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See detailMonthly oral ibandronate is effective and well tolerated after 3 years: the MOBILE long-term extension.
Stakkestad, Jacob A; Lakatos, Peter; Lorenc, Roman et al

in Clinical Rheumatology (2008), 27(8), 955-60

Oral ibandronate is the first bisphosphonate licensed for once-monthly treatment of postmenopausal osteoporosis. The 2-year Monthly Oral iBandronate In LadiEs (MOBILE) registration study assessed bone ... [more ▼]

Oral ibandronate is the first bisphosphonate licensed for once-monthly treatment of postmenopausal osteoporosis. The 2-year Monthly Oral iBandronate In LadiEs (MOBILE) registration study assessed bone mineral density (BMD) and markers of bone turnover and showed that monthly oral ibandronate was at least as effective and well tolerated as a 2.5-mg daily oral regimen. In this study, we report the first year of a long-term extension study to MOBILE and a post hoc analysis of patients receiving 3 years of continuous treatment with monthly ibandronate. Patients who completed MOBILE were eligible for the partially randomized, double-blind extension study and received 100 mg (n = 359) or 150 mg (n = 360) monthly oral ibandronate. A post hoc analysis included patients who received either 100 mg (n = 173) or 150 mg (n = 169) monthly ibandronate continuously throughout the original 2-year MOBILE study and during the first year of the extension study. After one additional year of treatment (total of 3 years), mean lumbar spine BMD increased a further 1.5 and 1.1% in the 150 and 100 mg arms, respectively, compared with 2-year data (original MOBILE study). Total hip BMD changed by 0.3 and -0.08%, respectively. In the post hoc analysis, 3-year increases in lumbar spine BMD were significant in patients receiving ibandronate 150 mg monthly (7.6%; p < 0.0001 vs. baseline) and 100 mg monthly (6.4%; p < 0.0001 vs. baseline). Both groups achieved significant increases in total hip BMD after 3 years compared with baseline (3.4%, 100 mg; 4.1%, 150 mg; p < 0.0001). Serum C-telopeptide of the alpha chain of type I collagen decreased significantly over 3 years' treatment (p < 0.001; all comparisons vs. baseline), remaining within the premenopausal range. Once-monthly oral ibandronate was well tolerated with a low incidence of clinical osteoporotic fractures and upper gastrointestinal events. In conclusion, 150-mg monthly oral ibandronate is an effective and well-tolerated long-term treatment for postmenopausal osteoporosis, with consistent improvement in BMD and bone turnover during 3 years' continuous treatment. [less ▲]

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See detailMonthly oral ibandronate is well tolerated and efficacious in postmenopausal women: Results from the monthly oral pilot study
Reginster, Jean-Yves ULg; Wilson, K. M.; Dumont, Etienne et al

in Journal of Clinical Endocrinology and Metabolism (2005), 90(9), 5018-5024

Context: Ibandronate, a potent, nitrogen-containing bisphosphonate developed for intermittent administration in postmenopausal osteoporosis, aims to overcome current adherence issues with daily and weekly ... [more ▼]

Context: Ibandronate, a potent, nitrogen-containing bisphosphonate developed for intermittent administration in postmenopausal osteoporosis, aims to overcome current adherence issues with daily and weekly oral bisphosphonates through once-monthly oral dosing. Objective: The purpose of this study was to investigate the safety, pharmacodynamics, and pharmacokinetics of once-monthly oral ibandronate. Design: A randomized, 3-month, double-blind, placebo-controlled, phase I study (Monthly Oral Pilot Study) was conducted. Setting: The study was conducted at five clinical trial centers in the United Kingdom and Belgium. Patients or Other Participants: Subjects were postmenopausal women (age, 55 - 80 yr; >= 3 yr post menopause; n = 144). Intervention(s): Once-monthly oral ibandronate 50, 100, or 150 mg or placebo was used. After the first cycle, the 50-mg arm was split, with participants continuing on either 50 or 100 mg. Main Outcome Measure(s): Primary outcome measures were safety, serum and urinary C-telopeptide (CTX), and serum ibandronate AUC(0-infinity). Results: Once- monthly oral ibandronate was well tolerated, with a similar overall and upper gastrointestinal safety profile to placebo. Once- monthly ibandronate was also highly effective in decreasing bone turnover; substantial reductions from baseline in serum CTX (-56.7% and -40.7% in the 150- and 100- mg arms, respectively; P < 0.001 vs. placebo) and urinary CTX (-54.1% and -34.6%, respectively; P < 0.001 vs. placebo) were observed at d 91 (30 d after the final dose). Analysis of the area under the effect curve (d1 - 91) for change from baseline (percent x days) in serum CTX and urinary CTX indicated a dose- response relationship. The AUC(0-infinity) for ibandronate increased with dose but not in a dose- proportional manner. Conclusions: These findings indicate a potential role for once-monthly oral ibandronate in the treatment of postmenopausal osteoporosis. [less ▲]

