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See detailAn intra-articular supplementation method for treating joint diseases and injuries
Henrotin, Yves ULg; Sanchez, Christelle ULg; Oprenyeszk, Frédéric ULg et al

Patent (2011)

A method of producing a hydrogel for intra-articular supplement comprising the steps of: - providing a solution of alginate, - providing a solution with chitosan having a Mw between lower than 60 kD ... [more ▼]

A method of producing a hydrogel for intra-articular supplement comprising the steps of: - providing a solution of alginate, - providing a solution with chitosan having a Mw between lower than 60 kD, - mixing the solution of alginate and the solution of chitosan, wherein the mixed solution comprises between 0.5 and 0.7 % (w/v) of chitosan and between 1 and 1.4 % alginate (w/v), - introducing droplets of the mixed solution into a solution with Ca2+ or Sr2+ cations and - isolating polymerised beads from the solution with cations [less ▲]

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See detailIntra-articular use of a medical device composed of hyaluronic acid and chondroitin sulfate (Structovial CS): effects on clinical, ultrasonographic and biological parameters
Henrotin, Yves ULg; Hauzeur, Jean-Philippe; Bruel, Pierre et al

in BMC Research Notes (2012), 5(1), 407

BACKGROUND:This pilot open noncontrolled study was designed to assess the efficacy of intra articular injections of a solution combining hyaluronic acid (HA) and chondroitin sulphate (CS) in the treatment ... [more ▼]

BACKGROUND:This pilot open noncontrolled study was designed to assess the efficacy of intra articular injections of a solution combining hyaluronic acid (HA) and chondroitin sulphate (CS) in the treatment of outpatients affected by knee osteoarthrosis. Findings - Thirty patients with knee OA have been included. The primary objective was to assess clinical efficacy as measured by pain and Lequesne's index. Secondary objectives were to assess potential effect of the treatment on ultrasound parameters, safety and biomarkers of cartilage metabolism and joint inflammation. After a selection visit (V1), the study treatment was administered 3 times on a weekly basis (V2, V3, V4). Follow-up was planned 6 (V5) and 12 weeks (V6) after the first intra-articular injection. Efficacy results showed a reduction in mean pain at V3 and V6 and in functional impairment, the most marked changes being measured at the two follow-up visits (V5 and V6). Although statistical significance was not achieved due to small sample size, a clear tendency towards improvement was detectable for ultrasound assessments as well as biomarkers. Except for a mild injection site hematoma for which the drug causal relationship could not be excluded, no adverse effect of clinical relevance was recorded during the study.CONCLUSION:Although this pilot study was performed according to an open design only, the ultrasound as well as biomarkers changes strongly suggest a non-placebo effect. These preliminary results call now for a randomized controlled study to confirm the clinical relevance of the observed results. Trial registration #ISRCTN91883031 [less ▲]

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See detailIntra-cultivar potential of Desmanthus spp. as a greenhouse gas mitigation strategy for tropical livestock pastoral systems
Vandermeulen, Sophie ULg; Ramírez-Restrepo, Carlos Alberto; Singh, Sultan et al

Poster (2015, November)

Improved agricultural efficiency and reduction in the impacts of tropical livestock farming on habitat degradation require global approaches that enhance ruminant farming functionality in terms of feed ... [more ▼]

Improved agricultural efficiency and reduction in the impacts of tropical livestock farming on habitat degradation require global approaches that enhance ruminant farming functionality in terms of feed use efficiency, emissions and food security. This study evaluated the in vitro mitigation potential of the prostrate to erect, herbaceous Desmanthus spp. pasture legume adapted to semiarid clay soil land types in northern Australia. D. bicornutus, D. leptophyllus and D. virgatus were seasonally harvested from commercial plots by Agrimix Pty. Ltd. Samples of the legumes and the control Rhodes grass (Chloris gayana) using ruminal fluid from grazing Brahman (Bos indicus) steers were incubated in vitro (Ankom RF1 Technology) for 24, 48 and 72 h. Overall, the in vitro organic matter degradability (OMD) and methane production between Desmanthus species differed (P < 0.001). Compared to the control (0.656 ± 0.027 proportion of total OM) at 48 h of incubation, D. leptophyllus showed lower OMD (0.479 ± 0.016), while D. bicornutus (0.688 ± 0.016) and D. virgatus (0.619 ± 0.015) were different from each other, but similar to the control. Methane production (ml/g OM) was 15.7 ± 1.54, 3.7 ± 0.89, 12.0 ± 0.95 and 11.7 ± 0.95, respectively. It is suggested that the impact of these attributes may benefit household farmers in developing economies to expand productivity, improve livelihoods and meet the growing food consumption. Further analyses of the intra-cultivar characteristics of Desmanthus spp. will complement the design of sustainable and efficient interventions across tropical pastoral feeding systems, with a particular emphasis on large-scale grazing operations. [less ▲]

