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See detailImplementing Network Virtualization for a Future Internet
Papadimitriou, Panagiotis; Maennel, Olaf; Greenhalgh, Adam et al

in 20th ITC Specialist Seminar on Network Virtualization Proceedings (2009, May)

The Internet has become an essential communication medium upon which billions of people rely every day. However, necessary evolution of the Internet has been severely limited by reliability constrains and ... [more ▼]

The Internet has become an essential communication medium upon which billions of people rely every day. However, necessary evolution of the Internet has been severely limited by reliability constrains and social-economic factors. Experts fear that current growth rates will threaten the future of the Internet as a whole, despite the fact that new core technologies already exist. Network virtualization presents a promising approach to overcome ossification and facilitate service deployment for a future Internet. Exploring this approach, we present a prototype implementation which realizes a subset of the 4WARD virtual network (VNet) architecture, allowing multiple VNets to coexist on top of a shared physical infrastructure. We discuss the functionality of our prototype and demonstrate experimental results to assess its performance. [less ▲]

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See detailImplementing new technologies in PE : The arduous path of a group of teachers
Cloes, Marc ULg; Renier, Damien

Conference (2016, June 11)

Nowadays, adolescents are totally integrated into the digital generation. Tablets, smartphones, and other apps belong to their normal life while most of their teachers sometimes try yet to discover what a ... [more ▼]

Nowadays, adolescents are totally integrated into the digital generation. Tablets, smartphones, and other apps belong to their normal life while most of their teachers sometimes try yet to discover what a computer is. In physical education, several authors showed that new tools can be used during practical lessons in a way to improve the learning environment and motivation of the students. As the videotape recorder in the past, current technologies represent resources that have to be adapted to the teaching strategies and not considered as miraculous tools that will solve all problems. On the other hand, one has to consider that youth are particularly attracted by digital tools that offers a growing range of possibilities to stimulate students’ critical thinking, autonomy, and involvement. This study aimed to help a group of PE teachers to use new technologies in their classes. Considering that his colleagues and he (grades 10-12) were not effective in using new technologies, one PE teacher from a secondary school invited us to propose a series of activities in order to let them identifying a way to take benefit from available ICTs. An interactive process has been implemented in order to put the teachers in the center of their development. A four steps approach was designed: (1) identification of the perceived benefits of ICTs and of the available tools, selection of one objective and one tool (4 teachers/5); (2) organization of a focus group to identify a practical way to use the selected tool (2/3); (3) preparation of a model lesson (3/3); follow up after 6 months (3/3). For several reasons, even if interesting projects of lessons were developed, they did not have been implemented. The study underlines the difficulties that PE teachers can meet when trying to innovate. [less ▲]

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See detailImplementing pedagogic strategies between vets and farmers to create synergies in udder health management: Project Mammipack®
Theron, Léonard ULg; Sustronck, Bart; Bertozzi, Carlo et al

Poster (2009, December)

Udder health is usually considered as a health and economic problem for farmers. We now consider that mastitis is the result of many factors related to the environment, the pathogen and the host. What may ... [more ▼]

Udder health is usually considered as a health and economic problem for farmers. We now consider that mastitis is the result of many factors related to the environment, the pathogen and the host. What may have been forgotten in the process is the fact that nowadays, the main interface with mastitis is the farmer, and their knowledge about mastitis is very heterogeneous. This reflexion has led to the creation of a technical and pedagogical pack called “Mammipack” which contains different tools, from all actors of the dairy chain. We included small charts explaining the most important risk factors identified through epidemiology, good dairy practices and its effect on milk flow, milking machine check-up, how-to for mastitis milk sample, a how-to for performance records use for udder health management, a resume on genetic selection of sires and mastitis, charts upon nutrition factors and their main effect on udder physiology during lactation and dry-off, resume on veterinary drugs good management in the farm. Small laminated sheets upon milk sampling for bacteriology and teats evaluation were also joined in order to be use in parlors, sterile sampling tubes were also given in the pack. A mastitis record pad was designed to record the main clinical forms and the treatment chosen. Eventually, the book Udder Health® was added to have a complete modern look on that problem in dairy farms. 25 farmers were selected on a voluntary base by 12 veterinarians, and they answered to questionnaires about their main practices regarding herd structure, mastitis treatment, and southern Belgium main 19 risk factors. They had to answer basic questions concerning udder health on 15 points. They agreed to keep a record of all next mastitis cases in their farms and take milk samples for bacteriology each time at day 0 and day 21 during 3 months. The main objective is to show to a group of dairy farmers that mastitis could take several different forms from one farm to another, in term of incidence, pathogens and clinical forms. One other purpose is to show the difficulty to have bacteriological cure, even when physical cure has happened. After all, one collateral objective was to create the Mammipack®, designed for farmers and vets to increase their ability to collaborate on mastitis management through most dairy chain actors’ expertise. [less ▲]

