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See detailNeuroanatomical specificity of sex differences in expression of aromatase mRNA in the quail brain
Voigt, C.; Ball, G. F.; Balthazart, Jacques ULg

in Journal of Chemical Neuroanatomy (2007), 33(2), 75-86

In birds and mammals, aromatase activity in the preoptic-hypothalamic region (HPOA) is usually higher in males than in females. It is, however, not known whether the enzymatic sex difference reflects the ... [more ▼]

In birds and mammals, aromatase activity in the preoptic-hypothalamic region (HPOA) is usually higher in males than in females. It is, however, not known whether the enzymatic sex difference reflects the differential activation of aromatase transcription or some other control mechanism. Although sex differences in aromatase activity are clearly documented in the HPOA of Japanese quail (Coturnix japonica), only minimal or even no differences at all were observed in the number of aromatase-immunoreactive (ARO-ir) cells in the medial preoptic nucleus (POM) and in the medial part of the bed nucleus striae terminalis (BSTM). We investigated by in situ hybridization the distribution and possible sex differences in aromatase mRNA expression in the brain of sexually active adult quail. The distribution of aromatase mRNA matched very closely the results of previous immunocytochemical studies with the densest signal being observed in the POM, BSTM and in the mediobasal hypothalamus (MBH). Additional weaker signals were detected in the rostral forebrain, arcopallium and mesencephalic regions. No sex difference in the optical density of the hybridization signal could be found in the POM and MBH but the area covered by mRNA was larger in males than in females, indicating a higher overall expression in males. In contrast, in the BSTM, similar areas were covered by the aromatase expression in both sexes but the density of the signal was higher in females than in males. The physiological control of aromatase is thus neuroanatomically specific and with regard to sex differences, these controls are at least partially different if one compares the level of transcription, translation and activity of the enzyme. These results also indirectly suggest that the sex difference in aromatase enzyme activity that is present in the quail HPOA largely results from differentiated controls of enzymatic activity rather than differences in enzyme concentration. (c) 2007 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 39 (0 ULg)
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See detailNeuroanatomie chimique de la moelle épinière humaine.
Schoenen, Jean ULg

in Revue Neurologique (1988), 144(11), 630-42

Modern neuroanatomical methods, specifically immunocytochemistry and receptor autoradiography, have greatly increased our knowledge on the organization of the human nervous system. This review, based on ... [more ▼]

Modern neuroanatomical methods, specifically immunocytochemistry and receptor autoradiography, have greatly increased our knowledge on the organization of the human nervous system. This review, based on the literature and largely on personal results, is devoted to the chemical neuroanatomy of the normal human spinal cord. It provides a comprehensive overview of the differential distribution of various chemical messengers, their metabolizing enzymes and their receptors (acetylcholine, amino acids, monoamines, neuropeptides) in the neuronal laminae of the spinal gray matter. At the level of the dorsal horn, lamina II, i.e. Rolando's substantia gelatinosa, is characterized by a heavy concentration of several transmitters and receptors. Within the intermediate gray matter the autonomic nuclei receive a dense peptidergic input, e.g. substance P, enkephalin and VIP afferents. In the ventral horn close contacts are numerous between serotonergic or peptidergic (SP, TRH, enkephalins...) fibers and motoneuronal perikarya or dendrites. The present knowledge on the putative role of certain neurotransmitters in spinal functions is summarized. [less ▲]

Detailed reference viewed: 35 (1 ULg)
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See detailNeuroanatomie chimique de la moelle épinière humaine: application à des cas pathologiques dans la sclérose latérale amyotrophique
Schoenen, Jean ULg

in Revue Neurologique (1988), 144(11), 630-42

Modern neuroanatomical methods, specifically immunocytochemistry and receptor autoradiography, have greatly increased our knowledge on the organization of the human nervous system. This review, based on ... [more ▼]

Modern neuroanatomical methods, specifically immunocytochemistry and receptor autoradiography, have greatly increased our knowledge on the organization of the human nervous system. This review, based on the literature and largely on personal results, is devoted to the chemical neuroanatomy of the normal human spinal cord. It provides a comprehensive overview of the differential distribution of various chemical messengers, their metabolizing enzymes and their receptors (acetylcholine, amino acids, monoamines, neuropeptides) in the neuronal laminae of the spinal gray matter. At the level of the dorsal horn, lamina II, i.e. Rolando's substantia gelatinosa, is characterized by a heavy concentration of several transmitters and receptors. Within the intermediate gray matter the autonomic nuclei receive a dense peptidergic input, e.g. substance P, enkephalin and VIP afferents. In the ventral horn close contacts are numerous between serotonergic or peptidergic (SP, TRH, enkephalins...) fibers and motoneuronal perikarya or dendrites. The present knowledge on the putative role of certain neurotransmitters in spinal functions is summarized. [less ▲]