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See detailIntra-European Mobility: Patterns of Immigration Flows and Policies
Barbulescu, Roxana; Lafleur, Jean-Michel ULg; Stanek, Mikolaj

in Europa, Publications (Ed.) Western Europe 2016 (2015)

For decades, immigration has been at the core of the political and social debate in Europe. In the post-crisis environment, recent events have inflamed the migration agenda further, as freedom of movement ... [more ▼]

For decades, immigration has been at the core of the political and social debate in Europe. In the post-crisis environment, recent events have inflamed the migration agenda further, as freedom of movement is an essential decision-making point in the planned referendum on European Union (EU) membership in the United Kingdom, and the humanitarian crisis in the Mediterranean is testing the limits of the EU and of its member states to manage migration in a humane and fair way. Large- scale immigration has long challenged the Westphalian tradition of nation-state sovereignty in Europe (Joppke, 1998). However, these tensions have only increased over the last decade, following conflicts in Europe’s neighbourhood, the fall of the ‘Iron Curtain’ and the eastern enlargement of the EU, or the 2008 global economic and financial crisis. If until recently the most controversial aspect of immigration has been migrants and asylum-seekers from outside the EU and an invisibility of European migration and European migrants, in the last few years we observe that the very principle of migration from the other member states is challenged in a systematic manner for the first time since its proclamation in the Treaty of Rome (establishing the European Economic Community in 1958). The rebellion against the status quo on freedom of movement of people in the EU is led by Western European states. They are the almost exclusive receivers of EU migration, either from the other Western European states, or from the new member states in Central and Western Europe. This essay traces the transformation of EU migration over the last decade, following the most recent enlargements and the south–north migration which has re-emerged since the financial crisis, and examines the causes of an unprecedented contestation of free movement rights. [less ▲]

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See detailThe intra-nasal administration of insulin induces significant hypoglycaemia and classical counterregulatory hormonal responses in normal man.
Paquot, Nicolas ULg; Scheen, André ULg; Franchimont, P. et al

in Diabète & Métabolisme (1988), 14(1), 31-6

The present study aimed at investigating the metabolic and hormonal consequences of intra-nasal administration of insulin in normal man. Lyophylisated regular porcine insulin (Insuline Ordinaire Organon ... [more ▼]

The present study aimed at investigating the metabolic and hormonal consequences of intra-nasal administration of insulin in normal man. Lyophylisated regular porcine insulin (Insuline Ordinaire Organon) diluted with a non ionic detergent (Laureth-9 0,25%) was administered intra-nasally in 8 overnight fasted healthy volunteers using a calibrated aerosol delivery device (90 microliters = 9 U of insulin/spray) up to a total insulin dose close to 1 U/kg body weight. After intra-nasal insulin administration, plasma insulin levels rose from 5 +/- 1 to 38 +/- 10 mU/l (2p less than 0.01) at min 15, blood glucose concentrations decreased from 4.4 +/- 0.2 to 3.2 +/- 0.3 mmol/l (2p less than 0.01) at min 45, plasma C-peptide levels diminished from 327 +/- 31 to 174 +/- 28 mumol/l (2p less than 0.01) at min 60 and plasma free fatty acids concentrations fell from 336 +/- 109 to 130 +/- 31 mumol/l (2p less than 0.05) at min 30. The fall in blood glucose resulted in a prompt increase in plasma glucagon levels (from 78 +/- 28 to 150 +/- 24 ng/l at min 45; 2p less than 0.05) and in later rises in plasma growth hormone and cortisol concentrations. There was a close relationship between the individual maximal decreases in blood glucose levels and the individual maximal increases in plasma insulin (r = 0.81), glucagon (r = 0.88), cortisol (r = 0.87) and growth hormone (r = 0.76) concentrations.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailIntra-operative autologous transfusion in cancer patients.
Joris, Jean ULg

in Acta Anaesthesiologica Belgica (2004), 55(1), 49-51

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See detailIntra-patient variability of SUV in normal tissues.
PAQUET, N.; HUSTINX, Roland ULg; FOIDART-WILLEMS, Jacqueline ULg

in European Journal of Nuclear Medicine and Molecular Imaging (2003), 30(SUPPL 2), 327