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See detailImplementing principles of Quality by Design (QbD) in validation context
Hubert, Cédric ULg; Lebrun, Pierre ULg; Rozet, Eric et al

Conference (2016, May 10)

Analytical method performances have to be specified by the analyst trough the definition of the “Analytical Target Profile (ATP)”, as proposed by the regulatory bodies. In the specific context of the ... [more ▼]

Analytical method performances have to be specified by the analyst trough the definition of the “Analytical Target Profile (ATP)”, as proposed by the regulatory bodies. In the specific context of the pharmaceutical industry, regulatory authorities have recently imposed the assessment and management of risk throughout the entire product lifecycle. This includes the analytical procedure and consequently its own lifecycle. The development step of an analytical method is still largely addressed using a “Changing One Separate Factor a Time (COST)” approach (also known as the “Quality-by-Testing (QbT)” approach). This strategy can lead to a suitable method for assessing the risk of routine use, even where the experimental domain is not examined. However, in order to consider an experimental domain rather than a set of specific experimental conditions during the development phase, a multivariate approach must be considered: the “Quality-by-Design (QbD)” strategy. This strategy allows the definition of a “Design Space (DS)” by means of design of experiments (DoE). This DS, computed considering critical method parameters, allows the analyst to focus on the main objective of an analytical method: obtaining reliable results using a robust method. In the course of a specific case study, the benefits of the QbD strategy in terms of managing the qualitative part of the analytical process were highlighted. Working in the context of analytical procedure, the validation step is a major part of the analytical method lifecycle. Indeed, the objective of analytical method validation is to demonstrate that this method is suited for quantifying the target analytes with an established and suitable level of accuracy, as defined by the “ATP”. This is sometimes called the “fit-for-future-purpose” concept. The decision regarding the validity of a method based on prediction can be achieved by using the “β-expectation tolerance interval” (accuracy profile). The capability of this approach to manage the quantitative part of the analytical procedure is nowadays largely illustrated in scientific literatures. Considering the assessment and management of risk throughout the analytical lifecycle, a global strategy allowing the unification of the development and validation phases in a single step was considered. With this innovative approach, a strategy allowing the management of global analytical risk (i.e., for both qualitative and quantitative part of the analytical method) was proposed. Indeed, the developed strategy allows validating an entire experimental domain by means of the accuracy profile rather than a single set of specific experimental conditions. With this strategy, the DS is no longer simply the place where qualitative performances are obtained, but also the space where quantitative performances of the analytical procedure are assessed and managed. [less ▲]

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See detailImplementing quantum algorithms in hyperfine levels of ultracold polar molecules
Vranckx, Stéphane; Pellegrini, Philippe; Desouter-Lecomte, Michèle ULg

in Journal of Physics: Conference Series (2012), 388(11), 112010

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See detailImplementing quantum algorithms in hyperfine levels of ultracold polar molecules by optimal control
Pellegrini, Philippe; Vranckx, Stéphane; Desouter, Michèle ULg

in Physical Chemistry Chemical Physics [=PCCP] (2011), 13

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See detailImplementing river restoration taking into account constraints of water supply protection: the case study of the Bocq River at Spontin
Peeters, Alexandre ULg; De le Court, Bernard; Verniers, Gisèle et al

Poster (2013, October)

In the Bocq basin, eastern tributary of the Meuse, restoration works consist of making 20 obstacles passable to improve the free movement of fish and sediment. This presentation focuses on a particular ... [more ▼]

In the Bocq basin, eastern tributary of the Meuse, restoration works consist of making 20 obstacles passable to improve the free movement of fish and sediment. This presentation focuses on a particular case study involving river restoration in a groundwater abstraction zone. In the sixties, a reach of more than 600 meters of the Bocq was completely channelized in order to avoid any risk of contamination of the nearby important drinking water well field area. Ecological quality was consequently impoverished due to the loss of natural habitats (streambed and banks made of concrete and masonry). In addition, the hydraulic conditions (high flow, low depth) make it totally insurmountable for fish. The restoration project started with a 3-year period of consultation with the water abstraction owner to finally reach an agreement on a restoration project taking into account the need of protection of the water abstraction. The project consisted on building rock weirs at regular interval in order to create a succession of 23 steps and pools. Furthermore, various habitats schemes were implemented such as fish shelter, rock berms for aquatic vegetation, and spawning gravel introduction. In addition a small dike and an expansion area for flooding have been completed to protect the water abstraction. This project is being monitored on the basis of geomorphological and ecological analysis. Geomorphological monitoring focuses on the bedload transport with an analysis of flood and the clogging of the gravel layer. Ecological monitoring is based on two indicators (macroinvertebrates and fishes) as well as the analysis of microhabitats. The first results show an improvement after 1 year. [less ▲]

