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See detailMultiaxial fatigue damage modeling of Ti6Al4V alloy
Marmi, Abdeljalil ULg; Habraken, Anne ULg; Duchene, Laurent ULg

in Proceedings of the ICMFF9 Conference (2010)

The aim of this study is to present a new multiaxial fatigue model based on phenomenological approach for the proportional loading. The model estimations are compared to the classical Lemaitre-Chaboche [1 ... [more ▼]

The aim of this study is to present a new multiaxial fatigue model based on phenomenological approach for the proportional loading. The model estimations are compared to the classical Lemaitre-Chaboche [1] fatigue model and experimental results. The comparison is done by simulation of SN curves of notched and un-notched forged TA6V samples. To take into account the effect of stress gradient near notch root, the applied loads such as stress amplitude and Von Mises stress are affected by the triaxialty function introduced by Lemaitre [2]. The models enhanced by triaxialty function give correct results for life estimation of notched samples. [less ▲]

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See detailMultiaxial fatigue damage modelling at Macro scale of Ti6AL4V alloy
Marmi, Abdeljalil ULg; Habraken, Anne ULg; Duchene, Laurent ULg

in International Journal of Fatigue (2009), 31

The Lemaitre and Chaboche fatigue model is investigated in order to predict the fatigue life of tensile samples with and without notches, defining different stress concentration fields. Elastoplastic FE ... [more ▼]

The Lemaitre and Chaboche fatigue model is investigated in order to predict the fatigue life of tensile samples with and without notches, defining different stress concentration fields. Elastoplastic FE simulations based on anisotropic yield locus description were carried out in order to obtain the stress and strain distributions near the notch root. The Lemaitre and Chaboche fatigue model was applied using the point method (local approach) and the gradient method (non-local approach). [less ▲]

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See detailMultibody Dynamics Analysis of Differentials in Vehicle Drivetrains
Virlez, Geoffrey ULg; Bruls, Olivier ULg; Poulet, Nicolas et al

in Proceedings of the First Joint International Conference on Multibody System Dynamics (2010, May 26)

Differentials are critical components whose behaviour influences the dynamics of vehicles. They often include complex phenomena whose modeling is not always easy. In this paper, a model has been developed ... [more ▼]

Differentials are critical components whose behaviour influences the dynamics of vehicles. They often include complex phenomena whose modeling is not always easy. In this paper, a model has been developed for a limited slip differential (type C Torsen) which is mainly composed of an epicyclic gear train. In order to take into account flexibility, the nonlinear finite element method based on the absolute nodal coordinates has been chosen. The differential is modeled as a multibody system with various gear pairs and contact conditions. The model has been validated qualitatively and future work will address the identification of the various parameters and comparisons with experimental data. [less ▲]

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See detailMultibody Dynamics Analysis of Differentials in Vehicle Drivetrains with SAMCEF MECANO
Virlez, Geoffrey ULg; Pretot, Philippe

Conference (2010, October 13)

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See detailMULTICENTER BELGIAN SURVEY ON DONOR MORBIDITY AND MORTALITY IN ADULT-TO-ADULT LIVING DONOR LIVER TRANSPLANTATION
Troisi, Roberto I; Vogelaers, Dirk; Lerut, Jan et al

in Transplant International (2011, September), 24(2), 13-13

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See detailA multicenter collaborative study to measure the prevalence of pituitary disease : methodology and preliminary findings
Tikhomirova, M.; Daly, Adrian ULg; Petrossians, Patrick ULg et al

in 15th Meeting of the Belgian Endocrine Society : Bruxelles, 26 novembre 2005 (2005, November)

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See detailA multicenter collaborative study to measure the prevalence of pituitary disease : methodology and preliminary findings
Daly, Adrian ULg; Petrossians, Patrick ULg; Murat, A. et al

in 9th International Pituitary Congress - Abstract book (2005)

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See detailMulticenter evaluation of analytical performance of the Liaison((R)) troponin I assay
Pagani, F.; Stefini, F.; Chapelle, Jean-Paul ULg et al

in Clinical Biochemistry (2004), 37(9), 750-757

Objectives: This study evaluated the analytical characteristics of the Liaison(R) immunoassay for cardiac troponin I (cTnI). Design and methods: The protocol consisted of eight sections: evaluation of ... [more ▼]