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See detailIntra-specific variation in nitrate tolerance in tadpoles of the Natterjack toad.
Miaud, C.; Oromi Farrús, Neus ULg; Guerrero, S. et al

in Ecotoxicology (2011), 20

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See detailINTRA-TUMORAL HETEROGENEITY AND RATIONAL SELECTION OF ANTIGENS FOR TARGETED THERAPY OF LIVER METASTASES
Turtoi, Andrei ULg; Blomme, Arnaud ULg; Delvaux, David ULg et al

in Acta Chirurgica Belgica (2012, May), 112(3), 8953

Objectives: Targeted therapies of liver metastases are gaining a major stake in current and future treatment options. However, the malignant lesions are heterogeneous in nature offering niches for cancer ... [more ▼]

Objectives: Targeted therapies of liver metastases are gaining a major stake in current and future treatment options. However, the malignant lesions are heterogeneous in nature offering niches for cancer cells causing treatment resistance and relapse. Therefore, a rational strategy is needed to select targetable antigens that would overcome this intra-tumoral heterogeneity. Methods: After ethical committee approval, 48 fresh liver metastases of colorectal origin were prospectively collected from patients undergoing liver resection. Here we macroscopically divided the lesion in different zones and generated a unique quantitative picture of the proteome heterogeneity in colorectal carcinoma liver metastases. Particular focus was laid on accessible proteins, a protein subclass comprising cell membrane associated and extracellular proteins. Accordingly, the tissues were ex-vivo biotinylated, affinity purified and analyzed for each zone separately using nano-UPLC-MSe proteomics technique. In total over 1500 unique proteins were statistically divided into different patterns of expression. Results: We have generated a quantitative picture of the proteome heterogeneity in colorectal carcinoma liver metastases. The study offers insight into novel targets but also antigens against which the antibodies are already involved in clinical trials or treatment of liver metastases. Extensive clustering and validation experiments highlight novel markers that offer the potential to homogeneously cover the metastatic lesion and become better targets. Conclusions: Two such antigens, LTBP2 and TGFBI were selected for functional analysis in colorectal carcinoma cells. In vitro and in vivo experiments showed that in particular TGFBI is relevant for migration and proliferation capacity of colorectal cancer cells. The suppression of this protein led to significant inhibition of tumor growth, crystalizing it as bona fide target for the development of anti-metastases therapies. [less ▲]

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See detailIntraarterial spiral CT angiography combined with DSA in pretherapeutic assessment of cerebral aneurysms.
Flandroy, P.; Vanderschelden, P.; Dondelinger, Robert ULg et al

Conference (1996, September 21)

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See detailIntracardiac defect demonstrated by cardiac CTA.
Ghekiere, O.; Djekic, J.; NCHIMI LONGANG, Alain ULg

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2010), 93(2), 113

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See detailIntracardiac flow visualization: current status and future directions.
Rodriguez Munoz, Daniel; Markl, Michael; Moya Mur, Jose Luis et al

in European Heart Journal - Cardiovascular Imaging (2013)

Non-invasive cardiovascular imaging initially focused on heart structures, allowing the visualization of their motion and inferring its functional status from it. Colour-Doppler and cardiac magnetic ... [more ▼]

Non-invasive cardiovascular imaging initially focused on heart structures, allowing the visualization of their motion and inferring its functional status from it. Colour-Doppler and cardiac magnetic resonance (CMR) have allowed a visual approach to intracardiac flow behaviour, as well as measuring its velocity at single selected spots. Recently, the application of new technologies to medical use and, particularly, to cardiology has allowed, through different algorithms in CMR and applications of ultrasound-related techniques, the description and analysis of flow behaviour in all points and directions of the selected region, creating the opportunity to incorporate new data reflecting cardiac performance to cardiovascular imaging. The following review provides an overview of the currently available imaging techniques that enable flow visualization, as well as its present and future applications based on the available literature and on-going works. [less ▲]

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See detailIntracellular and extracellular vaccinia virions enter cells by different mechanisms
Vanderplasschen, Alain ULg; Hollinshead, M.; Smith, G. L.

