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See detailIpilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma?
PIERARD, Gérald ULg; Aubin, Francois; Humbert, Philippe

in Dermatology Research and Practice (2012), 2012

Malignant melanoma (MM) is one of the most aggressive skin cancer. The therapeutic options remain limited for advanced MM, and those directed to the neoplastic cells have not brought major survival ... [more ▼]

Malignant melanoma (MM) is one of the most aggressive skin cancer. The therapeutic options remain limited for advanced MM, and those directed to the neoplastic cells have not brought major survival advantage so far. Immunotherapy is another targeted option. Ipilimumab, a monoclonal antibody directed to CTLA-4 present on cytotoxic T cells boosts immunity, particularly its anti-MM activity. Under treatment, the overall survival of patients with MM metastases is moderately but significantly increased. The immuno-related adverse effects may be severe and life threatening. [less ▲]

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See detailIPM in Asia - A review of existing projects in the Philippines and Indonesia
Wynn, Nigel R.; Schiffers, Bruno ULg; Seghers, N. et al

in Agro-Chemicals News in Brief (1997), XX(2), 1-18

Integrated Pest Management means a pest management system that, in the context of the associated environment and the population dynamics of the pest species, utilizes ail suitable techniques and methods ... [more ▼]

Integrated Pest Management means a pest management system that, in the context of the associated environment and the population dynamics of the pest species, utilizes ail suitable techniques and methods in as compatible a manner as possible and maintains the pest populations at levels below those causing economically unacceptable damage or 1055. FAO-Code- of Conduct 1984. [less ▲]

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See detailIpNose : Electronic nose for remote bad odour monitoring system in landfill sites.
Perera, A.; Pardo, T.; Sundi, T. et al

in Proceedings of the 8th conference Eurodeur (2001)

Electronic noses are intelligent instruments that are able to classify and quantify different gas/odours. Here we suggest the integration of a small form factor computer inside the electronic nose. This ... [more ▼]

Electronic noses are intelligent instruments that are able to classify and quantify different gas/odours. Here we suggest the integration of a small form factor computer inside the electronic nose. This concept allows us to easily provide remote connectivity, large data storage and complex signal processing. The evolution of this technology will permit distributed sensing with applications to agriculture and environment. Proposed instrument allows incoming connections for remote control of bad odours in landfill sites. Preliminary approach to this application using commercial sensors and mixture model pattern recognition scheme is exposed. [less ▲]

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See detailIPOPv2 : Photoionization of Ni XIV - a test case
Delahaye, F.; Palmeri, P.; Quinet, Pascal ULg et al

in European Astronomical Society Publications Series (2013), 63

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See detailThe iPot Project: improved potato monitoring in Belgium using remote sensing and crop growth modelling
Piccard, I.; Nackaerts, K.; Gobin, A. et al

Poster (2015, April)

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See detailiPot: Industrial Potato monitoring for the Belgian potato sector using remote sensing and crop growth modelling
Wellens, Joost ULg

in Qu, Dongyu (Ed.) Develop Together for a Better Future (2015 Beijing World Potato Congress) (2015, July)

The Belgian potato processing industry has known a spectacular growth during the last decades. The companies active in this sector (most of them family owned enterprises) have succeeded – together with ... [more ▼]

The Belgian potato processing industry has known a spectacular growth during the last decades. The companies active in this sector (most of them family owned enterprises) have succeeded – together with primary producers and traders – to grow from 500.000 tons of processed potatoes in 1990 till 3.650.000 tons of raw material in 2012. When considering the production (in tons) per habitant, Belgium is ranked on the 4th place with a production of 395 tons per 1.000 inhabitants. Nowhere in the world are higher yields obtained than in Belgium. To keep up its position on the forefront of innovation, the potato processing industries are continuously looking at promising novel technologies that could improve business processes at any stage of growth. The close follow up of parcels on the land as form above is becoming an important tool to improve the quantity and the quality of the potato crop, and reduce the risks in order to plan the storage, packaging or processing and as such to strengthen the competiveness of the Belgian potato in a global market. The iPot project, financed by the Belgian Science Policy Office (BELSPO), aims to provide the Belgian potato sector, represented by Belgapom, with near real time information on field condition (weather-soil) and crop development, and with early yield estimates, derived from a combination of satellite images and crop growth models. Satellite images are used since long for crop monitoring at regional level by the public sector. Traditionally, low to medium resolution images, with pixel sizes from 250m to 1km are used for providing information on crop growth and development, and on yield at regional scale. However, the recent launch of constellations of high resolution optical sensors (DMC, Sentinel-2) offering spatially detailed information (20m pixel size) at high frequency (every 2 to 3 days) and at low cost, is creating a (r)evolution in the world of crop monitoring. Automatic processing chains have been developed to derive vegetation indices (NDVI) and biophysical parameters (fAPAR, LAI, fCover). Maps are being derived on a regular basis with for each pixel the actual development stage of the potato crop. This on-line scanning of the growth (phenology) is expected to result in an increased performance of crop growth models and better yield predictions. Once the data for crop phenology are incorporated into the model (B-CGMS), the yield data collected at the parcel level will be assimilated into the model using optimization algorithms to minimize the discrepancies between observed and simulated yield time series in order to improve further yield estimations. The combination of these new earth observation and modelling techniques arose the interest of a new type of users, mainly from the private sector (agro-industry, agricultural insurers, etc.). The iPot project aims to bridge the gap between the latest research efforts regarding crop growth monitoring and the industry. An intuitive web based geo-information platform is being developed to allow both the Belgian potato industry and research centers to access, analyze and combine the data with their own field observations in closed collaboration with the farmers, for improved decision-making. [less ▲]