Objectives: This study evaluated the analytical characteristics of the Liaison(R) immunoassay for cardiac troponin I (cTnI). Design and methods: The protocol consisted of eight sections: evaluation of antibody specificity, linearity, detection limit and imprecision, method comparison, evaluation of endogenous interferents, anticoagulant interference, sample stability, and reference values. Results: The assay equally measured free and complexed cTnI. The minimum detectable cTnI concentration was 0.021 mug/l. The cTnI concentration corresponding to a total CVof 10% was 0.056 mug/l. Linearity of response was demonstrated along the entire dynamic range of the assay. Assay interferences were minimal. cTnI concentrations in serum and heparinized plasma were significantly different. Values in EDTA plasma were on average approximately 5% higher than in matched serum, but this difference was not significant. The 99th percentile cTnI value in healthy subjects was 0.036 mug/l. Conclusions: Being sensitive, specific, and precise, the Liaison(R) cTnI assay meets current requirements to aid in the diagnosis of myocardial necrosis. (C) 2004 The Canadian Society of Clinical Chemists. All rights reserved. [less ▲]

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See detailMulticenter implementation of geriatric assessment in Belgian patients with cancer: A survey on treating physicians' general experiences and expectations.
Kenis, Cindy; Heeren, Pieter; Bron, Dominique et al

in Journal of geriatric oncology (in press)

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A ... [more ▼]

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A survey was carried out in 9 Belgian hospitals, which participated in a national GA implementation project focusing on older patients with cancer. A newly developed questionnaire was completed by their treating physicians. Data collection comprised of reviewing hospital data, general respondent data, and treating physicians' general experiences and expectations regarding GA. Descriptive statistics were calculated. RESULTS: Eighty-two physicians from 9 hospitals participated. The GA team composition can vary substantially, with a nurse as core member. Ideally, all older patients with cancer in whom a treatment decision is necessary, should benefit from the GA. Nearly all GA domains are reported as very important. Availability of GA results can be improved. Treating physicians want geriatricians to coordinate geriatric recommendations related to the identified GA problems, and expect from trained healthcare workers (THCWs) to collect GA data, to report GA results, and to follow-up the implementation of geriatric recommendations. CONCLUSION: This study identifies relevant information for improving the implementation of GA in older patients with cancer in Belgium and reveals priorities for a THCW from the treating physician's point of view. To increase the effectiveness of GA, further efforts are needed to improve the implementation of geriatric recommendations. [less ▲]

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See detailA multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis.
Pierard, Claudine ULg; Goffin, Véronique ULg; Decroix, Jacques et al

in Skin Pharmacology & Applied Skin Physiology (2002), 15(6), 434-41

Ketoconazole (KET) and zinc pyrithione (ZPT) are compounds active against the Malassezia spp. yeasts, which are believed to play a major role in dandruff and seborrheic dermatitis. We compared the ... [more ▼]

Ketoconazole (KET) and zinc pyrithione (ZPT) are compounds active against the Malassezia spp. yeasts, which are believed to play a major role in dandruff and seborrheic dermatitis. We compared the efficacy and safety of KET 2% and ZPT 1% in shampoo formulations for the alleviation of severe dandruff and seborrheic dermatitis. This open randomized, parallel-group trial began with a 2-week run-in phase during which subjects applied a neutral non-antidandruff shampoo. It was followed by a 4-week randomized treatment phase and a subsequent 4-week follow-up phase without treatment. Shampooing during the treatment period was carried out twice weekly for the KET group and at least twice weekly for the ZPT group in accordance with the label instructions. A total of 343 subjects were recruited to enter the trial. Of the 331 eligible volunteers, 171 were randomized to KET 2% and 160 to ZPT 1%. Clinical assessments were performed. Beneficial effects were evidenced for both medicated shampoos, but the effect was significantly better for KET 2%, which achieved a 73% improvement in the total dandruff severity score compared with 67% for ZPT 1% at week 4 (p < 0.02). The recurrence rate of the disease was also significantly lower following KET 2% treatment than following ZPT 1% treatment. As a consequence, the overall clearing of the skin condition at the end of treatment and follow-up phase was in favor of the KET 2% formulation (p = 0.004). Side effects were minimal. It is concluded that after a 4-week treatment, KET 2% shampoo was significantly superior to ZPT 1% shampoo in the treatment of subjects with severe dandruff or seborrheic dermatitis of the scalp. It is our assumption that this difference is noticeable for the patient and as a consequence relevant. Both formulations were well tolerated. [less ▲]

