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Peer Reviewed
See detailThe Impact of the Salience of Fluency in Recognition Memory in Alzheimer’s Disease
Simon, Jessica ULg; Bastin, Christine ULg; SALMON, Eric ULg et al

Poster (2014, March 11)

Introduction: According to the dual-process models, recognition memory is supported by recollection and familiarity (Yonelinas, 2002). Familiarity is a complex function that depends on several processes ... [more ▼]

Introduction: According to the dual-process models, recognition memory is supported by recollection and familiarity (Yonelinas, 2002). Familiarity is a complex function that depends on several processes. One of the most important mechanisms is the sense of familiarity driven by the fluency processing (Whittlesea, 1993). The fluency can be defined by the enhancement of processing speed and the ease of processing due to an earlier encounter with the stimulus. Our objective is to explore the effect on an increase of salience of fluency cues on the recognition memory performance of patients with Alzheimer disease (AD). Methods: Sixteen AD patients and sixteen healthy elderly controls (HC) performed two conditions of a memory task. In the study phase, 25 words were presented at a rate of one word every 1.5s. Participants were instructed to read the words aloud and to try and remember them. After a break of 5 minutes, participant performed a yes/no recognition task with 25 studied words and 25 new words. In the Non-Overlap condition, the 25 studied words were composed of a subset of letters of the alphabet and the 25 new words of the remaining letters. In the Overlap condition, the 50 words were based on the whole alphabet. The two recognition tasks were separated by a delay of 24h. Results: The capacity to discriminate between old and new items was measured by the index d’. A 2 (group) by 2 (condition) repeated measure ANOVA on d’ scores revealed that discrimination was poorer in the AD group than in the HC [F(1,30)=48.07, p<.001] and also poorer in the Overlap condition than in the Non-Overlap condition [F(1,30)=19.901, p<.001]. Conclusion: The current results showed that to increase salience of fluency at the level of letter by eliminating letter-overlap between old and new words increases the recognition performance to the same extent in both groups but the amplitude of AD memory deficit was not reduced (Bastin, Willems, Genon, & Salmon, 2013). [less ▲]

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Peer Reviewed
See detailThe impact of the salience of fluency in recognition memory in Alzheimer’s disease
Simon, Jessica ULg; Bastin, Christine ULg; SALMON, Eric ULg et al

Poster (2013, December 06)

According to the dual-process models, recognition memory is supported by recollection and familiarity (Yonelinas, 2002). Familiarity is a complex function that depends on several processes. One of the ... [more ▼]

According to the dual-process models, recognition memory is supported by recollection and familiarity (Yonelinas, 2002). Familiarity is a complex function that depends on several processes. One of the most important mechanisms is the sense of familiarity driven by the fluency processing (Whittlesea, 1993). The fluency can be defined by the enhancement of processing speed and the ease of processing due to an earlier encounter with the stimulus. Our objective is to explore the effect on an increase of salience of fluency cues on the recognition memory performance of patients with Alzheimer disease (AD). Sixteen AD patients and sixteen healthy elderly controls (HC) performed two conditions of a memory task. In the study phase, 25 words were presented at a rate of one word every 1.5s. Participants were instructed to read the words aloud and to try and remember them. After a break of 5 minutes, participant performed a yes/no recognition task with 25 studied words and 25 new words. In the Non-Overlap condition, the 25 studied words were composed of a subset of letters of the alphabet and the 25 new words of the remaining letters. In the Overlap condition, the 50 words were based on the whole alphabet. The two recognition tasks were separated by a delay of 24h. The capacity to discriminate between old and new items was measured by the index d’. An ANOVA on d’ scores revealed that discrimination was poorer in the AD group than in the HC and also poorer in the Overlap condition than in the Non-Overlap condition. The current results showed that to increase salience of fluency at the level of letter by eliminating letter-overlap between old and new words increases the recognition performance to the same extent in both groups but the amplitude of AD memory deficit was not reduced (Bastin, Willems, Genon, & Salmon, 2013). [less ▲]