Detailed reference viewed: 32 (1 ULg)
See detailNeuroanatomie chimique du thymus et des organes lymphoïdes
Geenen, Vincent ULg

Conference given outside the academic context (1987)

Detailed reference viewed: 15 (1 ULg)
See detailNeuroanesthésie
Martin, Didier ULg

Scientific conference (2006, November)

Detailed reference viewed: 5 (0 ULg)
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See detailNeurobiological and genetic aspects of alcohol addiction: a special focus on acetaldehyde, the first metabolite of ethanol
Quertemont, Etienne ULg

Scientific conference (2007)

Although alcoholism is one of the most common forms of addiction, its neurobiological mechanisms still remain unclear. The reinforcing properties of ethanol are mediated by the interaction of multiple ... [more ▼]

Although alcoholism is one of the most common forms of addiction, its neurobiological mechanisms still remain unclear. The reinforcing properties of ethanol are mediated by the interaction of multiple neurotransmitter systems, including dopamine, serotonin, glutamate, GABA, endogenous opioids and endocannabinoids. Additionally, long term changes in these neurotransmitter systems are believed to promote the development of alcoholism, probably through specific alterations of brain regions involved in motivation. In humans, it has been clearly demonstrated that alcohol dependence is a genetically heritable disease, at least to some extent. Twin and adoptions studies indicate that 50-60% of the phenotypic variations in alcohol dependence are accounted for by a genetic component. Among the multiple genes that are possibly involved in the development of alcohol dependence and addiction, there is very strong evidence that genes related to the metabolism of ethanol play a major role. For example, genetic polymorphisms in alcohol and aldehyde dehydrogenase enzymes strongly affect alcoholism susceptibility in humans. In recent years, several studies have also provided evidence that acetaldehyde, the first metabolite of ethanol, contributes to alcohol abuse and alcoholism. In rodents such as rats and mice, low doses of brain acetaldehyde induce reinforcing and stimulant effects, although high concentrations of peripheral blood acetaldehyde produce adverse reactions. These results led to the controversial theory that acetaldehyde mediates or at least contributes to the reinforcing and addictive properties of ethanol. [less ▲]

Detailed reference viewed: 30 (3 ULg)
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See detailNeurobiological bases of suicidality in major depression
Desseilles, Martin ULg; Scwartz, Sophie; Dang Vu, Thanh et al

in World Journal of Biological Psychiatry (2009), 9(Suppl. 1),

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See detailA Neurobiologically Inspired Model of Working Memory Based on Neuronal Synchrony and Rythmicity
Sougné, Jacques ULg; French, R. M.; Bullinaria, J. A. et al

in Proceedings of the Fourth Neural Computation and Psychology Workshop: Connectionist Representations (1997)

The connectionist model of reasoning presented here, INFERNET, implements a working memory that is the activated part of long-term memory. This is achieved by making use of temporal properties of the node ... [more ▼]

The connectionist model of reasoning presented here, INFERNET, implements a working memory that is the activated part of long-term memory. This is achieved by making use of temporal properties of the node spikes. A particular solution of the problem of multiple instantiation is proposed. This model makes predictions that have been tested experimentally and the results of these experiments are reported here. These results would seem to challenge modular models of memory. [less ▲]

Detailed reference viewed: 26 (1 ULg)
See detailNeurobiologie Comportementale de l'éthanol et de l'acétaldéhyde
Quertemont, Etienne ULg; De Witte, Philippe

in Alcoologie (1998), 20(4), 391-391

Detailed reference viewed: 21 (0 ULg)
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See detailNeurobiologie de l'addiction
Scuvée, Jacqueline ULg

in Revue Médicale de Liège (2013), 68(5-6), 211-217

Detailed reference viewed: 34 (6 ULg)
See detailNeurobiologie de l’impasse. Stress et troubles de l'attachement
Gauthier, Jean-Marie ULg; Sami, Ali; Cady, Sylvie et al

in Entre lâme et le corps, les pathologies humaines (2008)

Detailed reference viewed: 79 (11 ULg)
See detailNeurobiologie de la dépression
Scantamburlo, Gabrielle ULg

Conference (2010)