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See detailMulticenter randomized-control led clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after ileo-caecal resection
Van Gossum, André; Dewit, Olivier; Louis, Edouard ULg et al

in Inflammatory Bowel Diseases (2007), 13(2), 135-142

Background: Seventy percent of Crohn's disease (CD) patients exhibit anastomotic recurrence within I year after ileo-caecal surgery, Recent clinical trials suggest the beneficial use of probiotics in the ... [more ▼]

Background: Seventy percent of Crohn's disease (CD) patients exhibit anastomotic recurrence within I year after ileo-caecal surgery, Recent clinical trials suggest the beneficial use of probiotics in the control of intestinal inflammation in pouchitis and ulcerative colitis. This study is a multicenter clinical trial evaluating the efficacy of an oral administration of the probiotic LA1 on early postoperative endoscopic recurrence of CD. Methods: Seventy patients with CD were enrolled prior to elective ileo-caecal resection and randomly assigned after surgery to daily treatment with either Lactobacillus johnsonii, LA1, Nestle (10(10) colony-forming units, CFU) (group A, n = 34) or placebo (group B, n = 36) for 12 weeks. The primary objective was to assess the effect of LA1 on the endoscopic recurrence rate at 12 weeks. Stratification was performed according to smoking status at randomization. Results: Seven and 14 patients were excluded in the LA1 and placebo groups, respectively. In intention-to-treat analysis, the mean endoscopic score was not significantly different between the two treatment groups at 3 months (LA1 versus placebo: 1.50 +/- 1.32 versus 1.22 +/- 1.37, treatment effect: P = 0.48, smoke effect: P = 0.72). The percentage of patients with severe recurrence (i3 + i4) was 21% and 15% in the LA1 and placebo groups, respectively (P = 0.33). Using a per-protocol (PP) analysis, the mean endoscopic score was not significantly different between the two treatment groups (LA1 versus placebo groups: 1.44 +/- 1.31 versus 1.05 +/- 1.21, P = 0.32). The percentage of patients with severe recurrence (i3 + i4) was 19% and 9% in the LA1 and placebo groups, respectively (P = 0.054). Clinical relapse rate (CDAI [CD activity index] > 150, with an increase of CDAI > 70 points or greater from baseline) in the LAI and placebo groups was 15% (4/27) and 13.5% (3/22), respectively (PP analysis: chi-square test, P = 0.91 and log-rank test: P = 0.79). Conclusion: Oral administration of the probiotic LA1 in patients with CID failed to prevent early endoscopic recurrence at 12 weeks after ileo-caecal resection. [less ▲]

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See detailMulticenter Study of 19 Aortopulmonary Window parathyroid Tumors : The callenge of Embryologic origin
Arnault, Vincent; Beaulieu, Anthony; Lifante, Jean-Christophe et al

in World Journal of Surgery (2010), 34

Background Ectopic abnormal parathyroid glands are relatively common in the superior mediastinum but are rarely situated in the aortopulmonary window (APW). The embryological origin of these abnormal ... [more ▼]