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See detailMonthly oral ibandronate therapy in postmenopausal osteoporosis: 1-year results from the MOBILE study
Miller, Paul D.; McClung, Michael R.; Macovei, Liviu et al

in Journal of Bone and Mineral Research (2005), 20(8), 1315-1322

Introduction: Suboptimal adherence to daily and weekly oral bisphosphonates can potentially compromise therapeutic outcomes in postmenopausal osteoporosis. Although yet to be prospectively shown in ... [more ▼]

Introduction: Suboptimal adherence to daily and weekly oral bisphosphonates can potentially compromise therapeutic outcomes in postmenopausal osteoporosis. Although yet to be prospectively shown in osteoporosis, evidence from randomized clinical trials in several other chronic conditions shows that reducing dosing frequency enhances therapeutic adherence. Ibandronate is a new and potent bisphosphonate with antifracture efficacy proven for daily administration and also intermittent administration with a dose-free interval of > 2 months. This report presents comparative data on the efficacy and safety of monthly and daily oral ibandronate regimens. Materials and Methods: MOBILE is a 2-year, randomized, double-blind, phase III, noninferiority trial. A total of 1609 women with postmenopausal osteoporosis were assigned to one of four oral ibandronate regimens: 2.5 mg daily, 50 mg/50 mg monthly (single doses, consecutive days), 100 mg monthly, or 150 mg monthly. Results: After 1 year, lumbar spine BMD increased by 3.9%, 4.3%, 4.1%, and 4.9% in the 2.5, 50/50, 100, and 150 mg arms, respectively. All monthly regimens were proven noninferior, and the 150 mg regimen superior, to the daily regimen. All monthly regimens produced similar hip BMD gains, which were larger than those with the daily regimen. All regimens similarly decreased serum levels of C-telopeptide, a biochemical marker of bone resorption. Compared with the daily regimen, a significantly larger proportion of women receiving the 100 and 150 mg monthly regimens achieved predefined threshold levels for percent change from baseline in lumbar spine (6%) or total hip BMD (3%). All regimens were similarly well tolerated. Conclusions: Monthly ibandronate is at least as effective and well tolerated as the currently approved daily ibandronate regimen in postmenopausal osteoporosis. [less ▲]

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See detailLe monticule frasnien de la carrière du Nord à Frasnes (Belgique): sédimentologie, stratigraphie séquentielle et coraux
Boulvain, Frédéric ULg; Coen-Aubert, M.

in Professional Paper Belgian Geological Survey (1998), 285

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See detailLe monticule frasnien de la carrière du Nord à Frasnes (Belgique): sédimentologie, stratigraphie séquentielle et coraux
Boulvain, Frédéric ULg; Coen-Aubert, M.

in Professional Paper Belgian Geological Survey (1998), 285

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See detailLe monticule frasnien de la carrière Saint-Remy : faciès et genèse
Boulvain, Frédéric ULg

in Toussaint, Jacques (Ed.) Marbres jaspés de Saint-Remy et de la région de Rochefort (2012)

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See detailMontrer des corps... libres
Englebert, Jérôme ULg

in Nollet, Lieven (Ed.) Condamné, pas coupable (2010)

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See detailMontrer l’invisible. Les dieux et leurs statues dans la céramique grecque
Collard, Hélène ULg

in Borgeaud, Philippe; Fabiano, Doralice (Eds.) Perception et construction du divin dans l'Antiquité (2013)

Cette étude examine un groupe de vases particuliers, qui amènent une série de questions intéressantes sur le statut de l’image divine et sur les modes de représentation du divin en Grèce ancienne. Il ... [more ▼]

