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See detailLes anti-inflammatoires non stéroïdiens
Malaise, Michel ULiege

in Revue Médicale de Liège (1996), 51(1), 123-125

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See detailAnti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease.
Esser, Nathalie ULiege; Paquot, Nicolas ULiege; Scheen, André ULiege

in Expert opinion on investigational drugs (2015), 24(3), 283-307

Introduction: There is a growing body of evidence to suggest that chronic silent inflammation is a key feature in abdominal obesity, metabolic syndrome, type 2 diabetes (T2DM) and cardiovascular disease ... [more ▼]

Introduction: There is a growing body of evidence to suggest that chronic silent inflammation is a key feature in abdominal obesity, metabolic syndrome, type 2 diabetes (T2DM) and cardiovascular disease (CVD). These observations suggest that pharmacological strategies, which reduce inflammation, may be therapeutically useful in treating obesity, type 2 diabetes and associated CVD. Area covered: The article covers novel strategies, using either small molecules or monoclonal antibodies. These strategies include: approaches targeting IKK-b-NF-kB (salicylates, salsalate), TNF-alpha (etanercept, infliximab, adalimumab), IL-1beta (anakinra, canakinumab) and IL-6 (tocilizumab), AMP-activated protein kinase activators, sirtuin-1 activators, mammalian target of rapamycin inhibitors and C-C motif chemokine receptor 2 antagonists. Expert opinion: The available data supports the concept that targeting inflammation improves insulin sensitivity and beta-cell function; it also ameliorates glucose control in insulin-resistant patients with inflammatory rheumatoid diseases as well in patients with metabolic syndrome or T2DM. Although promising, the observed metabolic effects remain rather modest in most clinical trials. The potential use of combined anti-inflammatory agents targeting both insulin resistance and insulin secretion appears appealing but remains unexplored. Large-scale prospective clinical trials are underway to investigate the safety and efficacy of different anti-inflammatory drugs. Further evidence is needed to support the concept that targeting inflammation pathways may represent a valuable option to tackle the cardiometabolic complications of obesity. [less ▲]

Detailed reference viewed: 87 (12 ULiège)
See detailAnti-inflammatory and anti-oxidative feed ingredients
Lekeux, Pierre ULiege; de Moffarts

in Lindner, A. (Ed.) Applied Equine Nutrition, Equine Nutrition Conference (ENUCO) (2005)

Detailed reference viewed: 26 (2 ULiège)
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See detailAnti-inflammatory and chondroprotective activity of prodelphinidins isolated from Ribes nigrum leaves.
Tits, Monique ULiege; de Leval, Xavier; Diercksens, Yves et al

Poster (2000)

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See detailAnti-Inflammatory and Immunological Effects of Centaurea Cyanus Flower-Heads
Garbacki, Nancy ULiege; Gloaguen, Vincent; Damas, Jacques ULiege et al

in Journal of Ethnopharmacology (1999), 68(1-3), 235-41

Centaurea cyanus flower-heads are used in European phytotherapy for the treatment of minor ocular inflammations. Different pharmacological experiments (inhibition of carrageenan, zymosan and croton oil ... [more ▼]

Centaurea cyanus flower-heads are used in European phytotherapy for the treatment of minor ocular inflammations. Different pharmacological experiments (inhibition of carrageenan, zymosan and croton oil-induced oedemas, inhibition of plasma haemolytic activity, induction of anaphylatoxin activity) showed that polysaccharides extracted from C. cyanus flower-heads had anti-inflammatory properties and interfered with complement. Moreover, these polysaccharides were found to be mainly composed of galacturonic acid, arabinose, glucose, rhamnose and galactose. [less ▲]

Detailed reference viewed: 129 (8 ULiège)
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See detailAnti-inflammatory effect of natural proanthocyanidins: pharmacological evaluation on in vivo models.
Garbacki, Nancy ULiege; Tits, Monique ULiege; Damas, Jacques ULiege

in Pflügers Archiv : European Journal of Physiology (2003), 446

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See detailAnti-inflammatory effects of Centaurea cyanus (Asteraceae) flower-heads.
Garbacki, Nancy ULiege; Gloaguen, Vincent; Damas, Jacques ULiege et al

Poster (2001)

Detailed reference viewed: 34 (2 ULiège)
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See detailAnti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats.
Zhang, W.; Fievez, Laurence ULiege; Cheu, Esteban ULiege et al

in European Journal of Pharmacology (2010), 628(1-3), 171-178

In this study, the anti-inflammatory properties of formoterol and ipratropium bromide, alone or in combination, were investigated in a rat model of acute pulmonary inflammation induced by cadmium ... [more ▼]