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See detailLes IPP au très long cours: le problème est-il uniquement économique?
Vanmeerbeek, Marc ULg; Louis, Edouard ULg

in Revue Médicale de Liège (2006), 61(5-6), 483-7

Proton pump inhibitors are among the most prescribed drugs in Belgium, due to the high prevalence of gastrooesophageal reflux disease and significant impairment of health-related well-being. Short-term ... [more ▼]

Proton pump inhibitors are among the most prescribed drugs in Belgium, due to the high prevalence of gastrooesophageal reflux disease and significant impairment of health-related well-being. Short-term and long-term efficacy is superior to that of H2-receptor antagonists. Long-term safety is established. Empirical short-term treatment of symptomatic patients under 50 years of age without alarm signs is acceptable, but endoscopic investigation should always be performed before starting a long-term treatment. Doses for management of low-grade oesophagitis may be tailored to the patient's response. Continuous maintenance of full-dose is recommended for high grade oesophagitis. Surgical alternative is to be discussed with patients. Efficacy and mean cost for insurance plans are comparable. Endoscopic procedures are not yet sufficiently evaluated to be considered. Simple lifestyle advice is still useful. The burden of proton pump inhibitors cost is acceptable if they are prescribed at adequate doses. Cost-effective drugs should be chosen first. [less ▲]

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See detailIpriflavone has no effect on bone metabolism and causes lymphopenia in osteopenic women
Alexandersen, P; Toussaint, A; Reginster, Jean-Yves ULg et al

in Journal of Bone and Mineral Research (2000), 15(S1), 198

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See detailIpriflavone in prevention and treatment of postmenopausal and senile osteoporosis
Reginster, Jean-Yves ULg

in Osteoporosis News (1996), 4

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See detailIpriflavone in the treatment of postmenopausal osteoporosis: a randomized controlled trial.
Alexandersen, P; Toussaint, André ULg; Christiansen, C et al

in JAMA : Journal of the American Medical Association (2001), 285(11), 1482-8

CONTEXT: Data on the efficacy and safety of ipriflavone for prevention of postmenopausal bone loss are conflicting. OBJECTIVES: To investigate the effect of oral ipriflavone on prevention of ... [more ▼]