Cette étude examine un groupe de vases particuliers, qui amènent une série de questions intéressantes sur le statut de l’image divine et sur les modes de représentation du divin en Grèce ancienne. Il s’agit de documents attiques et italiotes sur lesquels une divinité est représentée à côté de sa propre statue. La question qui se pose d’emblée est celle du sens de ce type de figuration, qui « redouble » en quelque sorte la divinité. On tente de montrer ici que le « redoublement » n’est pas une simple redondance, car ces images mettent en scènes deux modes de présence différents. [less ▲]

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See detailMontrer, calculer, explorer, analyser. Ce que l'informatique fait (faire) à l'analyse qualitative
Lejeune, Christophe ULg

in Recherches Qualitatives (2010), 9

Au delà de ses implications techniques, l'informatisation de l'analyse de texte soulève des questions de méthode. Après un recensement des motivations à recourir à des logiciels pour assister l'analyse de ... [more ▼]

Au delà de ses implications techniques, l'informatisation de l'analyse de texte soulève des questions de méthode. Après un recensement des motivations à recourir à des logiciels pour assister l'analyse de données textuelles, nous proposons une typologie distinguant cinq fonctionnalités proposées par ces outils : la lexicométrie, les concordances, les automates, les outils réflexifs et les dictionnaires. Chacune de ces fonctionnalités éclaire les textes d'une manière originale (et partielle). Rapportée à ses usages attestés, chacune de ces potentialités articule des présupposés épistémologiques spécifiques. En définitive, le choix d'un logiciel caractérise autant une démarche de recherche que l'inscription dans un paradigme. [less ▲]

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See detailLe monument à Léopold Ier
Houbart, Claudine ULg

Conference given outside the academic context (2003)

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See detailLe monument à Léopold Ier: approche architecturale et typologique
Houbart, Claudine ULg

in Bulletin de la Classe des Beaux-Arts (2003)

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See detaille monument à Léopold Ier: aux origines de l'urbanisation de Laeken
Houbart, Claudine ULg

in Notre Comté. Annales du cercle d'histoire, d'archéologie et de folklore du comté de Jette et de sa région (2003), XXX

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See detailLes monuments de la Ville de Laon et la dendrochronologie
Hoffsummer, Patrick ULg; Plouvier, Martine

in Le bois dans l'architecture (1995)

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See detailThe monzonorite-anorthosite connection; the petrogenesis of terrestrial KREEP
Longhi, John; Vander Auwera, Jacqueline ULg

in Lunar and Planetary Science Conference Abstracts (1993), 24

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See detailMonzonorites from Rogaland (Southwest Norway): a series of rocks coeval but not comagmatic with massi-type anorthosites
Duchesne, Jean-Clair ULg; Wilmart, Edith; Demaiffe, Daniel et al

in Precambrian Research (1989), 45

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See detailLes Mooc : étude énonciative d’une pédagogie multimodale
Dondero, Maria Giulia ULg; Eléni, Mouratidou

in Leclercq, Pierre (Ed.) Communication multimodale et collaboration instrumentée. Regards croisés sur Énonciations, Représentations, Modalités (2014, September 15)

Cette contribution interroge les pratiques de pédagogie multimodale instrumentée des Massive Open Online Courses au travers d’une étude énonciative. Partant du principe que la communication multimodale ... [more ▼]

Cette contribution interroge les pratiques de pédagogie multimodale instrumentée des Massive Open Online Courses au travers d’une étude énonciative. Partant du principe que la communication multimodale instrumentée utilise différentes médiations sémiotiques (vidéo, peinture, dessin à la main, graphique, schéma, sonorité, musique etc.) nous nous proposons d’observer et d’analyser ces types de modalités communicationnelles telles que mises en place par les mooc. Ce, dans l’objectif de saisir la variété des pratiques multimodales auxquelles recourent les Massive Open Online Courses. Nous tentons également de souligner ce qui définit la spécificité de ces pratiques et la manière dont l’étude sémiotique des stratégies énonciatives peut-elle contribuer aux questionnements actuels en sciences de la communication. Nous répondons à ces questions à travers l’analyse de deux mooc issus de deux plateformes différentes : The Future of Storytelling de la plateforme Iversity et Scientific Humanities de la plateforme France Université Numérique. [less ▲]

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