in Journal of General Virology (The) (1998), 79(Pt 4), 877-887

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See detailIntracellular cation concentrations in essential hypertension and chronic renal failure
Krzesinski, Jean-Marie ULg; Du, F.; Rorive, Georges ULg

in Clinical & Experimental Hypertension (1993), 15(3), 461-478

The aim of this study was to test basal and after treatment erythrocyte sodium and calcium concentrations, and calcium-ATPase activity and platelet cytosolic free calcium and pH in 20 normotensive ... [more ▼]

The aim of this study was to test basal and after treatment erythrocyte sodium and calcium concentrations, and calcium-ATPase activity and platelet cytosolic free calcium and pH in 20 normotensive controls, 20 hemodialysis-dependent chronic renal failure patients and in 18 essential hypertensives. Prior to treatment, essential hypertensive and uremic patients presented similar higher platelet calcium concentrations and lower pH than the normotensive control group. The erythrocyte sodium, calcium, and magnesium concentrations were only significantly elevated in chronic renal failure, with a significant decrease in the calcium-ATPase activity in the latter population. Hemodialysis partially reversed these intracellular ionic abnormalities with normalization of platelet pH. Significant correlations have been noted between weight loss and decreases in platelet calcium concentration (r = 0.60, p < 0.01) or in erythrocyte sodium (r = 0.50, p < 0.05). The systolic blood pressure decrease was only correlated to the increase in calcium-ATPase activity (r = 0.57, p < 0.05). Antihypertensive treatment (captopril and nifedipine) only tended to normalize the intracellular calcium concentration with correlation between the decrease of the latter and blood pressure decrease (r = 0.64 for the systolic blood pressure and 0.68 for the diastolic blood pressure, p < 0.01). Thus, in essential hypertension and in uremia, some cellular ionic abnormalities exist in platelets in baseline condition. Moreover, in uremia, erythrocyte presents abnormal ionic pattern. Some, but not all of these abnormalities could be corrected by treatment affecting blood pressure (cellular calcium) in essential hypertension or by hemodialysis (cellular sodium, calcium, and pH). In the latter treatment, the changes are linked to extracellular fluid modification. In essential hypertension, the intracellular calcium reduction was linked to blood pressure decrease. [less ▲]

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See detailIntracellular concentration of cryoprotectant during vitrification and slow-freezing cryopreservation procedures
Vanderzwalmen, Pierre ULg; Ectors, Fabien ULg; Wirleitner, Barbara et al

in Tucker, Mickael; Lieberman, Juergen (Eds.) Vitrification in assisted reproduction: second edition (2015)

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See detailIntracellular damages induced by singlet oxygen are signals for HIV-1 reactivation
Piette, Jacques ULg; Legrand-Poels, Sylvie ULg

in Journal of Free Radicals in Biology & Medicine (1993)

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See detailIntracellular distribution of the ORF4 gene product of varicella-zoster virus is influenced by the IE62 protein
Defechereux, Patricia; Debrus, Serge; Baudoux, Laurence et al

in Journal of General Virology (1996), 77(Part 7), 1505-1513

Varicella-zoster virus (VZV) open reading frame 4-encoded protein (IE4) possesses transactivating properties for VZV genes as well as for genes of heterologous viruses, The major regulatory immediate ... [more ▼]

Varicella-zoster virus (VZV) open reading frame 4-encoded protein (IE4) possesses transactivating properties for VZV genes as well as for genes of heterologous viruses, The major regulatory immediate-early protein of VZV (IE62) is a transactivator of VZV gene expression, In transfection assays, IE4 has been shown to enhance activation induced by IE62, To investigate the functional interactions underlying this observation, indirect immunofluorescence studies were undertaken to determine whether IE62 could influence IE4 intracellular localization in transfected cells, In single transfections, IE4 was predominantly found in cytoplasm, In cotransfection with IE62, the IE4 localization pattern was altered, with nuclear staining predominating over cytoplasmic staining, This effect was specific to the IE62 protein since the gene products of ORF63 and ORF61, which are also regulatory proteins, did not influence IE4 distribution, The use of IE62 mutants indicated that IE62 influence is independent of its transactivation function and that the integrity of regions 3 and 4 is required, IE62 remained nuclear whether IE4 was present or not, These observations underline differences in the regulation of gene expression between VZV proteins and their herpes simplex virus type 1 homologues, In infected cells, IE4 was only sometimes found to colocalize with IE62 in nuclei, This observation suggests that when all VZV proteins are present, complex interactions probably occur which could diminish the influence of IE62. [less ▲]

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