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See detailImpact of the somatotrope Growth Hormone (GH)/Insulin-like Growth Factor 1 (IGF-1) axis upon thymus function: Pharmacological implications in regeneration of immune functions
Goffinet, Lindsay ULg; Mottet, Marie ULg; Kermani, Hamid et al

in Immunology, Endocrine & Metabolic Agents - Medicinal Chemistry (2011), 11

The thymus is the central lymphoid structure where T-cell differentiation takes place, and a crucial organ for the maintenance of homeostasis in the immune system. Thymopoiesis includes intrathymic ... [more ▼]

The thymus is the central lymphoid structure where T-cell differentiation takes place, and a crucial organ for the maintenance of homeostasis in the immune system. Thymopoiesis includes intrathymic proliferation of T-cell precursors, selection and output of both self-tolerant and competent effector T cells, as well as of natural regulatory T cells (nTreg). In the crosstalk between the neuroendocrine and immune systems, peptide hormones have been more and more implicated in immunomodulation for the last thirty years. The somatotrope growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in particular has been repeatedly shown to play a major regulatory role upon thymus function and T-cell development. This review will focus on the important thymotropic properties of the somatotrope GH/IGF-1 axis, and will try to discriminate these properties in function of the endocrine or paracrine/autocrine pathways involved in their mediation. Most importantly, in light of an increasing number of recent studies, GH and IGF-1 now appear as a novel therapeutic agents that could be used for enhancing thymopoiesis in different cases of immune deficiencies, including aging-related immune dysfunction. [less ▲]

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See detailImpact of the spatial resolution on the Greenland Ice Sheet Surface Mass Balance modelling using the regional climate model MAR with the aim to force an ice sheet model.
Franco, Bruno ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

Poster (2011, April 05)

By using the regional climate model MAR (Modèle Atmosphérique Régional), validated for Greenland at 25km resolution and forced every 6 hours with the ERA-INTERIM reanalysis (Fettweis 2007, Fettweis et al ... [more ▼]

By using the regional climate model MAR (Modèle Atmosphérique Régional), validated for Greenland at 25km resolution and forced every 6 hours with the ERA-INTERIM reanalysis (Fettweis 2007, Fettweis et al. 2010), we have modelled the Greenland Ice Sheet (GrIS) Surface Mass Balance (SMB) at 20, 25, 30, 40 and 50km resolution to assess the impact of the spatial resolution. As part of the ICE2SEA project, the 25km-resolution SMB outputs of the MAR model are used as forcing fields for ice sheet models, in order to produce future projections of the GrIS contribution to sea-level rise over the next 200 years. Although the current spatial resolution of the MAR model (25km) is much higher than the general circulation models (GCM) resolution (150-300km), the ice sheet models often run at a higher resolution (typically 5-10km). Nevertheless, such higher-resolution runs of the MAR model on the same integration domain generate a significant additional computing time and are not doable until now. Moreover, conventional linear interpolations of the SMB outputs onto a higher-resolution grid, generally induce biases because ice sheet masks at different spatial resolutions do not match and the SMB is a very complex function of the spatial resolution and the topography . That is why several enhanced SMB interpolations are tested here in order to reduce biases when interpolating the MAR outputs onto higher resolution, in the framework of the ICE2SEA project. [less ▲]

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See detailImpact of the spray drying conditions on inulin's physical properties
Ronkart, Sébastien; Blecker, Christophe ULg; Deroanne, Claude et al

Poster (2008, July)

Detailed reference viewed: 27 (8 ULg)
See detailImpact of the Structure of Biocompatible Aliphatic Polycarbonate on siRNA Transfection Ability
Frère, Antoine ULg; Kawalec, Michal; Tempelaar, Sarah et al

Poster (2014, May 26)

Detailed reference viewed: 57 (22 ULg)
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Peer Reviewed
See detailImpact of the Structure of Biocompatible Aliphatic Polycarbonates on siRNA Transfection Ability
Frère, Antoine ULg; Kawalec, Michal; Tempelaar, Sarah et al

in Biomacromolecules (2015)

RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium and/or ... [more ▼]

RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium and/or morpholino functionalized biocompatible and biodegradable polycarbonate vectors. The impact of different functions (morpholino-, guanidinium-, hydrophobic groups), of the architecture (linear homopolymer to dumbbell-shape) and of the molecular weight of these copolymers on their capacity to form polyplexes and to decrease the expression of two epigenetic regulators of gene expression, HDAC7 and HDAC5 was evaluated. The use of one of these polymers combining morpholine and guanidine functions at the ratio >1 and hydrophobic trimethylene carbonate groups showed a significant decrease of mRNA and protein level in HeLa cells, similar to PEI. These results highlight the potential of polycarbonate vectors for future in vivo application as an anti-cancer therapy. [less ▲]

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See detailIMPACT OF THE TEMPERAMENT OF YOUNG STALLIONS ON THEIR STRESS REACTIONS WHEN SUBJECTED TO A STANDARDISED VETERINARY EXAMINATION
Peeters, Marie ULg; Verwilghen, Denis ULg; Serteyn, Didier ULg et al

in Journal of Veterinary Behavior: Clinical Applications and Research (2011, September), 6

Detailed reference viewed: 38 (5 ULg)
Peer Reviewed
See detailImpact of the transfer climate on the transfer of training: moderating role of job satisfaction and job engagement
Peters, Stéphanie ULg; Liégeois, Arnaud; Faulx, Daniel ULg

Conference (2011, May 28)

This paper presents first results of a study that examines the impact of the workplace climate on workplace training effectiveness. Here training effectiveness is conceptualised in terms of transfer of ... [more ▼]

This paper presents first results of a study that examines the impact of the workplace climate on workplace training effectiveness. Here training effectiveness is conceptualised in terms of transfer of training and the workplace climate is specified in terms of transfer climate. According to the theoretical framework by Carr, Schmidt, Ford and DeShon (2003), we hypothesise that the impact of the transfer climate on the transfer of training will be moderated and/or mediated by cognitive and affective states. Statistical analyses will be conducted to check the hypothesised mediating and moderating role of job satisfaction (affective state) and job engagement (cognitive state) between the transfer climate and the transfer of the newly acquired knowledge. Transfer climate has been broadly studied for its direct impact on transfer of training. The major issue of this study is to examine the interaction of the transfer climate with other variables In a longitudinal quantitative study, data are collected at the Belgian Sickness Fund. Participants are employees who took part to a training session between March and December 2010 (N=680). Right after the conclusion of the training program, each trainee is invited to fill the Learning transfer System Inventory (Holton, Bates, & Ruona, 2000), a scale measuring 16 dimensions of the transfer climate. One month later, participants are asked to fill a second questionnaire about their perception of the transfer (general and specific performance), job satisfaction (Price, 1977) and job engagement (Schaufeli & Bakker, 2003). [less ▲]

Detailed reference viewed: 157 (6 ULg)
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See detailImpact of the treatment conditions of a formic/acetic acid delignification method on chemical structure and antioxidant activity of beech wood lignin
Simon, Mathilde ULg; Vanderghem, Caroline ULg; Richel, Aurore ULg et al

Poster (2011)

The interest in lignocellulosic substrates is increasing because they are clearly identified for their high potential of development in energy and value-added molecules production. Indeed lignocellulosic ... [more ▼]

The interest in lignocellulosic substrates is increasing because they are clearly identified for their high potential of development in energy and value-added molecules production. Indeed lignocellulosic biomass constitutes a promising resource for a sustainable production of organic compounds and biobased products that could progressively replace molecules from the petrochemical industry. Until now lignocellulosic substrates were mainly used for the valorization of cellulose. Hemicelluloses and lignins were less valorized and often degraded after the process. However, due to their phenolic structure, lignins can be valorized in a lot of high-valued applications like vanillin production, replacement of petrochemical polymers, antioxidants for cosmetics and food industry, resins… In this study, a representative sample of beech wood (Fagus sylvatica L.) was collected in the region of Gaume in Belgium. Beech wood was delignified at atmospheric pressure by an organosolv process using a mixture of formic acid/acetic acid/water. The effect of cooking time and temperature was evaluated on the structure, physico-chemical properties and antioxidant activity of the lignins obtained from the black liquor after treatments. The structural and physico-chemical characteristics of the lignins were investigated with different tools like infrared spectrometry, thermogravimetric analysis, gel permeation chromatography after acetylation of lignins, NMR 1H, 13C and HSQC. The antioxidant activity was assessed by a spectrophotometric method using the α,α-diphenyl-β-picrylhydrazyl radical (DPPH). [less ▲]