Background Ectopic abnormal parathyroid glands are relatively common in the superior mediastinum but are rarely situated in the aortopulmonary window (APW). The embryological origin of these abnormal parathyroid glands is controversial. The purpose of this investigation was to investigate the embryological origin and the surgical management of abnormal parathyroid glands situated in the APW. Methods The databases of patients operated on for primary, secondary, and tertiary hyperparathyroidism at eight European medical centers with a special interest in endocrine surgery were reviewed to identify those with APW adenomas. Demographic features, localization procedures, and perioperative and pathology findings were documented. The embryological origin was determined based on the number and position of identified parathyroid glands. Results Nineteen (0.24%) APW parathyroid tumors were identified in 7,869 patients who underwent an operation for hyperparathyroidism (HPT) and 181 patients (2.3%) with mediastinal abnormal parathyroid glands. Ten patients had primary, eight had secondary, and one had tertiary HPT. Sixteen patients had undergone previous unsuccessful cervical exploration. In three patients, an APW adenoma was suspected by preoperative localization studies and was cured at the initial operation. Sixteen patients had persistent HPTof whom 15 were reoperated, resulting in 6 failures. Evaluation of 17 patients who had bilateral neck exploration allowed us to determine the most probable origin of the APW parathyroid tumors: 12 were supernumerary, 4 appeared to originate from a superior, and 1 from an inferior gland. Conclusions Abnormal parathyroid glands situated in the APW are rare and usually identified after an unsuccessful cervical exploration. Preoperative imaging of the mediastinum and neck are essential. The origin of these ectopically situated tumors is probably, as suggested by our data, from a supernumerary fifth parathyroid gland or from abnormal migration of a superior parathyroid gland during the embryologic development. [less ▲]

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See detailA multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation
Wlodarczyk, Zbigniew; Vanrenterghem, Yves; Krämer, Bernhard k et al

in BMC Nephrology (2012), 13

Background: This multicenter phase II study in renal transplantation compared 3 concentration-controlled ranges of FK778 (manitimus) with mycophenolate mofetil (MMF) both given in combination with ... [more ▼]

Background: This multicenter phase II study in renal transplantation compared 3 concentration-controlled ranges of FK778 (manitimus) with mycophenolate mofetil (MMF) both given in combination with tacrolimus and corticosteroids. Methods: 364 patients were randomized to 12-month treatment: high-level FK778 group (H, N = 87) received 4x600mg/day (4 days) followed by 120 mg/day; mid-level FK778 group (M, N = 92) received 3x600mg/day (3 days) followed by 110 mg/day, low-level FK778 group (L, N = 92) received 2x600mg/day (2 days) followed by 100 mg/day, and control group received MMF 1 g/day (MMF, N = 93). After week 6, FK778 doses were adjusted to trough ranges of 75–125 μg/mL (H), 50–100 μg/mL (M) and 25–75 μg/mL (L). Tacrolimus and steroids were administered at the same dose in each of the 4 groups. Results: Biopsy proven acute rejection (BPAR) at 24 weeks, the primary study endpoint, was comparable in the L (22.8%) and MMF (17.2%) groups but higher in the H (34.5%) and M (29.3%) groups. BPAR at 12 months was comparable in the L (23.9%) and MMF (19.4%) groups but higher in the H (34.5%) and M (31.5%) groups. Graft and patient survival were lowest in the H group and renal function was poorest in the H and M groups. Premature study withdrawal was highest in the H group. Conclusions: Efficacy was similar between the low-level FK778 and MMF groups. Increased FK778 exposure was poorly tolerated and did not improve efficacy. [less ▲]

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See detailMulticentre Evaluation of a Second Generation Point-of-Care Assay with an Extended Range for the Determination of N-Terminal Pro-Brain Natriuretic Peptide
Jorgensen, Bo; Bertsch, Thomas; Bröker, Hans-Joachim et al

in Clinical Laboratory (2012), 58

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See detailMulticentre evaluation of the Tosoh HbA1c G8 analyser
Chapelle, Jean-Paul ULg; Teixeira, Jelda ULg; Maisin, Diane et al

in Clinical Chemistry & Laboratory Medicine (2010), 48(3), 365-371

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See detailA multicentre, double-blind, placebo-controlled, dose-ranging study to investigate the efficacy and safety of oral doses dose of 311C90 in the acute treatment of migraine
Dahlöf, C.; Diener, H. C.; Goadsby, P. et al

in Clifford-Rose, F. (Ed.) New Advances in headache research (1994)

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See detailA multicentre, double-blind, randomized, placebo-controlled, parallel group study of multiple treatments of botulinum toxin type A (BoNTA) for the prophylaxis of episodic migraine headaches
Relja, M.; Poole, A. C.; Schoenen, Jean ULg et al

in Cephalalgia : An International Journal of Headache (2007), 27(6), 492-503

Our aim was to evaluate the safety and efficacy of botulinum toxin type A (BoNTA; BOTOX (R)) for prophylaxis of episodic migraine. In this double-blind, placebo-controlled study, patients were randomized ... [more ▼]