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See detailImplementing river restoration taking into account constraints of water supply protection: the case study of the Bocq River at Spontin
Peeters, Alexandre ULg; De le Court, Bernard; Verniers, Gisèle

Poster (2013, September)

In the Bocq basin, eastern tributary of the Meuse, restoration works consist of making 20 obstacles passable to improve the free movement of fish and sediment. This presentation focuses on a particular ... [more ▼]

In the Bocq basin, eastern tributary of the Meuse, restoration works consist of making 20 obstacles passable to improve the free movement of fish and sediment. This presentation focuses on a particular case study involving river restoration in a groundwater abstraction zone. In the sixties, a reach of more than 600 meters of the Bocq was completely channelized in order to avoid any risk of contamination of the nearby important drinking water well field area. Ecological quality was consequently impoverished due to the loss of natural habitats (streambed and banks made of concrete and masonry). In addition, the hydraulic conditions (high flow, low depth) make it totally insurmountable for fish. The restoration project started with a 3-year period of consultation with the water abstraction owner to finally reach an agreement on a restoration project taking into account the need of protection of the water abstraction. The project consisted on building rock weirs at regular interval in order to create a succession of 23 steps and pools. Furthermore, various habitats schemes were implemented such as fish shelter, rock berms for aquatic vegetation, and spawning gravel introduction. In addition a small dike and an expansion area for flooding have been completed to protect the water abstraction. This project is being monitored on the basis of geomorphological and ecological analysis. Geomorphological monitoring focuses on the bedload transport with an analysis of flood and the clogging of the gravel layer. Ecological monitoring is based on two indicators (macroinvertebrates and fishes) as well as the analysis of microhabitats. The first results show an improvement after 1 year. [less ▲]

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See detailImplementing sustainability strategies through accounting controls: An exploration of practices in seven multinational corporations
Crutzen, Nathalie ULg; Schaltegger, Stefan

in Proceedings of the 36th Annual Congress of the European Accounting Association (EAA) (2013, May)

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See detailImplementing the Bianco and Yohai estimator for logistic regression
Croux, C.; Haesbroeck, Gentiane ULg

in Computational Statistics & Data Analysis (2003), 44(1-2), 273-295

A fast and stable algorithm to compute a highly robust estimator for the logistic regression model is proposed. A criterium. for the existence of this estimator at finite samples is derived and the ... [more ▼]

A fast and stable algorithm to compute a highly robust estimator for the logistic regression model is proposed. A criterium. for the existence of this estimator at finite samples is derived and the problem of the selection of an appropriate loss function is discussed. It is shown that the loss function can be chosen such that the robust estimator exists if and only if the maximum likelihood estimator exists. The advantages of using a weighted version of this estimator are also considered. Simulations and an example give further support for the good performance of the implemented estimators. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailImplementing the European Marine Strategy Framework Directive: Scientific challenges and opportunities
Newton, Alice; Borja, Angel; Solidoro, Cosimo et al

in Continental Shelf Research (2015)

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See detailL'implication dans la recherche clinique : un chemin vers la psychanalyse
Naziri, Despina ULg

in Revue Belge de Psychanalyse (2002), 40

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See detailL’implication dans la recherche clinique : un chemin vers la psychanalyse
Naziri, Despina ULg

in Revue Belge de Psychanalyse (2003), 40(printemps), 3-24

L'article débute par un bref rappel des liens entre psychologie clinique et modèle psychanalytique et de la spécificité de la recherche clinique. Puis j’illustrerai ce type de recherche à travers mon ... [more ▼]

L'article débute par un bref rappel des liens entre psychologie clinique et modèle psychanalytique et de la spécificité de la recherche clinique. Puis j’illustrerai ce type de recherche à travers mon travail sur le recours répétitif à l’avortement en explicitant mon cheminement, tant au niveau de la pensée que de l’expérience, et en reprenant quelques repères de mon itinéraire personnel. [less ▲]

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See detailImplication de la clusterine dans la survie des cellules prostatiques lors de l'apoptose
Ammar, Hayet ULg

Doctoral thesis (2014)

Prostate cancer is the second leading cause of cancer death in men. Although androgen ablation remains the most effective management option, most patients with advanced disease progress to castration ... [more ▼]