Detailed reference viewed: 48 (2 ULg)
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See detailNeurobiologie et pharmacothérapie du trouble obsessionnel-compulsif.
Ansseau, Marc ULg; Scantamburlo, Gabrielle ULg; Pinto, Emmanuel ULg et al

in Revue Médicale de Liège (2008), 63

Detailed reference viewed: 28 (0 ULg)
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See detailNeuroblastome primitif du système nerveux central
Jamblin, Paul; Collignon, J.; Flandroy, P. et al

in Revue Neurologique (1993), 149

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See detailLes neuroblastomes de l'enfant. A propos de 23 cas.
Piette, Catherine ULg; Dresse, Marie-Françoise ULg; Forget, Patricia ULg et al

in Revue Médicale de Liège (2005), 60(3), 173-80

In this retrospective study, we analyse epidemiology, clinical symptoms and therapeutic results in a group of 23 children with neuroblastoma. Half of them were less than 2 years of age; in 19 of 23, the ... [more ▼]

In this retrospective study, we analyse epidemiology, clinical symptoms and therapeutic results in a group of 23 children with neuroblastoma. Half of them were less than 2 years of age; in 19 of 23, the primitive tumour was abdominal; 35% of them were initially metastatic. The overall survival was 83% at 5 years and the event free survival, 75% at 5 years. Pronostic factors are age, extension of the disease at diagnosis, biologic parameters and genetic study of the neuroblast cells (amplification of N-myc oncogen). Our study shows the deleterious effect of bone lesions. [less ▲]

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See detailLa neuroborréliose: quand la tique a piqué
Cuvelier, M.L.; LEONARD, Philippe ULg; RIKIR, Estelle ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 349-353

L’infection à Borrelia burgdorferi est fréquente dans nos régions. Les complications neurologiques de cette infection se rencontrent essentiellement lors de la phase de dissémination précoce et à la phase ... [more ▼]

L’infection à Borrelia burgdorferi est fréquente dans nos régions. Les complications neurologiques de cette infection se rencontrent essentiellement lors de la phase de dissémination précoce et à la phase tardive de l’infection. La neuroborréliose se manifeste surtout par des radiculalgies rebelles au traitement, parfois associées à une neuropathie crânienne, en grande majorité faciale. L’évolution est satisfaisante sous antibiothérapie adaptée. Celle-ci reste nécessaire en dépit du fait que la plupart des complications de la neuroborréliose disparaissent spontanément. Le traitement permet d’éviter la survenue de complications tardives ou de voir apparaître des atteintes extraneurologiques éventuelles. [less ▲]

Detailed reference viewed: 34 (4 ULg)
See detailNeurochemical and behavioral effects of ethnaol-conditioned stimuli: implication for alcohol consumption
Quertemont, Etienne ULg; De Witte, Philippe

in Cahiers de l'I.R.E.B. (2001), 15

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See detailNeurochemical control of rapid stress-induced changes in brain aromatase activity
Dickens, Molly; Cornil, Charlotte ULg; Balthazart, Jacques ULg

in Journal of Neuroendocrinology (2013), 25(4), 329-39

In the male brain, the medial preoptic nucleus (POM) is known to be a critical relay for the activation of sexual behaviour, with the aromatisation of testosterone into 17b-oestradiol (E2) playing a key ... [more ▼]

In the male brain, the medial preoptic nucleus (POM) is known to be a critical relay for the activation of sexual behaviour, with the aromatisation of testosterone into 17b-oestradiol (E2) playing a key role. Acute stress has been shown to differentially modulate the aromatase enzyme in this and other brain nuclei in a sex-specific manner. In POM specifically, stress induces increases in aromatase activity (AA) that are both rapid and reversible. How the physiological processes initiated during an acute stress response mediate sex- and nuclei- specific changes in AA and which stress response hormones are involved remains to be determined. By examining the relative effects of corticosterone (CORT), arginine vasotocin (AVT, the avian homologue to arginine vasopressin) and corticotrophin-releasing factor (CRF), the present study aimed to define the hormone profile regulating stress-induced increases in AA in the POM. We found that CORT, AVT and CRF all appear to play some role in these changes in the male brain. In addition, these effects occur in a targeted manner, such that modulation of the enzyme by these hormones only occurs in the POM rather than in all aromatase-expressing nuclei. Similarly, in the female brain, the experimental effects were restricted to the POM but only CRF was capable of inducing the stress-like increases in AA. These data further demonstrate the high degree of specificity (nuclei-, sex- and hormone-specific effects) in this system, highlighting the complexity of the stress–aromatase link and suggesting modes through which the nongenomic modulation of this enzyme can result in targeted, rapid changes in local oestrogen concentrations. [less ▲]

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See detailNeurochirurgie et grossesse
EMONTS, Patrick ULg; HENROTEAUX, Adrienne ULg; Martin, Didier ULg

Scientific conference (2014, January 15)

Detailed reference viewed: 30 (4 ULg)
See detailNeurochirurgie et Médecine d'expertise
Martin, Didier ULg

Scientific conference (2007, March 14)

Detailed reference viewed: 3 (0 ULg)