Our aim was to evaluate the safety and efficacy of botulinum toxin type A (BoNTA; BOTOX (R)) for prophylaxis of episodic migraine. In this double-blind, placebo-controlled study, patients were randomized to 225, 150 or 75 U of BoNTA or placebo after a 30-day placebo run-in for three 90-day treatment cycles. The primary efficacy end-point was the mean reduction from baseline in the frequency of migraine episodes at day 180 in the placebo non-responder stratum. All groups (N = 495) improved, with no significant differences. At day 180, the frequency of migraine episodes was reduced from baseline means of 4.3, 4.7, 4.7 and 4.4 by 1.6, 1.7, 1.5 and 1.4 for BoNTA 225 U, 150 U and 75 U and placebo, respectively. The primary end-point was not met. Treatment-related adverse events were transient and mild to moderate. BoNTA treatment was safe and well tolerated but did not result in significantly greater improvement than placebo in this study. Several factors may have confounded the results. [less ▲]

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See detailMulticentre, prospective, open study to evaluate the safety and efficacy of hylan G-F 20 in knee osteoarthritis subjects presenting with pain following arthroscopic meniscectomy.
Huskin, Jean-Pierre ULg; Vandekerckhove, B.; Delince, P. et al

in Knee Surgery, Sports Traumatology, Arthroscopy (2008), 16(8), 747-52

The aim of the study was to evaluate the safety and efficacy of viscosupplementation with hylan G-F 20 in patients with mild to moderate osteoarthritis (OA) presenting with persistent knee pain 4-12 weeks ... [more ▼]

The aim of the study was to evaluate the safety and efficacy of viscosupplementation with hylan G-F 20 in patients with mild to moderate osteoarthritis (OA) presenting with persistent knee pain 4-12 weeks after arthroscopic meniscectomy. A prospective, multi-centre, open study was carried out in patients with pain due to OA of the knee, not resolved by simple analgesics, 4-12 weeks after undergoing arthroscopic meniscectomy. To be eligible, patients had to score > or =50 mm and < or =90 mm on both walking pain and patient global assessment visual analogue scales (VAS; 0-100 mm) at baseline and be radiologically diagnosed pre-operatively with OA grade I or II on the Kellgren-Lawrence scale, with <50% joint space narrowing. Patients received three intra-articular, 2 ml injections of hylan G-F 20 in the target knee with an interval of 1 week between injections, and were followed for 52 weeks. The primary efficacy endpoint was the change from baseline in the walking pain VAS score at 26 weeks. Secondary outcome measures were the walking pain VAS scores at all other time points, the WOMAC Index at all time points, and patient and physician global assessment at all time points. The safety of the treatment was assessed using adverse event (AE) reports. A total of 62 patients (mean age 55.4 years, 52% male) were enrolled. The mean walking pain VAS score decreased by 36.8 mm from baseline at 26 weeks (P < 0.0001), and also showed statistically significant decreases (P < 0.0001) at all other time points. The change in WOMAC total and subscale scores from baseline were statistically significant (P < 0.0001) at all time points, as were the decreases in the physician and patient global assessment VAS scores. There were 18 target knee AEs (mostly pain and/or swelling and/or effusion) in 12 patients (19%) considered to be at least possibly related to treatment. The majority of these (78%) were mild or moderate in intensity. One patient (1.6%) experienced a serious adverse event (synovitis) in the target knee that was considered possibly related to study treatment. Hylan G-F 20 provides effective pain relief and improves stiffness and physical function in patients with mild to moderate OA presenting with persistent osteoarthritic pain 4-12 weeks after arthroscopic meniscectomy. Symptomatic efficacy was maximised at 12 weeks and maintained at 26 and 52 weeks. The type (pain and/or swelling and/or effusion) and the intensity (mostly mild/moderate) of AEs reported in this study are similar to those reported in other trials in different patient populations, but the incidence was higher (19%). The risk/benefit of hylan G-F 20 in this particular population of patients is favourable. [less ▲]

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See detailMulticentric evaluation of a turbidimetric myoglobin immunoassay
Lammers, M.; Chapelle, Jean-Paul ULg; Delanghe, J. et al

Poster (1992, August)

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