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See detailAromatase-Immunoreactive Cells in the Quail Brain: Effects of Testosterone and Sex Dimorphism
Foidart, Agnès ULg; de Clerck, A.; Harada, N. et al

in Physiology & Behavior (1994), 55(3), 453-64

We previously demonstrated that testosterone (T) increases aromatase activity (AA) and that AA is sexually dimorphic (males > females) in the quail preoptic area (POA). The precise anatomical localization ... [more ▼]

We previously demonstrated that testosterone (T) increases aromatase activity (AA) and that AA is sexually dimorphic (males > females) in the quail preoptic area (POA). The precise anatomical localization of these effects is, however, impossible to obtain by biochemical assays even when samples are dissected by the Palkovits punch technique. We were recently able to set up an immunocytochemical (ICC) procedure that permits visualization of aromatase-immunoreactive (ARO-ir) cells in the quail brain. This showed that the ARO-ir cells of the quail POA actually outline the sexually dimorphic medial preoptic nucleus (POM). This ICC technique was used here to analyze the sex dimorphism of the quail preoptic aromatase and the localization of T effects on ARO-ir cells. In Experiment 1, the number of ARO-ir cells was counted in one section every 100 microns throughout the rostral to caudal extent of the POM of castrated birds that had been treated with increasing doses of T (5, 10, or 20 mm long Silastic implants). These T-treatments produced a dose-related increase in the sexual behavior of the birds and they increased the number of ARO-ir cells in POM, in the septal regions, and in the bed nucleus of the stria terminalis (BNST). The effect had a particularly large amplitude in the part of the POM located under the anterior commissure (AC). In Experiment 2, the same procedure was used to reanalyze the sex difference of the preoptic aromatase system. This showed that the POM of adult males contains more stained cells than the POM of females but only in a restricted region located just under and rostral to the AC. No significant sex difference was observed in the septum or in the BNST. In Experiment 3, the number of ARO-ir cells was determined in the POM of males and females that had been gonadectomized and treated with a same dose of T (40 mm implants). No sex difference in the number of ARO-ir cells could be detected in these conditions. This suggests that the sex difference in AA that had been previously observed in T-treated birds results either from a difference in aromatase concentration or activity in a similar number of positive cells or from a difference in the number of ARO-ir cells that is very discrete from the anatomical point of view.(ABSTRACT TRUNCATED AT 400 WORDS) [less ▲]

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See detailAromatic chlorination of toluene and of anisole using clay-supported iron(III) chloride and m-chloroperbenzoic Acid - A biomimetic approach
Delaude, Lionel ULg; Laszlo, Pierre ULg

in Catalysis Letters (1990), 5(1), 35-44

n the presence of meta-chloroperbenzoic acid, clay-supported ferric chloride is an efficient aromatic chlorinating agent for toluene and anisole. Influence of various experimental factors such as the ... [more ▼]

n the presence of meta-chloroperbenzoic acid, clay-supported ferric chloride is an efficient aromatic chlorinating agent for toluene and anisole. Influence of various experimental factors such as the nature of the solvent, the peracid or the metallic cation were investigated. These reactions represent a laboratory equivalent to biological halogenations through oxidation of halide ions by peroxidases in the presence of hydrogen peroxide. [less ▲]

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See detailAromatic Side-Chain Interactions In Proteins. I. Main Structural Features
Thomas, Annick ULg; Meurisse, R.; Charloteaux, Benoît ULg et al

in Proteins-Structure Function and Genetics (2002), 48(4), 628-34

In a data set of 593 nonhomologous proteins from the PDB, we have analyzed the pairing of phenylalanine, tyrosine, tryptophan, and histidine residues with their closest aromatic partner. The frequency ... [more ▼]

