose-dependent increase in the capillary filtration coefficient (Kf,c). This effect has been previously related to the activation of the capsaicin-sensitive nerve fibres and the release of substance P. Atropine, pirenzepine (M1-selective antagonist) and 4-DAMP (M3-selective antagonist) altered this response, producing a dose-dependent shift to the right of the ACh concentration-Kf,c response curve. By contrast, the M2-selective antagonist AFDX-116 shifted the ACh concentration-response curve to the left. Atropine, pirenzepine and 4-DAMP also significantly reduced the capsaicin-induced increase in the Kf,c, while AFDX-116 enhanced it. We conclude that multiple muscarinic receptor subtypes are present in the rabbit lung, located on the C-fibres, and are involved in the ACh-induced pulmonary oedema. M1 and M3 receptors seem to stimulate the release of neuropeptides from C-fibres, whereas M2 receptors have an inhibitory effect on these fibers. [less ▲]

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See detailMultiple myeloma cells instruct myeloid-derived suppressor cells to release pro-angiogenic cytokines
Binsfeld, Marilène ULg; Heusschen, Roy ULg; Lamour, Virginie et al

in Belgian Journal of Hematology (2014)

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See detailMultiple Myeloma, an update on diagnosis and treatment.
Caers, Jo ULg; Vande Broek, Isabelle; De Raeve, Hendrik et al

in European Journal of Haematology (2008), 81(5), 329-343

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See detailMultiple peroxysomal deficiency syndromes: a comparative and multidisciplinary study in Zellweger and Neonatal Adrenoleukodystrophy patients
Vamecq, Joseph; Draye, J. P.; Van Hoof, François et al

in American Journal of Pathology (1986), 125

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See detailMultiple peroxysomal deficiency syndromes: a comparative and multidisciplinary study in Zellweger and Neonatal Adrenoleukodystrophy patients
Vamecq, Joseph; Draye, J. P.; Van Hoof, François et al

in American Journal of Pathology (1986), 125

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See detailMultiple pitfalls in the diagnosis of a complex liver disease
HARVENGT, Julie ULg; Wanty, Catherine; Lissens, Willy et al

Conference (2013, June 14)

A one year old girl, born to consanguineous parents, presented with unexplained liver disease. Liver biopsies revealed respiratory chain complex I and IV deficiencies. Progressive liver failure at 19 ... [more ▼]

A one year old girl, born to consanguineous parents, presented with unexplained liver disease. Liver biopsies revealed respiratory chain complex I and IV deficiencies. Progressive liver failure at 19 months led to liver transplantation. One year later, anemia and thrombocytopenia occurred due to hypersplenism. Histopathological analyses of partial splenectomy showed the presence of Gaucher cells, and Gaucher disease was confirmed by enzyme and genetic analyses. Respiratory chain deficiency was considered as a possible artifact due to liver failure and cirrhosis. She was treated by ERT. Clinical follow-up showed developmental delay, strabism, nystagmus and external ophthalmoplegia. A mitochondrial disorder was considered again, and molecular analysis revealed a mtDNA depletion syndrome due to homozygous MPV17 mutation. In the meantime, a young sister presented with acute abdominal pain, pancytopenia and major hepatosplenomegaly. ERT for Gaucher disease allowed visceral normalization, without any developmental delay or neurological symptom. She was unaffected by the mtDNA depletion syndrome. Unfortunately, a third sister systematically screened, was affected by both conditions. Despite ERT, she presents chronic moderate liver dysfunction and mild hepatomegaly. Aged 3 years, she has marked developmental delay and ophthalmoplegia. Metabolic investigations showed normal blood lactate, in basal condition as well as following an oral glucose load [less ▲]

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See detailMultiple pregnancy-associated glycoproteins are secreted by day 100 sheep placenta
Xie, Sancai; Green, Jonathan; Bao, Bagna et al

in Biology of Reproduction (1997), 57(6), 1384-1393

Pregnancy-associated glycoprotein (PAG)-1 (PAG1) and pregnancy-specific protein B are either identical or closely related antigens released by trophoblast binucleate cells of placentas of cattle. Sheep ... [more ▼]

