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See detailMyocardial expression of cytokines influence postoperative outcome after cardiac surgery for congenital cardiac defects
Sprute, Johanna; Heying, Ruth; Buding, Brigitte et al

Conference (2014, January)

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See detailMyocardial infarct size quantification in mice by SPECT using a novel algorithm independent of a normal perfusion database
Roelants, Véronique; DELGAUDINE, Marie ULg; Walrand, Stephan et al

in European Journal of Nuclear Medicine and Molecular Imaging Research (2012), 2

Background: There is a growing interest in developing non-invasive imaging techniques permitting infarct size (IS) measurements in mice. The aim of this study was to validate the high-resolution rodent ... [more ▼]

Background: There is a growing interest in developing non-invasive imaging techniques permitting infarct size (IS) measurements in mice. The aim of this study was to validate the high-resolution rodent Linoview single photon emission computed tomography (SPECT) system for non-invasive measurements of IS in mice by using a novel algorithm independent of a normal database, in comparison with histology. Methods: Eleven mice underwent a left coronary artery ligature. Seven days later, animals were imaged on the SPECT 2h30 after injection of 173 ± 27 MBq of Tc-99m-sestamibi. Mice were subsequently killed, and their hearts were excised for IS determination with triphenyltetrazolium chloride (TTC) staining. SPECT images were reconstructed using the expectation maximization maximum likelihood algorithm, and the IS was calculated using a novel algorithm applied on the 20-segment polar map provided by the commercially available QPS software (Cedars-Sinai Medical Center, CA, USA). This original method is attractive by the fact that it does not require the implementation of a normal perfusion database. Results: Reconstructed images allowed a clear delineation of the left ventricles borders in all mice. No significant difference was found between mean IS determined by SPECT and by TTC staining [37.9 ± 17.5% vs 35.6 ± 17.2%, respectively (P = 0.10)]. Linear regression analysis showed an excellent correlation between IS measured on the SPECT images and IS obtained with TTC staining (y = 0.95x + 0.03 (r = 0.97; P < 0.0001)), without bias, as demonstrated by the Bland-Altman plot. Conclusion: Our results demonstrate the accuracy of the method for the measurement of myocardial IS in mice with the Linoview SPECT system. [less ▲]

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See detailMyocardial Viability. Stress Echocardiography Vs Nuclear Medicine
Pierard, Luc ULg; Lancellotti, Patrizio ULg; Benoit, T.

in European Heart Journal (1997), 18(Suppl D), 117-23

Myocardial dyssynergy does not necessarily indicate myocardial necrosis in patients with coronary artery disease. The differentiation between viable and non-viable tissue is of great clinical importance ... [more ▼]

Myocardial dyssynergy does not necessarily indicate myocardial necrosis in patients with coronary artery disease. The differentiation between viable and non-viable tissue is of great clinical importance in order to make the most appropriate clinical decision in the individual patient. Several techniques are used to assess myocardial viability. Nuclear medicine gives reliable information on regional perfusion, metabolism and cell membrane integrity, while echocardiography provides real time visualization of myocardial thickening in basal conditions and continuously during pharmacological interventions. The presence or absence of contractile reserve in akinetic regions can be evaluated by pharmacological stress echocardiography. This article presents the semiology of myocardial viability as characterized by these different methods and reviews their relative value in different clinical settings. [less ▲]

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See detailLa myocardiopathie hypertrophique obstructive: options therapeutiques chirurgicales.
Radermecker, Marc ULg; SAKALIHASAN, Natzi ULg; Partoune, B. et al

in Revue Médicale de Liège (1993), 48(12), 659-65

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See detailMyocellular Enzyme Leakage, Polymorphonuclear Neutrophil Activation and Delayed Onset Muscle Soreness Induced by Isokinetic Eccentric Exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Deby-Dupont, G. et al

in Archives of Physiology & Biochemistry (1996), 104(3), 322-9

To address the question of whether delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of the arachidonic acid derived product ... [more ▼]

To address the question of whether delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of the arachidonic acid derived product prostaglandin E2 (PGE2). 10 healthy male subjects were submitted to eccentric and concentric isokinetic exercises on a Kin Trex device at 60 degrees/s angular velocity. Exercise consisted of 8 stages of 5 maximal contractions of the knee extensor and flexor muscle groups of both legs separated by 1 min rest phases. There was an interval of at least 30 days between eccentric and concentric testing, and the order of the two exercise sessions was randomly assigned. The subjective presence and intensity of DOMS was evaluated using a visual analogue scale, immediately, following 24 h and 48 h after each test. Five blood samples were drawn from an antecubital vein: at rest before exercise, immediately after, after 30 min recovery, 24 h and 48 h after the tests. The magnitude of the acute inflammatory response to exercise was assessed by measuring plasma levels of polymorphonuclear elastase ([EL]), myeloperoxidase ([MPO]) and PGE2 ([PGE2]). Using two way analysis of variance, it appeared that only eccentric exercise significantly increased [EL] and DOMS, especially of the hamstring muscles. Furthermore, a significant decrease in eccentric peak torque of this muscle group only was observed on day 2 after eccentric work (- 21%; P < 0.002). Serum activity of creatine kinase and serum concentration of myoglobin increased significantly 24 and 48 h after both exercise tests. However, these variables reached significantly higher values following eccentric contractions 48 h after exercise. Mean [PGE2] in the two exercise modes remained unchanged over time and were practically equal at each time point. On the basis of these findings, we conclude that the magnitude of polymorphonuclear (PMN) activation, muscle damage, and DOMS are greater after eccentric than after concentric muscle contractions. However, the hypothesized interplay between muscle damage, increased PGE2 production, DOMS sensations, and reduced isokinetic muscle performance was not substantiated by the present results. [less ▲]