In a data set of 593 nonhomologous proteins from the PDB, we have analyzed the pairing of phenylalanine, tyrosine, tryptophan, and histidine residues with their closest aromatic partner. The frequency distribution of the shortest interatomic distance of partners is bimodal with a sharp peak at approximately 3.8 A and a wider one at a longer distance. Only the 3.8 A peak corresponds to direct ring-ring interactions thus aromatic pairs. The aromatic pairs were separated into two classes, near-sequence pairs and far-sequence pairs. Near sequence pairs stabilize local structure, and far-sequence pairs stabilize tertiary structure. Far-sequence pairs (74% of all pairs) mainly bridge two beta-strands, followed by pairs that bridge a beta-strand and a helix, and pairs that bridge a beta-strand and a random coil structure. Pairs that bridge helices are rare. The secondary structure of the near-sequence pairs depends on the partner distance in the sequence. When the partners are 1, 3, or 4 residues apart in the sequence, pairs are mostly found in helical structures. When the partners are two apart, pairs are mostly found in the same beta-strand. Analysis of the frequency of near sequence pairs supports the hypothesis that aromatic pairing occurs after, rather than before, the formation of secondary structures. [less ▲]

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See detailAromatic Side-Chain Interactions In Proteins. II. Near- And Far-Sequence Phe-X Pairs
Thomas, Annick ULg; Meurisse, R.; Brasseur, Robert ULg

in Proteins-Structure Function and Genetics (2002), 48(4), 635-44

We have collected all aromatic pairs (3152) involving an N-phenyl partner in a dataset of 593 proteins of the PDB: 728 of these pairs involve a partner residue less than 6 apart in the sequence. These ... [more ▼]

We have collected all aromatic pairs (3152) involving an N-phenyl partner in a dataset of 593 proteins of the PDB: 728 of these pairs involve a partner residue less than 6 apart in the sequence. These near-sequence Phe-X pairs correspond to specific conformations that stabilize secondary structures, mainly alpha-helices when the residues are 1, 3, and 4 apart, and beta-strands when they are 2 apart in the sequence. These conformations are not spatially random and have been examined in detail. The remaining phenylalanine pairs (2424) are between partners more than 5 apart in the sequence. Of these far-sequence pairs, 34% of occurrences are in sheets. Next in frequencies are pairs that bridge a beta-strand to a helix (24%), followed by pairs that bridge a beta-strand to a random coiled structure (15%). Helix to helix pairs only constitute 12% of these far-sequence pairs. Analysis of the pairing frequency supports the hypothesis that aromatic interactions are late events of protein folding. [less ▲]

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See detailAromatic Side-Chain Interactions In Proteins. Near- And Far-Sequence His-X Pairs
Meurisse, R.; Brasseur, Robert ULg; Thomas, Annick ULg

in Biochimica et Biophysica Acta-Proteins and Proteomics (2003), 1649(1), 85-96

Several studies have analysed aromatic interactions, involving mostly phenylalanine, tyrosine and tryptophan. Only a few studies have considered histidine as an interacting aromatic residue. An extensive ... [more ▼]

Several studies have analysed aromatic interactions, involving mostly phenylalanine, tyrosine and tryptophan. Only a few studies have considered histidine as an interacting aromatic residue. An extensive analysis of aromatic His-X interactions is performed here on a data set of 593 PDB structures: 68% of the histidine are involved in aromatic pairs and 1271 non-redundant His-X pairs were analysed. Thirty percent of these pairs involve an aromatic partner less than 6 apart in the sequence. These near-sequence pairs correspond to conformations which stabilise secondary structures, mainly alpha-helices when the residues are 4 apart and beta-strands when they are 2 apart in the sequence. The partners of the other His-X pairs (887, 70%) are more than 5 apart in the sequence. Of these far-sequence pairs, 35% bridge beta strands and only 9% helices. The near-sequence pairs are sterically constrained as supported by conformer distribution. The X partners of far-sequence His-X pairs are mainly "above" the histidine ring with tilted and normal rings, corresponding to a "T shape; face to edge" orientation. Phenylalanine, the only aromatic residue with no heteroatom, is a disfavoured partner, whereas histidine is the preferred one. Heteroatom-heteroatom interactions are favoured in near-sequence as well as in far-sequence His-His, His-Trp and His-Tyr pairs. [less ▲]