In this study, the anti-inflammatory properties of formoterol and ipratropium bromide, alone or in combination, were investigated in a rat model of acute pulmonary inflammation induced by cadmium inhalation. Airway resistance and inflammatory responses, including matrix metalloproteinease-2 (MMP-2) and matrix metalloproteinease-9 (MMP-9) activities, were evaluated. Compared to values obtained in rats exposed to cadmium, pretreatment by bronchodilators administered alone significantly prevented the cadmium-induced increase of airway resistance. Formoterol elicited a significant decrease in total cell number, neutrophil and macrophage counts in bronchoalveolar lavage fluid, whereas ipratropium bromide reduced neutrophil numbers. The two compounds administered alone significantly attenuated the lung lesions associated with parenchyma inflammatory cell influx and congestion observed in the cadmium group. The increased MMP-9 activity was significantly attenuated. Although only formoterol induced a decrease protein concentration in bronchoalveolar lavage fluid, both compounds inhibited the pulmonary edema by reducing wet-to-dry weight ratio which returned to values similar to those recorded in the sham group. All the effects of formoterol on the cadmium-induced inflammatory responses were reversed by propranolol. Similar anti-inflammatory effects were obtained in rats pretreated with ilomastat which showed a significant reduction on inflammatory cell infiltration and MMP-9 activity in bronchoalveolar lavage fluid. Neither synergistic nor additive effects were obtained when the two bronchodilators were administered in combination. In conclusion, formoterol and ipratropium bromide partially protect the lungs against the inflammation by reducing neutrophilic infiltration. This protective effect is associated with reduced MMP-9 activity known to play an important pro-inflammatory role in acute inflammatory process. [less ▲]

Detailed reference viewed: 96 (10 ULiège)
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See detailAnti-inflammatory effects of formoterol in rats after a single dose inhalation of nebulized cadmium
Zhang, W. H.; Fievez, Laurence ULiege; Cheu, Esteban ULiege et al

in Fundamental & Clinical Pharmacology (2007), 74

Detailed reference viewed: 32 (7 ULiège)
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See detailAnti-inflammatory effects of ipratropium bromide in rats with cadmium-induced acute pulmonary inflammation
Zhang, W.; Fievez, Laurence ULiege; Cheu, Esteban ULiege et al

in Proceedings of the 12th Annual Meeting of the French Society of Pharmacology and Therapeutics (2008)

Detailed reference viewed: 39 (2 ULiège)
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See detailAnti-inflammatory effects of ipratropium bromide in rats with cadmium-induced acute pulmonary inflammation
Zhang, Yinghong ULiege; Fievez, Laurence ULiege; Cheu, Esteban ULiege et al

in Fundamental & Clinical Pharmacology (2008), 22(1), 7

Detailed reference viewed: 55 (3 ULiège)
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See detailAnti-inflammatory potency of the traditionally used antimalarial plant Fagraea fragrans
Jonville, Marie ULiege; Baghdikian, Béatrice; Ollivier, Evelyne et al

in Planta Medica (2010, September), 76(12), 1171

Detailed reference viewed: 74 (7 ULiège)
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See detailAnti-inflammatory properties of capsular polymers from blue-green algae.
Garbacki, Nancy ULiege; Gloaguen, Vincent; Damas, Jacques ULiege et al

Conference (1999)

Detailed reference viewed: 12 (1 ULiège)
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See detailAnti-inflammatory properties of stigmasterol in cartilage: new insights
Gabay, Odile; Sanchez, Christelle ULiege; Chevy, F. et al

Poster (2008)

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See detailAnti-inflammatory properties of stigmasterol in cartilage: new insights
Gabay, Odile; Sanchez, Christelle ULiege; Chevy, F. et al

in Osteoarthritis and Cartilage (2008), 16(Suppl 4), 79

Detailed reference viewed: 151 (3 ULiège)
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See detailThe anti-invasive flavonoid (+)-catechin binds to laminin and abrogates the effect of laminin on cell morphology and adhesion
Bracke, M. E.; Castronovo, Vincenzo ULiege; Van Cauwenberge, R. M. et al

in Experimental Cell Research (1987), 173(1), 193-205

To study the effect of the flavonoid (+)-catechin on cell-matrix interactions two cell types with a different morphology on and adhesion to laminin were used. MO4 virally transformed fetal mouse cells ... [more ▼]