CONTEXT: Data on the efficacy and safety of ipriflavone for prevention of postmenopausal bone loss are conflicting. OBJECTIVES: To investigate the effect of oral ipriflavone on prevention of postmenopausal bone loss and to assess the safety profile of long-term treatment with ipriflavone in postmenopausal osteoporotic women. DESIGN AND SETTING: Prospective, randomized, double-blind, placebo-controlled, 4-year study conducted in 4 centers in Belgium, Denmark, and Italy from August 1994 to July 1998. PARTICIPANTS: Four hundred seventy-four postmenopausal white women, aged 45 to 75 years, with bone mineral densities (BMDs) of less than 0.86 g/cm(2). INTERVENTIONS: Patients were randomly assigned to receive ipriflavone, 200 mg 3 times per day (n = 234), or placebo (n = 240); all received 500 mg/d of calcium. MAIN OUTCOME MEASURES: Efficacy measures included spine, hip, and forearm BMD and biochemical markers of bone resorption (urinary hydroxyproline corrected for creatinine and urinary CrossLaps [Osteometer Biotech, Herlev, Denmark] corrected for creatinine), assessed every 6 months. Laboratory safety measures and adverse events were recorded every 3 months. RESULTS: Based on intent-to-treat analysis, after 36 months of treatment, the annual percentage change from baseline in BMD of the lumbar spine for ipriflavone vs placebo (0.1% [95% confidence interval (CI), -7.9% to 8.1%] vs 0.8% [95% CI, -9.1% to 10.7%]; P =.14), or in any of the other sites measured, did not differ significantly between groups. The response in biochemical markers was also similar between groups (eg, for hydroxyproline corrected for creatinine, 20.13 mg/g [95% CI, 18.85-21.41 mg/g] vs 20.67 mg/g [95% CI, 19.41-21.92 mg/g]; P =.96); urinary CrossLaps corrected for creatinine, 268 mg/mol (95% CI, 249-288 mg/mol) vs 268 mg/mol (95% CI, 254-282 mg/mol); P =.81. The number of women with new vertebral fracture was identical or nearly so in the 2 groups at all time points. Lymphocyte concentrations decreased significantly (500/microL (0.5 x 10(9)/L]) in women treated with ipriflavone. Thirty-one women (13.2%) in the ipriflavone group developed subclinical lymphocytopenia, of whom 29 developed it during ipriflavone treatment. Of these, 15 (52%) of 29 had recovered spontaneously by 1 year and 22 (81%) of 29 by 2 years. CONCLUSIONS: Our data indicate that ipriflavone does not prevent bone loss or affect biochemical markers of bone metabolism. Additionally, ipriflavone induces lymphocytopenia in a significant number of women. [less ▲]

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See detailIpriflavone inhibits interleukin-I stimulated neutral metalloprotease synthesis in human chondrocytes cultivated in clusters
Franchimont, P; Bassleer, C; Henrotin, Yves ULg et al

in Osteoarthritis and Cartilage (1994), 2(S1), 52

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See detailIpriflavone: Pharmacological Properties and Usefulness in Postmenopausal Osteoporosis
Reginster, Jean-Yves ULg

in Bone and Mineral (1993), 23(3), 223-32

Ipriflavone (IP) is an isoflavone derivative available in several countries for investigational and/or therapeutic use. Inhibition of bone resorption was demonstrated in several models, both in vitro and ... [more ▼]

Ipriflavone (IP) is an isoflavone derivative available in several countries for investigational and/or therapeutic use. Inhibition of bone resorption was demonstrated in several models, both in vitro and in vivo for IP and its metabolites. Their mechanisms of action on bone are not yet fully elucidated but some of them are widely accepted. IP does not possess, per se, any estrogenic activity. It appears that IP-related inhibition of bone resorption might be mediated by an indirect effect on osteoclast and related to an inhibition of recruitment and/or differentiation of pre-osteoclast, maybe through a modulation of osteoblast response to PTH. Clinical studies in Paget's disease of bone or primary hyperparathyroidism have confirmed preferential inhibition of bone resorption suggesting a clinical interest in postmenopausal osteoporosis. Preliminary (1 year) results of double blind placebo controlled studies designed in postmenopausal and senile osteoporosis confirm a reduction in bone turnover rate in patients treated with 600 mg/day of IP, resulting in a significant bone-sparing effect both at lumbar and radial levels. All clinical and pharmacological trials confirm a very good tolerance of IP with a frequency of adverse reactions equal to that observed during administration of a placebo. Providing ongoing studies will confirm the actual promising preliminary results, IP seems a very interesting new non hormonal approach for prevention and treatment of postmenopausal and senile osteoporosis. [less ▲]

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See detailIPSAS in a nutshell - from principles to practice
Schumesch, Patrice ULg; De Laet, Jan; De Greef, Anton

Book published by PwC (2012)

Whilst there are calls for adopting high-quality, transparent and international accounting rules for governments and other public sector entities, many government officials and public sector accountants ... [more ▼]

Whilst there are calls for adopting high-quality, transparent and international accounting rules for governments and other public sector entities, many government officials and public sector accountants are not familiar with the requirements of IPSAS (International Public Sector Accounting Standards) and with the often substantial changes that adoption of these rules may imply, mainly for those entities that use cash accounting. Consequently they are not fully aware of the implications of applying IPSAS for their own organisation. The book aims to create an awareness of IPSAS; it avoids reproducing exhaustively the IPSAS texts but rather seeks to highlight the main accounting issues and principles, and explains how to apply them in practice. The objective is to be didactic and easy to read. Throughout the book, comments are inserted to provide practical guidance for professionals who work or may work with IPSAS as preparers or users of financial statements. [less ▲]

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See detailIPSAS in a nutshell - from principles to practice
Schumesch, Patrice ULg; De Greef, Anton; De Laet, Jan