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See detailAromatic Side-Chain Interactions In Proteins: Near- And Far-Sequence Tyr-X Pairs
Meurisse, R.; Brasseur, Robert ULg; Thomas, Annick ULg

in Proteins-Structure Function and Genetics (2004), 54(3), 478-90

In the present study, an extensive analysis of the aromatic Tyr-X interactions is performed on a data set of 593 PDB structures, X being Phe, His, Tyr, and Trp. The nonredundant Tyr-X pairs (2645) were ... [more ▼]

In the present study, an extensive analysis of the aromatic Tyr-X interactions is performed on a data set of 593 PDB structures, X being Phe, His, Tyr, and Trp. The nonredundant Tyr-X pairs (2645) were retained and separated by both the residue distance in the sequence and the secondary structures they bridge. Similar to the Phe-X and His-X pairs, the far-sequence Tyr-X pairs (X partner > five apart in the sequence: 74%) show comparable secondary structures and conformers for either type of X partner, in contrast with the near-sequence Tyr-X pairs (26%). As the Phe-X pairs, the near-sequence Tyr-X pairs stabilize secondary structures, mainly the alpha- helices (positions 1, 3, and 4) and the beta-strands (position 2). Like the Phe-X and His-X pairs, most far-sequence Tyr-X pairs (34%) bridge beta-strands and only 11% bridge helices. As for the Phe-X and the His-X pairs, the X partners of the far-sequence Tyr-X pairs are frequently "above" the tyrosine ring with tilted and normal rings, whereas the X partner of the near-sequence Tyr-X pairs gradually moves from the "aside" to the "above" location, together with a progressive decrease of normal and increase of parallel rings, respectively. Unlike the His-X pairs, the interactions of the hetroatom in Tyr-X pairs are only favored with a sequence position +4 and over, owing to the spatial accessibility of the heteroatom. [less ▲]

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See detailAromatization of androgens into estrogens reduces response latency to a noxious thermal stimulus in male quail
Evrard, H. C.; Balthazart, Jacques ULg

in Hormones & Behavior (2004), 45(3), 181-189

We recently demonstrated the presence of estrogen synthase (aromatase) and of estrogen receptors in the dorsal horn (laminae I-II) throughout the rostrocaudal extent of the spinal cord in male and female ... [more ▼]

We recently demonstrated the presence of estrogen synthase (aromatase) and of estrogen receptors in the dorsal horn (laminae I-II) throughout the rostrocaudal extent of the spinal cord in male and female Japanese quail. The spinal laminae I-II receive and process abundant sensory information elicited, among others, by acute noxious stimulation of the skin and resulting in rapid, reflex-like withdrawal behavior. In the present study, we demonstrate that systemic treatment with estradiol or testosterone markedly decreases the latency of the foot withdrawal in the hot water test. A simultaneous treatment with an aromatase inhibitor blocks the effects of testosterone demonstrating, hence, that they are mediated by a conversion of testosterone into an estrogen by aromatase. Furthermore, the testosterone- or estradiol-induced decrease in foot withdrawal latency is blocked by a treatment with the estradiol receptor antagonist, tamoxifen, indicating that the effects are largely mediated by the interaction of estradiol with estrogen receptors. Together, these data suggest that sex steroids modulate sensitivity to noxious stimuli possibly by a direct action at the level of the dorsal hom of the spinal cord. (C) 2004 Elsevier Inc. All rights reserved. [less ▲]

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See detailAround Robert Wyatt
Delville, Michel ULg

Article for general public (2009)

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See detailAROUSAL, EXPERIENCES, AND PSYCHO-EMOTIONAL MANAGEMENT OF THE NORMS’ CONFLICTS IN AFRICAN POSTCOLONIAL CONTEXT: CASE STUDY OF THE SUCCESSION PRACTICE IN CAMEROON
Bomda, Joseph ULg