Prostate cancer is the second leading cause of cancer death in men. Although androgen ablation remains the most effective management option, most patients with advanced disease progress to castration resistant prostate cancer (CRPC), within two years of treatment. This results, in part, from the increase in the anti-apoptotic molecules expression following androgen withdrawal. Among the proteins involved in this phenomenon, clusterin, also known as testosterone repressed message-2 (TRPM- 2), which exists in two forms: a pro-apoptotic nuclear form (nClU) and a secreted survival factor (sClU). In our study we investigated the role of the secreted form of clusterin in preventing cells from TNFα-induced apoptosis. For this, we first generated a sCLU inducible stable prostatic cancer MLL rat cell line by using the Tet-On gene expression system. With this model we revealed a new mechanism by which sCLU promotes survival in androgenindependent prostate cancer cells, implicating its receptor megalin and the Akt survival pathway. By applying a comparative proteomic analysis in the androgen-independent epithelial cell line MLLTet-sClu induced to overexpress sClu or non induced control-cells, we identified five proteins known to play a role in cancer. These proteins candidates are heat shock proteins Hsp90 and Hsp70, osteopontin (bone sialoprotein, OPN), proliferating cell nuclear antigen (PCNA) and ADP-ribosylation factor 1 (Arf1). Altogether, our data provide new mechanistic insight in sCLU dependent activation of the major survival pathway upregulated in refractory prostate cancer. The identification of the new sCLU protein targets open new avenues for more research to elucidate the significance of clusterin in prostate cancer progression and resistance to therapy. [less ▲]

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See detailImplication de la compétition pour les acides aminés dans le contrôle biologique de la pourriture bleue des pommes en post-récolte
Krimi Bencheqroun, S.; Bajji, M.; Labhilili, M. et al

Conference (2008, April)

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See detailImplication de la dipeptidyl peptidase IV dans l’insuffisance cardiaque expérimentale et clinique
Gomez Malaver, Nelson ULg

Doctoral thesis (2012)

BNP1-32 is a cardiac hormone showing cardiac and renal protection. Paradoxically, in overt congestive heart failure, high levels of plasma BNP seem devoid of biological effectiveness. Moreover, treatments ... [more ▼]

BNP1-32 is a cardiac hormone showing cardiac and renal protection. Paradoxically, in overt congestive heart failure, high levels of plasma BNP seem devoid of biological effectiveness. Moreover, treatments targeting the BNP system are less effective in dogs with severe heart failure than in healthy dogs or dogs in mild heart failure. The origin of this paradox is not yet clear. Dipeptidyl peptidase IV (DPP4) is an ubiquitary exopeptidase that cleaves small peptides having a proline or an alanine in the N-terminal second position. Human BNP1-32 is a known substrate for DPP4, its second amino acid is a proline and this structure is conserved among several species including the pig and the dog. In dogs, BNP3-32, coming from the cleavage of BNP1-32 by DPP4, shows reduced biological activity. We made 2 hypotheses: (1) in canine congestive heart failure, increased DPP4 activity participates in the “resistance to BNP” and (2) in a pig model of tachycardiomyopathy, inhibition of DPP4 reduces cardiorenal dysfunction increases the effectiveness of exogenous BNP1-32 and decreases myocardial molecular alterations. In the first study, we identified physiologic determinants of plasma DPP4 activity and evaluated DPP4 activity in dogs in heart failure. Population included 81 healthy dogs and 47 dogs at different stages of heart failure. Plasma DPP4 activity was higher in healthy growing dogs than in healthy adults. In healthy adults, DPP4 activity was positively correlated with body weight with no effect of age, sex and of circadian rhythm. DPP4 activity was higher in dogs in asymptomatic cardiac insufficiency than in healthy dogs and in dogs in congestive heart failure without any effect of the disease. In the second study, a tachycardiomyopathy was induced in 12 pigs by rapid right ventricular pacing. Sitagliptin, an oral inhibitor of DPP4, was administered in half of the pigs. In this model, inhibition of plasma DPP4 activity improved global cardiac function, maintained glomerular filtration rate and, increased cardiac contractility during BNP perfusion. Functional improvement was associated with a reduction of myocardial gene expression of calmoduline, sodium-calcium exchanger, BNP and interleukin-6 as well as an increase in myocardial SDF-1 protein concentration. In conclusion, the “BNP resistance” observed in congestive heart failure is not due to increased plasma DPP4 activity but DPP4 inhibition reduces cardiorenal alterations in experimental myocardial failure. DPP4 inhibitors have been developed for treatment of type 2 diabetes. It remains to be studied (1) if this treatment, initially targeted to control glycemia, may protect the heart and the kidney in patients with type 2 diabetes with or without metabolic syndrome (2) if this treatment may be used to treat heart failure and the cardiorenal syndrome. [less ▲]

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