Pregnancy-associated glycoprotein (PAG)-1 (PAG1) and pregnancy-specific protein B are either identical or closely related antigens released by trophoblast binucleate cells of placentas of cattle. Sheep and other ruminants produce similar products. There is evidence, however, that these antigens, which are related structurally to the pepsinogens and other aspartic proteinases, are not single gene products but members of an extensive family. Here, the sequential use of ammonium sulfate precipitation and Sepharose blue, anion-exchange, and cation-exchange chromatographies, as well as isoelectric elution from a Mono P column, has allowed several PAG1-related molecules to be purified from the medium after culture of explants from Day 100 sheep placentas. Each of these PAGs cross-reacted to a varying extent with a panel of three different anti-PAG1 antisera. Four of them, all of which were major secretory products of the placenta, were subjected to amino-terminal microsequencing. Although each was related to ovine (ov) PAG1, none was identical. Reverse transcription-polymerase chain reaction was then used to amplify PAG1-related cDNA from Day 100 placental RNA. Seven novel full-length cDNA, all distinct from ovPAG1, were identified from 25 cDNA selected for sequencing. Only two of these (ovPAG3 and ovPAG7) encoded polypeptides identical in sequence at their inferred amino termini to one of the PAGs (ovPAG65) purified from explant cultures. Even so, they were only 84% identical in overall sequence. The remaining five cDNA were unique. In situ hybridization analysis revealed that expression of ovPAG3 and ovPAG7, like that of ovPAG1, is confined to trophoblast binucleate cells. The data confirm that at Day 100 of pregnancy the ovine placenta produces many different PAGs, which differ considerably in sequence and immunological cross-reactivity. [less ▲]

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See detailMultiple pulmonary arteriovenous malformations.
Quaden, C.; Ghaye, Benoit ULg; Dondelinger, Robert ULg et al

in Lancet (2002), 359(9322),

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See detailMultiple Realities of Virtual Architecture, Opening Session of Virtual Techniques for Architecture
Leclercq, Pierre ULg; Martin, G.

in Fisher, X.; Coutellier, D. (Eds.) Proceedings of Virtual Concept Conference '05 - Research in Interactive Design (2005)

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See detailMultiple Redox Regulation in Nf-Kappab Transcription Factor Activation
Piette, Jacques ULg; Piret, Bernard; Bonizzi, Giuseppina et al

in Biological Chemistry (1997), 378(11), 1237-45

The well-known Rel/NF-kappaB family of vertebrate transcription factors comprises a number of structurally related, interacting proteins that bind DNA as dimers and whose activity is regulated by ... [more ▼]

The well-known Rel/NF-kappaB family of vertebrate transcription factors comprises a number of structurally related, interacting proteins that bind DNA as dimers and whose activity is regulated by subcellular location. This family includes many members (p50, p52, RelA, RelB, c-Rel, ...), most of which can form DNA-binding homo- or hetero-dimers. All Rel proteins contain a highly conserved domain of approximately 300 amino-acids, called the Rel homology domain (RH), which contains sequences necessary for the formation of dimers, nuclear localization, DNA binding and IkappaB binding. Nuclear expression and consequent biological action of the eukaryotic NF-kappaB transcription factor complex are tightly regulated through its cytoplasmic retention by ankyrin-rich inhibitory proteins known as IkappaB. The IkappaB proteins include a group of related proteins that interact with Rel dimers and regulate their activities. The interaction of a given IkappaB protein with a Rel complex can affect the Rel complex in distinct ways. In the best characterized example, IkappaB-alpha interacts with a p50/RelA (NF-kappaB) heterodimer to retain the complex in the cytoplasm and inhibit its DNA-binding activity. The NF-kappaB/IkappaB-alpha complex is located in the cytoplasm of most resting cells, but can be rapidly induced to enter the cell nucleus. Upon receiving a variety of signals, many of which are probably mediated by the generation of reactive oxygen species (ROS), IkappaB-alpha undergoes phosphorylation at serine residues by a ubiquitin-dependent protein kinase, is then ubiquitinated at nearby lysine residues and finally degraded by the proteasome, probably while still complexed with NF-kappaB. Removal of IkappaB-alpha uncovers the nuclear localization signals on subunits of NF-kappaB, allowing the complex to enter the nucleus, bind to DNA and affect gene expression. Like proinflammatory cytokines (e.g. IL-1, TNF), various ROS (peroxides, singlet oxygen, ...) as well as UV (C to A) light are capable of mediating NF-kappaB nuclear translocation, while the sensor molecules which are sensitive to these agents and trigger IkappaB-alpha proteolysis are still unidentified. We also show that a ROS-independent mechanism is activated by IL-1beta in epithelial cells and seems to involve the acidic sphingomyelinase/ceramide transduction pathway. [less ▲]

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See detailMultiple regression and crops yields prediction on basis of meteorological data
Dagnelie, P.; Palm, Rodolphe ULg

in XVIth International Biometric Conference Proceedings, Hamilton, New Zealand, 7-11 December 1992 : Proceedings of contributed papers (1992, December)

Detailed reference viewed: 12 (1 ULg)