Poster (2011, October)

More than a half-century after its independence, Cameroonians, like other African people, are experiencing many conflicts of norms in their succession practices. Among other conflicts, one can mention: 1 ... [more ▼]

More than a half-century after its independence, Cameroonians, like other African people, are experiencing many conflicts of norms in their succession practices. Among other conflicts, one can mention: 1. “Residual” or Interreligious conflict between Christians, Muslims, and Animists. 2. “Virtual” conflicts between Anglophone and Francophone people. 3. But the main source of conflicts is the “Ordinary” or Interpersonal conflicts between ancestral and modern laws (of French or English inspiration), because both are legally accepted. SEEING THE CONFLICTS BETWEEN ANCESTRAL AND MODERN LEGAL NORMS RELATED TO SUCCESSION, 1. What do the victims of such conflicts experience from psycho-emotional point of view? 2. How do they manage these experiences of conflicts? 3. In which way can these experiences and their management contribute to the debates on social psychology? [less ▲]

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See detail"Arrachez-moi ce coeur!": de la crainte du rejet au délire après transplantation cardiaque
Triffaux, Jean-Marc ULg; Demoulin, J. C.; Limet, Raymond ULg

in Revue Médicale de Liège (2002), 57(6), 389-92

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See detailArrangement au présent, compromis au futur. Les ‘cadres de l’expérience’ d’un groupe de jeunes garçons dans le contexte tunisien
Nachi, Mohamed ULg

in Briviglierie et Cicchelli, Marc et Vincenzo (Ed.) Adolescences méditerranéennes. L’espace public à petits pas (2007)

Enquête pour suivre les expériences d’un groupe de jeunes en Tunisie et analyser la manière dont ils s'arrandent entre-eux, se mattent d'accord, nouer des compromis pour pouvoir vivre en commun

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See detailArrangement au présent, compromis au futur. Les ‘cadres de l’expérience’ d’un groupe de jeunes garçons dans le contexte tunisien
Nachi, Mohamed ULg

in BREVIGLIERI et CICCHELLI, Marc et Vincenzo (Ed.) Adolescences méditerranéennes. L’espace public à petits pas (2007)

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See detailArray Interpolation Applied to Conformal Array STAP
Ries, Philippe; Lapierre, Fabian D.; Verly, Jacques ULg

Conference (2005)

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See detailArray of microsystem for live monitoring of high voltage power lines
Renson, Luc ULg; Jamar, Claude ULg; Guérard, Suzanne ULg et al

in Proceedings of the 1st IOMAC (2005, April)

How to use microsystems placed on power lines environment.

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See detailArray-CGH analysis in Rwandan patients presenting development delay/intellectual disability with multiple congenital anomalies.
Uwineza, Annette; CABERG, Jean-Hubert ULg; Hitayezu, Janvier et al

in BMC medical genetics (2014), 15(1), 79

BACKGROUND: Array-CGH is considered as the first-tier investigation used to identify copy number variations. Right now, there is no available data about the genetic etiology of patients with development ... [more ▼]

BACKGROUND: Array-CGH is considered as the first-tier investigation used to identify copy number variations. Right now, there is no available data about the genetic etiology of patients with development delay/intellectual disability and congenital malformation in East Africa. METHODS: Array comparative genomic hybridization was performed in 50 Rwandan patients with development delay/intellectual disability and multiple congenital abnormalities, using the Agilent's 180 K microarray platform. RESULTS: Fourteen patients (28%) had a global development delay whereas 36 (72%) patients presented intellectual disability. All patients presented multiple congenital abnormalities. Clinically significant copy number variations were found in 13 patients (26%). Size of CNVs ranged from 0,9 Mb to 34 Mb. Six patients had CNVs associated with known syndromes, whereas 7 patients presented rare genomic imbalances. CONCLUSION: This study showed that CNVs are present in African population and show the importance to implement genetic testing in East-African countries. [less ▲]