Detailed reference viewed: 62 (14 ULg)
Peer Reviewed
See detailImpact of the trophic strategy on the eco-functional diversification of a coral reef fish family
Gajdzik, Laura ULg; Aguilar-Medrano, Rosalia; Parmentier, Eric ULg et al

Conference (2015, September)

The analyses of the role of trophic strategies as promoter or constraint on processes of diversification remain understudied, especially in fish. The Pomacentridae (damselfishes), a species-rich (394 ... [more ▼]

The analyses of the role of trophic strategies as promoter or constraint on processes of diversification remain understudied, especially in fish. The Pomacentridae (damselfishes), a species-rich (394 species) and worldwide distributed reef fish family, include three main trophic guilds: (1) pelagic zooplankton feeders, (2) benthic feeders grazing on turf algae or biting polyps and (3) an intermediate group feeding on zooplankton, small benthic invertebrates and algae. Our study aims to analyze the role of the trophic strategies in the eco-functional diversity of Pomacentridae. Due to its feeding versatility, we hypothesize that the intermediate trophic group is the most successful group in terms of eco-functional diversity through evolutionary time. To target our aim, we compiled detailed dietary, environmental and behavioral data for 201 pomacentrid species, and compared the eco-functional diversity among trophic guilds. Various metrics, such as functional entity (i.e. unique combinations of functional traits) and functional richness revealed that the intermediate trophic group exhibited the lowest diversity. Then, we used time-calibrated phylogenies and comparative methods to evaluate the impact of trophic strategies on the tempo of ecological diversification. Results were consistent and the lowest rate of diversification was found for the intermediate trophic group. Our study shows that a generalist trophic strategy does not promote ecological diversification but being specialized may increase the ability to evolve greater diversity. [less ▲]

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See detailImpact of the Use of Crumb Rubber Modified Binder on Tire/Road Noise Generation
Luong, Jeanne ULg; Bueno, M.; Teran, F. et al

Conference (2011, June)

The recycling of waste material produced by human activity is one of the challenges of our generation. One of the most serious environmental problems of the recent years is mass production of tire and the ... [more ▼]

The recycling of waste material produced by human activity is one of the challenges of our generation. One of the most serious environmental problems of the recent years is mass production of tire and the di􏰟culty of disposing of them. The material and energetic valorization of the wasted tires is possible through the extension of 􏰔green roads􏰕. The incorporation of crumb rubber from wasted tires in bi- tuminous binders allows the design of new asphalt pavements with a higher viscosity. A preliminary study to determine the impact of the use of crumb rubber modi􏰝ed bituminous binder in the sound generation level for a thin layer type BBTM11A, has been carried out by the LA2IC. These results are compared with sound level from a BBTM11A with a conventional binder. This work presents the acoustical characterization performed on the regional road CM-3102 in Ciudad Real (Castilla- La Mancha), based on the close proximity methodology (Tiresonic Mk4-LA2IC ). In addition, mea- surements of super􏰝cial macrotexture pro􏰝le have been realized with the LaserDynamicPG-LA2IC to study the relationship with close proximity road noise. Furthermore, sound absorption measurements of BBTM11A compacted samples have been analyzed to understand the mechanisms involved in the sound generation. The results show that addition of crumb rubber by the wet process leads, in this case (20% crumb rubber content), to a decrease in the sound level emitted by the interaction between tire and road surface, at low frequency by mu􏰠ing the vibrations and by sounf absorption at high frequency. [less ▲]

Detailed reference viewed: 19 (0 ULg)