To study the effect of the flavonoid (+)-catechin on cell-matrix interactions two cell types with a different morphology on and adhesion to laminin were used. MO4 virally transformed fetal mouse cells adhere and spread when cultured on top of laminin-coated coverslips or on human amnion basement membrane. M5076 mouse reticulum cell sarcoma cells poorly adhere to these substrates and remain round. Both cell types are invasive in confronting cultures with embryonic chick heart fragments. (+)-Catechin binds to laminin in a pH-dependent way. Pretreatment of laminin-coated coverslips or amnion basement membrane with 0.5 mM (+)-catechin abrogates the effect of laminin on cell morphology and adhesion. MO4 cells do not adhere to the pretreated substrates and remain round, while M5076 cells now adhere and spread. (+)-Catechin inhibits the invasion of MO4 cells but not of M5076 cells into embryonic chick heart in vitro. We speculate that the anti-invasive activity of the flavonoid to MO4 cells is the result of its interference with MO4 cell adhesion to laminin. Invasion of M5076 cells does not imply adhesion to and spreading on laminin. [less ▲]

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See detailAnti-invasive, antitumoral, and antiangiogenic efficacy of a pyrimidine-2,4,6-trione derivative, an orally active and selective matrix metalloproteinases inhibitor
Maquoi, Erik ULiege; Sounni, Nor Eddine ULiege; Devy, L. et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2004), 10(12, Pt 1), 4038-4047

Purpose: The implication of matrix metalloproteinases (MMPs) in the major stages of cancer progression has fueled interest in the design of synthetic MMP inhibitors (MMPIs) as a novel anticancer therapy ... [more ▼]

Purpose: The implication of matrix metalloproteinases (MMPs) in the major stages of cancer progression has fueled interest in the design of synthetic MMP inhibitors (MMPIs) as a novel anticancer therapy. Thus far, drugs used in clinical trials are broad-spectrum MMPIs the therapeutic index of which proved disappointingly low. The development of selective MMPIs for tumor progression-associated MMPs is, thus, likely to offer improved therapeutic possibilities. Experimental Design: The anti-invasive capacity of a series of pyrimidine-trione derivatives was tested in vitro in a chemoinvasion assay, and the most potent compound was further evaluated in vivo in different human tumor xenograft models. The activity of this novel selective MMPI was compared with BB-94, a broad-spectrum inhibitor. Results: Ro-28-2653, an inhibitor with high selectivity for MMP-2, MMP-9, and membrane type 1 (MT1)-MMP, showed the highest anti-invasive activity in vitro. In vivo, Ro-28-2653 reduced the growth of tumors induced by the inoculation of different cell lines producing MMPs and inhibited the tumor-promoting effect of fibroblasts on breast adenocarcinoma cells. Furthermore, Ro-28-2653 reduced tumor vascularization and blocked angiogenesis in a rat aortic ring assay. In contrast, BB-94 up-regulated MMP-9 expression in tumor cells and promoted angiogenesis in the aortic ring assay. Conclusion: Ro-28-2653, a selective and orally bioavailable MMPI with inhibitory activity against MMPs expressed by tumor and/or stromal cells, is a potent antitumor and antiangiogenic agent. In contrast to broad-spectrum inhibitors, the administration of Ro-28-2653 was not associated with the occurrence of adverse side effects that might hamper the therapeutic potential of these drugs. [less ▲]

Detailed reference viewed: 66 (15 ULiège)
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See detailAnti-laminin antibodies in Sprague-Dawley and brown Norway rats chronically exposed to cadmium.
Bernard, A.; Lauwerys, R.; Gengoux, P. et al

in Toxicology (1984), 31(3-4), 307-13

Sprague-Dawley and Brown-Norway female rats were chronically exposed to cadmium. The metal was administered either in drinking water at a concentration of 20 or 100 ppm for 13 months or intraperitoneally ... [more ▼]

Sprague-Dawley and Brown-Norway female rats were chronically exposed to cadmium. The metal was administered either in drinking water at a concentration of 20 or 100 ppm for 13 months or intraperitoneally (i.p.) at the dose of 1 mg/kg, 5 times a week for 4 months. Anti-laminin and anti-type IV procollagen antibodies (laminin and type IV procollagen are components of the glomerular basement membranes) were sequentially assessed by radioimmunoassay in serial serum samples. Anti-type IV procollagen antibodies were never detectable whereas anti-laminin antibodies were transiently found in the serum of Sprague-Dawley rats only. In the i.p. group, the antibodies were detected between week 4 and 8, whereas in the oral treatment group, they were detected between month 6 and 8. At the same time, the concentration of cadmium in kidney cortex averaged about 100 ppm in the 20 ppm cadmium group and about 200 ppm in the 2 other treatment groups. The pathogenic significance of these antibodies in chronic cadmium intoxication of Sprague-Dawley rats remains to be assessed since their occurrence was not associated with concomitant immunoglobulin deposits in the kidneys. [less ▲]

Detailed reference viewed: 7 (0 ULiège)