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See detailArray-CGH analysis of T-ALL patients and cell lines
Lahortiga, I.; Graux, C.; Mentens, N. et al

in Blood (2006, November 16), 108(11, Part 2), 195-196

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See detailArrest of apoptosis in auditory neurons: Implications for sensorineural preservation in cochlear implantation
Scarpidis, U.; Madnani, D.; Shoemaker, C. et al

in Otology & Neurotology (2003), 24(3), 409-417

Hypothesis: The JNK/c-Jun cell death pathway is a major pathway responsible for the loss of oxidative stress-damaged auditory neurons. Background: Implantation of patients with residual hearing ... [more ▼]

Hypothesis: The JNK/c-Jun cell death pathway is a major pathway responsible for the loss of oxidative stress-damaged auditory neurons. Background: Implantation of patients with residual hearing accentuates the need to preserve functioning sensorineural elements. Although some auditory function may survive electrode insertion, the probability of initiating an ongoing loss of auditory neurons and hair cells is unknown. Cochlear implantation can potentially generate oxidative stress, which can initiate the cell death of both auditory neurons and hair cells. Methods: Dissociated cell cultures of P4 rat auditory neurons identified the apoptotic pathway initiated by oxidative stress insults (e.g., loss of trophic factor support) and characterized this pathway by arresting translation of pathway-specific mRNA with antisense oligonucleotide treatment and with the use of pathway specific inhibitors. The presence or absence of apoptosis-specific protein and changes in the level of neuronal survival measured the efficacy of these interventional strategies. Results: These in vitro studies identified the JNK/c-Jun cascade as a major initiator of apoptosis of auditory neurons in response to oxidative stress. Neurons pretreated with c-jun antisense oligonucleotide and exposed to high levels of oxidative stress were rescued from apoptosis, whereas neurons in treatment control cultures died. Treatment of oxidative-stressed cultures with either curcumin, a MAPKKK pathway inhibitor, or PD-098059, a MEK1 inhibitor, blocked loss of neurons via the JNK/c-Jun apoptotic pathway. Conclusion: Blocking the JNK/c-Jun cell death pathway is a feasible approach to treating oxidative stress-induced apoptosis within the cochlea and may have application as an otoprotective strategy during cochlear implantation. [less ▲]

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See detailArrest of MCF-7 cell migration by laminin in vitro: possible mechanisms.
Coopman, P.; Verhasselt, B.; Bracke, M. et al

in Clinical & Experimental Metastasis (1991), 9(5), 469-84

Laminin, a major basement membrane component, arrested the migration of MCF-7/AZ human breast adenocarcinoma cells that were not invasive in vitro. Migration of invasive MCF-7/6 cells was not affected by ... [more ▼]

Laminin, a major basement membrane component, arrested the migration of MCF-7/AZ human breast adenocarcinoma cells that were not invasive in vitro. Migration of invasive MCF-7/6 cells was not affected by laminin. Both cell types expressed the 67 kD laminin receptor, at both mRNA and protein level, but did not express the alpha 6 subunit of the VLA-6 integrin-type laminin receptor. The presence of YIGSR peptides (100 micrograms/ml), reported to block the interaction between laminin and its 67 kD receptor, did not change the migratory response of MCF-7/AZ or MCF-7/6 cells when meeting laminin lanes. In addition, the migration of these cell types was not affected by the presence of 17-beta-estradiol (10(-6) M) or all-trans retinoic acid (10(-6) M), which were both reported to increase the number of 67 kD receptors. We could therefore not assign an involvement of the 67 kD receptors in migration of MCF-7 cells on laminin, nor did we find evidence that conditioned medium of MCF-7/6 cells contains factors that are able to initiate migration of MCF-7/AZ cells on laminin. [less ▲]

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See detailArrêt "Commission c. Autriche" : la lutte contre la pollution aux prises avec la libre circulation des marchandises
Sibony, Anne-Lise ULg; Lieven, Sophie ULg

in Journal de Droit Européen [=JDE] (2012), (187), 80-82

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