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See detailMyoclonin1/EFHC1 in cell division, neuroblast migration, synapse/dendrite formation in juvenile myoclonic epilepsy
Grisar, Thierry ULg; Lakaye, Bernard ULg; de Nijs, Laurence ULg et al

in Noebels, JL; Avoli, M; Rogawski, MA (Eds.) et al Jasper's Basic Mechanisms of the Epilepsies, 4th edition (2012)

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See detailMyoferlin is a key regulator of EGFR activity in breast cancer.
Turtoi, Andrei ULg; Blomme, Arnaud ULg; Bellahcene, Akeila ULg et al

in Cancer Research (2013)

Myoferlin is a member of the ferlin family of proteins that participate in plasma membrane fusion, repair and endocytosis. While some reports have implicated myoferlin in cancer, the extent of its ... [more ▼]

Myoferlin is a member of the ferlin family of proteins that participate in plasma membrane fusion, repair and endocytosis. While some reports have implicated myoferlin in cancer, the extent of its expression in and contributions to cancer are not well established. In this study, we show that myoferlin is overexpressed in human breast cancers and that it is has a critical role in controlling degradation of the EGFR after its activation and internalization in breast cancer cells. Myoferlin depletion blocked EGF-induced cell migration and epithelial-to-mesenchymal transition. Both effects were induced as a result of impaired degradation of phosphorylated EGFR via dysfunctional plasma membrane caveolae and alteration of caveolin homooligomerization. In parallel, myoferlin depletion reduced tumor development in a chicken chorioallantoic membrane xenograft model of human breast cancer. Considering the therapeutic significance of EGFR targeting, our findings identify myoferlin as an novel candidate function to target for future drug development. [less ▲]

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See detailMyofibrillar composition of some red- and white-blooded Antarctic teleosts
Feller, Georges ULg; Boinet, P.

in Molecular Physiology (1984), 5

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See detailMyofibroblastic inflammatory urinary bladder tumors in dogs: report of 8 cases
Bohme, Béatrice; Ngendahayo, P.; Hamaide, Annick ULg et al

Poster (2008, July)

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See detailMyoglobine et infarctus du myocarde
Chapelle, Jean-Paul ULg

Conference (1990, June 27)

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See detailMyoglobine: méthodes analytiques et interprétation clinique
Chapelle, Jean-Paul ULg

Conference (1991, March 25)

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See detailMyoglobinurie atypique chez les chevaux au pré
Delguste, Catherine ULg

Conference (2002, November 30)

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See detailMyoglobinurie atypique chez les chevaux au pré: une série de cas en Belgique
Delguste, Catherine ULg

Master of advanced studies dissertation (2002)

Atypical myoglobinuria in grazing horses was described in United Kingdom and Germany between 1984 and 1996. Fourteen horses were presented at the University of Liège between November 2000 and April 2001 ... [more ▼]

Atypical myoglobinuria in grazing horses was described in United Kingdom and Germany between 1984 and 1996. Fourteen horses were presented at the University of Liège between November 2000 and April 2001, with a clinical history suggesting atypical myoglobinuria. Lesions were similar to those previously described. All horses were at rest and grazing when they developed clinical signs. Three times, the syndrome killed several horses grazing together. Horses were generally found recumbent, nearly or totally unable to stand up. They were presenting tachycardia, polypnoea and myoglobinuria, and died rapidly. When performed, blood analysis revealed severe muscular enzymatic activity rises. Histopathology revealed pulmonary congestion and oedema, and squeletal muscular fibers degeneration, mostly in respiratory and postural muscles. These observations are in accordance with cases of atypical myoglobinuria previously described in UK and Germany. The aetiology of this pathology is still unknown, despite of research attempts. An epidemiological inquiry protocol was developed in order to investigate upcoming cases within the scope of aetiologic research. Atypical myoglobinuria in grazing horses was described in United Kingdom and Germany between 1984 and 1996. Fourteen horses were presented at the University of Liège between November 2000 and April 2001, with a clinical history suggesting atypical myoglobinuria. Lesions were similar to those previously described. All horses were at rest and grazing when they developed clinical signs. Three times, the syndrome killed several horses grazing together. Horses were generally found recumbent, nearly or totally unable to stand up. They were presenting tachycardia, polypnoea and myoglobinuria, and died rapidly. When performed, blood analysis revealed severe muscular enzymatic activity rises. Histopathology revealed pulmonary congestion and oedema, and squeletal muscular fibers degeneration, mostly in respiratory and postural muscles. These observations are in accordance with cases of atypical myoglobinuria previously described in UK and Germany. The aetiology of this pathology is still unknown, despite of research attempts. An epidemiological inquiry protocol was developed in order to investigate upcoming cases within the scope of aetiologic research. [less ▲]

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See detailMyoglobinurie atypique: nouveaux cas en Belgique et en France
Delguste, Catherine ULg; Amory, Hélène ULg

in Proceedings of the 19th annual meeting of the Belgian Equine Practitioners Society (BEPS) (2002)

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See detailMyoglobinurie atypique: nouveaux cas en Belgique et en France
Delguste, Catherine ULg; Amory, Hélène ULg

Conference (2002, November 09)

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See detailMyoglobinurie atypique: une série de cas en Belgique
Delguste, Catherine ULg; Cassart, Dominique ULg

Conference (2001, November 10)

Detailed reference viewed: 12 (3 ULg)