Book published by PwC - 2nd edition (2015)

The second edition of PwC’s IPSAS handbook: IPSAS in a nutshell - From principles to practice includes up-to-date information on standards and guidelines issued up to 31 March 2015. This latest edition is ... [more ▼]

The second edition of PwC’s IPSAS handbook: IPSAS in a nutshell - From principles to practice includes up-to-date information on standards and guidelines issued up to 31 March 2015. This latest edition is accompanied by the IPSAS in a nutshell - Test your IPSAS knowledge, a volume containing 200 questions and answers with two levels of difficulty designed to help the reader assess its understanding of IPSAS (International Public Sector Accounting Standards), the reference accounting and reporting framework for governments and other public sector entities. The book is written in a concise, easy-to-read and easy-to-use manner, and is designed as a guide to help readers enhance their understanding of current developments in public sector accounting, as well as key accounting and operational implications of IPSAS adoption. The 380-page handbook is a must-read for anyone in a role impacted by IPSAS. It includes practical tips and comments derived from the authors' extensive experience in applying IPSAS. The volumes are specifically aimed at practitioners and non-practitioners, government officials and other public sector decision makers. They also make an inspiring reference manual for anyone interested in the public accounting debate. [less ▲]

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See detailIpsilateral motor responses to focal TMS in normal man and stroke patients.
ALAGONA G.; DELVAUX, Valérie ULg; Delwaide, Paul ULg et al

in Clinical Neurophysiology (2000), 111(Suppl. 1), 11512-05

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See detailIpsilateral motor responses to focal transcranial magnetic stimulation in healthy subjects and acute-stroke patients
Alagona, Giovanna; DELVAUX, Valérie ULg; GERARD, Pascale ULg et al

in Stroke (2001), 32(6), 1304-1309

BACKGROUND AND PURPOSE: Prevalence and characteristics of ipsilateral upper limb motor-evoked potentials (MEPs) elicited by focal transcranial magnetic stimulation (TMS) were compared in healthy subjects ... [more ▼]

BACKGROUND AND PURPOSE: Prevalence and characteristics of ipsilateral upper limb motor-evoked potentials (MEPs) elicited by focal transcranial magnetic stimulation (TMS) were compared in healthy subjects and patients with acute stroke. METHODS: Sixteen healthy subjects and 25 patients with acute stroke underwent focal TMS at maximum stimulator output over motor and premotor cortices. If present, MEPs evoked in muscles ipsilateral to TMS were analyzed for latency, amplitude, shape, and center of gravity (ie, preferential coil location to elicit them). In stroke patients, possible relationships between early ipsilateral responses and functional outcome at 6 months were sought. RESULTS: With relaxed or slightly contracting target muscle, maximal TMS over the motor cortex failed to elicit ipsilateral MEPs in the first dorsal interosseous (FDI) or biceps of any of 16 normal subjects. In 5 of 8 healthy subjects tested, ipsilateral MEPs with latencies longer than contralateral MEPs were evoked in FDI muscle (in biceps, 6 of 8 subjects) during strong (>50% maximum) contraction of the target muscle. In 15 of 25 stroke patients, ipsilateral MEPs in the unaffected relaxed FDI (in biceps, 6 of 25 stroke patients) were evoked by stimulation of premotor areas of the affected hemisphere. Their latencies were shorter than those that MEPs evoked in the same muscle by stimulation of the motor cortex of the contralateral unaffected hemisphere. Such responses were never obtained in normal subjects and were mostly observed in patients with subcortical infarcts. Patients harboring these responses had slightly better bimanual dexterity after 6 months. CONCLUSIONS: Ipsilateral MEPs obtained in healthy individuals and stroke patients have different characteristics and probably different origins. In the former, they are probably conveyed via corticoreticulospinal or corticopropriospinal pathways, whereas in the latter, early ipsilateral MEPs could originate in hyperexcitable premotor areas. [less ▲]

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See detailIpsilateral motor responses to focal transcranial magnetic stimulation in normal and stroke patients.
ALAGONA G.; DELVAUX, Valérie ULg; GERARD, Pascale ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (2000), Neurosurgery and Psychiatry

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See detailIpsilateral responses after a stroke : an electrophysiological study by focal TMS
Alagona, Giovanna; Rapisarda, giuseppe; DELVAUX, Valérie ULg

Poster (1999)

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See detailThe Iq motif defines the conformation of the interacting calmodullin
Rebowski; Terrak, Mohammed ULg; Lu, R. C. et al

in Biophysical Journal (2004, January), 86

Detailed reference viewed: 11 (5 ULg)